Rotational Population Measurement of Ultracold 85Rb^133Cs Molecules in the Lowest Vibrational Ground State

We measure the rotational populations of ultracold SS Rbla3 Cs molecules in the lowest vibrational ground state by a depletion spectroscopy and quantify the molecular production rate based on the measurement of single ion signal area. The SSRb133Cs molecules in the X1∑＋（v = 0） are formed from the short-range （2）^3П0＋（V = 10, J = 0） molecular state. A home-made external-cavity diode laser is used as the depletion laser to measure the rotational populations of the formed molecules. Based on the determination of single ion signal, the production rates of molecules in the J=0 and J = 2 rotational levels are derived to be 4800mole/s and 7200mole/s, respectively. The resolution and quantification of molecules in rotational states are facilitative for the manipulation of rotational quantum state of ultracold molecules.

Pesticide exposures and respiratory health in general populations

Human exposures to pesticides can occur in the workplace,in the household and through the ambient environment.While several articles have reviewed the impact of pesticide exposures on human respiratory health in occupational settings,to the best of our knowledge,this article is the first one to review published studies on the association between pesticide exposures and human respiratory health in the general populations.In this article,we critically reviewed evidences up to date studying the associations between non-occupational pesticide exposures and respiratory health in general populations.This article also highlighted questions arising from these studies,including our recent analyses using the data from the Canadian Health Measures Survey（CHMS）,for future research.We found few studies have addressed the impact of environmental pesticide exposures on respiratory health,especially on lung function,in general populations.In the studies using the data from CHMS Cycle 1,exposures to OP insecticides,pyrethroid insecticides,and the organochlorine pesticide DDT were associated with impaired lung function in the Canadian general population,but no significant associations were observed for the herbicide 2,4-D.Future research should focus on the potential age-specific and pesticide-specific effect on respiratory health in the general population,and repeated longitudinal study design is critical for assessing the temporal variations in pesticide exposures.Research findings from current studies of non-occupational pesticide exposures and their health impact in general population will help to improve the role of regulatory policies in mitigating pesticide-related public health problems,and thereafter providing greater benefit to the general population.

Modelling the dynamics of population viral load measures under HIV treatment as prevention

In 2011 the Centers for Disease Control and Prevention(CDC)published guidelines for the use of population viral load(PVL),community viral load(CVL)and monitored viral load(MVL),defined as the average viral load(VL)of all HIV infected individuals in a population,of all diagnosed individuals,and of all individuals on antiretroviral treatment(ART),respectively.Since then,CVL has been used to assess the effectiveness of ART on HIV transmission and as a proxy for HIV incidence.The first objective of this study was to investigate how aggregate VL measures change with the HIV epidemic phase and the drivers behind these changes using a mathematical transmission model.Secondly,we aimed to give some insight into how well CVL correlates with HIV incidence during the course of the epidemic and roll out of ART.We developed a compartmental model for disease progression and HIV transmission with disease stages that differ in viral loads for epidemiological scenarios relevant to a concentrated epidemic in a population of men who have sex with men(MSM)in Western Europe(WE)and to a generalized epidemic in a heterosexual population in Sub-Saharan Africa(SSA).The model predicts that PVL and CVL change with the epidemic phase,while MVL stays constant.These dynamics are linked to the dynamics of infected subgroups(undiagnosed,diagnosed untreated and treated)in different disease stages(primary,chronic and AIDS).In particular,CVL decreases through all epidemic stages:before ART,since chronic population builds up faster than AIDS population and after ART,due to the build-up of treated population with low VL.The trends in CVL and incidence can be both opposing and coinciding depending on the epidemic phase.Before ART is scaled up to sufficiently high levels,incidence increases while CVL decreases.After this point,CVL is a useful indicator of changes in HIV incidence.The model predicts that during the ART scale-up HIV transmission is driven by undiagnosed and diagnosed untreated individuals,and that new infections decline due to the increase in the number of treated.Although CVL is not able to capture the contribution of undiagnosed population to HIV transmission,it declines due to the increase of people on ART too.In the scenarios described by our model,the present epidemic phase corresponds to declining trends in CVL and incidence.