The role of fecal lactoferrin and calprotectin has been extensively studied in many areas of inflammatory bowel disease(IBD) patients' management. The postoperative setting in both Crohn's disease(CD) and ulce...The role of fecal lactoferrin and calprotectin has been extensively studied in many areas of inflammatory bowel disease(IBD) patients' management. The postoperative setting in both Crohn's disease(CD) and ulcerative colitis(UC) patients has been less investigated although few promising results come from small, crosssectional studies. Therefore, the current post-operative management still requires endoscopy 6-12 mo after intestinal resection for CD in order to exclude endoscopic recurrence and plan the therapeutic strategy. In patients who underwent restorative proctocolectomy, endoscopy is required whenever symptoms includes the possibility of pouchitis. There is emerging evidence that fecal calprotectin and lactoferrin are useful surrogate markers of inflammation in the post-operative setting, they correlate with the presence and severity of endoscopic recurrence according to Rutgeerts' score and possibly predict the subsequent clinical recurrence and response to therapy in CD patients. Similarly, fecal markers show a good correlation with the presence of pouchitis, as confirmed by endoscopy in operated UC patients. Fecal calprotectin seems to be able to predict the short-term development of pouchitis in asymptomatic patients and to vary according to response to medical treatment. The possibility of both fecal markers to used in the routine clinical practice for monitoring IBD patients in the postoperative setting should be confirmed in multicentric clinical trial with large sample set. An algorithm that can predict the optimal use and timing of fecal markers testing, the effective need and timing of endoscopy and the cost-effectiveness of these as a strategy of care would be of great interest.展开更多
人stathmin也称原癌基因蛋白18(oncogene protein 18,Op18),是一种广泛存在于细胞质的蛋白质,其相对分子质量约为19×103,可与微管蛋白结合,参与微管和纺锤体的组装;与细胞的增殖、分化、再生和运动均有关,并具有信号活性调节的功...人stathmin也称原癌基因蛋白18(oncogene protein 18,Op18),是一种广泛存在于细胞质的蛋白质,其相对分子质量约为19×103,可与微管蛋白结合,参与微管和纺锤体的组装;与细胞的增殖、分化、再生和运动均有关,并具有信号活性调节的功能。近年来有研究发现,stathmin在多种肿瘤中高表达,并可通过调节微管的解聚,促进肿瘤细胞的运动及侵袭。Stathmin翻译后修饰状态的改变,可影响与p53蛋白的相互作用,参与肿瘤的发生发展。目前单独或者联合化疗药物使用的抗stathmin效应剂已用于某些肿瘤的治疗。虽然stathmin与肿瘤病因学的内在联系尚不十分清楚,但其作为一个潜在的肿瘤标志物或药物靶点值得进一步研究探讨。展开更多
目的：观察骨康胶囊联合钙尔奇D治疗绝经后骨质疏松症（PMOP）临床疗效及其对患者骨转换标志物Ⅰ型胶原羧基端肽β特殊序列（β-CTX）、Ⅰ型胶原氨基端延长肽（PINP）、骨钙素N端片段（N-MID-OT）、25羟基D（25（OH）D）水平的影响。方...目的：观察骨康胶囊联合钙尔奇D治疗绝经后骨质疏松症（PMOP）临床疗效及其对患者骨转换标志物Ⅰ型胶原羧基端肽β特殊序列（β-CTX）、Ⅰ型胶原氨基端延长肽（PINP）、骨钙素N端片段（N-MID-OT）、25羟基D（25（OH）D）水平的影响。方法：60例PMOP患者随机分骨康胶囊＋钙尔奇D治疗组30例（治疗组）和骨康胶囊模拟剂＋钙尔奇D治疗组30例（对照组）,两组患者治疗6个月。观察2组患者的临床疗效,测定骨密度（bone mineral density,BMD）,并检测血清中β-CTX、PINP、N-MID-OT、25（OH）D水平。结果 治疗6个月后,治疗组与对照组腰椎L_（2~4）和左侧股骨颈BMD均明显升高（P〈0.05）,且治疗组与对照组相比变化更为显著（P〈0.05）。此外,治疗组的β-CTX水平在治疗6个月后极显著下降,与对照组相比,治疗组变化更为显著（P〈0.05）。治疗后试验组总有效率显著高于对照组（P〈0.05）。结论：骨康胶囊联合钙尔奇D治疗PMOP可显著降低β-CTX水平,改善骨质疏松症状。展开更多
管道标识是保障管道安全的重要设施,国内管道标识标准存在的问题是管道标识的设置位置、制作材料等要求不一致,甚至存在矛盾。提出了借鉴国外标准改进国内标准的理念,介绍了API RP 1109-2010《液体石油管道设施标识推荐做法》。该标准...管道标识是保障管道安全的重要设施,国内管道标识标准存在的问题是管道标识的设置位置、制作材料等要求不一致,甚至存在矛盾。提出了借鉴国外标准改进国内标准的理念,介绍了API RP 1109-2010《液体石油管道设施标识推荐做法》。该标准先进性表现在给出了管道标识定义,管道标识类型多样化;规定了管道标识设置原则,以及确定管道标识埋设深度和埋设间距应该考虑的因素;规定了空中巡检牌的设置原则和设计样式等。最后,提出了借鉴API RP1109-2010先进理念,改进国内标准的建议。展开更多
评价了国内管道地面标识标准,存在的问题主要是国内标准针对管道标识的设置位置、制作材料等要求不一致,甚至存在矛盾。介绍了API RP 1109-2010《液体石油管道设施标识推荐做法》,该标准技术先进性表现在给出了管道标识定义,管道标识类...评价了国内管道地面标识标准,存在的问题主要是国内标准针对管道标识的设置位置、制作材料等要求不一致,甚至存在矛盾。介绍了API RP 1109-2010《液体石油管道设施标识推荐做法》,该标准技术先进性表现在给出了管道标识定义,管道标识类型多样化;规定了管道标识设置原则,以及确定管道标识埋设深度和埋设间距应该考虑的因素;规定了空中巡检牌的设置原则和设计样式等。最后提出了借鉴API RP 1109-2010先进理念,提升我国管道地面标识标准的技术水平的建议。展开更多
文摘The role of fecal lactoferrin and calprotectin has been extensively studied in many areas of inflammatory bowel disease(IBD) patients' management. The postoperative setting in both Crohn's disease(CD) and ulcerative colitis(UC) patients has been less investigated although few promising results come from small, crosssectional studies. Therefore, the current post-operative management still requires endoscopy 6-12 mo after intestinal resection for CD in order to exclude endoscopic recurrence and plan the therapeutic strategy. In patients who underwent restorative proctocolectomy, endoscopy is required whenever symptoms includes the possibility of pouchitis. There is emerging evidence that fecal calprotectin and lactoferrin are useful surrogate markers of inflammation in the post-operative setting, they correlate with the presence and severity of endoscopic recurrence according to Rutgeerts' score and possibly predict the subsequent clinical recurrence and response to therapy in CD patients. Similarly, fecal markers show a good correlation with the presence of pouchitis, as confirmed by endoscopy in operated UC patients. Fecal calprotectin seems to be able to predict the short-term development of pouchitis in asymptomatic patients and to vary according to response to medical treatment. The possibility of both fecal markers to used in the routine clinical practice for monitoring IBD patients in the postoperative setting should be confirmed in multicentric clinical trial with large sample set. An algorithm that can predict the optimal use and timing of fecal markers testing, the effective need and timing of endoscopy and the cost-effectiveness of these as a strategy of care would be of great interest.
文摘人stathmin也称原癌基因蛋白18(oncogene protein 18,Op18),是一种广泛存在于细胞质的蛋白质,其相对分子质量约为19×103,可与微管蛋白结合,参与微管和纺锤体的组装;与细胞的增殖、分化、再生和运动均有关,并具有信号活性调节的功能。近年来有研究发现,stathmin在多种肿瘤中高表达,并可通过调节微管的解聚,促进肿瘤细胞的运动及侵袭。Stathmin翻译后修饰状态的改变,可影响与p53蛋白的相互作用,参与肿瘤的发生发展。目前单独或者联合化疗药物使用的抗stathmin效应剂已用于某些肿瘤的治疗。虽然stathmin与肿瘤病因学的内在联系尚不十分清楚,但其作为一个潜在的肿瘤标志物或药物靶点值得进一步研究探讨。
文摘目的：观察骨康胶囊联合钙尔奇D治疗绝经后骨质疏松症（PMOP）临床疗效及其对患者骨转换标志物Ⅰ型胶原羧基端肽β特殊序列（β-CTX）、Ⅰ型胶原氨基端延长肽（PINP）、骨钙素N端片段（N-MID-OT）、25羟基D（25（OH）D）水平的影响。方法：60例PMOP患者随机分骨康胶囊＋钙尔奇D治疗组30例（治疗组）和骨康胶囊模拟剂＋钙尔奇D治疗组30例（对照组）,两组患者治疗6个月。观察2组患者的临床疗效,测定骨密度（bone mineral density,BMD）,并检测血清中β-CTX、PINP、N-MID-OT、25（OH）D水平。结果 治疗6个月后,治疗组与对照组腰椎L_（2~4）和左侧股骨颈BMD均明显升高（P〈0.05）,且治疗组与对照组相比变化更为显著（P〈0.05）。此外,治疗组的β-CTX水平在治疗6个月后极显著下降,与对照组相比,治疗组变化更为显著（P〈0.05）。治疗后试验组总有效率显著高于对照组（P〈0.05）。结论：骨康胶囊联合钙尔奇D治疗PMOP可显著降低β-CTX水平,改善骨质疏松症状。
文摘管道标识是保障管道安全的重要设施,国内管道标识标准存在的问题是管道标识的设置位置、制作材料等要求不一致,甚至存在矛盾。提出了借鉴国外标准改进国内标准的理念,介绍了API RP 1109-2010《液体石油管道设施标识推荐做法》。该标准先进性表现在给出了管道标识定义,管道标识类型多样化;规定了管道标识设置原则,以及确定管道标识埋设深度和埋设间距应该考虑的因素;规定了空中巡检牌的设置原则和设计样式等。最后,提出了借鉴API RP1109-2010先进理念,改进国内标准的建议。
文摘评价了国内管道地面标识标准,存在的问题主要是国内标准针对管道标识的设置位置、制作材料等要求不一致,甚至存在矛盾。介绍了API RP 1109-2010《液体石油管道设施标识推荐做法》,该标准技术先进性表现在给出了管道标识定义,管道标识类型多样化;规定了管道标识设置原则,以及确定管道标识埋设深度和埋设间距应该考虑的因素;规定了空中巡检牌的设置原则和设计样式等。最后提出了借鉴API RP 1109-2010先进理念,提升我国管道地面标识标准的技术水平的建议。
