BACKGROUND Immunoglobulin G4-related disease(IgG4-RD)is a complex immune-mediated condition that causes fibrotic inflammation in several organs.A significant clinical feature of IgG4-RD is hypertrophic pachymeningitis...BACKGROUND Immunoglobulin G4-related disease(IgG4-RD)is a complex immune-mediated condition that causes fibrotic inflammation in several organs.A significant clinical feature of IgG4-RD is hypertrophic pachymeningitis,which manifests as inflammation of the dura mater in intracranial or spinal regions.Although IgG4-RD can affect multiple areas,the spine is a relatively rare site compared to the more frequent involvement of intracranial structures.CASE SUMMARY A 70-year-old male presented to our hospital with a two-day history of fever,altered mental status,and generalized weakness.The initial brain magnetic resonance imaging(MRI)revealed multiple small infarcts across various cerebral regions.On the second day after admission,a physical examination revealed motor weakness in both lower extremities and diminished sensation in the right lower extremity.Electromyographic evaluation revealed findings consistent with acute motor sensory neuropathy.Despite initial management with intravenous immunoglobulin for presumed Guillain-Barrésyndrome,the patient exhibited progressive worsening of motor deficits.On the 45th day of hospitalization,an enhanced MRI of the entire spine,focusing specifically on the thoracic 9 to lumbar 1 vertebral level,raised the suspicion of IgG4-related spinal pachymeningitis.Subsequently,the patient was administered oral prednisolone and participated in a comprehensive rehabilitation program that included gait training and lower extremity strengthening exercises.CONCLUSION IgG4-related spinal pachymeningitis,diagnosed on MRI,was treated with corticosteroids and a structured rehabilitation regimen,leading to significant improvement.展开更多
Taking a heavy-duty truck as a research platform,the changing characteristics of shifting force,shift time,and slipping work are obtained through theoretical analysis and manual shift test of a real vehicle. Based on ...Taking a heavy-duty truck as a research platform,the changing characteristics of shifting force,shift time,and slipping work are obtained through theoretical analysis and manual shift test of a real vehicle. Based on the analysis of the test results,a gear-shifting control strategy of the hydraulic automated shift control system is designed and experimentally verified on the bench. By optimizing the control parameters of high-speed switching valves,a control strategy and parameters are obtained,which can meet the requirements of dynamic performance and reliability.展开更多
A series of triaxial laboratory experiments are performed on thick-walled hollow cylindrical samples of boom clay.The aim of this testing program is to better understand the anisotropic deformation during the excavati...A series of triaxial laboratory experiments are performed on thick-walled hollow cylindrical samples of boom clay.The aim of this testing program is to better understand the anisotropic deformation during the excavation.The testing conditions are similar to those to be experienced by host rocks around disposal galleries for radioactive waste.X-ray computed tomography is performed at different steps for each test with the samples remaining inside the loading cell.Initial analysis of the tomography images allows of the observation of the deformation of the central hole.In addition,particles manual tracking and 3D volumetric digital image correlation processing methods are considered being used to analyze the particles displacements and the boundary deformation of the sample quantitatively.An unsymmetrical damaged zone is induced around the hole,with a reverse deformation trend being found at the boundary after unloading,which indicates that the significant anisotropic deformation of boom clay can be induced by mechanical unloading.展开更多
Through reusing software test components, automated software testing generally costs less than manual software testing. There has been much research on how to develop the reusable test components, but few fall on how ...Through reusing software test components, automated software testing generally costs less than manual software testing. There has been much research on how to develop the reusable test components, but few fall on how to estimate the reusability of test conlponents for automated testing. The purpose of this paper is to present a method of minimum reusability estimation for automated testing based on the return on investment （ROI） model. Minimum reusability is a benchmark for the whole automated testing process. If the reusability in one test execution is less than the minimum reusability, some new strategies must be adopted ill the next test execution to increase the reusability. Only by this way, we can reduce unnecessary costs and finally get a return on the investment of automated testing.展开更多
文摘BACKGROUND Immunoglobulin G4-related disease(IgG4-RD)is a complex immune-mediated condition that causes fibrotic inflammation in several organs.A significant clinical feature of IgG4-RD is hypertrophic pachymeningitis,which manifests as inflammation of the dura mater in intracranial or spinal regions.Although IgG4-RD can affect multiple areas,the spine is a relatively rare site compared to the more frequent involvement of intracranial structures.CASE SUMMARY A 70-year-old male presented to our hospital with a two-day history of fever,altered mental status,and generalized weakness.The initial brain magnetic resonance imaging(MRI)revealed multiple small infarcts across various cerebral regions.On the second day after admission,a physical examination revealed motor weakness in both lower extremities and diminished sensation in the right lower extremity.Electromyographic evaluation revealed findings consistent with acute motor sensory neuropathy.Despite initial management with intravenous immunoglobulin for presumed Guillain-Barrésyndrome,the patient exhibited progressive worsening of motor deficits.On the 45th day of hospitalization,an enhanced MRI of the entire spine,focusing specifically on the thoracic 9 to lumbar 1 vertebral level,raised the suspicion of IgG4-related spinal pachymeningitis.Subsequently,the patient was administered oral prednisolone and participated in a comprehensive rehabilitation program that included gait training and lower extremity strengthening exercises.CONCLUSION IgG4-related spinal pachymeningitis,diagnosed on MRI,was treated with corticosteroids and a structured rehabilitation regimen,leading to significant improvement.
基金Supported by the National High Technology Engineering Program(302011)
文摘Taking a heavy-duty truck as a research platform,the changing characteristics of shifting force,shift time,and slipping work are obtained through theoretical analysis and manual shift test of a real vehicle. Based on the analysis of the test results,a gear-shifting control strategy of the hydraulic automated shift control system is designed and experimentally verified on the bench. By optimizing the control parameters of high-speed switching valves,a control strategy and parameters are obtained,which can meet the requirements of dynamic performance and reliability.
基金supported by Fundamental Research Funds for the Central Universities (No.FRF-TP-14-033A1)TIMODAZ project as part of the sixth EURATOM framework programme for nuclear research and training activities (2002–2006)The Department of Diagnostic and Interventional Radiology of the CHUV and the collaboration with Laboratoire 3S-R,Grenoble are gratefully acknowledged
文摘A series of triaxial laboratory experiments are performed on thick-walled hollow cylindrical samples of boom clay.The aim of this testing program is to better understand the anisotropic deformation during the excavation.The testing conditions are similar to those to be experienced by host rocks around disposal galleries for radioactive waste.X-ray computed tomography is performed at different steps for each test with the samples remaining inside the loading cell.Initial analysis of the tomography images allows of the observation of the deformation of the central hole.In addition,particles manual tracking and 3D volumetric digital image correlation processing methods are considered being used to analyze the particles displacements and the boundary deformation of the sample quantitatively.An unsymmetrical damaged zone is induced around the hole,with a reverse deformation trend being found at the boundary after unloading,which indicates that the significant anisotropic deformation of boom clay can be induced by mechanical unloading.
基金Foundation item： the National Natural Science Foundation of China （No. 90718037）
文摘Through reusing software test components, automated software testing generally costs less than manual software testing. There has been much research on how to develop the reusable test components, but few fall on how to estimate the reusability of test conlponents for automated testing. The purpose of this paper is to present a method of minimum reusability estimation for automated testing based on the return on investment （ROI） model. Minimum reusability is a benchmark for the whole automated testing process. If the reusability in one test execution is less than the minimum reusability, some new strategies must be adopted ill the next test execution to increase the reusability. Only by this way, we can reduce unnecessary costs and finally get a return on the investment of automated testing.
