腺癌多发转移合并Sister Mary Joseph结节

报告1例腺癌多发转移合并Sister Mary Joseph结节。患者男,49岁。脐部斑块、结节6个月,腰痛2个月。皮肤科检查:脐部一直径3.5 cm的淡红色浸润性斑块,表面可见多个直径1~5 mm淡红色丘疹、结节,簇集呈菜花样外观,质地坚韧,活动度差。CT检查示纵隔内淋巴结增大,腰3~腰5椎体等多处骨质破坏;锝亚甲基二膦酸盐(^(99m)Tc-MDP)全身骨显像示全身骨骼多处异常放射性浓聚灶。皮损组织病理检查:表皮大致正常,真皮全层致密增生的胶原束间肿瘤细胞呈单个或条索状、列兵样排列,部分肿瘤细胞核大、深染,有明显异形性。免疫组化:细胞角蛋白(CK)、CK7、绒毛蛋白(villin)均阳性表达。腰4椎体针吸组织病理检查符合转移性腺癌,免疫组化示CK及低分子质量细胞角蛋白(CAM)5.2均阳性表达。诊断:腺癌多发转移合并Sister Mary Joseph结节。治疗:患者拒绝接受治疗,随访至13个月时死亡。

Novel insights in phosphodiesterase 4 subtype inhibition to target neuroinflammation and stimulate remyelination

In neurodegenerative and classically demyelinating disorders such as multiple sclerosis(MS),spinal cord injury(SCI),stroke,and Charcot-Marie-Tooth disease,glial functioning is compromised and nervous tissue integrity is lost.Recently,primary neurodegenerative disorders such as Alzheimer’s disease,amyotrophic lateral sclerosis(ALS),and Parkinson’s disease(PD)are increasingly linked to impaired oligodendroglia functioning upon neurodegeneration.Due to the destructive micro-environment created by nervous tissue damage,the progressive cellular loss in these disorders,and the amitotic nature of neurons,spontaneous endogenous repair process are limited in nature.Hence,there is a medical need for efficient therapeutic strategies capable of supporting neuro-reparative processes to occur,likely supported by improved oligodendroglia cell functioning.

Targeting muscle to treat Charcot-Marie-Tooth disease

Charcot-Marie-Tooth disease(CMT)is a hereditary peripheral neuropathy causing muscle weakness/wasting and sensory dysfunction predominantly in limb extremities.CMT patients display gait abnormalities,foot deformities,loss of sensation and decreased/absent deep tendon reflexes,with motor symptoms usually being more prominent than sensory.

Autophagy-targeting modulation to promote peripheral nerve regeneration

Nerve regeneration following traumatic peripheral nerve injuries and neuropathies is a complex process modulated by diverse factors and intricate molecular mechanisms.Past studies have focused on factors that stimulate axonal outgrowth and myelin regeneration.However,recent studies have highlighted the pivotal role of autophagy in peripheral nerve regeneration,particularly in the context of traumatic injuries.Consequently,autophagy-targeting modulation has emerged as a promising therapeutic approach to enhancing peripheral nerve regeneration.Our current understanding suggests that activating autophagy facilitates the rapid clearance of damaged axons and myelin sheaths,thereby enhancing neuronal survival and mitigating injury-induced oxidative stress and inflammation.These actions collectively contribute to creating a favorable microenvironment for structural and functional nerve regeneration.A range of autophagyinducing drugs and interventions have demonstrated beneficial effects in alleviating peripheral neuropathy and promoting nerve regeneration in preclinical models of traumatic peripheral nerve injuries.This review delves into the regulation of autophagy in cell types involved in peripheral nerve regeneration,summarizing the potential drugs and interventions that can be harnessed to promote this process.We hope that our review will offer novel insights and perspectives on the exploitation of autophagy pathways in the treatment of peripheral nerve injuries and neuropathies.

How Marie Sklodowska-Curie Doctoral Networks Can Support European Refractory Ecosystem in Context of The European Green Deal

The movement of the Iron&Steelmaking(I&S)industry towards Net-Zero emissions and digitalized processes through disruptive,breakthrough technologies will be achieved through the use of Hydrogen.The biggest challenge for the refractory industry is to continue to meet the performance expectations while,at the same time,moving to a more sustainable production direction.The complexity and urgency of these technological changes,highlighted by the European Green Deal,requires ambitious,international,interdisciplinary and intersectoral projects,bringing together institutes from across the global value chain,to carry out cutting edge research.The European Union,through its flagship doctoral training program,MSCA,has,and continues to support research and development as well as the promotion of the refractory industry in Europe.An introduction to two MSCA projects and some of the results achieved are highlighted within this article.

MEET YOUR TEACHER Anne Marie

Q:What kinds of things do youtake pictures of?A:I love taking pictures of food!I like to visit cute cafés and try new foods.Before I take the first bite,I always snap a photo first!

Ultrasound in Ti-Rads Classification of Thyroid Nodules at the Marie Curie Medical Clinic

Introduction: A thyroid nodule is a localized hypertrophy within the thyroid parenchyma. The aim of our study was to study the benefit of ultrasound in the Ti-rads classification of thyroid nodules. Methodology: This was a prospective study with a descriptive aim, with prospective collection, which took place over a period of 17 months at the “Marie Curie” medical clinic. The ultrasound machine used was a Voluson E8 from 2011 and the examinations were carried out by two radiologists and two experienced sonographers. The parameters studied were sociodemographic data;clinical data and ultrasound aspects of the Ti-rads classification in the management of nodules. Results: We collected 235 patients out of 738 patients referred to the service for a cervical ultrasound, i.e. a frequency of 31.84% of cases. There was a female predominance with 95.7% of cases and a sex ratio of 0.04. The average age of our patients was 50 years. We found on cervical ultrasound: Isthmo-lobar glandular hyperplasia in 99 patients, i.e. a frequency of 42.1%. The Ti-rads 3 classification was the most represented in 69.4% of cases. The benignity criterion represented 85.6% of cases in our patients and the malignancy criterion represented 14.4% of cases. Conclusion: The precise description of a thyroid nodule provided by ultrasound (Ti-rads) is essential in the management of nodules.

Long-term survival of the Sister Mary Joseph nodule originating from breast cancer:A case report

BACKGROUND A Sister Mary Joseph nodule(SMJN)is an uncommon cutaneous metastasis found in the umbilicus,indicating an advanced malignancy.SMJNs typically originate from intra-abdominal sources,rarely from breast cancer.Diagnosis suggests a poor prognosis with a median survival of approximately 8 mo after detection.Managing patients with SMJNs is challenging,as most receive limited palliative care only.The optimal strategy for long-term survival of these patients remains unclear.CASE SUMMARY A 58-year-old female,previously diagnosed with right breast cancer 17 years ago and underwent breast-conserving surgery,adjuvant radiotherapy,and endocrine therapy,presented with a 2-cm umbilical nodule.Thirteen years previously,metastases were detected in the right supraclavicular,infraclavicular,hilar,and mediastinal lymph nodes.An umbilical nodule emerged four years before the date of presentation,confirmed as a skin metastasis of primary breast cancer upon excisional biopsy.Despite initial removal,the nodule recurred and grew,leading to her referral to our hospital.The patient underwent extensive excision of the umbilical tumor and immediate abdominal wall reconstruction.Endocrine therapy was continued postoperatively.Five years later,no local recurrence was observed,and the patient continued to work full-time,achieving over 9 years of survival following SMJN diagnosis.CONCLUSION This case study aimed to identify the optimal strategy for achieving extended survival outcomes in patients with SMJN through comprehensive treatment.We presented a case of the longest survival in a patient after undergoing a multidisciplinary treatment regimen.Our findings underscore the significance of adopting a multimodal treatment approach comprising timely and wide excision along with adjunctive therapy.This approach can control the disease,prolong survival,and improve the quality of life in patients with SMJN.

Sister Mary Joseph结节一例

患者,男,54岁。脐部肿块3天。1年前确诊胃癌并行胃大部切除术-空肠吻合术。脐部肿物组织病理示:浸润性或转移性低分化腺癌,部分为印戒细胞癌。结合病史及免疫组化,符合胃来源。诊断为Sister Mary Joseph结节,给予手术切除。

Facilitating Economic Engagement:Cameroonian CEO drives the dynamic partnership between China and his country

The Cameroon Economic and Trade Day in China,a forum that frequently brings together Cameroonian and Chinese businesspeople,was founded by Jean Marie Aboganena.He also serves as the CEO of African Business Development and Representation,a Yaoundébased organisation for African business development and representation.

Diverse CMT2 neuropathies are linked to aberrant G3BP interactions in stress granules

Complex diseases often involve the interplay between genetic and environmental factors. Charcot-Marie-Tooth type 2neuropathies (CMT2) are a group of genetically heterogeneous disorders, in which similar peripheral neuropathology isinexplicably caused by various mutated genes. Their possible molecular links remain elusive. Here, we found that uponenvironmental stress, many CMT2-causing mutant proteins adopt similar properties by entering stress granules (SGs), where theyaberrantly interact with G3BP and integrate into SG pathways. For example, glycyl-tRNA synthetase (GlyRS) is translocated fromthe cytoplasm into SGs upon stress, where the mutant GlyRS perturbs the G3BP-centric SG network by aberrantly binding toG3BP. This disrupts SG-mediated stress responses, leading to increased stress vulnerability in motoneurons. Disrupting thisaberrant interaction rescues SG abnormalities and alleviates motor deficits in CMT2D mice. These findings reveal a stressdependentmolecular link across diverse CMT2 mutants and provide a conceptual framework for understanding geneticheterogeneity in light of environmental stress.

约会撞期风波

找找看Phil在公园做什么?“嘿,Mary,真高兴见到你!”Phil说。他和Mary是好朋友。“嗨,Phil!你这么早到公园来做什么?”Many问。“今天早上公园有好多漂亮的鸟,我在给它们拍照。”Phil说。“你拍好再给我看吧。”Mary说。“没问题。我们今天晚上还要去看电影,对吗?”Phil问。

一只逆天改命的白色肉鸡

下面这张照片里的公鸡叫 Boo,今年 5 岁。 按照它原本的生命轨迹,它从破壳开始就要每天被塞满饲 料,度过自己短暂的一生,然后被人宰杀,做成各种食物送到人类的餐桌上。幸运的是,它遇到了 Mary,让它能有机会这样傻兮兮地从胯下看人。

右侧结肠癌伴Sister Mary Joseph’s结节及腹股沟淋巴结转移——一例报告及文献综述(英文)

Sister Mary Joseph’s结节(Sister Mary Joseph’s nodule,SMJN)是指腹腔内恶性肿瘤导致的脐部转移性结节,1949年由Hamilton Bailey命名以纪念St.Mary’s Hospital的护士Sister Joseph。SMJN并不多见,但个案报道屡屡见诸文献。这种脐部转移可以与腹腔内肿瘤同时出现或异时出现,是预后极差的表现。SMJN最常见原发肿瘤为胃癌及卵巢癌,结肠癌特别是右侧结肠癌引起的SMJN极其罕见。另外右侧结肠癌转移至腹股沟淋巴结未见文献报道。本文报道一例右侧结肠癌同时伴有SMJN及腹股沟淋巴结转移,并对相关文献进行综述。

非乘积解随机Petri网的乘积形式近似求解

讨论了非乘积解随机 Petri网的近似求解问题 .将 Marie方法引入到随机 Petri网的近似分析中 ,利用随机 Petri网中已有的结论将该方法中的分解原则推广到更一般的情形 ,使其应用范围更广 .利用运算分析法对这些分解原则作了形式化描述 ,在此基础上 ,给出了有关结论的数学证明 .最后 ,对这种近似方法作了误差分析 ,找出了产生误差的原因 。

Sister Mary Joseph结节

患者男,69岁。主诉:脐部及脐周红色丘疹、结节伴触痛5个月余。现病史:患者5个月前脐部及脐周无明显诱因出现数个红色丘疹、结节,凸起于皮面并伴触痛,曾就诊于外科,考虑为皮肤感染,经口服联合外用抗生素(具体成分不详)治疗效果欠佳,于2019年6月19日就诊于我科,自诉病程中常伴有胃部不适。既往史和家族史:既往有肾结石病史;家族史及个人史无特殊。

Sister Mary Joseph结节

报告1例可能为胃癌转移的Sister Mary Joseph结节1例。患者男,44岁。脐部出现暗红色大小不等的结节7个月。皮损组织病理检查:真皮全层胶原束间散在呈腺样分化的肿瘤细胞,免疫组化染色:癌胚抗原(CEA)阳性、细胞角蛋白(CK)20阳性、CK7阳性、甲状腺转录因子(TTF)-1阴性。糖链抗原(CA)19-9、CA72-4、CA24-2均升高。腹部B超检查示:胃幽门部胃壁增生性病变,肝右叶多发偏强回声结节,腹水。

奥杜威工业石制品分类综述

石制品是旧石器时代考古的主要研究对象,其分类是旧石器生产技术和文化研究的基础与前提,然而,中国旧石器时代考古有关石制品分类目前尚无一致标准,这对开展旧石器时代考古学术研究的国际交流产生了负面影响。鉴于似奥杜威(Oldowan-like)或模式I工业在我国古人类石器工业面貌占有非常特殊的地位,因此,本文对以非洲为代表的奥杜威(Oldowan)工业(模式I)石器技术研究中有关石制品的分类体系进行整合和梳理,同时借鉴Mary Leakey、Glynn Isaac和Nicholas Toth等为代表的不同分类系统,并对中国境内有关石制品分类的现状进行讨论。

极端条件下辐射与物质相互作用(MaRIE)研究装置概况

极端条件下的辐射与物质相互作用实验装置,是洛斯·阿拉莫斯国家实验室针对美国核武器库存维护计划需要,正在建设的旗舰级实验装置,其主要任务是促进对核武器相关材料的鉴定、认证和评估。本文从建设目的、组成部分和发展规划等方面简述了该装置的概况,并结合美国核库存维护目前面临的挑战,分析了该装置的建设对美国核库存维护的重要意义。