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Mannose-binding Lectin Two Gene Polymorphisms and Tuberculosis Susceptibility in Chinese Population: A Meta-analysis 被引量:2
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作者 施静 谢敏 +3 位作者 王坚苗 徐永健 熊维宁 刘先胜 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 2013年第2期166-171,共6页
Numerous studies have been done to explore the association between mannose-binding lectin two (MBL2) gene polymorphisms and the risk of tuberculosis (TB). However, the results are inconsistent. We performed a meta... Numerous studies have been done to explore the association between mannose-binding lectin two (MBL2) gene polymorphisms and the risk of tuberculosis (TB). However, the results are inconsistent. We performed a meta-aualysis to investigate whether polymorphisms in the MBL2 gene were associated with TB risk. Databases including PubMed, Medline, Chinese Biomedicine Database, China National Knowledge Infrastructure, Wanfang Database, and Weipu Database were searched to find relevant articles published up to 2 October, 2012. Odds ratio (OR) with 95% confidence interval (CI) was used to evaluate the strength of association. All statistical tests were performed by using Revman 5.1 software and STATA 11.0 software. Six case-control studies including 1106 cases and 1190 controls were accepted in the meta-analysis. The results indicated that individuals carrying the MBL2 codon 54 B allele may have an increased risk of TB as compared with AA homozygotes (BB+AB vs. AA: OR=1.52, 95% CI: 1.22-1.88), whereas MBL2 +4 P/Q was possibly not associated with TB susceptibility in Chinese population. 展开更多
关键词 META-ANALYSIS TUBERCULOSIS mannose-binding lectin POLYMORPHISM
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Mannose-binding lectin and maladies of the bowel and liver 被引量:2
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作者 Daniel L Worthley Peter G Bardy +1 位作者 David L Gordon Charles G Mullighan 《World Journal of Gastroenterology》 SCIE CAS CSCD 2006年第40期6420-6428,共9页
Mannose-binding lectin (MBL) is a pattern-recognition molecule that binds to characteristic carbohydrate mo-tifs present on the surface of many different pathogens. MBL binding stimulates the immune system via the lec... Mannose-binding lectin (MBL) is a pattern-recognition molecule that binds to characteristic carbohydrate mo-tifs present on the surface of many different pathogens. MBL binding stimulates the immune system via the lectin pathway of complement activation. In certain clinical situations, often characterized by pre-existing immune compromise, MBL deficiency increases the risk of infec-tious and other disease-specific complications. Many of the key pathogenic processes inherent to common gastroenterological diseases, such as infection, immuno-logical damage, and carcinogenesis, have been linked to MBL. This editorial reviews the biology of MBL, outlines key disease associations to document the breadth of influence of MBL, and finally, highlights the relevance of MBL to both gastroenterological health and disease. 展开更多
关键词 mannose-binding lectin Collectins Innate immunity POLYMORPHISM INFECTION
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Mannose-binding lectin 2 rs11003123 polymorphism is associated with the development of hepatocellular carcinoma in patients with hepatitis B-related cirrhosis in the Chinese population 被引量:1
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作者 Pu-Sen Wang Jing Kuai +3 位作者 Hao Li Chun-Guang Wang Bao-Jie Shi Lin Zhong 《Hepatobiliary & Pancreatic Diseases International》 SCIE CAS CSCD 2016年第3期282-288,共7页
BACKGROUND: Mannose-binding lectin 2 (MBL2) plays a key role in the host immune response, but whether it is associ- ated with hepatocellular carcinoma (HCC) is not dear. The present study aimed to identify the as... BACKGROUND: Mannose-binding lectin 2 (MBL2) plays a key role in the host immune response, but whether it is associ- ated with hepatocellular carcinoma (HCC) is not dear. The present study aimed to identify the association between MBL2 gene polymorphisms and HCC in patients with hepatitis B virus (I-IBV)-related cirrhosis in the Chinese population. 展开更多
关键词 mannose-binding lectin 2 POLYMORPHISM hepatitis B CIRRHOSIS hepatocellular carcinoma
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Early expression of mannose-binding lectin 2 during Aspergillus fumigatus infection in human corneal epithelial cells
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作者 Cheng-Ye Che Jing-Fen Zhang +6 位作者 Ji-Eun Lee Jing Lin Li-Ting Hu Nan Jiang Qian Wang Qiang Xu Gui-Qiu Zhao 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2015年第1期35-38,共4页
AIM: To evaluate the early expression of mannose-binding lectin 2(MBL2) in human corneal epithelial cells(HCECs) infected by Aspergillus fumigatus(AF).METHODS: HCECs cultured in vitro with AF antigens and sampled at 0... AIM: To evaluate the early expression of mannose-binding lectin 2(MBL2) in human corneal epithelial cells(HCECs) infected by Aspergillus fumigatus(AF).METHODS: HCECs cultured in vitro with AF antigens and sampled at 0, 0.5, 1, 2, 4, 6 and 8h. The expression of MBL2 m RNA was evaluated by semiquantitative reverse transcription-polymerase chain reaction(RT-PCR). The expression of MBL2 protein in supernatant fluid was shown by enzyme linked immunosorbent assay(ELISA). MBL2 protein in HCECs was detected by immunocytochemistry at 0 and 24 h.RESULTS: MBL2 m RNA and protein are expressed in normal HCECs. The expression of MBL2 m RNA and protein in supernatant fluid begin to increase after being stimulated with AF antigens. The most significantly peak of MBL2 m RNA is in 2h. The protein of MBL2 in supernatant fluid decrease gradually after 0.5h. The protein in HCECs expression increase after stimulation of24 h.· CONCLUSION: MBL2 receptor expressed in normal HCECs in vitro. The stimulation by AF antigens can increase the early expression of it. 展开更多
关键词 mannose-binding lectin human corneal epithelial cells Aspergillus fumigatus
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Dietary sugars inhibit biologic functions of the pattern recognition molecule, mannose-binding lectin
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作者 Kazue Takahashi Wei-Chuan Chang +6 位作者 Patience Moyo Mitchell R. White Parool Meelu Anamika Verma Gregory L. Stahl Kevan L. Hartshorn Vijay Yajnik 《Open Journal of Immunology》 2011年第2期41-49,共9页
Mannose-binding lectin (MBL), a mammalian lectin, is a pattern recognition molecule of the innate immune system and recognizes carbo-hydrates that are exposed on pathogens. In this study, we observed that fructose dow... Mannose-binding lectin (MBL), a mammalian lectin, is a pattern recognition molecule of the innate immune system and recognizes carbo-hydrates that are exposed on pathogens. In this study, we observed that fructose down regu-lates MBL-mediated innate immune mechanisms against both influenza A virus (IAV) and Staphy-lococcus aureus. These mechanisms include the lectin complement pathway and coagulation enzyme-like activities on both pathogens. Fur-thermore, fructose also reduces MBL-mediated phagocytosis of S. aureus and IAV and MBL- mediated IAV infection to epithelial cells. In contrast, sucrose inhibits MBL-mediated im-mune mechanisms against S. aureus but not IAV. Together, our studies show that dietary sugars, in particular fructose, negatively regulate the innate immunity against viral and bacterial pathogens. 展开更多
关键词 mannose-binding lectin FRUCTOSE Influenza A Virus STAPHYLOCOCCUS AUREUS COMPLEMENT Coagulation
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Expressions and clinical significances of mannose-binding lectin(MBL) and MBL-associated serine protease 2(MASP-2) in patients with thyroid neoplasm
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作者 Yanping Shi Geling Liu +5 位作者 Huiqin Zhang Fang Yu Xiuxiu Xiang Yifang Lu Xiaomei Dong Xiaohua Li 《The Chinese-German Journal of Clinical Oncology》 CAS 2013年第3期106-108,共3页
Objective: The aim of the study was to detect the levels of mannose-binding lectin (MBL), MBL-associated serine protease 2 (MASP-2) and explore the clinical significances of them in patients with primary thyroid ... Objective: The aim of the study was to detect the levels of mannose-binding lectin (MBL), MBL-associated serine protease 2 (MASP-2) and explore the clinical significances of them in patients with primary thyroid neoplasms. Methods: By using ELISA method, we detected the serum levels of MBL and MASP-2 in 26 patients with papillary thyroid carcinoma (PTC), 30 patients with thyroid adenoma (TA) and 26 healthy people, respectively. Results: Serum MBL level was (565.23 ± 76.70) μg/L in PTCs higher than (324.267 ±24.74) μg/L in TAs, and (152.69± 16.95) IJg/L in healthy of controlling group. There was statistical significance between PTC and TA (P 〈 0.05), however there was no difference between TA and healthy (P 〉 0.05). Serum MASP-2 level was (726.153± 78.88) pg/L in PTCs higher than (379.266 ± 30.26) μg/L in TAs, and (203.846 ± 29.09) μg/L in healthy. Serum MASP-2 level was higher in PTCs than TAs, and the difference had statistical significance (P 〈 0.01). But no difference was observed between in TAs and healthy. Conclusion: These findings might reflect inflammatory processes induced by defense mechanisms, in response to the development of the turnout. MBL may also be involved in the elimination of possible tumourigenic pathogens. 展开更多
关键词 thyroid neoplasm mannose-binding lectin (MBL) MBL-associated serine protease 2 (MASP-2) DETECTION
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Mannose-binding lectin 2 gene polymorphisms and their association with tuberculosis in a Chinese population 被引量:3
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作者 Jun-Xian Zhang Wen-Ping Gong +7 位作者 Dong-Lin Zhu Hui-Ru An You-Rong Yang Yan Liang Jie Wang Jing Tang Wei-guo Zhao Xue-Qiong Wu 《Infectious Diseases of Poverty》 SCIE 2020年第2期38-49,共12页
Background:Immune-and inflammation-related genes(IIRGs)play an important role in the pathogenesis of tuberculosis(TB).However,the relationship between IIRG polymorphisms and TB risk remains unknown.In this study,the g... Background:Immune-and inflammation-related genes(IIRGs)play an important role in the pathogenesis of tuberculosis(TB).However,the relationship between IIRG polymorphisms and TB risk remains unknown.In this study,the gene polymorphisms and their association with tuberculosis were determined in a Chinese population.Methods:We performed a case-control study involving 1016 patients with TB and 507 healthy controls of Han Chinese origin.Sixty-four single-nucleotide polymorphisms(SNPs)belonging to 18 IIRGs were genotyped by the PCR-MassArray assay,and the obtained data was analyzed withχ2-test,Bonferroni correction,and unconditional logistic regression analysis.Results:We observed significant differences in the allele frequency of LTA rs2229094*C(P=0.015),MBL2 rs2099902*C(P=0.001),MBL2 rs930507*G(P=0.004),MBL2 rs10824793*G(P=0.004),and IL12RB1 rs2305740*G(P=0.040)between the TB and healthy groups.Increased TB risk was identified in the rs930507 G/G genotype(Padjusted=0.027)under a codominant genetic model as well as in the rs2099902(C/T+C/C)vs T/T genotype(Padjusted=0.020),rs930507(C/G+G/G)vs C/C genotype(Padjusted=0.027),and rs10824793(G/A+G/G)vs A/A genotype(Padjusted=0.017)under a dominant genetic model after Bonferroni correction in the analysis of the overall TB group rather than the TB subgroups.Furthermore,the rs10824793_rs7916582*GT and rs10824793_rs7916582*GC haplotypes were significantly associated with increased TB risk(P=0.001,odds ratio[OR]=1.421,95%confidence interval[CI]:1.152-1.753;and P=0.018,OR=1.364,95%CI:1.055-1.765,respectively).Moreover,the rs10824793_rs7916582*AT/AT or rs10824793_rs7916582*GT/GT diplotype showed a protective(P=0.003,OR=0.530,95%CI:0.349-0.805)or harmful(P=0.009,OR=1.396,95%CI:1.087-1.793)effect against the development of TB.Conclusions:This study indicated that MBL2 polymorphisms,haplotypes,and diplotypes were associated with TB susceptibility in the Han Chinese population.Additionally,larger sample size studies are needed to further confirm these findings in the future. 展开更多
关键词 TUBERCULOSIS mannose-binding lectin Single-nucleotide polymorphism GENOTYPE HAPLOTYPE
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The extracellular secretion of miR-1825 wrapped by exosomes increases CLEC5A expression:A potential oncogenic mechanism in ovarian cancer
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作者 QIAOLING WU ZHAOLEI CUI +4 位作者 HONGMEI XIA SHAN JIANG JING BAI ZHUO SHAO YANG SUN 《BIOCELL》 SCIE 2023年第5期1039-1050,共12页
Background:Ovarian cancer(OC)is a leading cause of gynecological cancer-linked deaths worldwide.Exosomal miR-1825 and its target gene C-type lectin domain family 5 member A(CLEC5A)are associated with tumorigenesis in ... Background:Ovarian cancer(OC)is a leading cause of gynecological cancer-linked deaths worldwide.Exosomal miR-1825 and its target gene C-type lectin domain family 5 member A(CLEC5A)are associated with tumorigenesis in cancers that was further probed.Methods:Exosomal miR-1825 expression in exosomes and its impact on overall survival(OS)prediction were determined using Gene Expression Omnibus(GEO)and The Cancer Genome Atlas(TCGA)data.Target genes of miR-1825 were searched in five prediction databases and prognostically significant differentially expressed genes were identified.Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analyses were carried out.The ability of CLEC5A to predict OS was evaluated using univariate and multivariate Cox regression analyses and Kaplan-Meier curves.The CLEC5A expression pattern in OC was validated using immunohistochemistry.The CIBERSORT algorithm was used to compare the immune cell landscape,and the results were validated in a GEO cohort.Finally,the predicted half maximal inhibitory concentration(IC50)values for five commonly used chemotherapy agents were also compared.Results:MiR-1825 level was higher in exosomes derived from OC cells and served as a tumor suppressor.The CLEC5A gene was found to be a target of miR-1825,the upregulation of which was correlated with a poor prognosis.M2 macrophage infiltration was significantly enhanced in the CLEC5A high expression group,while T follicular helper cell infiltration was reduced in it.While the predicted IC50 for cisplatin and doxorubicin was higher in the CLEC5A high expression group,that of docetaxel,gemcitabine,and paclitaxel was lower.Conclusion:MiR-1825,a promising OC biomarker,may promote OC progression by increasing CLEC5A expression via exosome-mediated efflux from tumor cells. 展开更多
关键词 EXOSOME MicroRNA-1825 C-type lectin domain family 5 member A PI3K-Akt pathway Tumor immune microenvironment
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Molecular Modeling and Docking of Mannose-binding Lectin from Lycoris radiata 被引量:1
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作者 ZHU Qian-kun ZHU Meng-li ZOU Jia-xin FENG Pei-chun FAN Gao-tao LIU Zu-bi WANG Wan-jun 《Chemical Research in Chinese Universities》 SCIE CAS CSCD 2013年第6期1153-1158,共6页
Lycoris radiata mannose-binding lectin(LRL) is a protein which binds mannose residues specifically. The maturation peptide and three mannose-binding domains(residues 49-57, 80-88 and 113--121) of LRL were identifi... Lycoris radiata mannose-binding lectin(LRL) is a protein which binds mannose residues specifically. The maturation peptide and three mannose-binding domains(residues 49-57, 80-88 and 113--121) of LRL were identified by sequence analysis. The 3D structure of LRL constructed by homology modeling shaped a flstular triangular prism. Three flanks of the prism are mainly composed of β-sheets and each flank has a mannose-binding domain. According to the docking and dynamics simulation, the bindings of residues 49--57 and 80--88 with mannose are more stable than that of residues 113--121 with it. The key residues for binding mannose are Gin80, Asp82, Ash84 and Tyr88. The study preliminarily analyzed the interaction sites and mechanism of LRL with mannoses, which could be useful for the study on insect-resistance and related drug discovery of LRL. 展开更多
关键词 mannose-binding lectin Lycoris radiata Molecular modeling Molecular docking Dynamics simulation
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The clinical relevance of MBL2 gene polymorphism and sepsis 被引量:2
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作者 Shao-Wen Cheng Li-Na Xian +8 位作者 Zhi-Xing Lin Xue Ao Jun-Yi Yao Ying-Qing Li Yong-Yan Li Xiu-Ru Li Wei-Cheng Wang Chuan-Zhu Lyu Ying Li 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2018年第3期251-254,共4页
Objective:To detect the clinical relevance of mannose-binding lectin 2(MBL2) gene polymorphism and sepsis in Chinese lived in Hainan island.Methods: Blood samples from 57 patients with sepsis and 69 patients without s... Objective:To detect the clinical relevance of mannose-binding lectin 2(MBL2) gene polymorphism and sepsis in Chinese lived in Hainan island.Methods: Blood samples from 57 patients with sepsis and 69 patients without sepsis were collected in the ICU of several large hospitals in Hainan province. Genomic DNA was extracted from whole blood and then PCR purification product was sequenced and typed by 3730 sequencing analyzer. The concentration of MBIL2 in serum was detected by ELISA.Results: We found that genotype and allele distributions in two groups were in accordance with the Hardy-Weinberg Equilibrium. The frequency of GA genotype was significantly higher than that in non-sepsis group(P=0.013). A allele frequency in sepsis group was also much higher than that in non-sepsis group(P=0.028).Logister regression analysis showed that the patients who carried A allele were more prone to get sepsis than G allele carrier(P=0.014, OR=2,550, 95%CI=1.207-5.386). The MBL2 level in serum of sepsis patients with genotype GG and GA was significantly lower than that in non-sepsis group(P<0.05). In sepsis group, the MBL2 serum level of patients with genotype GA was obviously lower than that in patients with genotype GG(P<0.05).Conclusions: The variation of rs 1800450 G→A increased the incidence of sepsis and decreased the level of MBL2 in serum. 展开更多
关键词 mannose-binding lectin 2 POLYMORPHISM SEPSIS
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Genetic variants of innate immune receptors and infections after liver transplantation 被引量:1
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作者 Gemma Sanclemente Asuncion Moreno +2 位作者 Miquel Navasa Francisco Lozano Carlos Cervera 《World Journal of Gastroenterology》 SCIE CAS 2014年第32期11116-11130,共15页
Infection is the leading cause of complication after liver transplantation, causing morbidity and mortality in the first months after surgery. Allograft rejection is mediated through adaptive immunological responses, ... Infection is the leading cause of complication after liver transplantation, causing morbidity and mortality in the first months after surgery. Allograft rejection is mediated through adaptive immunological responses, and thus immunosuppressive therapy is necessary after transplantation. In this setting, the presence of genetic variants of innate immunity receptors may increase the risk of post-transplant infection, in comparison with patients carrying wild-type alleles. Numerous studies have investigated the role of genetic variants of innate immune receptors and the risk of complication after liver transplantation, but their results are discordant. Tolllike receptors and mannose-binding lectin are arguably the most important studied molecules; however, many other receptors could increase the risk of infection after transplantation. In this article, we review the published studies analyzing the impact of genetic variants in the innate immune system on the development of infectious complications after liver transplantation. 展开更多
关键词 Innate immunity Genetic variants Single nucleotide polymorphisms Liver transplantation Post-transplant infections Toll-like receptors mannose-binding lectin
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Bioinformatics analysis of interaction between MBL2 and MASPs family proteins
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作者 Shao-Wen Cheng Yang-Ping Chen +3 位作者 An-Qiang Zhang Lei Peng Hua-Ping Liang Chuan-Zhu Lyu 《Journal of Hainan Medical University》 2019年第15期1-4,共4页
Objective:To predict and analyze the interaction between mannose-binding lectin 2(MBL2)protein and mannan-binding lectin-related serine proteases(MASPs)family proteins by bioinformatics.Methods:Homology modeling(Swiss... Objective:To predict and analyze the interaction between mannose-binding lectin 2(MBL2)protein and mannan-binding lectin-related serine proteases(MASPs)family proteins by bioinformatics.Methods:Homology modeling(Swiss-model)and fold recognition(Phyre 2)were used to construct the structure of MBL2 protein and MASPs family proteins,respectively.STRING database and ZDOCK 3.02 were used to predict and analyze the interaction between MBL2 and MASP1 and MASP2 proteins.Results:MBL2 had direct interaction with MASP1 and MASP2,and formed an interaction network with COLEEC11,COLEC10,FCN2,and C4B.The binding sites of MBL2 and MASP1 and MASP2 overlapped highly.MBL2 participated in the binding of MASP1 residues,and most of them(77%)were also involved in the binding of MASP2,suggesting that MBL2 interacted with the proteins of MASPs family through the same region.Conclusion:MBL2 and MASPs family proteins play an important role in the activation of the complement system and immune defense of the body. 展开更多
关键词 mannose-binding lectin 2 SERINE PROTEASE BIOINFORMATICS
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Overexpression of OsJAC1, a Lectin Gene, Suppresses the Coleoptile and Stem Elongation in Rice 被引量:4
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作者 Jia-Fu Jiang Yun-Yuan Xu Kang Chong 《Journal of Integrative Plant Biology》 SCIE CAS CSCD 2007年第2期230-237,共8页
Lectin plays an Important role In defense signaling In plants, but its function In plant growth and development is not well known. Previously, we cloneds rice (Oryza sativa L.) gene OsJAC1 encoding s msnnose-blndlng... Lectin plays an Important role In defense signaling In plants, but its function In plant growth and development is not well known. Previously, we cloneds rice (Oryza sativa L.) gene OsJAC1 encoding s msnnose-blndlng Jscslln-relsted lectln, and found that OsJAC1 was Jssmonlc acid (JA) Inducible. Here we cloned the promoter of OsJAC1, and GUS activity was detected In young roots, coleoptlles, sheaths, leaves, nodes of stems, stems, rschlses, pistils, stsmens and lemmss of OsJAC1::GUS trsnsgenlc rice, suggesting that OsJAC1 Is s constitutive expression gene In rice. Moreover, OsJAC1-overexpressed (Ubi::OsJAC1) rice showed dwarfism with shorter coleptlles resulting from the failure of cell elongation of coleoptlles. In addition, compared with coleoptlles of wild-type plants, those of OsJAC1 overexpresslon rice were more sensitive to JA treatment. These data revealed that, besides Its roles in defense response, lectin plays an Important role in rice growth and development. 展开更多
关键词 COLEOPTILE jasmonic acid mannose-binding lectin Oryza sativa OsJAC1.
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