Pharmaceutical interfaces: Drug development,performance, regulation and e-health

Interfaces have always been of concern with respect to the delivery of bioactives.Interfaces within the delivery system that can affect stability are a concern;however,there are other interfaces of importance,such as the interface with the body tissue,the regulatory interface and the emerging interface when drug delivery is linked to e-health applications.This presentation will address all these interfaces covering basic science aspects as well as discussion of e-health applications.There are interfaces between different phases in formulations such as emulsions,foams,suspensions etc.There are interfaces between actives and excipients within a formulation.The actives as well as excipients may be in different states.

User Interface Development Based on Ontologies

The user interface is a central component of any mo de rn application program. It determines how well end users accept, learn, and effi ciently work with the application program. The user interface is very difficult to design, to implement, to modify. It takes approximately 70% of the time requ ired for designing an application program. All the existing tools for user interface design can be divided into two basic c ategories-Interface Builders and Model-based Interface development tools, whic h trace their roots from user interface management systems. Interface Builders a re the most widespread and excellent to create layouts and manipulate widgets. H owever, Interface Builders have the follow demerits. An interface designed using Interface Builders can contain hundreds of procedures. Interface Builders give us no possibility to develop different pieces of the same interface separately. They do not help us in managing user tasks and can be used only by programmers. Model-based interface development tools have attracted a high degree of interes t in last few years. The basic premise of model based technology is that the interface development can be fully supported by declarative models of all user interface characteristics such as their presen tation, dialogue, domain of application etc, and then the user interface develop ment can be centered around such models. The high potential of this technology has not been realized yet. This fact has the following reasons. The known interface models are partial representations of interfaces. They cannot be readily modified by developers, and are not publicly available to the HCI community. The central ingredient for success in model-ba sed systems is a declarative, complete, versatile interface model that can expre ss a wide variety of interface designs. Therefore tool developers have to avoid the following disadvantages of current interface models: inflexibility, system- dependence, and incompleteness. The main idea to achieve these model character istics mention above is to use ontologies. This broadened interest in ontologies is based on the fact that they provide ma chine-understandable representation of semantics for information, and a shared and common understanding of a domain that can be communicated between people and across application systems. Support in data, information, and knowledge exchang e becomes the key issue in current computer technology. At the moment we are on the brink of the second Web generation called Semantic Web or Knowledgeable Web. Given the increasing amount of information available on-line, this kind of sup port is becoming more important day by day. The main idea of the proposed approach is to replace interface models by appropr iate ontologies. Some parts of these ontologies will be available from the Inter net; the other parts will be built by developers. As a result of the Semantic We b development we will have increasing the number of ontologies formally describe d in the Internet. The terminology and content of these ontologies will be inter nationally standardized. Reusing these ontologies will bring down the cost of de velopment and improve the quality of user interface. The parts of a user interface model are-a domain ontology model, a dialog ontol ogy model, presentation ontology model, "business- logic" variable ontology mod el and correspondences between these parts. Thus, the user interface development based on ontologies is an evolution of th e model-based approach, where appropriate ontologies are used instead of models .

6-15 Development of the User Interface for C-ADS Accelerator System Using CS-Studio

CSS (Control System Studio) is one of the interface development tools that can be used for the EPICS (ExperimentalPhysics and Industrial Control System) distributed control system structure. It is composed of Javadevelopments, independent of platform, that can provide monitoring control system interface display, data archivingand analysis, PV management and alarm system.

Influence of interface morphology on dynamic behavior and energy dissipation of bi-material discs

To investigate the dynamic behavior and energy dissipation of the rock−concrete interface,dynamic splitting tests on bi-material discs were conducted by using the split Hopkinson pressure bar.The test results reveal that with the change of the interface inclination angles(θ),the influence of interface groove width on the bearing capacity of specimens also varies.Whenθincreases from 0°to 30°,the bearing capacity of the specimen increases first and then decreases with the rise of the interface groove width;the optimal groove width on the rock surface in this range of interface inclination angles is 5 mm.Whenθincreases from 45°to 90°,the bearing capacity of the specimen has no obvious change.Moreover,whenθincreases from 0°to 45°,the dissipated energy of the specimens rises obviously at first and then tends to be stable as the width of the interface groove increases.

Analysis of Drivers＇Burden and Man－Machine Interfaces in High－Speed Locomotive Driving Cab

With the introduction of high-speed trains into chinese railway system, closeattention should be paid to the aspects of safety in hish-speed railways. Thereare many interfaces which are very important and directly related to drivmgsafety. This paper focuses on features of design and analyses the principles ofsafety.

Artificial Intelligence and the Sustainable Development Goals: An Exploratory Study in the Context of the Society Domain

Artificial Intelligence (AI) experienced significant advancements in recent years, and its potential power is already recognized across various industries. Yet, the rise of AI has led to a growing concern about its impact on meeting the Sustainable Development Goals (SDGs). The aim of this paper was to evaluate contributions and the potential influence of AI to sustainable development in the society domain. Furthermore, the study analyzed GPT-3 responses, as one of the largest language models developed by OpenAI, descriptively. We conducted a set of queries on the SDGs to gather information on GPT-3’s perceptions of AI impact on sustainable development. Analysis of GPT-3’s contribution potential towards the SDGs showcased its broad range of capabilities for contributing to the SDGs in areas such as education, health, and communication. The study findings provide valuable insights into the contributions of AI to sustainable development in the society domain and highlight the importance of proper regulations to promote the responsible use of AI for sustainable development. We highlighted the potential for improvement in neural language processing skills of GPT-3 by avoiding imitating weak human writing styles with more mistakes in longer texts.

Usability-Driven Mobile Application Development

Recently,a specific interest is being taken in the development of mobile application(app)via Model-Based User Interface Development(MBUID)approach.MBUID allows the generation of mobile apps in the target platform(s)from conceptual models.As such it simplified the development process of mobile app.However,the interest is only focused on the functional aspects of the mobile app while neglecting the non-functional aspects,such as usability.The latter is largely considered as the main factor leading to the success or failure of any software system.This paper aims at addressing non-functional aspects of mobile apps generated using MBUID approach.As such,we propose a usability-driven approach for the development of mobile apps.The main stages of the proposed approach are defined in a generic way so that they can be integrated with any MBUID method.A case study is presented,in the paper,with the aim of illustrating the feasibility of this approach.

Framework to Design Type-based Transfer Processes Between Technology and Product Development

To stay globally competitive, manufacturing companies are increasingly under pressure to bring new products and applications to market, improve existing products, and discover new technologies to produce them at a lower price. New technological findings can enable companies to overcome these challenges. In practice, technology development associated with a long time horizon is often given a lower priority compared with short-term focused product development thus being stronger restricted by everyday business. More and more companies separate their technology development department from product development to promote technological innovations. Due to this additional interface in the R＆D organization new problems arise, resulting in technologies not being implemented in products. The reasons for these problems amongst others concern wrong timing for the transfer or inadequate definition of responsibilities. In this paper of ongoing research, authors introduce a framework to design the transfer processes between technology development and product development. Although there are a number of options for designing the operative transfer, there is no regulatory framework specifying which configuration options are at this particular interface. The approach is to develop a model, which is able to design different company-specific transfer processes taking into account the object being transferred at this interface. Thus, for different objects to be transferred, different transfer processes are designed. The model＇s aim is to enable responsibility of the R＆D management to design their company-specific transfer processes to enable more technologies being implemented into products, thus giving the whole company the possibility to act more innovatively.

Customized Development of CAXASolid

CAXASolid, a 3D CAD innovation platform with open structure, provides users with kinds of customized development strategies at different levels. The whole theoretical framework of CAXASolid is introduced. Users can customize their system through application integration, data integration, integration by DLL or integration by COM. Focusing on the customization techniques with COM components, the development method and process are illustrated with some case studies.

基于VRNET Developer网络半实物仿真方法研究

半实物仿真是网络仿真中的一项关键技术,在网络设计和规划中具有很广阔的应用空间。为了实现虚拟网络与物理网络相互连接,利用VRNET Developer仿真工具进行建模,在此基础上深入研究VRNET Developer的DSITL模型和接口模型,基于DSITL模块搭建一个半实物仿真网络,实现仿真网络与物理网络连通。仿真结果表明,这种网络仿真模型可以将仿真网络和物理网络有效地连接起来。

语言规划学与生态语言学:渊源、融合与发展

语言规划学是以满足国家和社会需要为目标,研究语言调控和优化的学科;生态语言学关注语言使用者、语言及其生存环境之间的互动关系;语言规划以语言生态为依据,语言生态又深受语言规划的影响。然而,受限于文献梳理的系统性,当前对二者关系的认识尚不充分。对20世纪50~60年代至今的文献进行整合式述评,可统观语言规划学和生态语言学的渊源、融合和发展。二者的渊源发端于挪威裔美国语言学家Einar Haugen:在他20世纪50~60年代的语言规划研究中初现生态构想,其生态语言学研究又以语言规划为落脚点。自80年代中期,语言规划学出现生态转向,生态语言学隐喻范式的出现标志着语言规划学和生态语言学的融合。90年代至今,语言规划学话语转向和生态语言学非隐喻范式的兴起象征着二者交互发展的新动向,其发展成果还将继续涌现于语言生态评估和规划、语言资源档案、政策话语微观分析等多方面。

A Domain Knowledge Driven Approach for User Interface Software Development

A domain knowledge driven user interface development approach is described.As a conceptual de- sign of the user interface,the domain knowledge defines the user interface in terms of objects,actions and their relationships that the user would use to interact with the application system.It also serves as input to a user interface management system(UIMS)and is the kernel of the target user interface. The principal ideas and the implementation techniques of the approach is discussed.The user interface model,user interface designer oriented high-level specification notation,and the transformation algorithms on domain knowledge are presented.

基于PatSnap数据库的医疗领域脑机接口技术专利分析

当今社会正迈入信息大数据时代,人工智能、人机交互等科学研究成为信息技术创新领域的研究热点。其中,脑机接口技术是医、理、工等多学科交叉的研究重点。为全方位探讨全球脑机接口在医疗领域技术发展情况,本研究开展了基于PatSnap专利数据库分析平台的脑机接口在医疗领域的专利分析,利用专利数据挖掘2003—2023年脑机接口在医疗领域申请的相关专利文献并对其申请趋势、申请地域、技术领域与主要申请人进行可视化分析。结果表明,脑机接口已经从科学理论研究走到了技术爆发的阶段;美国脑机接口在医疗领域的专利申请量最多,中国尚需增强该领域核心技术的研发和创新能力;全球大量公司企业加大对脑机接口领域的技术研发投入,高校和科研机构也积极展开关键技术研究和应用实践;但伦理与安全、高额研发成本等问题,对专利发展态势造成一定的影响。本文通过对全球脑机接口技术在医疗领域的专利信息进行系统性的分析,揭示了其在医疗领域的技术发展趋势、核心技术布局、行业内的领先者和竞争态势等关键信息,为解决脑机接口技术发展与应用将会面临的问题提供参考,为推动关键技术创新和制定高质量人才培养策略贡献了新方案。

基于SolidWorks的钢丝绳参数化建模系统

针对空间结构复杂的钢丝绳,设计和建模过程较繁琐的问题,对SolidWorks进行二次开发,实现钢丝绳快速参数化建模。该方法首先对特定型号钢丝绳参数方程和扫掠所需法平面圆进行计算,对计算结果进行编程化处理,基于Visual Studio编程平台,利用VB.net语言和对应API函数,实现钢丝绳快速参数化建模。以弯曲状6×7+IWS钢丝绳为例,对钢丝法平面圆的参数方程推导过程进行了详细介绍,一键绘制了弯曲状6×7+IWS钢丝绳模型,对所建模型进行有限元分析,验证所得此建模方法所建模型精确可靠,可提高钢丝绳建模效率,具有一定实用性。

论煤-水-土多资源协调开发

煤炭及其伴生资源是地质体的重要组成部分,大规模和高强度开采会引起近地表岩石圈、土壤圈、水圈的联动响应,进而反向制约煤炭及其伴生资源的安全开采与开发。围绕煤矿区的煤-水-土多资源协调开发,基于多学科知识交叉的地球关键带理念,阐述煤-水-土协调开发的必要性以及多圈层、多过程、多尺度、多目标的耦合关系,为煤炭安全绿色开发和生态环境可持续发展提供战略思考。(1)立足煤炭安全高效开采、土壤-水资源安全和生态环境保护多目标多维度角度,剖析大规模、高强度开发背景下采前、采中、采后地质条件动态演化、多资源时空关系、生态环境响应特征,提出煤炭资源开发生命周期条件下的煤炭资源区的地质调查战略和开发策略。(2)开展煤-水-土多资源量的系统调查和地质结构精细表征,全面理解和综合评价煤-水-土赋存特征和相互依存关系,形成集资源禀赋、生态环境、人口经济等于一体的地质调查评价体系和方法,提出基于煤炭开发、多资源利用、水土保护、生态屏障、土地安全等一体化的全链条调控措施和开发策略与开发政策。(3)监控开发过程中地层地质功能结构变化,理解煤-水-土空间组合结构及分层界面效应和煤(岩)-水-土相互作用的动态演化规律,构建复杂地层结构煤炭安全开采和水-土资源协调开发覆岩变形的演化模型,厘清煤-水-土空间结构及其对开采活动的约束效应,发展地球科学、采矿学、生态学、水文学等多学科交叉的煤炭绿色开发地质保障理论与技术。煤-水-土协调开发研究服务于煤炭安全开采与地质环境保护协调发展,破解多资源开发瓶颈及其地质环境制约之间矛盾,通过对煤炭开采全生命周期内的地质条件和环境效应的关键影响因素、状态参数阈值、演化驱动机制的理解,构建地质环境约束、开采模式调控、系统规划利用的煤-水-土多资源协调开发时空格局。

异种有色金属电磁脉冲焊接研究现状及发展趋势

电磁脉冲焊接技术由电磁脉冲成形技术演化而来,通过电磁力驱动被焊接金属发生高速碰撞,实现碰撞界面的冶金结合进而获得焊接接头,作为一种固相连接技术,尤其适用于性能差异显著的异种材料焊接。随着国内外研究者对电磁脉冲焊接技术的深入研究,发现该技术在铝与镁、铝与铜、铝与钛、铝与镍钛等异种有色金属焊接领域的应用前景日益广阔。然而,目前缺乏对异种有色金属电磁脉冲焊接研究现状及发展趋势的综述研究,未能明确该技术在异种有色金属焊接中存在的问题和发展方向。因此,本文详细探讨了异种有色金属电磁脉冲焊接接头的微观结构特征、元素分布规律及显微组织特性,并阐述了接头形成机理,主要包括碰撞界面结合模型和缺陷形成机制。研究发现,不同异种有色金属组合的焊接界面结构明显不同,电磁脉冲焊接接头的力学性能优化需要通过进一步揭示焊接界面结构的形成机制来实现,电磁脉冲焊接技术难以对电学性能差、厚度大以及强度高的材料进行高质量焊接,需要加强相关辅助焊接技术、辅助装备的研究开发。最后对电磁脉冲焊接技术在异种有色金属的焊接过程中存在的问题及未来发展方向进行了展望,提出了未来该技术的研究发展方向,为电磁脉冲焊接技术的相关研究奠定了基础。

桥梁信息模型——有限元模型转换接口研发

针对当前桥梁信息模型难以自动转换为有限元模型,且转换过程中存在关键几何信息丢失、荷载和边界条件难以添加等问题,本文基于Revit API二次开发技术,采用C#语言在Visual Studio2022平台开发了Revit信息模型与ANSYS有限元模型之间的转换接口。该接口实现了从信息模型获取构件几何信息、空间位置、物理信息、荷载和边界条件等功能,并将这些信息转换为ANSYS APDL命令流,通过后台启动ANSYS导入命令流生成有限元模型,完成荷载添加和边界条件设置,进行计算分析。本文详细介绍了转换接口的开发思路、工具和关键技术,并通过工程案例验证了该接口的准确性、便捷性和高效性。

Planetary Homeostasis of Reactive Nitrogen Through Anaerobic Ammonium Oxidation

The availability of nitrogen(N)is crucial for both the productivity of terrestrial and aquatic ecosystems globally.However,the overuse of artificial fertilizers and the energy required to fix nitrogen have pushed the global nitrogen cycle(N-cycle)past its safe operating limits,leading to severe nitrogen pollution and the production of significant amounts of greenhouse gas nitrous oxide(N2O).The anaerobic ammonium oxidation(anammox)mechanism can counteract the release of ammonium and N2O in many oxygenlimited situations,assisting in the restoration of the homeostasis of the Earth’s N biogeochemistry.In this work,we looked into the characteristics of the anammox hotspots’distribution across various types of ecosystems worldwide.Anammox hotspots are present at diverse oxic-anoxic interfaces in terrestrial systems,and they are most prevalent at the oxic-anoxic transition zone in aquatic ecosystems.Based on the discovery of an anammox hotspot capable of oxidizing ammonium anoxically into N2 without N2O by-product,we then designed an innovative concept and technical routes of nature-based anammox hotspot geoengineering for climate change,biodiversity loss,and efficient utilization of water resources.After 15 years of actual use,anammox hotspot geoengineering has proven to be effective in ensuring clean drinking water,regulating the climate,fostering plant and animal diversity,and enhancing longterm environmental quality.The sustainable biogeoengineering of anammox could be a workable natural remedy to resolve the conflicts between environmental pollution and food security connected to N management.

基于成组技术的滚刀复合加工零编程系统开发

针对齿轮滚刀个性化、小批量的需求现状和多工序、低效率的加工现状,利用成组技术原理对齿轮滚刀进行分类,通过分析现存滚刀加工工艺设计车铣复合加工工艺,提出基于成组技术零编程实现滚刀的半成品加工。以整体式滚刀为研究对象,车铣复合机床BHR700V为平台,设计各工序的结构和工艺参数化变量,实现各工序的参数化编程,在西门子SINUMERIK 840d数控系统上开发出齿轮滚刀的定制化人机界面,并在车铣复合机床BHR700V上成功用于滚刀半成品加工。

多级构型界面下致密砂岩储层构造裂缝发育特征——以川西坳陷须家河组二段为例

裂缝对四川盆地川西坳陷须家河组二段致密砂岩储层天然气的高产稳产至关重要,不同沉积环境下形成的砂体构型界面控制了储层裂缝的发育。通过野外露头勘测、岩心观测、测井识别和岩相精细刻画等方法,提出了川西坳陷须二段砂体构型界面划分方案,识别划分了研究区的2~4级砂体构型界面,厘清了不同级次构型界面约束下裂缝发育的特征及其油气地质意义。不同级次构型界面控制着储层裂缝的产状、开启程度、发育程度和储渗能力;2级、3级界面的有效控制范围分别为0~0.35 m和0~3 m,4级界面控制范围较大(0~11 m)。不同构型界面控制下裂缝发育特征存在差异,其中2级界面下裂缝欠发育,4级界面下裂缝一般发育,3级界面下裂缝最发育,主要为低角度斜缝;裂缝走向主要为NNE—SSW、SEE—NWW和SSE—NNW,开度较大(>0.04 mm)和倾角较大的裂缝较多。多级界面控制下裂缝发育段的岩心孔渗呈明显的正相关,3级界面下裂缝对储层物性的改善作用最强,对油气贡献度最高;4级界面次之,2级界面最弱。明确不同级次构型界面对裂缝发育的控制作用,有利于研究区致密砂岩储层气藏的有效开发。