Hepatitis B virus(HBV)reactivation is a clinically significant challenge in disease management.This review explores the immunological mechanisms underlying HBV reactivation,emphasizing disease progression and manageme...Hepatitis B virus(HBV)reactivation is a clinically significant challenge in disease management.This review explores the immunological mechanisms underlying HBV reactivation,emphasizing disease progression and management.It delves into host immune responses and reactivation’s delicate balance,spanning innate and adaptive immunity.Viral factors’disruption of this balance,as are interac-tions between viral antigens,immune cells,cytokine networks,and immune checkpoint pathways,are examined.Notably,the roles of T cells,natural killer cells,and antigen-presenting cells are discussed,highlighting their influence on disease progression.HBV reactivation’s impact on disease severity,hepatic flares,liver fibrosis progression,and hepatocellular carcinoma is detailed.Management strategies,including anti-viral and immunomodulatory approaches,are critically analyzed.The role of prophylactic anti-viral therapy during immunosuppressive treatments is explored alongside novel immunotherapeutic interventions to restore immune control and prevent reactivation.In conclusion,this compre-hensive review furnishes a holistic view of the immunological mechanisms that propel HBV reactivation.With a dedicated focus on understanding its implic-ations for disease progression and the prospects of efficient management stra-tegies,this article contributes significantly to the knowledge base.The more profound insights into the intricate interactions between viral elements and the immune system will inform evidence-based approaches,ultimately enhancing disease management and elevating patient outcomes.The dynamic landscape of management strategies is critically scrutinized,spanning anti-viral and immunomodulatory approaches.The role of prophylactic anti-viral therapy in preventing reactivation during immunosuppressive treatments and the potential of innovative immunotherapeutic interventions to restore immune control and proactively deter reactivation.展开更多
Testing is the premise and foundation of realizing equipment health management （EHM）. To address the problem that the static periodic test strategy may cause deficient test or excessive test, a dynamic sequential te...Testing is the premise and foundation of realizing equipment health management （EHM）. To address the problem that the static periodic test strategy may cause deficient test or excessive test, a dynamic sequential test strategy （DSTS） for EHM is presented. Considering the situation that equipment health state is not completely observable in reality, a DSTS optimization method based on partially observable semi-Markov decision pro- cess （POSMDP） is proposed. Firstly, an equipment health state degradation model is constructed by Markov process, and the control limit maintenance policy is also introduced. Secondly, POSMDP is formulated in great detail. And then, POSMDP is converted to completely observable belief semi-Markov decision process （BSMDP） through belief state. The optimal equation and the corresponding optimal DSTS, which minimize the long-run ex- pected average cost per unit time, are obtained with BSMDP. The results of application in complex equipment show that the proposed DSTS is feasible and effective.展开更多
This paper analyzes a problem processing mechanism in a new collaboration system between the main manufacturer and the supplier in the"main manufacturer-supplier"mode,which has been widely applied in the col...This paper analyzes a problem processing mechanism in a new collaboration system between the main manufacturer and the supplier in the"main manufacturer-supplier"mode,which has been widely applied in the collaborative development management of the complex product.This paper adopts the collaboration theory,the evolutionary game theory and numerical simulation to analyze the decision-making mechanism where one upstream supplier and one downstream manufacturer must process an unpredicted problem without any advance contract in common.Results show that both players'decision-makings are in some correlation with the initial state,income impact coefficients,and dealing cost.It is worth noting that only the initial state influences the final decision,while income impact coefficients and dealing cost just influence the decision process.This paper shows reasonable and practical suggestions for the manufacturer and supplier in a new collaboration system for the first time and is dedicated to the managerial implications on reducing risks of processing problems.展开更多
This paper introduces the main content of the national standard of quality management in China---the GB/T 19580 Criteria for Performance excellence.The scope,purpose,the difference from ISO 9001 and evaluation require...This paper introduces the main content of the national standard of quality management in China---the GB/T 19580 Criteria for Performance excellence.The scope,purpose,the difference from ISO 9001 and evaluation requirements are described.展开更多
文摘Hepatitis B virus(HBV)reactivation is a clinically significant challenge in disease management.This review explores the immunological mechanisms underlying HBV reactivation,emphasizing disease progression and management.It delves into host immune responses and reactivation’s delicate balance,spanning innate and adaptive immunity.Viral factors’disruption of this balance,as are interac-tions between viral antigens,immune cells,cytokine networks,and immune checkpoint pathways,are examined.Notably,the roles of T cells,natural killer cells,and antigen-presenting cells are discussed,highlighting their influence on disease progression.HBV reactivation’s impact on disease severity,hepatic flares,liver fibrosis progression,and hepatocellular carcinoma is detailed.Management strategies,including anti-viral and immunomodulatory approaches,are critically analyzed.The role of prophylactic anti-viral therapy during immunosuppressive treatments is explored alongside novel immunotherapeutic interventions to restore immune control and prevent reactivation.In conclusion,this compre-hensive review furnishes a holistic view of the immunological mechanisms that propel HBV reactivation.With a dedicated focus on understanding its implic-ations for disease progression and the prospects of efficient management stra-tegies,this article contributes significantly to the knowledge base.The more profound insights into the intricate interactions between viral elements and the immune system will inform evidence-based approaches,ultimately enhancing disease management and elevating patient outcomes.The dynamic landscape of management strategies is critically scrutinized,spanning anti-viral and immunomodulatory approaches.The role of prophylactic anti-viral therapy in preventing reactivation during immunosuppressive treatments and the potential of innovative immunotherapeutic interventions to restore immune control and proactively deter reactivation.
基金supported by the National Natural Science Foundation of China (51175502)
文摘Testing is the premise and foundation of realizing equipment health management （EHM）. To address the problem that the static periodic test strategy may cause deficient test or excessive test, a dynamic sequential test strategy （DSTS） for EHM is presented. Considering the situation that equipment health state is not completely observable in reality, a DSTS optimization method based on partially observable semi-Markov decision pro- cess （POSMDP） is proposed. Firstly, an equipment health state degradation model is constructed by Markov process, and the control limit maintenance policy is also introduced. Secondly, POSMDP is formulated in great detail. And then, POSMDP is converted to completely observable belief semi-Markov decision process （BSMDP） through belief state. The optimal equation and the corresponding optimal DSTS, which minimize the long-run ex- pected average cost per unit time, are obtained with BSMDP. The results of application in complex equipment show that the proposed DSTS is feasible and effective.
基金supported by the National Natural Science Foundation of China(7117111271502073)。
文摘This paper analyzes a problem processing mechanism in a new collaboration system between the main manufacturer and the supplier in the"main manufacturer-supplier"mode,which has been widely applied in the collaborative development management of the complex product.This paper adopts the collaboration theory,the evolutionary game theory and numerical simulation to analyze the decision-making mechanism where one upstream supplier and one downstream manufacturer must process an unpredicted problem without any advance contract in common.Results show that both players'decision-makings are in some correlation with the initial state,income impact coefficients,and dealing cost.It is worth noting that only the initial state influences the final decision,while income impact coefficients and dealing cost just influence the decision process.This paper shows reasonable and practical suggestions for the manufacturer and supplier in a new collaboration system for the first time and is dedicated to the managerial implications on reducing risks of processing problems.
文摘This paper introduces the main content of the national standard of quality management in China---the GB/T 19580 Criteria for Performance excellence.The scope,purpose,the difference from ISO 9001 and evaluation requirements are described.
基金supported by the National Natural Science Foundation of China (No. 52174099)the Science and Technology Innovation Program of Hunan Province, China (No. 2023RC3050)。
文摘为提升并联式混合动力汽车(parallel hybrid electric vehicle,PHEV)的燃油经济性,针对等效燃油消耗最小控制策略(equivalent fuel consumption minimum strategy,ECMS)在不同工况下适应性差的问题,以优化整车等效燃油消耗量为目标,设计基于工况识别算法的变等效因子ECMS能量管理策略。选取3类典型工况建立支持向量机分类模型,通过递归特征消除法对样本特征进行选择,采用鲸鱼算法对支持向量机进行参数优化,使用模拟退火算法分别对3类工况的ECMS等效因子进行离线全局最优求解,并分别存储于等效因子库中,通过训练好的支持向量机分类器对目标优化工况进行工况识别,不同类型的工况片段采用不同的等效因子进行转矩分配。仿真结果显示:相比于逻辑门限能量管理策略,基于工况识别算法的变等效因子ECMS能量管理策略的电池荷电状态(state of charge,SOC)变化量减少8.67%,节油率为13.11%;相比于优化前的ECMS策略电池SOC变化量减少3.47%,节油率约为6.63%。本文提出的基于工况识别算法的变等效因子ECMS能量管理策略可以有效地减少燃油消耗量,提升PHEV的整车经济性。
