The location of an acute ischemic stroke is associated with its prognosis. The widely used Gaussian model-based parameter, apparent diffusion coefficient(ADC), cannot reveal microstructural changes in different locati...The location of an acute ischemic stroke is associated with its prognosis. The widely used Gaussian model-based parameter, apparent diffusion coefficient(ADC), cannot reveal microstructural changes in different locations or the degree of infarction. This prospective observational study was reviewed and approved by the Institutional Review Board of Xiamen Second Hospital, China(approval No. 2014002).Diffusion kurtosis imaging(DKI) was used to detect 199 lesions in 156 patients with acute ischemic stroke(61 males and 95 females), mean age 63.15 ± 12.34 years. A total of 199 lesions were located in the periventricular white matter(n = 52), corpus callosum(n = 14), cerebellum(n = 29), basal ganglia and thalamus(n = 21), brainstem(n = 21) and gray-white matter junctions(n = 62). Percentage changes of apparent diffusion coefficient(ΔADC) and DKI-derived indices(fractional anisotropy [ΔFA], mean diffusivity [ΔMD], axial diffusivity [ΔD_a], radial diffusivity ΔDr, mean kurtosis [ΔMK], axial kurtosis [ΔK_a], and radial kurtosis [ΔK_r]) of each lesion were computed relative to the normal contralateral region. The results showed that(1) there was no significant difference in ΔADC, ΔMD, ΔD_a or ΔD_r among almost all locations.(2) There was significant difference in ΔMK among almost all locations(except basal ganglia and thalamus vs. brain stem; basal ganglia and thalamus vs. gray-white matter junctions; and brainstem vs. gray-white matter junctions.(3) The degree of change in diffusional kurtosis in descending order was as follows: corpus callosum > periventricular white matter > brainstem > gray-white matter junctions > basal ganglia and thalamus > cerebellum. In conclusion, DKI could reveal the differences in microstructure changes among various locations affected by acute ischemic stroke, and performed better than diffusivity among all groups.展开更多
Diffusion kurtosis imaging can be used to assess pathophysiological changes in tissue structure and to diagnose central nervous system diseases. However, its sensitivity in assessing hippocampal differences between pa...Diffusion kurtosis imaging can be used to assess pathophysiological changes in tissue structure and to diagnose central nervous system diseases. However, its sensitivity in assessing hippocampal differences between patients with Alzheimer’s disease and those with amnestic mild cognitive impairment has not been characterized. Here, we examined 20 individuals with Alzheimer’s disease (11 men and 9 women, mean 73.2 ± 4.49 years), 20 with amnestic mild cognitive impairment (10 men and 10 women, mean 71.55 ± 4.77 years), and 20 normal controls (11 men and 9 women, mean 70.45 ± 5.04 years). We conducted diffusion kurtosis imaging, using a 3.0 T magnetic resonance scanner, to compare hippocampal differences among the three groups. The results demonstrated that the right hippocampal volume and bilateral mean kurtosis were remarkably smaller in individuals with Alzheimer’s disease compared with those with amnestic mild cognitive impairment and normal controls. Further, the mean kurtosis was lower in the amnestic mild cognitive impairment group compared with the normal control group. The mean diffusion in the left hippocampus was lower in the Alzheimer’s disease group than in the amnestic mild cognitive impairment and normal control groups, while the mean diffusion in the right hippocampus was lower in the Alzheimer’s disease group than in the normal control group. Fractional anisotropy was similar among the three groups. These results verify that bilateral mean kurtosis and mean diffusion are sensitive to the diagnosis of Alzheimer’s disease and amnestic mild cognitive impairment. This study was approved by the Ethics Review Board of Affiliated Sixth People’s Hospital of Shanghai Jiao Tong University, China on May 4, 2010 (approval No. 2010(C)-6).展开更多
脑胶质瘤是颅内最常见的恶性肿瘤,复发率高,预后较差。较低级别脑胶质瘤是指2021世界卫生组织中枢神经系统肿瘤分类(World Health Organization Central Nervous System,WHO CNS)分级为2级和3级的肿瘤,较低级别脑胶质瘤的分子分型对其...脑胶质瘤是颅内最常见的恶性肿瘤,复发率高,预后较差。较低级别脑胶质瘤是指2021世界卫生组织中枢神经系统肿瘤分类(World Health Organization Central Nervous System,WHO CNS)分级为2级和3级的肿瘤,较低级别脑胶质瘤的分子分型对其治疗与预后有着重要的指导意义,因此分子分型诊断对脑胶质瘤的临床管理至关重要。分子分型诊断的金标准是病理检测,获取病理组织基因测序,但其有一定的有创性和滞后性。近年来,随着功能磁共振成像(functional MRI,fMRI)的发展,越来越多的研究明确了fMRI预测较低级别胶质瘤分子分型的价值,本文就近年来多种fMRI技术,包括扩散成像、灌注成像、酰胺质子转移成像等,对预测较低级别胶质瘤多种分子分型的研究进展作一综述,并就各种fMRI技术对不同分子分型的预测价值分别进行分析,旨在为预测较低级别胶质瘤分子分型提供影像学指标,从而达到临床精准诊治的目的。展开更多
目的探究弥散峰度成像参数对阿尔兹海默病的诊断价值。方法选取2019年4月至2020年12月绍兴市第七人民医院诊治的阿尔兹海默病患者50例为观察组,另外选取50例健康体检的人员为对照组。所有患者均进行弥散峰度成像技术,观察平均弥散率(ave...目的探究弥散峰度成像参数对阿尔兹海默病的诊断价值。方法选取2019年4月至2020年12月绍兴市第七人民医院诊治的阿尔兹海默病患者50例为观察组,另外选取50例健康体检的人员为对照组。所有患者均进行弥散峰度成像技术,观察平均弥散率(average diffusion rate,MD)、平均峰度(meankurtosis,MK)、参数各向异性分数(fraction of the parameter anisotropy,FA)参数。分析不同分组间及不同部位间的弥散峰度成像参数的差异,并比较其与患者认知功能情况。结果阿尔兹海默病患者海马、顶叶白质、额叶白质的MK、FA水平低于健康对照人群,MD高于健康对照人群(P<0.05)。重度阿尔兹海默病患者海马、顶叶白质、额叶白质的MK、FA水平较低于轻度组和中度组,MD高于轻度组和中度组(P<0.05)。阿尔兹海默病患者认知功能评分低于健康对照人群(P<0.05)。结论弥散峰度成像参数与疾病严重程度具有一定的相关性,且其在海马、顶叶白质、额叶白质中的表达对阿尔兹海默病患者具有诊断价值。展开更多
基金supported by the Science and Technology Planned Project from Xiamen Science and Technology Bureau,China,No.3502Z20154065(to LHZ)the Joint Project for Xiamen Key Diseases from Xiamen Science and Technology Bureau,China,No.3502Z20149032(to GG)
文摘The location of an acute ischemic stroke is associated with its prognosis. The widely used Gaussian model-based parameter, apparent diffusion coefficient(ADC), cannot reveal microstructural changes in different locations or the degree of infarction. This prospective observational study was reviewed and approved by the Institutional Review Board of Xiamen Second Hospital, China(approval No. 2014002).Diffusion kurtosis imaging(DKI) was used to detect 199 lesions in 156 patients with acute ischemic stroke(61 males and 95 females), mean age 63.15 ± 12.34 years. A total of 199 lesions were located in the periventricular white matter(n = 52), corpus callosum(n = 14), cerebellum(n = 29), basal ganglia and thalamus(n = 21), brainstem(n = 21) and gray-white matter junctions(n = 62). Percentage changes of apparent diffusion coefficient(ΔADC) and DKI-derived indices(fractional anisotropy [ΔFA], mean diffusivity [ΔMD], axial diffusivity [ΔD_a], radial diffusivity ΔDr, mean kurtosis [ΔMK], axial kurtosis [ΔK_a], and radial kurtosis [ΔK_r]) of each lesion were computed relative to the normal contralateral region. The results showed that(1) there was no significant difference in ΔADC, ΔMD, ΔD_a or ΔD_r among almost all locations.(2) There was significant difference in ΔMK among almost all locations(except basal ganglia and thalamus vs. brain stem; basal ganglia and thalamus vs. gray-white matter junctions; and brainstem vs. gray-white matter junctions.(3) The degree of change in diffusional kurtosis in descending order was as follows: corpus callosum > periventricular white matter > brainstem > gray-white matter junctions > basal ganglia and thalamus > cerebellum. In conclusion, DKI could reveal the differences in microstructure changes among various locations affected by acute ischemic stroke, and performed better than diffusivity among all groups.
基金supported by the Shanghai Municipal Education Commission-Gaofeng Clinical Medicine in China,No.2016427(to YHL)the Clinical Science and Technology Innovation Project of Shanghai Shen Kang Hospital Development Center in China,No.SHDC22015038(to YHL)the Shanghai Municipal Science and Technology Commission Medical Guide Project in China,No.16411968900(to YHL)
文摘Diffusion kurtosis imaging can be used to assess pathophysiological changes in tissue structure and to diagnose central nervous system diseases. However, its sensitivity in assessing hippocampal differences between patients with Alzheimer’s disease and those with amnestic mild cognitive impairment has not been characterized. Here, we examined 20 individuals with Alzheimer’s disease (11 men and 9 women, mean 73.2 ± 4.49 years), 20 with amnestic mild cognitive impairment (10 men and 10 women, mean 71.55 ± 4.77 years), and 20 normal controls (11 men and 9 women, mean 70.45 ± 5.04 years). We conducted diffusion kurtosis imaging, using a 3.0 T magnetic resonance scanner, to compare hippocampal differences among the three groups. The results demonstrated that the right hippocampal volume and bilateral mean kurtosis were remarkably smaller in individuals with Alzheimer’s disease compared with those with amnestic mild cognitive impairment and normal controls. Further, the mean kurtosis was lower in the amnestic mild cognitive impairment group compared with the normal control group. The mean diffusion in the left hippocampus was lower in the Alzheimer’s disease group than in the amnestic mild cognitive impairment and normal control groups, while the mean diffusion in the right hippocampus was lower in the Alzheimer’s disease group than in the normal control group. Fractional anisotropy was similar among the three groups. These results verify that bilateral mean kurtosis and mean diffusion are sensitive to the diagnosis of Alzheimer’s disease and amnestic mild cognitive impairment. This study was approved by the Ethics Review Board of Affiliated Sixth People’s Hospital of Shanghai Jiao Tong University, China on May 4, 2010 (approval No. 2010(C)-6).
文摘脑胶质瘤是颅内最常见的恶性肿瘤,复发率高,预后较差。较低级别脑胶质瘤是指2021世界卫生组织中枢神经系统肿瘤分类(World Health Organization Central Nervous System,WHO CNS)分级为2级和3级的肿瘤,较低级别脑胶质瘤的分子分型对其治疗与预后有着重要的指导意义,因此分子分型诊断对脑胶质瘤的临床管理至关重要。分子分型诊断的金标准是病理检测,获取病理组织基因测序,但其有一定的有创性和滞后性。近年来,随着功能磁共振成像(functional MRI,fMRI)的发展,越来越多的研究明确了fMRI预测较低级别胶质瘤分子分型的价值,本文就近年来多种fMRI技术,包括扩散成像、灌注成像、酰胺质子转移成像等,对预测较低级别胶质瘤多种分子分型的研究进展作一综述,并就各种fMRI技术对不同分子分型的预测价值分别进行分析,旨在为预测较低级别胶质瘤分子分型提供影像学指标,从而达到临床精准诊治的目的。
文摘目的探究弥散峰度成像参数对阿尔兹海默病的诊断价值。方法选取2019年4月至2020年12月绍兴市第七人民医院诊治的阿尔兹海默病患者50例为观察组,另外选取50例健康体检的人员为对照组。所有患者均进行弥散峰度成像技术,观察平均弥散率(average diffusion rate,MD)、平均峰度(meankurtosis,MK)、参数各向异性分数(fraction of the parameter anisotropy,FA)参数。分析不同分组间及不同部位间的弥散峰度成像参数的差异,并比较其与患者认知功能情况。结果阿尔兹海默病患者海马、顶叶白质、额叶白质的MK、FA水平低于健康对照人群,MD高于健康对照人群(P<0.05)。重度阿尔兹海默病患者海马、顶叶白质、额叶白质的MK、FA水平较低于轻度组和中度组,MD高于轻度组和中度组(P<0.05)。阿尔兹海默病患者认知功能评分低于健康对照人群(P<0.05)。结论弥散峰度成像参数与疾病严重程度具有一定的相关性,且其在海马、顶叶白质、额叶白质中的表达对阿尔兹海默病患者具有诊断价值。
