Studies on a Traditional Chinese Medical Prescription Ma Xing Shi Gan Tang by Bio-coordination Chemistry

本文报道 pH 电位滴定法测出麻黄碱与生石膏中的 Cu^(2+)、Fe^(2+)、Zn^(2+)、Mn^(2+)离子形成的 ML 及 ML_2型络合物的稳定常数。滴定曲线显示甘草酸与上述四种金属离子也能分别形成不同稳定程度的络合物。用麻黄碱加甘草酸和上述四种金属离子配制成的模拟麻杏石甘汤和单纯生石膏煎剂与麻性石甘汤一样均有使家兔退热的效果,与对照组比较均有显著性差异(P<0.05);而用麻黄碱加甘草酸配制成的溶液无退热效果。作者认为应从生物—配位无机化学的多金属—多配体体系的观点去研究某些传统中医药方剂。

Acquisition and Dissemination of Anti-Epidemic Medical Prescriptions During the Outbreaks in the Qing Dynasty of China

During the epidemics in the Qing dynasty,many medical professionals,nonprofessionals,and social organizations collected and sorted medical prescriptions related to infectious diseases.These people also compiled,published,disseminated,and consulted related medical formularies.The above historical event can be viewed as the construction and dissemination of medical knowledge.They edited and published medical formularies on infectious diseases with lower cost and in flexible ways by taking the initiative and giving full scope to creativity.Diverse anti-epidemic medical prescriptions from these medical formularies can be used for infectious diseases in the event of the outbreaks.However,the therapeutic effects of classical prescriptions and folk recipes cannot be regarded as the same.The wide circulation of anti-epidemic medical prescriptions and medical formularies was essentially a process of epidemic prevention resource allocation.Not only did it enable many nonprofessionals to participate in epidemic prevention and control,but it also enhanced awareness,knowledge,and capacity for epidemic prevention at the individual level.At the same time,due to the uneven quality and individual differences in the physical fitness and condition of the prescriptions and formularies,they had the capacity of causing inconveniences to the readers or patients.

The Application and Practice of TBL Method in the Teaching of “Zhuang Medical Prescriptions”

The application of TBL teaching method to"Zhuang Medical Prescriptions"is an actual practice of group cooperative learning mode.Through this method,a more active learning atmosphere can be constructed,and it is also an activity to jointly achieve the teaching goals.From the perspective of the practice of basic teaching,it is a creative teaching strategy.Let students develop the awareness and habit of using team groups for cooperative inquisitive learning,so as to gradually improve students'level of comprehensive application analysis.This paper discusses in detail from the perspective of practical research and building,and compares data under different teaching methods with test results to prove that TBL teaching method is superior to traditional teaching method.

Preliminary Investigation on Zhuang Folk Medicated Bath Prescriptions:A Case Study of Hechi Region

This paper summarizes the mechanism,methods and characteristics of Zhuang folk medicated bath,as well as the composition and application of prescriptions,which provides a basis for the popularization of Chinese ethnic medicine.

Trends in use and costs of prescription medication in patients with type 1 diabetes: 9-year follow-up after kidney transplantation

Aims: Weestimated long-term trends in prescription medication utilization and costs in patients with type 1 diabetes in two different transplant cohorts (Group 1: transplantation 1986-1999,n = 180;Group 2: transplantation 2000-2008, n = 150). Methods: Data obtained from the Finnish Diabetic Nephropathy Study were linked with the Drug Prescription Register (purchases of medications 1995-2009). Generalized linear mixed models under gamma distribution were used to evaluate the medication costs. Results: The total costs of medication decreased (Group 1 from€11,290 to €8760;Group 2 from €12,800 to €9790)during the follow-up (P< 0.0001). The sametrend was observed for immunosuppressive drugcosts (P< 0.0001). Although the cost profiles were similar for the groups (P= 0.9), the cost level in Group 2 was higher than in Group 1 (P< 0.0001). In Group 1 the most common immunosuppressive combination was cyclosporine, azathioprine and corticosteroid, while cyclosporine, mycophenolate mofetil (MMF) with/without corticosteroid was the most common in Group 2. The estimated average costs of cyclosporine in combination withMMFwere 84% (€4130) higher than with azathioprine. Conclusions: Since diabetes or other drugs had only marginal impact on the total costs, the decreasing trend wasmainly due to the costs of immunosuppressants.This finding is consistent with the recent guidelines which recommend reducing doses of immunosuppressants over time to minimize sideeffects.The cost levels differed depending on the combinations of immunosuppressive drugs in use. Those who had MMF in the regimen generated higher costs.

Prevalence of Potential Drug-Drug Interactions in Hospitalized Surgical Patients

The objective of this study is to estimate the prevalence and describe the characteristics of pDDIs （potential drug-drug interactions） in medical prescriptions of hospitalized surgical patients. In this cross-sectional study, we analyzed 370 medical prescriptions from the surgery unit of a Mexican public teaching hospital. The identification and classification of potential drug-drug interactions were performed with the Micromedex 2.0 electronic drug information database. Results were analyzed with descriptive statistics and we estimated OR （odds ratio） to determine associated risk factors. From the study, it was found that the prevalence of potential drug-drug interactions was 45.9%. A total of 385 interactions were identified. Of these, 54.3% were classified as major and 60.5% as pharmacodynamic. Prescriptions for more than seven drugs （OR =7.33, CI （confidence interval） = 4.59-11.71） and advanced age 〉 60 years, （OR = 1.79, CI = 1.06-2.74） were positively associated with the presence of potential drug-drug interactions. We found a high prevalence of clinically relevant pDDIs in the surgery unit. In view of this outcome, the safety of drug combinations in hospitalized surgical patients should be evaluated during the prescription process in order to prevent adverse events.

Research ideas and strategies on the dose-effect relationship of traditional Chinese medicine prescriptions and herbs

We discuss here the complexity of the doses of traditional Chinese medicine(TCM) prescriptions and herbs from different viewpoints,including the heterogeneity of drug quality,the flexibility of prescriptions,and the diversity of drug effects.Then,the corresponding research ideas and strategies are proposed.We can reveal the actual situation of clinical doses based on in-depth "real-world study" of the safety and effectiveness of TCM prescriptions,create an analytical method for dose-effect relationships in accordance with the features of TCM,and reveal the correlated regular nature of the effectiveness and dosage of TCM prescriptions and herbs.