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Cell-Based Biological Markers for Blood-Enriching Chinese Herbs: Erythropoietin Production in HepG2 Cells and Nitric Oxide Release in Human Umbilical Vein Endothelial Cells (HUVECs)
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作者 Hoi Yan Leung Kam Ming Ko 《Chinese Medicine》 2023年第2期57-67,共11页
Chinese tonifying herbs, which are classified into four functional categories (namely, Yang, Qi, Yin, Blood) are commonly used for restoring normal body function and the prevention of diseases. To explore cell-based b... Chinese tonifying herbs, which are classified into four functional categories (namely, Yang, Qi, Yin, Blood) are commonly used for restoring normal body function and the prevention of diseases. To explore cell-based biological markers for Blood-enriching Chinese herbs, we investigate the effect of 11 commonly used Blood-enriching herbs on erythropoietin (EPO) production in HepG2 cells. Herbs for nourishing Yin were tested for determining the specificity of Blood-enriching herbs in inducing EPO production. In addition, the effects of Blood-enriching herbs on nitric oxide (NO) production in both HepG2 cells and human umbilical vein endothelial cells (HUVECs) were also investigated. The results indicated that methanolic extracts of Blood-enriching herbs (but not Yin-nourishing herbs) showed characteristic pharmacological activity in inducing EPO production in HepG2 cells and NO release in HUVECs. The experimental findings, therefore, support the use of cell-based EPO production and NO release as biological markers for Blood-enriching Chinese tonifying herbs. 展开更多
关键词 Blood-Enriching Chinese herbs ERYTHROPOIETIN Nitric Oxide
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Herbs and management of hypertension:Claims,criticism,and challenges
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作者 Oluwakemi Elizabeth ADEOLA Oluwaseyi Abiodun AKPOR +2 位作者 Oghenerobor Benjamin AKPOR Modupe Motunrayo ADAMOLEKUN Olusola Bolaji ADEWALE 《Journal of Integrative Nursing》 2023年第3期216-222,共7页
Hypertension(HTN)is one of the most common chronic diseases affecting over 30%of the adult population globally,with a growing incidence rate.This article aims to identify the commonly used herbs for HTN treatment and ... Hypertension(HTN)is one of the most common chronic diseases affecting over 30%of the adult population globally,with a growing incidence rate.This article aims to identify the commonly used herbs for HTN treatment and examine their claims,criticisms,and challenges.It further aims to provide useful recommendations regarding the use of herbs for HTN treatment.HTN complications,such as coronary heart disease,stroke,peripheral vascular disease,vision impairment,and renal failure can result in morbidity and mortality.The high cost of conventional medications,which sometimes may not even be available or easily accessible with their unfavorable side effects as well as taking more than one pill per day,has led hypertensive patients,particularly those in rural areas,to explore alternative treatments such as herbal therapies.It is crucial to determine the different modes of action,doses,safety,and efficacy of herbal remedies used in combination with conventional medications to improve treatment adherence and enhance patient outcomes. 展开更多
关键词 CHALLENGES CLAIMS CRITICISM herbs HYPERTENSION
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Traditional Chinese medicine prescriptions and herbs for the treatment of hypothyroidism:a narrative review
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作者 Jun-Qi Li Ying Li +5 位作者 Jia-Chang Niu Yi-Han Huang Jia-Cheng Zhang Jing Zhang Meng-Yao Tang Wei Dang 《TMR Integrative Medicine》 2023年第24期1-24,共24页
The increasing prevalence of hypothyroidism,which can cause endocrine dysfunction,abnormal neurological function,and cardiovascular and cerebrovascular injuries,poses serious health problems.Thyroid hormone supplement... The increasing prevalence of hypothyroidism,which can cause endocrine dysfunction,abnormal neurological function,and cardiovascular and cerebrovascular injuries,poses serious health problems.Thyroid hormone supplementation constitutes the current main therapeutic method for hypothyroidism,yet it has many limitations and risks and is not suitable for everyone.Therefore,it is necessary to seek alternative and complementary treatment methods.It has been proven in practice that traditional Chinese medicine(TCM)possesses multi-channel comprehensive characteristics for the treatment of hypothyroidism and has more advantages than single thyroid hormone supplementation.Through a comprehensive examination of existing literature about TCM efficacy in addressing hypothyroidism,we have meticulously consolidated the most recent research findings on prescriptions and herbal substances employed in the treatment of this condition.Furthermore,we have explicated their respective functions in the management of hypothyroidism,thereby offering valuable perspectives and recommendations for the prospective utilization of natural remedies in its treatment. 展开更多
关键词 traditional Chinese medicine HYPOTHYROIDISM PRESCRIPTIONS single herb action mechanism
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Topology and Semantic Information Fusion Classification Network Based on Hyperspectral Images of Chinese Herbs
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作者 Boyu Zhao Yuxiang Zhang +2 位作者 Zhengqi Guo Mengmeng Zhang Wei Li 《Journal of Beijing Institute of Technology》 EI CAS 2023年第5期551-561,共11页
Most methods for classifying hyperspectral data only consider the local spatial relation-ship among samples,ignoring the important non-local topological relationship.However,the non-local topological relationship is b... Most methods for classifying hyperspectral data only consider the local spatial relation-ship among samples,ignoring the important non-local topological relationship.However,the non-local topological relationship is better at representing the structure of hyperspectral data.This paper proposes a deep learning model called Topology and semantic information fusion classification network(TSFnet)that incorporates a topology structure and semantic information transmis-sion network to accurately classify traditional Chinese medicine in hyperspectral images.TSFnet uses a convolutional neural network(CNN)to extract features and a graph convolution network(GCN)to capture potential topological relationships among different types of Chinese herbal medicines.The results show that TSFnet outperforms other state-of-the-art deep learning classification algorithms in two different scenarios of herbal medicine datasets.Additionally,the proposed TSFnet model is lightweight and can be easily deployed for mobile herbal medicine classification. 展开更多
关键词 Chinese herbs hyperspectral image deep learning non-local topological relationships convolutional neural network(CNN) graph convolutional network(GCN) LIGHTWEIGHT
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A Multilayer Network Constructed for Herb and Prescription Efficacy Analysis
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作者 Xindi Huang Liwei Liang +3 位作者 Sakirin Tam Hao Liang Xiong Cai Changsong Ding 《Computer Systems Science & Engineering》 2024年第3期691-704,共14页
Chinese Medicine(CM)has been widely used as an important avenue for disease prevention and treatment in China especially in the form of CM prescriptions combining sets of herbs to address patients’symptoms and syndro... Chinese Medicine(CM)has been widely used as an important avenue for disease prevention and treatment in China especially in the form of CM prescriptions combining sets of herbs to address patients’symptoms and syndromes.However,the selection and compatibility of herbs are complex and abstract due to intrinsic relationships between herbal properties and their overall functions.Network analysis is applied to demonstrate the complex relationships between individual herbal efficacy and the overall function of CM prescriptions.To illustrate their connections and correlations,prescription function(PF),prescription herb(PH),and herbal efficacy(HE)intranetworks are proposed based on CM theory to identify relationships between herbs and prescriptions.These three networks are then connected by PF-PH and PH-HE interlayer networks adopting herb dosage to form a multidimensional heterogeneous network,a Prescription-Herb-Function Network(PHFN).The network is applied to 112 classic prescriptions from Treatise on Exogenous Febrile and Miscellaneous Diseases to illustrate the application of PHFN.The PHFN is constructed including 146 functions in PF intra network,89 herbs in the PH intra network,and 163 herbal efficacies in the HE intra network.The results show that herb pairs with synergistic actions have stronger relevance,such as licorice-cassia twig,licorice-Chinese date,fresh ginger-Chinese date,etc.The integration of dosage to the network helps to indicate the main herbs for cluster analysis and automatic formulation.PHFN also reveals the internal relationships between the functions of prescriptions and composed herbal efficacies. 展开更多
关键词 Chinese medicine herb FORMULA network analysis herb dosage
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Chinese herbal medicine decreases incidence of hepatocellular carcinoma in diabetes mellitus patients with regular insulin management
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作者 Hsiang-Chun Lai Ju-Chien Cheng +2 位作者 Hei-Tung Yip Long-Bin Jeng Sheng-Teng Huang 《World Journal of Gastrointestinal Oncology》 SCIE 2024年第3期716-731,共16页
BACKGROUND Type 2 diabetes mellitus(DM)is an independent risk factor for hepatocellular carcinoma(HCC),while insulin is a potent mitogen.Identifying a new therapeutic modality for preventing insulin users from develop... BACKGROUND Type 2 diabetes mellitus(DM)is an independent risk factor for hepatocellular carcinoma(HCC),while insulin is a potent mitogen.Identifying a new therapeutic modality for preventing insulin users from developing HCC is a critical goal for researchers.AIM To investigate whether regular herbal medicine use can decrease HCC risk in DM patients with regular insulin control.METHODS We used data acquired from the Taiwan,Chinaese National Health Insurance research database between 2000 and 2017.We identified patients with DM who were prescribed insulin for>3 months.The herb user group was further defined as patients prescribed herbal medication for DM for>3 months per annum during RESULTS We initially enrolled 657144 DM patients with regular insulin use from 2000 to 2017.Among these,46849 patients had used a herbal treatment for DM,and 140547 patients were included as the matched control group.The baseline variables were similar between the herb users and nonusers.DM patients with regular herb use had a 12%decreased risk of HCC compared with the control group[adjusted hazard ratio(aHR)=0.88,95%CI=0.80–0.97].The cumulative incidence of HCC in the herb users was significantly lower than that of the nonusers.Patients with a herb use of>5 years cumulatively exhibited a protective effect against development of HCC(aHR=0.82,P<0.05).Of patients who developed HCC,herb users exhibited a longer survival time than nonusers(aHR=0.78,P=0.0001).Additionally,we report the top 10 herbs and formulas in prescriptions and summarize the potential pharmacological effects of the constituents.Our analysis indicated that Astragalus propinquus(Huang Qi)plus Salvia miltiorrhiza Bunge(Dan Shen),and Astragalus propinquus(Huang Qi)plus Trichosanthes kirilowii Maxim.(Tian Hua Fen)were the most frequent combination of single herbs.Meanwhile,Ji Sheng Shen Qi Wan plus Dan Shen was the most frequent combination of herbs and formulas.CONCLUSION This large-scale retrospective cohort study reveals that herbal medicine may decrease HCC risk by 12%in DM patients with regular insulin use. 展开更多
关键词 Hepatocellular carcinoma Diabetes mellitus INSULIN herb Taiwan Chinaese National health insurance research database
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Exploring the mechanism of action of herb pair Pinellia Ternata-Magnolia Officinalis in the treatment of liver cancer based on network pharmacology and molecular docking
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作者 Zi-Wei Du Meng-Wei Xu +6 位作者 Rui Peng Min Fang Yan Liu Guang-Shuai Zhang Si Yan Li-Na Yang Shuang-Lin Qin 《Pharmacology Discovery》 2024年第1期51-65,共15页
Background:Explore the anti-tumor mechanism of herb pair Pinellia ternate-Magnolia officinalis(BX-HP)in liver cancer through network pharmacology using molecular docking methods.Method:The active ingredients and corre... Background:Explore the anti-tumor mechanism of herb pair Pinellia ternate-Magnolia officinalis(BX-HP)in liver cancer through network pharmacology using molecular docking methods.Method:The active ingredients and corresponding targets of the herb pair Pinellia ternate-Magnolia officinalis were obtained from the HERB database.The relevant targets for liver cancer were obtained from GeneCards,DisGeNET,TTD,and Drugbank databases.Obtain common targets between herb pair Pinellia ternate-Magnolia officinalis and liver cancer through the Bioinformatics platform,establish a PPI network diagram using STRING software,and perform GO functional enrichment and KEGG pathway enrichment analysis on the DAVID platform.AutoDockTools 1.5.7 software and molecular dynamics simulation analysis are used to evaluate the binding of components to target proteins.HERB database,SwissTargetPrediction database,SwissADME database,UniProt database,GeneCards database,TTD database,DRUGBANK database,DisGeNET database,String,DAVID.Bioinformatics platform,PDB database,PubChem and TCMSP database.Result:A total of 22 active ingredients with a Probability>0.1 targets in Magnolia officinalis were screened,26 active ingredients with a Probability>0.1 targets in Pinellia ternata,ten vital active ingredients,corresponding to 979 and 803 targets with a Probability>0.1 targets,2536 liver cancer-related targets,and 279 targets in the herb pair Pinellia ternata-Magnolia officinalis.The GO functional enrichment analysis resulted in 1297 entries,namely 971 biological process entries,118 cell localization entries,and 208 molecular function entries.Three signaling pathways were annotated through the KEGG pathway.Based on molecular docking,ten vital active ingredients and five target proteins were validated to exhibit an excellent binding affinity.The above data indicates that combining the herb pair Pinellia ternata-Magnolia officinalis may treat liver cancer through specific targets and signaling pathways.Conclusion:Herb pair Pinellia ternata-Magnolia officinalis has a synergistic effect on treating liver cancer through multicomponent,multitarget,and multi-pathway approaches.This study provides a sufficient theoretical basis for subsequent research. 展开更多
关键词 liver cancer herb pair Pinellia ternata-Magnolia officinalis target prediction network pharmacology molecular docking MECHANISM
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Herbs祛斑系列治疗黄褐斑31例临床验证报告 被引量:6
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作者 余穗娟 刘永年 +1 位作者 金久宁 安志强 《中国美容医学》 CAS 2001年第5期387-389,共3页
目的 :研究中药植物萃取液加基质复配而成的系列产品 ,对治疗黄褐斑的疗效。 方法 :将 Herbs祛斑系列产品以不同剂型种类作用于体外。 结果 :治疗组治愈 6例 ,达 19.4% ;显效 14例 ,达 45 .2 % ,有效 5例 ,达 16 .1% ;总有效率为 80 .... 目的 :研究中药植物萃取液加基质复配而成的系列产品 ,对治疗黄褐斑的疗效。 方法 :将 Herbs祛斑系列产品以不同剂型种类作用于体外。 结果 :治疗组治愈 6例 ,达 19.4% ;显效 14例 ,达 45 .2 % ,有效 5例 ,达 16 .1% ;总有效率为 80 .6 %。对照组治愈 4例 ,达 13.3% ;显效 10例 ,达 33.3% ;有效 10例 ,达 33.3% ;总有效率为 79.9%。 结论 :Herbs祛斑系列在体表能明显抑制酪氨酸酶活性 ,清除氧自由基 。 展开更多
关键词 黄褐斑 herbs祛斑系列 中药植物萃取液 基质
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Advances in treatment of ulcerative colitis with herbs: From bench to bedside 被引量:21
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作者 Ping Wan Hao Chen +1 位作者 Yuan Guo Ai-Ping Bai 《World Journal of Gastroenterology》 SCIE CAS 2014年第39期14099-14104,共6页
Ulcerative colitis(UC), an idiopathic inflammatory disorder in the colon, has become a clinical challenge, owing to the increasing incidence and poor prognosis. The conventional treatments for UC including aminosalicy... Ulcerative colitis(UC), an idiopathic inflammatory disorder in the colon, has become a clinical challenge, owing to the increasing incidence and poor prognosis. The conventional treatments for UC including aminosalicylates, corticosteroids, and immunosuppressants, induce remission in only half of patients. Meanwhile, the treatments often come with serious side effects which can be life-threatening. Herbal medicine, one of the most common traditional Chinese medicine modalities, has been introduced for centuries into clinical treatment of many human diseases such as infections and functional disorders. Recently, the potential effectiveness of herbs has been suggested as the treatment of UC, as shown by a variety of clinical trials and experimental studies. The herbs reported in the literature include aloe vera gel, butyrate, tormentil extracts, wheat grass juice, and curcumin. In the review, bioactivity of the herbs and their involvement in UC treatment are discussed. 展开更多
关键词 Inflammatory BOWEL disease herbs herb medicine Ulc
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Anti-fungal and anti-bacterial activities of ethanol extracts of selected traditional Chinese medicinal herbs 被引量:23
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作者 Lin Zhang Anjaneya S.Ravipati +9 位作者 Sundar R Koyyalamudi Sang Chul Jeong Narsimha Reddy John Bartlett Paul T.Smith Mercedes de la Cruz Maria Cndida Monteiro ngeles Melguizo Ester Jimnez Francisca Vicente 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2013年第9期673-681,共9页
Objective:To evaluate in ritro antimicrobial activities of selected 58 ethno-medicinal plant extracts with a view to assess their therapeutic potential.Methods:A total of 58 traditional Chinese medicinal plants were c... Objective:To evaluate in ritro antimicrobial activities of selected 58 ethno-medicinal plant extracts with a view to assess their therapeutic potential.Methods:A total of 58 traditional Chinese medicinal plants were carefully selected based on the literature review and their traditional use.The antimicrobial activities of ethanol extracts of these medicinal plants were tested against fungi(Aspergillus funigaius),yeast(Candida albicans),gram-negative(Acirelobacter haumannii and Pseudornnruis aeruginosa)and gram-positive bacteria(Staphglococcus aureus).The activities were tested at three different concentrations of 1.00,0.10 and 0.01 mg/mL.The data was analysed using Gene data Screener program.Results:The measured antimicrobial activities indicated that out of the 58 plant extracts,15 extracts showed anti-fungal activity and 23 extracts exhibited anti-bacterial activity.Eight plant extracts have exhibited both anti-bacterial and anti-fungal activities.For instance,Eucommia ulmoides,Pohgonum cuspidcrtum,Poria cocas and Uncaria rhineophylla showed activity against both bacterial and fungal strains,indicating their broad spectrum of activity.Conclusions:The results revealed that the ethanol extracts of 30 plants out of the selected 58 possess significant antimicrobial activities.It is interesting to note that the findings from the current study are consistent with the traditional use.A clear correlation has also been found between the antimicrobial activity and the flavonoid content of the plant extracts which is in agreement with the literature.Hence.the results presented here can be used to guide the selection of potential plant species for the isolation and structure elucidation of novel antimicrobial compounds in order to establish the structure-activity relationship.This in turn is expected to lead the way to the discovery of novel antimicrobial agents for therapeutic use. 展开更多
关键词 ANTI-FUNGAL ACTIVITY ANTI-BACTERIAL ACTIVITY ETHANOL extract Chinese MEDICINAL herb
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Essential oils and functional herbs for healthy aging 被引量:4
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作者 Snezana Agatonovic-Kustrin Ella Kustrin David W.Morton 《Neural Regeneration Research》 SCIE CAS CSCD 2019年第3期441-445,共5页
As total life expectancy increases, the prevalence of age-related diseases such as diabetes and Alzheimer's disease is also increasing. Many hypotheses about Alzheimer's disease have been developed, including ... As total life expectancy increases, the prevalence of age-related diseases such as diabetes and Alzheimer's disease is also increasing. Many hypotheses about Alzheimer's disease have been developed, including cholinergic neuron damage, oxidative stress, and inflammation. Acetylcholine is a major neurotransmitter in the brain and cholinergic deficits leads to cognitive dysfunction and decline. Recent studies have linked diabetes as a risk factor in developing Alzheimer's disease and other types of dementia. The incidence of patients with type II diabetes and increased levels and activity of α-amylase is higher in patients with dementia. It has been shown that aromatherapy with essential oils from the mint family can improve cognitive performance in Alzheimer's disease patients. Selected monoterpenoids from these essential oils are reported to inhibit acetylcholinesterase, both in vitro and in vivo. Terpenoids are small, fat-soluble organic molecules that can transfer across nasal mucosa if inhaled, or penetrate through the skin after topical application, enter into the blood and cross the blood-brain barrier. Recent evidence supports the idea that the common constituents of essential oils also inhibit α-amylase, a starch digestive enzyme that plays an important role in the control of diabetes. The mint family is a fragrant plant family that contains most of the culinary herbs found in the Mediterranean diet. The Mediterranean diet is considered to be one of the healthiest diets in the world, and is found to be beneficial not only for the heart but also for the brain. Herbs used in this diet are rich in antioxidants that can prevent oxidative damage caused by free radicals. However, our study shows that they also contain biologically active compounds with potent α-amylase and acetylcholinesterase inhibitory activities. Consumption of fresh herbs can help boost memory and reduce sugar levels in the body. The use of herbs as a functional food could lead to significant improvements in health. Cognitive stimulation with medical food and medical herbs could delay development of cognitive decline, and improve the quality of life of Alzheimer's disease patients. This effect can be enhanced if combined with aromatherapy, topically or by inhalation, and/or by ingestion. Terpenes and terpenoids, the primary constituents of these essential oils are small, lipid soluble organic molecules that can be absorbed through the skin or across nasal mucosa into the systemic blood circulation. Many terpenes can also cross the blood-brain barrier. Therefore, topical application or inhalation of essential oils will also produce a systemic effect. 展开更多
关键词 FUNCTIONAL herbs essential oils DEMENTIA mediterranean diet diabetes ACETYLCHOLINESTERASE Α-AMYLASE MINT family
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Effective components of Chinese herbs reduce central nervous system function decline induced by iron overload 被引量:14
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作者 Xian-hui Dong Jiang-tao Bai +7 位作者 Wei-na Kong Xiao-ping He Peng Yan Tie-mei Shao Wen-guo Yu Xi-qing Chai Yan-hua Wu Cong Liu 《Neural Regeneration Research》 SCIE CAS CSCD 2015年第5期778-785,共8页
Abnormally increased levels of iron in the brain trigger cascade amplification in Alzheimer's dis- ease patients, resulting in neuronal death. This study investigated whether components extracted from the Chinese her... Abnormally increased levels of iron in the brain trigger cascade amplification in Alzheimer's dis- ease patients, resulting in neuronal death. This study investigated whether components extracted from the Chinese herbs epimedium herb, milkvetch root and kudzuvine root could relieve the abnormal expression of iron metabolism-related protein in Alzheimer's disease patients. An APPs,~JPSI^E9 double transgenic mouse model of Alzheimer's disease was used. The intragas- tric administration of compounds from epimedium herb, milkvetch root and kudzuvine root improved pathological alterations such as neuronal edema, increased the number of neurons, downregulated divalent metal transporter 1 expression, upregulated ferroportin 1 expression, and inhibited iron overload in the cerebral cortex of mice with Alzheimer's disease. These com- pounds reduced iron overload-induced impairment of the central nervous system, indicating a new strategy for developing novel drugs for the treatment of Alzheimer's disease. 展开更多
关键词 nerve regeneration neurodegenerative diseases Alzheimer's disease transgenic animalmodels mice epimedium herb milkvetch root kudzuvine root divalent metal transporter 1 ferroportin 1 neural regeneration
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Screening for anti-pancreatic lipase properties of 28 traditional Thai medicinal herbs 被引量:2
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作者 Ananya Dechakhamphu Nattapong Wongchum 《Asian Pacific Journal of Tropical Biomedicine》 SCIE CAS 2015年第12期1042-1045,共4页
Objective:To screen the effect of 28 medicinal plants on inhibition of pancreatic lipase and evaluate the phytochemical contents of extracts.Methods:The ethanolic extracts of 28 traditional Thai herbal medicines were ... Objective:To screen the effect of 28 medicinal plants on inhibition of pancreatic lipase and evaluate the phytochemical contents of extracts.Methods:The ethanolic extracts of 28 traditional Thai herbal medicines were assayed for their in vitro activities against porcine pancreatic lipase using p-nitrophenyl butyrate as a substrate.Quantitative estimation of flavonoids,phenolics,and alkaloids was done.Results:Extracts from four herbs,Memecylon edule Roxb.,Garcinia vilersiana Pierre,Cryptolepis elegans Wall.and Phyllanthus chamaepeuce Ridl.,at a concentration of100 mg/m L,strongly inhibited porcine pancreatic lipase by 90.97%,92.04%,94.64%and95.38%,respectively.There was a significant positive correlation between phenolic content and inhibition activity.Inhibition activity was significantly correlated with flavonoid and with alkaloid contents.Conclusions:From this result,it could be concluded that herbs represent a rich of antipancreatic lipase compounds,in particular,Cryptolepis elegans Wall.and Phyllanthus chamaepeuce Ridl.It is suggested that the phytochemical compounds from these plants may be applied for the prevention and treatment of obesity or hyperlipidemia. 展开更多
关键词 OBESITY MEDICINAL plant herb Anti-pancreatic lipas
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Effects of Chinese herbs on lactation of rat and performance of offspring 被引量:3
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作者 SHI Baoming SHAN Anshan 《Journal of Northeast Agricultural University(English Edition)》 CAS 2007年第1期22-26,共5页
An experiment was conducted to study the effects of different Chinese herbs on lactation in the rat. Seventy-two Sprague Dawley female rats at gestation day 18 were assigned to 9 groups randomly, with 8 rats each. Con... An experiment was conducted to study the effects of different Chinese herbs on lactation in the rat. Seventy-two Sprague Dawley female rats at gestation day 18 were assigned to 9 groups randomly, with 8 rats each. Control rats were offered basal diets until the end of the weaning period. Rats in the other 8 groups were administered diets supplemented with 1% Medulla tetmpanacis (MT), Astragalus membranacens (AM), Vaccaria segetalis (VS), Leonurus heterophyllus sweet (LHS), Radix rehmarmiae preparata (RRP), Squama man/t/s (SM), Schisandra chinensis (SC), Ligustrum lucidum (LL), respectively. After parturition, the litter size was culled to 8 pups per dam. Pup weight and milk yield were significantly higher in the VS, LHS, AM and SM groups than these in the control group during middle and late lactation (P〈0.05 or P〈0.01). The weight and feed intake were not different in the dams fed either diet. 展开更多
关键词 RAT LACTATION Chinese herbs
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Long-Term Chinese Herbs Decoction Administration for Management of Hot Flashes Associated with Endocrine Therapy in Breast Cancer Patients 被引量:2
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作者 Dong Xue Hong Sun Ping-ping Li 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 2011年第1期74-78,共5页
Objective:To evaluate the effect of Chinese herbs decoction Shu-Gan-Liang-Xue on endocrine therapy-associated hot flashes symptom in breast cancer patients.Methods:Sixty-six patients with breast cancer receiving adj... Objective:To evaluate the effect of Chinese herbs decoction Shu-Gan-Liang-Xue on endocrine therapy-associated hot flashes symptom in breast cancer patients.Methods:Sixty-six patients with breast cancer receiving adjuvant endocrine therapy were categorized to two groups,the control group received endocrine therapy alone,the other group is administered with Chinese herbs decoction Shu-Gan-Liang-Xue besides the endocrine therapy:Shu-Gan-Liang-Xue decoction was administered above 6 months per year for more than 2 years.Frequency of hot flashes per day was recorded,and the effect of Shu-Gan-Liang-Xue decoction on hot flashes symptom being assessed with Kupperman Scoring Index.Results:Sixty cases were analyzed,32 cases in endocrine therapy combining Chinese herbs decoction group,28 cases in mere endocrine therapy group.For hot flashes symptom,in Chinese herbs decoction administration group,7 cases(21.9%) reported symptom disappeared,22 cases(68.7%) reported symptom alleviated,3 cases(9.4%) reported symptom not changed;in endocrine therapy alone group,5 cases(17.9%) reported symptom disappeared,13 cases(46.4%) reported symptom alleviated,10 cases(10/28,35.7%) reported symptom not changed.The difference between two groups was statistically significant(P=0.013).For sleeping disorder,in Chinese herbs decoction administration group,27 cases(84.4%) reported symptom improved,5 cases(15.6%) reported no change;in endocrine therapy alone group,16 cases(57.1%) symptom improved,12 cases(42.9%) reported no change in sleeping disorder(P=0.019),the difference was also of significance statistically.Conclusion:Long-term Chinese herbs decoction administration remarkably improved hot flashes symptom and sleeping disorder associated with endocrine therapy,meanwhile without definite toxicity and influence on the risk of recurrence of tumor. 展开更多
关键词 Breast cancer Endocrine therapy TAMOXIFEN Hot flashes Chinese herbs decoction
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Rapid Profiling of Alkaloids in Several Medicinal Herbs by Matrix-assisted Laser Desorption/Ionization Mass Spectrometry 被引量:2
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作者 LU Lin YUE Hao +3 位作者 SONG Feng-rui TSAO Rong LIU Zhi-qiang LIU Shu-ying 《Chemical Research in Chinese Universities》 SCIE CAS CSCD 2010年第1期11-16,共6页
A simple method was developed for rapid and direct profiling of alkaloids in medical herbs via matrix-assisted laser desorption/ionization time-of-flight mass spectrometry(MALDI-TOF MS). The dry herbs were first gro... A simple method was developed for rapid and direct profiling of alkaloids in medical herbs via matrix-assisted laser desorption/ionization time-of-flight mass spectrometry(MALDI-TOF MS). The dry herbs were first ground to powder and passed through a stainless steel sieve, mixed with the matrix solution to form a homogeneous suspension, which was then directly applied to MALDI analysis. Several matrices were investigated and 2,5- dihydroxybenzoic acid(DHB) was chosen as the optimized one, and the particle with small size was found to favor the analysis. Using this method, the profiles of alkaloids in several medical herbs were readily obtained, and the toxicities of crude and processed Radix Aconiti Lateralis Preparata were compared via the relative intensities of the peaks of the corresponding toxic components shown in their MALDI spectra. This method therefore provides a rapid and reliable protocol for obtaining profiles of alkaloids in medical herbs by using MALDI-TOF MS. 展开更多
关键词 Matrix-assisted laser desorption/ionization ALKALOID Medical herb
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Perspectives and challenges of tropical medicinal herbs and modern drug discovery in the current scenario 被引量:1
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作者 Rajesh Kumar Kesharwani Krishna Misra Dev Bukhsh Singh 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2019年第1期1-7,共7页
Tropical diseases such as malaria, tuberculosis, trypanosomiasis, and leishmaniasis, account for a large number of deaths annually. Herbs are an excellent source of tropical medicines. Many advancements and discoverie... Tropical diseases such as malaria, tuberculosis, trypanosomiasis, and leishmaniasis, account for a large number of deaths annually. Herbs are an excellent source of tropical medicines. Many advancements and discoveries have taken place in the field of drug discovery but still, a major population of tropical diseases relies on herbal traditional medicine. There are some challenges related to policy implementation, efficacy, resistance and toxicity of tropical medicines. There are many tropical diseases such as such as schistosomiasis, leishmaniasis, African sleeping sickness, filariasis and chagas disease which are neglected because very few pharmaceutical companies have shown their interest in developing therapeutics against these diseases of poor people. There are many benefits associated with herbal medicine such as the cost of production, patient tolerance, large scale availability, efficacy, safety, potency, recyclability, and environment friendly. A large number of natural extracts such as curcumin, artemisinin, morphine, reserpine, and hypericin, are in use for treatment of different tropical diseases for a long time. The current review is to discuss the overview of tropical medicinal herbs, its scope and limitations in the modern drug discovery process. 展开更多
关键词 herbs Natural SOURCES Lead compounds Drug discovery COMPUTATIONAL approaches
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Safely Using TCM Herbs: Adverse Reactions and Precautions 被引量:4
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作者 陈楷 Angela Berscheid 《Chinese Journal of Integrated Traditional and Western Medicine》 2003年第2期146-147,共2页
Although most people believe that herbal remedies are relatively safe to use, some are toxic or possess adverse reactions, especially when used incorrectly.Commonly used TCM herbs with known adverse reactions, as well... Although most people believe that herbal remedies are relatively safe to use, some are toxic or possess adverse reactions, especially when used incorrectly.Commonly used TCM herbs with known adverse reactions, as well as the most toxic herbs in the Pharmacopoeia of People’s Republic of China are listed as follows: 展开更多
关键词 TCM IS of Adverse Reactions and Precautions Safely Using TCM herbs been ORAL in HAVE that
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Microdilution inhibition test of Chinese herbs to assess their effect against clinical strains of Ureaplasma urealyticum in vitro 被引量:2
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作者 Changtai Zhu Chunlei Dong +3 位作者 Yinze Kong Lingxia Liu Qingsi Wu Yuyou Yao 《Journal of Nanjing Medical University》 2009年第2期143-145,共3页
Objective:To explore the antibacterial effect of Chinese crude drugs against clinical strains of Ureaplasma urealyticum(UU), including eight pure herbs and three compound herbs, and determine their minimal inhibito... Objective:To explore the antibacterial effect of Chinese crude drugs against clinical strains of Ureaplasma urealyticum(UU), including eight pure herbs and three compound herbs, and determine their minimal inhibitory concentrations(MICs). Methods:Isolates were collected from clinical patients with UU infection, and cultured in UU broth. In order to test the different effects on clinical strains of UU, the assays were performed by microdilution inhibition tests, and MICs of the herbs against the clinical strains of UU were calculated. Results:The MICs of eight pure herbs against clinical strains of UU were as follows: Galla Chinensis:0.313-1.25 g/L; Fructus Forsythiae: 1.25-5.00 g/L; Cortex Phellodendri: 1.25-5.00 g/L; Radix Paeoniae Rubra: 1.25-2.50 g/L; Semen Plantaginis:2.50-10.00 g/L; Herba Lysimachiae: 5.00-20.00 g/L; Rhizoma Coptidis: 5.00-20.00g/L, Herba Houttuyniae: 10.00-20.00 g/L. The MICs of compound herbs were: Liuheji: 0.625-2.50 g/L; Bazhengsan: 5.00-20.00 g/L; Wulinsan:2.50-20.0 g/L.Conclusion:Galla Chinensis, Fructus Forsythiae, Cortex Phellodendrim, Radix Paeoniae Rubra, and Semen Plantaginis, exerted the stronger antibacterial effect against clinical strains of UU, whereas Herba Lysimachiae, Rhizoma Coptidis and Herba Houttuyniae, had relatively weaker activity against UU. Compound herbs, Bazhengsan and Wulinsan, and particularly Liuheji, also had antibacterial effects against UU. Further studies of the effects and mechanisms of action of Chinese crude drugs against UU infections are worthwhile. 展开更多
关键词 Ureaplasma urealyticum microdilution inhibition test Chinese herbs minimal inhibitory concentration ANTIBACTERIAL
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Reevaluation on Antioxidant Activity of Tonic Chinese Herbs Pseudostellaria heterophylla 被引量:4
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作者 Zhang Yanda 《Animal Husbandry and Feed Science》 CAS 2020年第1期11-16,共6页
Tonic Chinese herbs Pseudostellaria heterophylla has complex components,which has both medicinal and nutritional effects,and the clinical research on anti-oxidation of P.heterophylla has become a hotspot.By searching ... Tonic Chinese herbs Pseudostellaria heterophylla has complex components,which has both medicinal and nutritional effects,and the clinical research on anti-oxidation of P.heterophylla has become a hotspot.By searching domestic and foreign databases,the antioxidant literatures of P.heterophylla were searched,consulted,sorted,classified and analyzed,and systematic reevaluation of antioxidant function was conducted from three aspects of P.heterophylla extract in vitro chemical method,biological method and animal test method according to evaluation criteria for antioxidant activity of traditional Chinese medicine and Meta analysis statistical methods.The results would provide systematic reference for further research and development of P.heterophylla,especially for forage value excavation and development of P.heterophylla in the field of modern animal breeding. 展开更多
关键词 TONIC Chinese herbs Pseudostellaria heterophylla ANTIOXIDANT activity REEVALUATION
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