Design,preparation,application of advanced array structured materials and their action mechanism analyses for high performance lithium-sulfur batteries

Lithium-sulfur battery(LSB)has brought much attention and concern because of high theoretical specific capacity and energy density as one of main competitors for next-generation energy storage systems.The widely commercial application and development of LSB is mainly hindered by serious“shuttle effect”of lithium polysulfides(Li PSs),slow reaction kinetics,notorious lithium dendrites,etc.In various structures of LSB materials,array structured materials,possessing the composition of ordered micro units with the same or similar characteristics of each unit,present excellent application potential for various secondary cells due to some merits such as immobilization of active substances,high specific surface area,appropriate pore sizes,easy modification of functional material surface,accommodated huge volume change,enough facilitated transportation for electrons/lithium ions,and special functional groups strongly adsorbing Li PSs.Thus many novel array structured materials are applied to battery for tackling thorny problems mentioned above.In this review,recent progresses and developments on array structured materials applied in LSBs including preparation ways,collaborative structural designs based on array structures,and action mechanism analyses in improving electrochemical performance and safety are summarized.Meanwhile,we also have detailed discussion for array structured materials in LSBs and constructed the structure-function relationships between array structured materials and battery performances.Lastly,some directions and prospects about preparation ways,functional modifications,and practical applications of array structured materials in LSBs are generalized.We hope the review can attract more researchers'attention and bring more studying on array structured materials for other secondary batteries including LSB.

The action mechanisms and structures designs of F-containing functional materials for high performance oxygen electrocatalysis

Non-renewable fossil fuels have led to serious problems such as global warming,environmental pollution,etc.Oxygen electrocatalysis including oxygen reduction reaction(ORR)and oxygen evolution reaction(OER)plays a central role in clean energy conversion,enabling a number of sustainable processes for future air battery technologies.Fluorine,as the most electronegative element(4.0)not only can induce more efficient regulation for the electronic structure,but also can bring more abundant defects and other novel effects in materials selection and preparation for favorable catalysis with respect to the other nonmetal elements.However,an individual and comprehensive overview of fluorine-containing functional materials for oxygen electrocatalysis field is still blank.Therefore,it is very meaningful to review the recent progresses of fluorine-containing oxygen electrocatalysts.In this review,we first systematically summarize the controllable preparation methods and their possible development directions based on fluorine-containing materials from four preparation methods.Due to the strong electron-withdrawing properties of fluorine,its control of the electronic structure can effectively enhance the oxygen electrocatalytic activity of the materials.In addition,the catalytic enhancement effect of fluorine on carbonbased materials also includes the prevent oxidation and the layer peeling,and realizes the precise atomic control.And the catalytic improvement mechanism of fluorine containing metal-based compounds also includes the hydration of metal site,the crystal transformation,and the oxygen vacancy induction.Then,based on their various dimensions(0D–3D),we also have summarized the advantages of different morphologies on oxygen electrocatalytic performances.Finally,the prospects and possible future researching direction of F-containing oxygen electrocatalysts are presented(e.g.,novel pathways,advanced methods for measurement and simulation,field assistance and multi-functions).The review is considered valuable and helpful in exploring the novel designs and mechanism analyses of advanced fluorine-containing electrocatalysts.

System pharmacology-based dissection of the potential effective material basis and mechanism of Xiaoxianxiong decoction for type 2 diabetes mellitus

Background:Xiaoxianxiong decoction is a classic formula in traditional Chinese medicine used to treat type 2 diabetes mellitus and proven to be effective.But the material basis and underlying mechanisms remain unclear.The aim of the present study was to elucidate the potential effective material basis of Xiaoxianxiong decoction and molecular mechanism treating type 2 diabetes mellitus.Methods:The absorbed bioactive components were identified based on serum pharmacochemistry.Network analysis were performed to obtain effect targets for docking verification with the absorbed prototypes to determine the potential effective material basis.On the above basis,network pharmacology was conducted to explore the molecular mechanism.Results:76 compounds were identified of Xiaoxianxiong decoction and 61 absorbed bioactive compounds were investigated.Serine/threonine kinase 1 and ALB were key targets acquired by network analysis for molecular docking.Subsequently,5 compounds were considered as the potential effective material basis,namely berberine,berberrubine,lariciresinol and gingerenone A,jatrorrhizine.Further,the mechanism mainly lies in the insulin signaling pathway,HIF-1 signaling pathway,PI3K-Akt signaling pathway,FoxO signaling pathway,AGE-RAGE signaling pathway in diabetic complications,phospholipase D signaling pathway to regulate blood glucose levels on target tissues as well as organs and exhibit anti-inflammatory,promote cell differentiation and cell growth,maintain oxygen homeostasis and affect the enzymes along with key metabolites.Conclusion:This integrated research strategy to investigate the treatment of Xiaoxianxiong decoction on type 2 diabetes mellitus provides valuable insights for further study and clinical practice of Xiaoxianxiong decoction.

Research progress on mechanism of Chinese material medica in preventing and treating insulin resistance and type 2 diabetes mellitus

Insulin resistance(IR)is a significant feature and one of the basic links in the pathogenesis of type 2 diabetes mellitus(T2DM).Chinese material medica(CMM)has promoted the development of traditional Chinese medicine due to its definite clinical efficacy in the treatment of IR and T2DM.However,owing to the fact that the mechanism of CMM is characterized by“multiple components and multiple targets”,which has not been effectively interpreted,result in the scientificity of clinical efficacy with CMM is controversial.Therefore,this article summarized the mechanisms of CMM and its main active components in improving IR and preventing and treating T2DM,whose aim is to provide valuable reference for the research mechanism on the treatment of IR and T2DM.

Research on the potential mechanism of Huashi Baidu Recipe against novel coronavirus pneumonia(COVID-19)by network pharmacology and molecular docking technology

Objective:Use network pharmacology to explore the anti-COVID-19 mechanism of Huashi Baidu Recipe,supplemented by molecular docking verification.Methods:Thorugh databases such as TCMSP,GeneCard,String,and software such as Cytoscape,AutoDockVina,network relationships was established,and the binding ability of active ingredients and targets is calculated through molecular docking,and biological function enrichment analysis was conducted.Result:The ingredients in Huashi Baidu Recipe that had strong affinity with SARS-CoV-23CL hydrolase(3CLpro)and angiotensin converting enzyme 2(ACE2)receptors include Quercetin,Baicalein,Astragaloside IV,Wogonin and other ingredients;25 active ingredients which obtained by screening had strong affinity with targets such as IL6,IL1B,NOS2 and CCL2.The biological function enrichment analysis mainly focused on Th17,Th1 and Th2 cell differentiation,NF-κB,MAPK,TNF,IL-17signaling pathway,etc.Conclusion:The active ingredients of Huashi Baidu Recipe may inhibit the infection and replication of SARS-CoV-2 virus,regulate RAS system’balance,inhibit excessive immune inflammatory response,and prevent inflammatory storm from appearing to fight COVID-19.

A review of Al-based material dopants for high-performance solid state lithium metal batteries

As the world transitions to green energy, there is a growing focus among many researchers on the requirement for high-efficient and safe batteries. Solid-state lithium metal batteries(SSLMBs) have emerged as a promising alternative to traditional liquid lithium-ion batteries(LIBs), offering higher energy density, enhanced safety, and longer lifespan. The rise of SSLMBs has brought about a transformation in energy storage, with aluminum(Al)-based material dopants playing a crucial role in advancing the next generation of batteries. The review highlights the significance of Al-based material dopants in SSLMBs applications, particularly its contributions to solid-state electrolytes(SSEs), cathodes, anodes,and other components of SSLMBs. Some studies have also shown that Al-based material dopants effectively enhance SSE ion conductivity, stabilize electrode and SSE interfaces, and suppress lithium dendrite growth, thereby enhancing the electrochemical performance of SSLMBs. Despite the above mentioned progresses, there are still problems and challenges need to be addressed. The review offers a comprehensive insight into the important role of Al in SSLMBs and addresses some of the issues related to its applications, endowing valuable support for the practical implementation of SSLMBs.

Research progress and application prospect of functional adhesive materials in the field of oil and gas drilling and production

By summarizing the composition,classification,and performance characterization of functional adhesive materials,the adhesion mechanisms of functional adhesive materials,such as adsorption/surface reaction,diffusion,mechanical interlocking,and electrostatic adsorption,are expounded.The research status of these materials in oil and gas drilling and production engineering field such as lost circulation prevention/control,wellbore stabilization,hydraulic fracturing,and profile control and water plugging,and their application challenges and prospects in oil and gas drilling and production are introduced comprehensively.According to the applications of functional adhesive materials in the field of oil and gas drilling and production at this stage,the key research directions of functional adhesive materials in the area of oil and gas drilling and production are proposed:(1)blending and modifying thermoplastic resins or designing curable thermoplastic resins to improve the bonding performance and pressure bearing capacity of adhesive lost circulation materials;(2)introducing low-cost adhesive groups and positive charge structures into polymers to reduce the cost of wellbore strengthening agents and improve their adhesion performance on the wellbore;(3)introducing thermally reversible covalent bond into thermosetting resin to prevent backflow of proppant and improve the compressive strength of adhesive proppant;(4)introducing thermally reversible covalent bonds into thermoplastic polymers to improve the temperature resistance,salt-resistance and water shutoff performance of adhesive water shutoff agents.

Exploring the mechanism of action of DHI on myeloproliferative neoplasms based on network pharmacology

Objective:The aim of this study is to explore the active ingredients and mechanism of action of danhong injection(DHI)in treating myeloproliferative neoplasms using network pharmacology.Methods:The TCMSP platform and relevant literature were used to search for the active ingredients and targets of Radix Salviae and Carthami Flos in DHI.Disease targets related to myeloproliferative neoplasms were obtained from the GEO database,GeneCards,and DisGeNET database.The queried component targets were normalized using the UniProt database.Potential targets were identified by constructing protein-protein interactions networks using STRING 11.5 and visualized and analyzed using Cytoscape 3.9.1.GO and KEGG analysis were performed using the Metascape platform,and visualization was done using the built-in plug-in CluoGO or SangerBox platforms with Cytoscape 3.9.1.Results:The active ingredients of DHI for treating myeloproliferative neoplasms mainly consist of flavonoids and o-benzoquinones,including quercetin,luteolin,kaempferol,stigmasterol,tanshinone iia,cryptotanshinone,beta-carotene,2-isopropyl-8-methylphenanthrene-3,4-dione,and neocryptotanshinone ii.The potential targets are JUN,TP53,STAT3,AKT1,MAPK1,RELA,TNF,MAPK14,IL6,and FOS.The relevant signaling pathways involved are mainly TNFαsignaling pathway,PI3K-Akt signaling pathway,apoptosis,IL-17 signaling pathway,cellular senescence,MAPK signaling pathway,p53 signaling pathway,JAK-STAT signaling pathway,and NF-kappa B signaling.Conclusions:DHI acts mainly through flavonoids and o-benzoquinones to treat myeloproliferative neoplasms in a multi-targeted and multi-pathway manner.

Gaps and feasibility of fixed-dose combination strategy in the development of modern Chinese medicine

isTraditional Chinese medicine(TCM)is a highly complex chemical substance system,which not only reflected in the complexity of the chemical components and their interrelationships,but also in the intricacy of the prescription’s connection with the human body.Component compatibility strategy has been proposed for developing modern TCM since 2005 and established comprehensive relevant technologies and research approaches.Moreover,to meet the safety and efficacy of current pharmaceuticals,research on fixed-dose combination drugs is directed by modern scientific theories,conforms to TCM compatibility principles and clarifies material basis and pharmacological mechanisms and component-effect correlations.This review summarized gaps and feasibility of fixed-dose combination strategy in the development of modern TCM research and assessed their advantages and disadvantages in light of contemporary drug combination research practices.

甘草抗炎活性物质基础及其作用机制研究进展

炎症是机体对于刺激所产生的一种防御反应,随着炎症的发展可能导致组织的变异和增生,进一步加剧疾病的进程。甘草作为“众药之王”“国之药老”,早在《神农本草经》中就记载其清热作用较强,能“主五脏六腑寒热邪气”。现代研究表明,甘草提取物对肾小球肾炎、结肠炎症状改善明显,甘草及其制剂在治疗肝炎、胃炎、支气管炎、心肌炎、强直性脊柱炎等炎症性疾病方面亦具有一定的独特优势和发展潜力。该文旨在通过对近期国内外甘草抗炎活性物质基础及其作用机制方面的相关文献进行收集和整理,探索甘草发挥抗炎作用的主要活性成分及靶点通路,以期为甘草抗炎作用的进一步研究及抗炎药物的研发提供思路和参考。

UHPLC-QTOF-MS联合网络药理学及分子对接探讨青阳参总苷治疗社会挫败的物质基础及作用机制

目的运用UHPLC-QTOF-MS和网络药理学-分子对接技术,探讨青阳参总苷治疗社会挫败的物质基础和潜在的作用机制。方法首先,采用UHPLC-QTOF-MS鉴定青阳参总苷化学成分。其次,运用Pubchem下载青阳参总苷化学成分2D结构后,利用Swiss Target Prediction数据库预测其靶点;从TTD、GeneCards、CTD数据库获取社会挫败相关治疗靶点;通过Venny平台获取两者的交集靶点;采用Cytoscape构建“药物-活性成分-靶点-疾病”网络;运用String数据库构建蛋白互作(PPI)网络后,结合Cytoscape分析得交集靶点排名;使用DAVID数据库对交集靶点进行基因本体(GO)功能注释和京都基因与基因组百科全书(KEGG)通路富集分析。利用AutoDock vina软件进行分子对接验证。最后,构建社会挫败小鼠模型,采用ELISA法检测小鼠血清5-羟色胺(5-HT)、多巴胺(DA)含量,HE染色观察小鼠海马组织神经细胞病理变化。结果从青阳参总苷共鉴定152个化学成分。预测及筛选得到丝氨酸/苏氨酸蛋白激酶(AKT1)、单胺氧化酶A(MAOA)、多巴胺受体D3(DRD3)等26个青阳参总苷治疗社会挫败潜在作用靶点,对应85个青阳参总苷活性成分;富集分析得到45个GO注释条目(P<0.01)、11条KEGG信号通路。分子对接发现青阳参苷元、白桦脂酸、绿原酸等20个活性成分与AKT1、DRD4、DRD2、DRD3等10个核心靶蛋白均可自发结合。动物实验表明,与正常对照组相比,模型对照组小鼠血清中5-HT、DA含量均明显降低(P<0.05);小鼠海马组织神经细胞排列疏松,有明显的细胞丢失。与模型对照组相比,青阳参总苷各剂量组小鼠血清中5-HT、DA含量均显著升高(P<0.05,P<0.01);青阳参总苷中、高剂量组小鼠海马组织神经细胞间隙减小,且排列较为整齐。结论青阳参总苷对社会挫败具有治疗作用。主要药效物质为青阳参苷元、白桦脂酸、绿原酸等,可通过多靶点、多通路发挥抗社会挫败作用。

基于HPLC-Q-Exactive Orbitrap MS/MS整合网络药理学研究衢枳壳降糖的物质基础及作用机制

目的以入血成分为研究对象,基于网络药理学探究衢枳壳对糖尿病起效的物质基础及作用机制。方法采用高效液相色谱串联四极杆-静电场轨道阱高分辨质谱(high-performance liquid chromatography tandem quadrupole-electrostatic field orbitrap high resolution mass spectrometry,HPLC-Q-Exactive Orbitrap MS/MS)对衢枳壳入血成分进行鉴定,在此基础上通过Swiss Target Prediction与SuperPred数据库预测入血成分作用靶点,同时在OMIM,GeneCards等数据库获取糖尿病靶点。采用Cytoscape 3.9.1绘制中药衢枳壳“活性成分-靶点-疾病”网络关系图,利用String数据分析平台进行蛋白互作(protein-protein interaction,PPI)网络分析,筛选关键靶点。通过DAVID数据库对关键靶点进行基因本体功能(gene ontology,GO)和京都基因与基因组百科全书(kyoto encyclopedia of genes and genomes,KEGG)通路富集分析。应用Autodock 1.5.7软件进行分子对接验证。结果共鉴定衢枳壳入血成分20个,筛选出潜在靶点170个,核心靶点32个。GO功能富集和KEGG信号通路分析结果显示缺氧诱导因子(hypoxia-inducible factor,HIF)-1信号通路、晚期糖基化终末产物(advanced glycation end products,AGE)-晚期糖基化终产物受体(receptor for advanced glycation end products,RAGE)信号通路、表皮生长因子(epidermal growth factor receptor,EGFR)信号通路、癌症蛋白聚糖通路等为衢枳壳降糖的关键通路,丝氨酸/苏氨酸蛋白激酶(RAC serine/threonine-protein kinase,AKT)1、白蛋白(albumin,ALB)、细胞肿瘤抗原p53(cellular tumor antigenp 53,TP53)、肿瘤坏死因子(tumor necrosis factor,TNF)、EGFR为其中关键靶点,且衢枳壳中5个活性成分与核心靶点经分子对接后的结合活性较好。结论衢枳壳中的芦丁、新橙皮苷、橙皮苷、芸香柚皮苷、川陈皮素等可能为衢枳壳降糖的物质基础,可能是通过调控HIF-1、AGE-RAGE、EGFR等信号通路及AKT1、ALB、TP53等核心基因发挥降糖作用。

喷射混凝土用无碱液体速凝剂的现状与发展趋势

喷射混凝土常用于隧道、矿山井巷、城市地下空间等施工场景,已成为复杂工程施工必不可少的一种混凝土。速凝剂作为喷射混凝土必不可少的外加剂,经历了高碱粉体和低碱粉体的速凝剂时代,目前,无氯低碱液体速凝剂已得到大规模应用。然而,实际工程对速凝剂产品仍在不断提出更高的要求,液体速凝剂正朝着无氟无氯无碱的方向前进,从而继续推出更好的产品。本文回顾速凝剂的历史进程和发展,着重讨论速凝剂的作用机理,硫酸铝型无碱液体速凝剂主要组分的演变及由此带来的产品研制难题和对水泥基材料性能的影响,并论述课题组在无碱液体速凝剂与水泥的适应性研究方面取得的成果。

基于血瘀理论探析子宫内膜异位症的病理机制与物质基础研究

子宫内膜异位症具有形态多样性、病变广泛性和恶性生物学行为等致病特点,给临床治疗带来诸多困难。通过对古今文献资料的复习与梳理,基于血瘀相关理论从病名源流、发病机制、证候要素和生物学基础等方面深入探讨子宫内膜异位症的病理机制,发现“血瘕”“癥瘕”与子宫内膜异位症高度契合,认为“瘀血阻滞冲任、胞宫”是子宫内膜异位症关键病机,气滞、寒凝、痰湿、气虚和肾虚等是瘀血阻滞的诱因或后续病机,血瘀证为该病的基础证候,其中细胞增殖或血管形成因子、肿瘤标志物、血管收缩因子和某些差异蛋白等与该病血瘀证具有特异相关性,这些可能为探寻子宫内膜异位症血瘀证的物质基础提供了依据。

玉液汤药物降糖成分与方剂降糖机制研究进展

糖尿病(DM)是最为常见的内分泌代谢性疾病之一,我国糖尿病的类型以T2DM为主,其的发病率和病死率居世界首位。当下,人们对DM的发病机制尚未完全阐明。虽然西药降糖药物在糖尿病的治疗中获得较好的疗效,但仍会出现并发症多、敏感性降低、不良反应大等问题。玉液汤源自《医学衷中参西录》,临床应用已近百年,具有良好的润燥止渴、益气生津的临床疗效,是治疗消渴病的代表方。经临床观察和实验研究,发现玉液汤及其中每个单味药中的多种有效成分都能够对糖尿病的防治起到良好的疗效。中药有效成分多样、作用靶点多样,能够通过不同的机制作用治疗DM。因此,需要从分子生物学、网络药理学等层面进行系统深入地研究,全面揭示玉液汤防治DM的作用机制。目前玉液汤治疗糖尿病的作用机制主要集中于防止β细胞凋亡,降低炎症因子,改善肠道菌群紊乱等。通过对玉液汤防治DM的研究,阐明玉液汤防治DM的作用机制及其药效物质基础,为玉液汤的临床应用进一步提供重要的科学依据。通过检索中国知网(CNKI)、PubMed、万方(Wanfang Data)、维普(VIP)等数据库,从方证基础、药物的活性成分、网络药理学、临床与实验研究等方面对玉液汤治疗T2DM的方证基础、方中药物的活性成分、方剂的药理作用机制进行论述,为后续玉液汤治疗糖尿病的相关研究提供参考。

白虎汤纳米相态相关研究进展

中药汤剂包含真溶液、纳米相态、乳浊液和混悬液,是一种复杂的多分散相体系。中药汤剂的有效成分主要存在于纳米相态中,与中药汤剂相比,中药纳米相态具有溶解性强、稳定性高、药效佳等特点。随着研究的深入,有学者提出汤剂中的纳米粒子可能起着增溶与靶向递送的作用。白虎汤是清热类经典方剂之一,被称为“寒剂祖方”,由石膏、知母、炙甘草、粳米四味药材配伍而成,用于治疗阳明经证或气分热盛证,现代临床上应用广泛。白虎汤纳米相态可能包裹药物有效成分,实现药物的靶向性治疗。研究发现白虎汤药液的纳米相态中主要药效成分的含量明显高于药液中的其他相态,纳米相态对汤剂中主要解热成分芒果苷、新芒果苷、钙离子、甘草酸和甘草次酸起到了增溶作用,纳米相态是白虎汤发挥解热作用的关键组分。本文从白虎汤纳米相态的形成理论、物质基础、分子表征、药理作用等方面进行综述,为深入探究白虎汤的作用机制、创制纳米相态制剂提供思路,为推动纳米技术在中药方剂创新中的应用提供参考。

天然产物抗肺癌作用及其机制的研究进展

目的总结天然产物抗肺癌的机制,为候选治疗肺癌新的前瞻性药物提供理论基础。方法利用肺癌、中药、药理学及其组合等关键词,收集中国知网、万方、维普、PubMed、Science Direct和Web of science等数据库有关天然产物抗肺癌作用研究的文章,并进行总结。结果中医药治疗肺癌优势明显,具有药理机制新颖、毒性低、不良反应小的特点,可增效减毒、提高患者生活质量。天然产物主要包括黄酮类、生物碱类、多糖类、萜类、皂苷类和酚类,具有抑制肿瘤细胞周期、抑制增殖、诱导凋亡、促进自噬、抑制肿瘤细胞侵袭和转移的作用;天然产物与细胞毒性药物联合使用,可以增强疗效或降低耐药性,延缓肺癌的进展,延长患者的生存时间。结论中药含有多种黄酮、生物碱、萜及其苷类、多酚和其他可有效对抗肺癌的活性化合物,适合作为治疗肺癌的候选药物。

冰碛地层围岩隧道注浆材料组分优化与作用机理

冰碛层隧道围岩的地质组成情况复杂,整体胶结性差,结构不均匀,隧道在开挖过程中易出现围岩垮塌、涌水等问题。因此,以硅酸盐水泥为主材料,添加氧化镁、黄原胶、膨润土及水玻璃进行组分优化,通过析水率试验、凝固试验、流动度试验、力学试验、膨胀率试验及抗渗性能试验,研究一种适用于冰碛层围岩注浆条件的新型水泥基注浆材料,并分析注浆材料的微观形貌与固结机理。结果表明:新型注浆材料孔隙和缝隙基本被充填,结构紧密,抗渗性能相对较好。向材料中引入Mg^(2+)可形成Mg(OH)_(2)晶体以填补材料微孔结构,完善材料抗渗机制。大量纤维状水化硅酸钙(C—S—H)凝胶将钙矾石(AFt)、Ca(OH)_(2)、Mg(OH)_(2)等晶体和黄原胶螯合体胶结包裹成整体,可大幅提高材料抗渗能力。通过现场试验,验证了注浆材料的优良性能,材料可有效固结冰碛松散地层,确保隧道开挖安全。

植介入医疗器械涂层的研究进展

植介入医疗器械在手术过程中会直接接触人体器官组织、血管壁及血液,进而引发一系列如炎症、血管痉挛、血栓等副作用,在器械表面应用生物相容性材料构建涂层可以有效避免组织损伤和减少副作用。近年来,随着涂层技术和材料种类的迅速发展,涂层的功能性也得到了拓展,出现了亲水、疏水、抗菌、抗凝和载药等不同功能的涂层。综述了上述5种植介入医疗器械涂层的研究进展,从材料学角度探讨了涂层的组成成分和表面结构优化对其功能性的影响。其中,涂层的组成成分主要是高分子聚合物,例如聚乙二醇、聚两性离子、聚四氟乙烯等,将抗菌、抗凝以及其他药物掺杂在这些材料内构建涂层,可实现抑菌、抗凝、载药等目的。常见的表面结构优化策略主要通过在器械表面对涂层进行仿生微纳结构修饰等,形成纳米或微米尺度的结构,从而改变涂层的表面能、接触角、粗糙度等特性,以影响涂层的生物相容性、细胞附着和生长行为。总而言之,表面涂层可以显著改善植介入医疗器械的临床应用性能。然而,植介入医疗器械涂层在长期效果、材料耐久性和标准化制备等方面仍存在一些不足。最后,结合目前蓬勃发展的新型材料和制作工艺,对植介入医疗器械的涂层进行了展望。

复合激发剂对煤矸石胶凝材料性能的影响

以煤矸石为研究对象,探究了3种化学激发剂对煤矸石胶凝材料力学性能的影响,选取最优配比制备了煤矸石免烧砖。通过X射线衍射仪、扫描电子显微镜分析了化学激发剂的作用机理。煤矸石胶凝材料最佳配比为:活化温度800℃的煤矸石粉掺杂量90%,石灰掺杂量10%,脱硫石膏掺杂量1%,硫酸钠掺杂量0.5%(均为质量分数),在此条件下制备的煤矸石胶凝材料28d抗压强度最优,为17.02MPa。煤矸石胶凝材料水化产物中钙矾石、水化硅酸钙、水化铝酸钙和水化硅铝酸钙相互胶结,使得材料内部结构致密,提升了材料的强度,制备的煤矸石免烧砖达到JC/T422-2007中MU15强度标准。