High throughput construction for the deformation mechanism diagram and dynamic recrystallization of a bimodal-sized particle-reinforced Ti-2.5Zr-2Al-1(Si,C)titanium alloy

An in situ autogenous particle-reinforced Ti-2.5Zr-2Al-1(Si,C)titanium alloy is prepared by vacuum induction melting.The wide range of an effective strain between 0.2 and 1.2 and the corresponding microstructure are obtained by the double-cone high-throughput compression test and finite element simulation.The deformation mechanism diagram with strains of 0.2-1.2 and strain rates of 0.7-1.5 s^(-1)at 900℃ is constructed.When the strain rate is 1.3 s^(-1),dynamic recovery occurs in the small strain range(<0.377),dynamic recrystallization(DRX)occurs in the medium strain range(0.377-1.182),and deformation instability occurs in the large strain range(>1.182),resulting in the deformation bands.High-angle annular dark field and high-resolution transmission electron microscopy are used to determine the existence of bimodal particle distribution,namely micron-scale TiC particles and nano-scale Ti5Si3 and(Zr,Si)particles.The average radius of the(Zr,Si)nanoparticles measured by small angle neutron scattering is 19.3 nm,and the volume fraction is 0.35%.DRX grains with an average size of 0.49μm are obtained at 900°C,strain rate of 1.3 s^(-1),and strain of about 0.6.Micron-scale particles stimulated DRX nucleation,while nanoscale particles hindered the growth of new grains,resulting in grain refinement.

A Preliminary Study on Principle of Etiology Mechanism

Based on the inspiration from Hetu and Luoshu,a principle diagram of pathogenicity of pathogenic factors was established.Accordingly,the inner correlations between pathogenic factor type and biological factors,and between pathogenic factors and host were analyzed.Mechanism of pathogenesis was discussed with five representative cases.The result indicated that effect of biological factors on host could be proved only with the performance of internalization conditions of biological factor and host.The reciprocal transformation between biological factors and pathogenic factors was decided by interaction and state of co-existed factors and host.The results suggested that it is a better and attractive choice to regulate and optimize the host’s state in practice than direct elimination of pathogens with antibiotics.

Eosinophilic pancreatitis:a review of the pathophysiology,diagnosis,and treatment

Eosinophilic pancreatitis(EP)is an extremely rare disease caused by purely eosinophilic infiltration of the pancreas.EP is prone to being misdiagnosed as pancreatic cancer,causing unnecessary economic and physical harm to the patient.We report three cases of EP that were cured by steroids without relapse from 2017 to now.The clinical data of the three patients,including clinical manifestations,serological manifestations,imaging(ultrasound,computed tomography,and MRI),pathological diagnosis and treatment,and telephone follow-up of all patients,were retrospectively analysed.In addition,a literature search was conducted on the Web of Science and PubMed databases using key terms related to EP,considering case reports with no restrictions on the date of publication or language.In conclusion,we analysed 19 cases and determined the diagnostic criteria for EP.The diagnostic algorithm for EP can be used to diagnose EP easily.We hope that our standards and algorithm can reduce the rate of misdiagnosis and contribute to clinical diagnosis and treatment.In addition,we expect to evaluate more EP cases to test our diagnostic criteria and design a systematic diagnostic flow chart.