Ultra-fine fibrous mats with magnolol entrapped have been prepared by electrospinning biodegradable copolymer poly（ethylene glycol） blocked poly（L-lactide）.Drug entrapment was perfect which was confirmed by scanni...Ultra-fine fibrous mats with magnolol entrapped have been prepared by electrospinning biodegradable copolymer poly（ethylene glycol） blocked poly（L-lactide）.Drug entrapment was perfect which was confirmed by scanning electron microscopy and differential scanning calorimetry.According to in vitro drug release investigation by high performance liquid chromatography,it was found that fibers with 10%,20%and 30%drug entrapped respect to polymer（mass ratio） presented dramatically different drug release behavior and degradation behavior under the effect of proteinase K.The reason may be that fibers with 10%drug entrapped was more easily affected by enzyme while,to some degree,magnolol in fibers with 20% and 30%entrapped prevented polymer from being degraded by enzyme.展开更多
基金supported by the National Natural Science Foundation of China(Nos.20274048,50373043)Chinese Academy of Sciences(No.KJCX2-SW-H07)
文摘Ultra-fine fibrous mats with magnolol entrapped have been prepared by electrospinning biodegradable copolymer poly（ethylene glycol） blocked poly（L-lactide）.Drug entrapment was perfect which was confirmed by scanning electron microscopy and differential scanning calorimetry.According to in vitro drug release investigation by high performance liquid chromatography,it was found that fibers with 10%,20%and 30%drug entrapped respect to polymer（mass ratio） presented dramatically different drug release behavior and degradation behavior under the effect of proteinase K.The reason may be that fibers with 10%drug entrapped was more easily affected by enzyme while,to some degree,magnolol in fibers with 20% and 30%entrapped prevented polymer from being degraded by enzyme.
