Manner of Death and Fentanyl Related Drug Overdose Trends in Marion County, Indiana, US from 2018 to 2021

The purpose of this research was to investigate the manner of deaths in Marion County, throughout the years of 2018 to 2021 to see if there were any correlative increases in homicide, suicide, natural, accidental, or drug overdose related deaths. We surveyed the incidence of all deaths that occurred from 2018 through 2021 which came through the Marion County Coroner’s Office, Indiana. The data was then divided into two halves. According to the data, the leading manner of death in the first half and second half was accidental. This study revealed a total of 8732 cases: 3817 of them were observed to be accidental, 3092 natural, 956 homicide, 689 suicide, and 178 were undetermined. There were initially 318 drug overdose related deaths in 2018 and they increased to 2163 by 2021. In 2018, the number of deaths due to fentanyl related overdoses increased from 195 to 799 in 2021. This research will contribute to the forensic science field by providing information about the manner of death and fentanyl trends in Marion County over the last four years.

Barbara Longhi of Ravenna:A Devotional Self-Portrait

From the variety of types of portraiture,there evolved the imaging of a self-portrait as we see in Saint Catherine of Alexandria by Barbara Longhi of Ravenna(1552-1638).The self-portrait is a unique work of art,an intimate record of a sitter’s personality.It is an acknowledgment of worth,an exercise in technique,and a designator of era,style,and likeness.The self-portrait can be a study in expression,an impersonation of a virtue,or a document in a history of aging.As William Shakespeare noted in Hamlet,“[The self-portrait is]to show virtue her own feature,scorn her own image,and the very age and body of the time his form and pressure.”In the sixteenth-century in Italy,artists often included themselves or their self-portraits in religious and secular scenes as a type of signature,as seen in the paintings of the Longhi family.In their many depictions of Saint Catherine of Alexandria,the Longhis composed two types of such images:a single-solo-image of the saint;and also her presence in a group with saints-a theme known as holy conversation.In her paintings,Barbara Longhi preferred to depict the solo image of Saint Catherine of Alexandria,using herself as a model for the figure of the saint or as a muse impersonating or personifying the saint’s virgo virtue.This essay is composed of two parts:(1)a brief explanation of the meaning of self-portraits in sixteenth-century Italy;and(2)a study of Barbara Longhi’s self-portraits as Saint Catherine of Alexandria.

Barbara Longhi’s Saint Agnes of Rome:Iconic Images of Purity and Virtue

Barbara Longhi of Ravenna(1552-1638)enjoyed creating small devotional paintings depicting holy saints,in particular Saint Agnes(c.291-304).This saint’s life and martyrdom was recorded by the Bishop of Milan,Saint Ambrose(339-397),a Doctor of the Church and theologian,in his book Concerning Virgins(374)and by Jacobus de Voragine,the Archbishop of Genoa,in his Golden Legend(Legenda Aurea,1275).The saint’s story continues to be imaged and recounted to the present day because she is an icon of a pure and virtuous adolescent female.Barbara Longhi,along with her father,Luca Longhi(1507-1580),painted several versions of Saint Agnes.In their many depictions they composed two types of images:a single-solo-image of the saint;and her presence in a group of saints-a theme known as holy conversation.In her paintings of Saint Agnes,however,Barbara Longhi preferred to depict the solo image of the saint as virgo,a young maiden of virtue.This essay is composed of two parts:(1)an account of the life and martyrdom of Saint Agnes;and(2)an iconographical interpretation of Barbara Longhi’s Saint Agnes of Rome.

Giorgio Vasari’s Fine Arts From the Vite of 1550:The Splendor of Creativity and Design

Giorgio Vasari’s conception of artistic creativity is related to his theory of painting. He proposes two alternatives in a painter’s development or achievement of artistic creativity: imitation (imitazione) and invention (invenzione).Imitation is the copying of art as a method of learning, whereas invention is independent of imitation and constitutes the means for conceiving artistic ideas. Imitation serves to guide and teach the artist in composing and creating perfection. Vasari maintains that artists must study antiquity and the masters, so that they may learn how others acquired the experience of imitating nature. For Vasari, imitation draws upon three different sources: the first two are copying from nature (copia dal vero) and the third one is selecting from one’s work (imitare se stessi). He emphasizes that copying from nature is important for the artist so that he may learn to create forms that are alive as visualized in the Fine Arts.

Giuseppe Arcimboldo’s Grilli: Humor and Magic in Genre Portraits

This essay examines one aspect of Giuseppe Arcimboldo’s portraiture: His genre depictions where he expands the art of illusionism or magic visualization into grilli (intellectual whims) and teste composte (composite heads). These images of reversible portraits of genre scenes, caricatural conceits, and visual puns are seen in The Cook or The Chef reversed as The Bowl of Meats of 1570 at the Nationalmuseum, Stockholm;The Vegetable Gardener reversed as The Bowl of Vegetables of 1590 at the Museo Civico “Ala Ponzone”, Cremona;and Il Frutaio, The Fruit Vendor reversed as The Basket of Fruits of 1591, at the French & Company Gallery in New York. In his imagery, Arcimboldo focuses on the paradoxical meaning of objects,“what if?” adding a sense of ambiguity and mystery to his art. Is Arcimboldo teasing the viewer with a Mannerist flare, or is he composing or implying another type of intellectual conceit? Ultimately, Arcimboldo invents a new type of genre: the emblematic humorous portrait.

Giovanni Battista Naldini's Pietà:Humility and Love

In 1564,in honor of the death of Michelangelo Buonarroti(1475-1564),an artistic extravaganza was invented by the Benedictine monk Vincenzo Borghini(1515-1580)-prior of the hospital of the innocents,humanist,and administrator of the Florentine Academy of Design(Accademia del Disegno or Florentine Academy)-and was implemented by Giorgio Vasari(1511-1574)-artist,writer,and artistic director of the Academy,who engaged his Florentine assistants to work on the execution of the tomb in the Basilica of Santa Croce in Florence(see Figure 1).The commission of Michelangelo’s tomb was prompted by his nephew,Lionardo[Leonardo]Simoni-Buonarroti(1522-1599),and the Grand Duke of Tuscany,Cosimo I de’Medici(1519-1574).The tomb was completed in 1578.Vasari designed the architectural monument,and his assistants,members of the Florentine Academy,collaborated in the following manner:The sculptures of the Fine Arts were carved by Giovanni Bandini(1540-1599),who represented the personification of architecture;Valerio di Simone Cioli(1529-1599),who represented the personification of Sculpture;and Battista Lorenzi(1527-1594),who represented the personification of Painting and the portrait bust of Michelangelo.Giovanni Battista Naldini(1537-1591)completed al fresco the burning urns,the purple-colored doorway of the tomb,the suspended canopy,and the Pietàin the center of the marble tabernacle.This latter artistic contribution is the topic of this essay.

Giorgio Vasari’s Madonna of the Rosary: A Rose Garden of Blessings

In 1569,Giorgio Vasari(1511-1574)completed a painting of the Madonna of the Rosary for the private chapel of the Capponi family in the church of Santa Maria Novella in Florence.In his Ricordanze(Book of Records),Vasari explained the commission as well as documenting the assistance of his Florentine pupil,Jacopo Zucchi(1541-1590),in the completion of this painting.This essay discusses Vasari’s symbolism of the rosary as a reflection of the Tridentine Reform in Florence as well as a visual interpretation of Italian Mannerist painters on this devotional subject.

An Analysis in Business Etiquette among China, Britain and America

This paper analyzes the unique business etiquette under specific culture of different countries, the similarities and differences of business etiquette among China and main English-speaking countries, i.e. Britain, America, are discussed. Better understanding of how cultural differences influence the operations of international business is the most essential for people who look for standard of excellence.

Adapting Grice's maxims in the teaching of writing

Grice's maxims,which define the conditions for efficient spoken communication,can be adapted to the teaching of writing by providing both teachers and writers with a way of understanding successful and unsuccessful written correspondence in mono-and cross-cultural settings.A survey of lay readers' responses to a sample letter which show that,while there are individual differences in the way these maxims are interpreted,readers expect clarity,brevity,and sincerity,and writing which fails to meet these expectations will be unfavorably received.Also discussed are the issues of contrastive rhetoric,and ways of helping writers to position themselves in relation to their real or imagined reader.

Lavinia Fontana’s Galatea: Personification of Fortune and Venus

Lavinia Fontana’s(1552-1614)Galatea and Cherubs riding the Stormy Waves on a Sea Monster(aka Galatea)of 1590 is an intriguing mythological painting.Being painted on copper,it is a fine example of Lavinia’s exploration of new artistic techniques and materials as well as testimony to her bold artistic interpretations.Lavinia’s Galatea was part of a private collection in Bologna(Diletta Badeschi).This work fascinates the viewer with its erotic audacity and complex iconographical conceits.Recent scholarship by Daniele Benati,Fausto Gozzi,and Enrico Maria Dal Pozzolo assist in unraveling the meaning of this painting.In this essay there are additional interpretative suggestions.

Gut-lung crosstalk in pulmonary involvement with inflammatory bowel diseases

Pulmonary abnormalities,dysfunction or hyper-reactivity occurs in association with inflammatory bowel disease(IBD) more frequently than previously recognized.Emerging evidence suggests that subtle inflammation exists in the airways among IBD patients even in the absence of any bronchopulmonary symptoms,and with normal pulmonary functions. The pulmonary impairment is more pronounced in IBD patients with active disease than in those in remission. A growing number of case reports show that the IBD patients develop rapidly progressive respiratory symptoms after colectomy,with failure to isolate bacterial pathogens on repeated sputum culture,and often request oral corticosteroid therapy. All the above evidence indicates that the inflammatory changes in both the intestine and lung during IBD. Clinical or subclinical pulmonary inflammation accompanies the main inflammation of the bowel.Although there are clinical and epidemiological reports of chronic inflammation of the pulmonary and intestinal mucosa in IBD,the detailed mechanisms of pulmonaryintestinal crosstalk remain unknown. The lung has no anatomical connection with the main inflammatory site of the bowel. Why does the inflammatory process shift from the gastrointestinal tract to the airways? The clinical and subclinical pulmonary abnormalities,dysfunction,or hyper-reactivity among IBD patients need further evaluation. Here,we give an overview of the concordance between chronic inflammatory reactions in the airways and the gastrointestinal tract. A better understanding of the possible mechanism of the crosstalk among the distant organs will be beneficial in identifying therapeutic strategies for mucosal inflammatory diseases such as IBD and allergy.

Effect of initiation manners on the scattering characteristics of semi-preformed fragment warhead

The lethality of a semi-preformed fragment warhead is closely related to the expand velocity and spatial distribution of the fragments from ruptured metal casing. The topic of how to improve the utilization of charge of have been drawing great attention from researchers and designer in this filed. In present paper,in order to investigate the influence of charge initiation manners on the scattering characteristics of semi-preformed fragment warhead, the numerical simulations and experimental test are conducted.Firstly, the influence of grid density on numerical results is investigated, and a proper numerical model with relatively high accuracy and effectiveness is determined. Then. numerical simulations of three kinds of different initiation position of a semi-preformed fragment warhead are carried out. An experimental test of the explosion of a semi-preformed fragment warhead is carried out. By comparing and analyzing the numerical results and experimental data, it is found that the initiation manners have great influence on scattering characteristics of semi-preformed fragment warhead. The researcher work of this paper would provide an effective alternative method to optimize the design of warhead.

“医院-社区一体化”模式是中国精神卫生服务改革的重要方向(英文)

Prior to 2005 China’s mental health services were provided in the same manner as the other types of health services in the country. The hospital was the center of the service delivery network so medica staff only provided services to those who came to the hospital and there was no continuity between hospita services and community services. This delivery system did not provide preventive services and was not

Effect of Manganese Incorporation Manner on an Iron-Based Catalyst for Fischer-Tropsch Synthesis

A systematic study was undertaken to investigate the effects of the manganese incorporation manner on the textural properties, bulk and surface phase compositions, reduction/carburization behaviors, and surface basicity of an iron-based Fischer-Tropsch synthesis （FTS） catalyst. The catalyst samples were characterized by N2 physisorption, X-ray photoelectron spectroscopy （XPS）, H2 （or CO） temperature-programmed reduction （TPR）, CO2 temperature-programmed desorption （TPD）, and M5ssbauer spectroscopy. The FTS performance of the catalysts was studied in a slurry-phase continuously stirred tank reactor （CSTR）. The characterization results indicated that the manganese promoter incorporated by using the coprecipitation method could improve the dispersion of iron oxide, and decrease the size of the iron oxide crystallite. The manganese incorporated with the impregnation method is enriched on the catalyst＇s surface. The manganese promoter added with the impregnation method suppresses the reduction and carburization of the catalyst in H2, CO, and syngas because of the excessive enrichment of manganese on the catalyst surface. The catalyst added manganese using the coprecipitation method has the highest CO conversion （51.9%） and the lowest selectivity for heavy hydrocarbons （C12＋）.

Evaluation Method on Steering for the Shape-shifting Robot in Different Configurations

The evaluation method on steering is based on qualitative manner in existence, which causes the result inaccurate and fuzziness. It reduces the efficiency of process execution. So the method by quantitative manner for the shape-shifting robot in different configurations is proposed. Comparing to traditional evaluation method, the most important aspects which can influence the steering abilities of the robot in different configurations are researched in detail, including the energy, angular velocity, time and space. In order to improve the robustness of system, the ideal and slippage conditions are all considered by mathematical model. Comparing to the traditional weighting confirming method, the extent of robot steering method is proposed by the combination of subjective and objective weighting method. The subjective weighting method can show more preferences of the experts and is based on five-grade scale. The objective weighting method is based on information entropy to determine the factors. By the sensors fixed on the robot, the contract force between track grouser and ground, the intrinsic motion characteristics of robot are obtained and the experiment is done to prove the algorithm which is proposed as the robot in different common configurations. Through the method proposed in the article, fuzziness and inaccurate of the evaluation method has been solved, so the operators can choose the most suitable configuration of the robot to fulfil the different tasks more quickly and simply.

Cancer vaccines: prospects and problems

Cytokines provided locally at tbe tumor site mayinitiate an effective anti-tumor immune responsewhich leads to rejection of a tumor which otherwisegrows progressively. Experimentillly, this can betested by gene transfer into cultured tumor cellsfollowed by the analysis of the tumorigenicity of suchgenetically engincered cells. This approach allows

Protective effects of ginsenoside Rg1 against hydrogen peroxide-induced injury in human neuroblastoma cells

The active ingredient of ginseng,ginsenosides Rg1,has been shown to scavenge free radicals and improve antioxidant capacity.This study hypothesized that ginsenosides Rg1 has a protective role in human neuroblastoma cells injured by H2O2.Ginsenosides Rg1 at different concentrations（50 and 100 μM） was used to treat H2O2（150 μM）-injured SH-SY5 Y cells.Results demonstrated that ginsenoside Rg1 elevated the survival rate of SH-SY5 Y cells injured by H2O2,diminished the amount of leaked lactate dehydrogenase,and increased superoxide dismutase activity.Ginsenoside Rg1 effectively suppressed caspase-3 immunoreactivity,and contributed to heat shock protein 70 gene expression,in a dose-dependent manner.These results indicate that ginsenoside Rg1 has protective effects on SH-SY5 Y cells injured by H2O2 and that its mechanism of action is associated with anti-oxidation and the inhibition of apoptosis.

Neodymium Oxide Induces Cytotoxicity and Activates NF-κB and Caspase-3 in NR8383 Cells

We investigated whether Nd_2O_3 treatment results in cytotoxicity and other underlying effects in rat NR8383 alveolar macrophages.Cell viability assessed by the MTT assay revealed that Nd_2O_3 was toxic in a dose-dependent manner, but not in a time-dependent manner. An ELISA analysis indicated that exposure to Nd203 caused cell damage and enhanced synthesis and release of inflammatory chemokines. A Western blot analysis showed that protein expression levels of caspase-3, nuclear factor-KB （NF-KB） and its inhibitor IKB increased significantly in response to Nd203 treatment. Both NF-KB and caspase-3 signaling were activated, suggesting that both pathways are involved in Nd203 cytotoxicity.

Sharing experiences from a reference laboratory in the public health response for Ebola viral disease, MERS-CoV and H7N9 influenza virus investigations

The International Health Regulations was enforced in June 2007,emphasizing the obligation of State Parties to detect,report,and respond to public health emergencies[1].An effective public health response requires a coordinated laboratory response in the Ministry of Health(MOH)network with credible laboratories capable of providing accurate and reliable results in a timely manner to enable effective public health measures