Objective:To evaluate the therapeutic effects of Epimedium brevicornu Maxim.(EBM,Yin Yang Huo)on breast cancer using network pharmacology and in vitro validation.It also aimed to explore the novel targets and mechanis...Objective:To evaluate the therapeutic effects of Epimedium brevicornu Maxim.(EBM,Yin Yang Huo)on breast cancer using network pharmacology and in vitro validation.It also aimed to explore the novel targets and mechanisms of EBM in the treatment of breast cancer to facilitate the discovery of new drugs and their clinical application.Methods: Network pharmacology was used to identify and screen the components and targets of EBM for breast cancer treatment.Molecular docking was further screened the effective components and targets of EBM.Wound-healing assays and flow cytometry analysis were used to detect the ability of two compounds to intervene in the migration and apoptosis of MDA-MB-231 cells,and their mechanism of action was further explored using western blotting experiments.Results: EBM contained 19 active components.Among them wereβ-anhydroicaritin(Anhy)and isoliquiritigenin(Iso),which were selected for in vitro experiments.Treatment resulted in a dose-dependent suppression of MDA-MB-231 cell viability,with an IC_(50) of 23.73μmol/L for Iso and 21.28μmol/L for Anhy.In the wound healing assay,cells in Anhy and Iso groups exhibited considerable inhibition of migration at 48 h.In flow cytometry analysis,treatment with Iso(20μmol/L)for 96 h resulted in significantly higher levels of both early and late apoptosis in the Iso group than that in the control group(P=.004 and P=.014,respectively).Additionally,both Iso(20μmol/L)and Anhy(10 and 20μmol/L)induced cell necrosis at 96 h.Western blotting revealed that Anhy and Iso increased the expression of Bax and TBK1/NAK.Conclusion: These findings suggested that Anhy and Iso,the two components of EBM,inhibit MDA-MB-231 cell proliferation and migration of and induce their apoptosis,providing substantial support for future studies on breast cancer.展开更多
In this note, we give a short proof for the DiPerna-Lions flows associated to ODEs following the method of Crippa and De Lellis [3]. More precisely, assume that [divb] ∈ Ll∞oc（Rd）, ｜b｜/（1 ＋ ｜x｜ log ｜x｜） ...In this note, we give a short proof for the DiPerna-Lions flows associated to ODEs following the method of Crippa and De Lellis [3]. More precisely, assume that [divb] ∈ Ll∞oc（Rd）, ｜b｜/（1 ＋ ｜x｜ log ｜x｜） ∈ L∞（Rd） and ｜ b｜ φ（｜ b｜） ∈ Ll1oc（Rd）, where φ（r） = log log（r ＋ c）, c 0. Then, there exists a unique regular Lagrangian flow associated with the ODE X˙（t, x） = b（X（t, x））, X（0, x） = x.展开更多
Concurrent multipath transfer（CMT） using stream control transmission protocol（SCTP） multihoming has become an appealing option to increase the throughput and improve the performance of increasingly bandwidth-hungr...Concurrent multipath transfer（CMT） using stream control transmission protocol（SCTP） multihoming has become an appealing option to increase the throughput and improve the performance of increasingly bandwidth-hungry applications.To investigate the rate allocation for applications in CMT,this paper analyzes the capacities of paths shared by competing sources,then proposes the rate allocation model for elastic flows based on the framework of network utility maximization（NUM）.In order to obtain the global optimum of the model,a distributed algorithm is presented which depends only on local available information.Simulation results confirm that the proposed algorithm can achieve the global optimum within reasonable convergence times.展开更多
Reinforcement learning(RL)algorithms are expected to become the next generation of wind farm control methods.However,as wind farms continue to grow in size,the computational complexity of collective wind farm control ...Reinforcement learning(RL)algorithms are expected to become the next generation of wind farm control methods.However,as wind farms continue to grow in size,the computational complexity of collective wind farm control will exponentially increase with the growth of action and state spaces,limiting its potential in practical applications.In this Letter,we employ a RL-based wind farm control approach with multi-agent deep deterministic policy gradient to optimize the yaw manoeuvre of grouped wind turbines in wind farms.To reduce the computational complexity,the turbines in the wind farm are grouped according to the strength of the wake interaction.Meanwhile,to improve the control efficiency,each subgroup is treated as a whole and controlled by a single agent.Optimized results show that the proposed method can not only increase the power production of the wind farm but also significantly improve the control efficiency.展开更多
In this paper,we investigate spacelike graphs defined over a domain Ω⊂M^(n) in the Lorentz manifold M^(n)×ℝ with the metric−ds^(2)+σ,where M^(n) is a complete Riemannian n-manifold with the metricσ,Ωhas piece...In this paper,we investigate spacelike graphs defined over a domain Ω⊂M^(n) in the Lorentz manifold M^(n)×ℝ with the metric−ds^(2)+σ,where M^(n) is a complete Riemannian n-manifold with the metricσ,Ωhas piecewise smooth boundary,and ℝ denotes the Euclidean 1-space.We prove an interesting stability result for translating spacelike graphs in M^(n)×ℝ under a conformal transformation.展开更多
基金supported by the National Natural Science Foundation of China(81774319).
文摘Objective:To evaluate the therapeutic effects of Epimedium brevicornu Maxim.(EBM,Yin Yang Huo)on breast cancer using network pharmacology and in vitro validation.It also aimed to explore the novel targets and mechanisms of EBM in the treatment of breast cancer to facilitate the discovery of new drugs and their clinical application.Methods: Network pharmacology was used to identify and screen the components and targets of EBM for breast cancer treatment.Molecular docking was further screened the effective components and targets of EBM.Wound-healing assays and flow cytometry analysis were used to detect the ability of two compounds to intervene in the migration and apoptosis of MDA-MB-231 cells,and their mechanism of action was further explored using western blotting experiments.Results: EBM contained 19 active components.Among them wereβ-anhydroicaritin(Anhy)and isoliquiritigenin(Iso),which were selected for in vitro experiments.Treatment resulted in a dose-dependent suppression of MDA-MB-231 cell viability,with an IC_(50) of 23.73μmol/L for Iso and 21.28μmol/L for Anhy.In the wound healing assay,cells in Anhy and Iso groups exhibited considerable inhibition of migration at 48 h.In flow cytometry analysis,treatment with Iso(20μmol/L)for 96 h resulted in significantly higher levels of both early and late apoptosis in the Iso group than that in the control group(P=.004 and P=.014,respectively).Additionally,both Iso(20μmol/L)and Anhy(10 and 20μmol/L)induced cell necrosis at 96 h.Western blotting revealed that Anhy and Iso increased the expression of Bax and TBK1/NAK.Conclusion: These findings suggested that Anhy and Iso,the two components of EBM,inhibit MDA-MB-231 cell proliferation and migration of and induce their apoptosis,providing substantial support for future studies on breast cancer.
文摘In this note, we give a short proof for the DiPerna-Lions flows associated to ODEs following the method of Crippa and De Lellis [3]. More precisely, assume that [divb] ∈ Ll∞oc（Rd）, ｜b｜/（1 ＋ ｜x｜ log ｜x｜） ∈ L∞（Rd） and ｜ b｜ φ（｜ b｜） ∈ Ll1oc（Rd）, where φ（r） = log log（r ＋ c）, c 0. Then, there exists a unique regular Lagrangian flow associated with the ODE X˙（t, x） = b（X（t, x））, X（0, x） = x.
基金supported by the National Natural Science Foundation of China (60833002)the National Basic Research Program of China (973 Program) (2007CB307100)+2 种基金the National High Technology Research and Development Program of China (863 Program) (2007AA01Z202)the Program for Changjiang Scholars and Innovative Research Team in University (IRT0707)the Program of Introducing Talents of Discipline to Universities (111 Project) (B08002)
文摘Concurrent multipath transfer（CMT） using stream control transmission protocol（SCTP） multihoming has become an appealing option to increase the throughput and improve the performance of increasingly bandwidth-hungry applications.To investigate the rate allocation for applications in CMT,this paper analyzes the capacities of paths shared by competing sources,then proposes the rate allocation model for elastic flows based on the framework of network utility maximization（NUM）.In order to obtain the global optimum of the model,a distributed algorithm is presented which depends only on local available information.Simulation results confirm that the proposed algorithm can achieve the global optimum within reasonable convergence times.
基金supported by the National Natural Science Foundation of China (Grant No.12388101)the Science Challenge Project+1 种基金the Anhui NARI Jiyuan Electric Power Grid Technology Co.Ltd.through the Joint Laboratory of USTC-NARIthe advanced computing resources provided by the Supercomputing Center of the USTC
文摘Reinforcement learning(RL)algorithms are expected to become the next generation of wind farm control methods.However,as wind farms continue to grow in size,the computational complexity of collective wind farm control will exponentially increase with the growth of action and state spaces,limiting its potential in practical applications.In this Letter,we employ a RL-based wind farm control approach with multi-agent deep deterministic policy gradient to optimize the yaw manoeuvre of grouped wind turbines in wind farms.To reduce the computational complexity,the turbines in the wind farm are grouped according to the strength of the wake interaction.Meanwhile,to improve the control efficiency,each subgroup is treated as a whole and controlled by a single agent.Optimized results show that the proposed method can not only increase the power production of the wind farm but also significantly improve the control efficiency.
基金supported in part by the NSFC(11801496,11926352)the Fok Ying-Tung Education Foundation(China)the Hubei Key Laboratory of Applied Mathematics(Hubei University).
文摘In this paper,we investigate spacelike graphs defined over a domain Ω⊂M^(n) in the Lorentz manifold M^(n)×ℝ with the metric−ds^(2)+σ,where M^(n) is a complete Riemannian n-manifold with the metricσ,Ωhas piecewise smooth boundary,and ℝ denotes the Euclidean 1-space.We prove an interesting stability result for translating spacelike graphs in M^(n)×ℝ under a conformal transformation.
