This study aimed to explore the role of mechanical tension in hypertrophic scars and the change in nerve density using hematoxylin-eosin staining and S100 immunohistochemistry, and to observe the expression of nerve g...This study aimed to explore the role of mechanical tension in hypertrophic scars and the change in nerve density using hematoxylin-eosin staining and S100 immunohistochemistry, and to observe the expression of nerve growth factor by western blot analysis. The results demonstrated that mechanical tension contributed to the formation of a hyperplastic scar in the back skin of rats, in conjunction with increases in both nerve density and nerve growth factor expression in the scar tissue. These experimental findings indicate that the cutaneous nervous system plays a role in hypertrophic scar formation caused by mechanical tension.展开更多
Background Ectonucleotide pyrophosphatase/phosphodiesterase （ENPP）-I is a membrane-bound protein that catalyzes the hydrolysis of extracellular nucleoside triphosphates to monophosphate and extracellular inorganic p...Background Ectonucleotide pyrophosphatase/phosphodiesterase （ENPP）-I is a membrane-bound protein that catalyzes the hydrolysis of extracellular nucleoside triphosphates to monophosphate and extracellular inorganic pyrophosphate （ePPi）. Mechanical stimulation regulates ENPP-1 expression. This study sought to investigate the changes in ENPP-1 expression after stimulation using cyclic mechanical tension （CMT）.展开更多
The feasibility of reducing the welding residual stress through local tensile loading is verified using the finite element method （FEM）. The mechanism and effect of reducing stress during and after welding are compa...The feasibility of reducing the welding residual stress through local tensile loading is verified using the finite element method （FEM）. The mechanism and effect of reducing stress during and after welding are compared. The results show that the effect of the former is better than that of the latter. Applying an external tension load of 200 MPa after welding, the maximum residual stress drops down from 235 MPa to about 90 MPa, moreover, it decreases to 30MPa when an external tension load of 200 MPa is applied during welding.展开更多
基金supported by the Shandong Excellent Young Scientist Research Award Fund of the Natural Science Foundation of Shandong Province, No. BS2009YY043Shandong Medical and Health Science and Technology Development Program for Youth Fund, No. 2009QZ023the National Natural Science Foundation of China, No. 81272099
文摘This study aimed to explore the role of mechanical tension in hypertrophic scars and the change in nerve density using hematoxylin-eosin staining and S100 immunohistochemistry, and to observe the expression of nerve growth factor by western blot analysis. The results demonstrated that mechanical tension contributed to the formation of a hyperplastic scar in the back skin of rats, in conjunction with increases in both nerve density and nerve growth factor expression in the scar tissue. These experimental findings indicate that the cutaneous nervous system plays a role in hypertrophic scar formation caused by mechanical tension.
文摘Background Ectonucleotide pyrophosphatase/phosphodiesterase （ENPP）-I is a membrane-bound protein that catalyzes the hydrolysis of extracellular nucleoside triphosphates to monophosphate and extracellular inorganic pyrophosphate （ePPi）. Mechanical stimulation regulates ENPP-1 expression. This study sought to investigate the changes in ENPP-1 expression after stimulation using cyclic mechanical tension （CMT）.
文摘The feasibility of reducing the welding residual stress through local tensile loading is verified using the finite element method （FEM）. The mechanism and effect of reducing stress during and after welding are compared. The results show that the effect of the former is better than that of the latter. Applying an external tension load of 200 MPa after welding, the maximum residual stress drops down from 235 MPa to about 90 MPa, moreover, it decreases to 30MPa when an external tension load of 200 MPa is applied during welding.
