Do drones have a realistic place in a pandemic fight for delivering medical supplies in healthcare systems problems?

The advancement of Unmanned Aerial Vehicle(UAV) technology in terms of industrial processes and communication and networking technologies has led to an increase in their use in civil, business, and social applications. Global rules in most countries had previously limited the use of drones to military applications due to their deployment in the open air, drones are likely to be lost, destroyed, or physically hijacked. However, more recently, the presence of COVID-19 has forced the world to present new implementing measures which will also widen the use of drones in civil and commercial and social applications, especially now in the delivery of medicines for medical home care. In the period of required public isolation as a consequence of the SARS-COV-2 pandemic, this knowledge has become one of the principal partners in the fight against the coronavirus. This paper offers a summary of the medical drone manufacturing, with a specific emphasis on its approval by the pharmaceutical sector to solve logistical problems in healthcare during times of sensitive need. We also discuss the numerous challenges to be met in the integration of drones to save our lives and suggest future research directions. The question that arises for this problem, how to optimize delivery medical supplies times in-home health care made up of drones? We conducted a synthesis literature review devoted to the use of UAVs in healthcare with their different aspects. A total of different research made are given to describe the role of UAV in Home healthcare with the presence of SARS-COV-2. We conclude that the drones will be able to optimize the way of eliminating contamination with a very high percentage(through the reduction of human contact) with the increase of the flexibility of the flight(reaching the less accessible regions every hour of the day).

Total Flavonoids from Flowers of Abelmoschus manihot for Amelioration of α-naphthylisothiocyanate-induced Cholestasis by Regulating Expression of Transporters

Objective To explore the molecular mechanisms of the total flavonoids extracted from the flowers of Abelmoschus manihot（TFA） against α-naphthylisothiocyanate（ANIT）-induced cholestasis. Methods The hepatoprotective activities of TFA（125, 250 and 500 mg/kg） were investigated on ANIT-induced cholestatic liver injury in rats. Serum levels of alanine aminotransferase（ALT）, aspartate aminotransferase（AST）, total bilirubin（TBIL）, total bile acid（TBA）, and bile flow were measured to evaluate the protective effect of TFA. Furthermore, the hepatic m RNA and protein levels of transports, multidrug resistance-associated protein 2（MRP2）, bile salt export pump（BSEP）, and Na＋-taurocholate cotransporting polypeptide（NTCP） were investigated to elucidate the protective mechanisms of TFA against ANIT-induced cholestasis. Results Pretreatment of TFA significantly and dose-dependently decreased the ANIT-induced elevation of serum ALT, AST, TBIL, and TBA levels and increased the ANIT-induced suppression of bile flow. Moreover, TFA was found to increase the expression of liver MRP2, BSEP, and NTCP in both protein and m RNA levels in ANIT-induced liver injury in rats with cholestasis. Conclusion TFA exerts a therapeutic effect on ANIT-induced liver injury in rats with cholestasis, possibly through regulating the expressions of hepatic transporters.