Objective： To investigate the expression of apoptosis related genes p53 and bcl-2 in atypical hyperplasia of mammary duct and the relationship between the gene expression and oncogenesis of breast. Methods： mRNA of ...Objective： To investigate the expression of apoptosis related genes p53 and bcl-2 in atypical hyperplasia of mammary duct and the relationship between the gene expression and oncogenesis of breast. Methods： mRNA of apoptosis related gene p53 and bcl-2 were detected by in situ hybridization in 44 cases of atypical ductal hyperplasia. p53 protein expression was detected by immunohistochemistry. The data were compared with those of 6 cases of benign hyperplasia and 26 cases of breast carcinoma. Results： The expression of p53 mRNA was 66.7% in benign hyperplasia, 40% in atypical ductal hyperplasia （55.6% in mild, 41.7% in medium, 26.1% in severe） and 19.2% in carcinoma （of which 21.4% were intraductal carcinoma and 16.7% were invasive）. The expression of p53 protein was negative in benign hyperplasia, 24% in atypical hyperplasia （mild 11.1%, medium 25%, severe 34.8%）, 38.5% in carcinoma （intraductal carcinoma 35.7%, invasive ductal carcinoma 41.7%）. The expression of bcl-2 was negative in benign hyperplasia, 78.6% in intraductal carcinoma, 83.3% in invasive ductal carcinoma. Conclusion： Loss and mutation of p53 gene and excessive expression bcl-2 mRNA were detected in severe atypical ductal hyperplasia.展开更多
Background:Mammary duct ectasia is an acute or chronic inflammatory breast disease that occurs mainly in nonlactating women.It rarely occurs in the accessory breast.The etiology of this condition remains unclear.The l...Background:Mammary duct ectasia is an acute or chronic inflammatory breast disease that occurs mainly in nonlactating women.It rarely occurs in the accessory breast.The etiology of this condition remains unclear.The long course and complex clinicalmanifestations of this disease in some patients make it easy to misdiagnose.Case Presentation:Herein,we report a case of bilateral accessory breast duct ectasia.A 34-year-old nonlactating Chinese woman presented with a mass in the right axilla.Physical examination and ultrasonography revealed inflammatory lesions in both accessory breasts.Laboratory data and magnetic resonance imaging revealed hyperprolactinemia and pituitary microadenoma.Penicillin and bromocriptine were administered to prevent infection and reduce serum prolactin levels.We performed a simple mastectomy of the bilateral accessory breasts.The outcome was satisfactory.Conclusion:This article reports the first case of bilateral accessory breast associated with pituitary microadenoma and reviews the literature to provide a reference for clinicians.展开更多
基金This work was supported by the Natural Sciences Foundation of Liaoning Province (No.002037).
文摘Objective： To investigate the expression of apoptosis related genes p53 and bcl-2 in atypical hyperplasia of mammary duct and the relationship between the gene expression and oncogenesis of breast. Methods： mRNA of apoptosis related gene p53 and bcl-2 were detected by in situ hybridization in 44 cases of atypical ductal hyperplasia. p53 protein expression was detected by immunohistochemistry. The data were compared with those of 6 cases of benign hyperplasia and 26 cases of breast carcinoma. Results： The expression of p53 mRNA was 66.7% in benign hyperplasia, 40% in atypical ductal hyperplasia （55.6% in mild, 41.7% in medium, 26.1% in severe） and 19.2% in carcinoma （of which 21.4% were intraductal carcinoma and 16.7% were invasive）. The expression of p53 protein was negative in benign hyperplasia, 24% in atypical hyperplasia （mild 11.1%, medium 25%, severe 34.8%）, 38.5% in carcinoma （intraductal carcinoma 35.7%, invasive ductal carcinoma 41.7%）. The expression of bcl-2 was negative in benign hyperplasia, 78.6% in intraductal carcinoma, 83.3% in invasive ductal carcinoma. Conclusion： Loss and mutation of p53 gene and excessive expression bcl-2 mRNA were detected in severe atypical ductal hyperplasia.
文摘Background:Mammary duct ectasia is an acute or chronic inflammatory breast disease that occurs mainly in nonlactating women.It rarely occurs in the accessory breast.The etiology of this condition remains unclear.The long course and complex clinicalmanifestations of this disease in some patients make it easy to misdiagnose.Case Presentation:Herein,we report a case of bilateral accessory breast duct ectasia.A 34-year-old nonlactating Chinese woman presented with a mass in the right axilla.Physical examination and ultrasonography revealed inflammatory lesions in both accessory breasts.Laboratory data and magnetic resonance imaging revealed hyperprolactinemia and pituitary microadenoma.Penicillin and bromocriptine were administered to prevent infection and reduce serum prolactin levels.We performed a simple mastectomy of the bilateral accessory breasts.The outcome was satisfactory.Conclusion:This article reports the first case of bilateral accessory breast associated with pituitary microadenoma and reviews the literature to provide a reference for clinicians.
