It has been known for years that steroids （e. g. hydrocortisone and dexamethasone） have significant inhibitory effects on macrophage （M φ） activation for tumor cytotoxicity and secretion of interleukin 1, tumor n...It has been known for years that steroids （e. g. hydrocortisone and dexamethasone） have significant inhibitory effects on macrophage （M φ） activation for tumor cytotoxicity and secretion of interleukin 1, tumor necrosis factor-α（TNF-α） and prostaglandin E<sub>2</sub>. The mechanism of inhibition is, however, not well understood. We report here that the dexamethasone-induced inhibition of M φ activation for tumor cytotoxicity could be partially antagonized by high concentrations of activators and blocked by inhibitors of protein synthesis and energy metabolism.展开更多
文摘It has been known for years that steroids （e. g. hydrocortisone and dexamethasone） have significant inhibitory effects on macrophage （M φ） activation for tumor cytotoxicity and secretion of interleukin 1, tumor necrosis factor-α（TNF-α） and prostaglandin E<sub>2</sub>. The mechanism of inhibition is, however, not well understood. We report here that the dexamethasone-induced inhibition of M φ activation for tumor cytotoxicity could be partially antagonized by high concentrations of activators and blocked by inhibitors of protein synthesis and energy metabolism.
