Zhuang medicine medicated thread moxibustion is a kind of external therapy with ethnic medicine characteristics that spreads in Guangxi Zhuang region.It has a wide range of clinical application and significant curativ...Zhuang medicine medicated thread moxibustion is a kind of external therapy with ethnic medicine characteristics that spreads in Guangxi Zhuang region.It has a wide range of clinical application and significant curative effect,and can be used to treat diseases such as internal medicine,surgery,dermatology,gynecology,pediatrics,and five sense organs.Through reviewing and combing the literature on the Zhuang medicine medicated thread moxibustion in recent years,this paper summarizes and prospects its clinical application,with a view to further explaining the basic principles and application rules of Zhuang medicine medicated thread moxibustion and digging its clinical value.展开更多
Objective:To explore the efficacy and safety of Zhuang medicine medicated thread moxibustion(ZMTM)on psoriasis vulgaris.Methods:A multicenter,randomized,parallel controlled clinical trial was designed.A total of 241 o...Objective:To explore the efficacy and safety of Zhuang medicine medicated thread moxibustion(ZMTM)on psoriasis vulgaris.Methods:A multicenter,randomized,parallel controlled clinical trial was designed.A total of 241 outpatients with psoriasis vulgaris were randomly divided into a control group(120 cases)and a treatment group(121 cases)using a central block randomization from June 2015 to May 2018.The control group was treated with Western medicines alone including pidotimod dispersible tablets,vitamin B compound tablets,and compound cod liver oil-zinc oxide ointment.The treatment group was treated with ZMTM every 2 days combined with Western medicines.The two groups received continuous intervention for 30 days.The primary outcome was Psoriasis Area and Severity Index(PASI),and the secondary outcomes included Itch Rating Scale,Dermatology Quality of Life Index(DLQI),Hamilton Anxiety Rating Scale(HAMA),as well as PASI response rate.Meanwhile,adverse events were evaluated during the whole clinical trial.Follow-up was carried out 30 days after treatment.Results:There were 5 cases of shedding in this trial.In intention-to-treat analysis,236 cases were included and each group contained 118 cases.On the 30th and 60th days,PASI scores of patients in each group were significantly lower than that at baseline(P<0.01)and the PASI score reduction of the treatment group was greater than that of the control group(P<0.01).Itch Rating Scale,DLQI,and HAMA scale were decreased in both groups after treatment,and the treatment group showed a better therapeutic effect(P<0.01).The response rates of PASI 50 and 75 were significantly higher than those in the control group[81.4%(96/118),43.2%(51/118)vs.41.5%(49/118),11.0%(13/118),respectively,P<0.05].During follow-up,the improvements in scores of PASI,Itch Rating Scale,DLQI,and HAMA of the treatment group were significantly greater than those of the control group(P<0.01).The response rates of PASI 50 and 75 in the treatment group were significantly higher than those in the control group,respectively(both P<0.05).No obvious adverse reaction was found in either group.Conclusion:ZMTM combined with Western medicines showed a better therapeutic effect in the treatment of psoriasis vulgaris without obvious adverse reaction.(Trial Registration No.ChiCTR-IOR-16008159)展开更多
目的观察壮医药线点灸配合围针、外用药治疗艾滋病合并带状疱疹(AIDS patients with herpes zoster,AHZ)的疗效。方法采用随机对照方法,将60例AHZ患者随机分为试验组和对照组,每组30例。试验组采用壮医药线点灸配合围针及京万红烫伤膏治...目的观察壮医药线点灸配合围针、外用药治疗艾滋病合并带状疱疹(AIDS patients with herpes zoster,AHZ)的疗效。方法采用随机对照方法,将60例AHZ患者随机分为试验组和对照组,每组30例。试验组采用壮医药线点灸配合围针及京万红烫伤膏治疗;对照组给予泛昔洛韦片、尼美舒利分散片、维生素B1及利巴韦林软膏进行治疗。疗程均为14天。观察两组患者临床疗效和治疗前后视觉模拟评分(vsualan-aloguescale,VAS)、睡眠质量评分(sleepqualityscore,QS)及1年内后遗神经痛发生率。结果试验组愈显率显著高于对照组(86.7%vs53.3%,P<0.01)。两组总有效率比较,差异无统计学意义(96.7%vs80.0%,P>0.05)。试验组治疗后VAS评分、QS积分、疼痛消失时间、皮损修复时间、结痂时间及后遗神经痛发生率均显著低于对照组(P<0.05,P<0.01)。结论壮医药线点灸配合围针及京万红烫伤膏治疗AHZ患者,具有快速止痛、缩短病程、提高患者睡眠质量的效果。展开更多
目的:观察针刺联合壮医药线点灸对睡眠剥夺大鼠相关神经递质的影响。方法:80只SPF级Wistar大鼠随机分为对照组、模型组、治疗组、安定组4组,每组20只。模型组、治疗组、安定组通过睡眠剥夺进行失眠模型造模。治疗组在造模基础上给予针...目的:观察针刺联合壮医药线点灸对睡眠剥夺大鼠相关神经递质的影响。方法:80只SPF级Wistar大鼠随机分为对照组、模型组、治疗组、安定组4组,每组20只。模型组、治疗组、安定组通过睡眠剥夺进行失眠模型造模。治疗组在造模基础上给予针刺和壮医药线点灸治疗,每日1次,连续治疗14天。安定组按照3 mg·kg-1体质量给予安定灌胃,对照组则给予等体积生理盐水灌胃,均是每日1次,连续灌胃14天。检测增食素(Orexin)、去甲肾上腺素(Norepinephrine,NE)、5-羟色胺(5-Hydroxytryptamine,5-HT)、促肾上腺皮质激素释放激素(Corticotropin-Releasing Hormone,CRH)、促肾上腺皮质激素(Adrenocorticotropic Hormone,ACTH)水平,观察Orexin m RNA、c-Fos表达。结果:与对照组比较,模型组大鼠Orexin、ACTH、5-HT、NE、CRH水平升高或明显升高,差异均有统计学意义(P<0.05或P<0.01);模型组大鼠Orexin m RNA、c-Fos表达升高或明显升高,差异均有统计学意义(P<0.05或P<0.01)。与模型组比较,治疗组大鼠Orexin、ACTH、5-HT、NE、CRH水平下降或明显下降,差异也均有统计学意义(P<0.05或P<0.01);治疗组大鼠Orexin m RNA、c-Fos表达水平下降或明显下降,差异也均有统计学意义(P<0.05或P<0.01)。结论:针刺联合壮医药线点灸通过影响Orexin,进而调控下丘脑-垂体-肾上腺轴(Hypothalamic Pituitary Adrenal axis,HPA axis),降低应激反应性,促进觉醒向睡眠的转变可能是其治疗失眠的机制之一。展开更多
基金"Zhuang medicine",a key discipline of traditional Chinese medicine in Guangxi(No.GZXK-Z-20-60),the project to improve the basic scientific research ability of young and middle-aged teachers in Guangxi universities(No.2020KY07023),and the scientific research project of Guangxi Zhuang Autonomous Region Administration of Traditional Chinese Medicine(No.GXZYZ20210456).
文摘Zhuang medicine medicated thread moxibustion is a kind of external therapy with ethnic medicine characteristics that spreads in Guangxi Zhuang region.It has a wide range of clinical application and significant curative effect,and can be used to treat diseases such as internal medicine,surgery,dermatology,gynecology,pediatrics,and five sense organs.Through reviewing and combing the literature on the Zhuang medicine medicated thread moxibustion in recent years,this paper summarizes and prospects its clinical application,with a view to further explaining the basic principles and application rules of Zhuang medicine medicated thread moxibustion and digging its clinical value.
基金Supported by the Scientific Research Special Fund of Traditional Chinese Medicine Industry(No.201507006)。
文摘Objective:To explore the efficacy and safety of Zhuang medicine medicated thread moxibustion(ZMTM)on psoriasis vulgaris.Methods:A multicenter,randomized,parallel controlled clinical trial was designed.A total of 241 outpatients with psoriasis vulgaris were randomly divided into a control group(120 cases)and a treatment group(121 cases)using a central block randomization from June 2015 to May 2018.The control group was treated with Western medicines alone including pidotimod dispersible tablets,vitamin B compound tablets,and compound cod liver oil-zinc oxide ointment.The treatment group was treated with ZMTM every 2 days combined with Western medicines.The two groups received continuous intervention for 30 days.The primary outcome was Psoriasis Area and Severity Index(PASI),and the secondary outcomes included Itch Rating Scale,Dermatology Quality of Life Index(DLQI),Hamilton Anxiety Rating Scale(HAMA),as well as PASI response rate.Meanwhile,adverse events were evaluated during the whole clinical trial.Follow-up was carried out 30 days after treatment.Results:There were 5 cases of shedding in this trial.In intention-to-treat analysis,236 cases were included and each group contained 118 cases.On the 30th and 60th days,PASI scores of patients in each group were significantly lower than that at baseline(P<0.01)and the PASI score reduction of the treatment group was greater than that of the control group(P<0.01).Itch Rating Scale,DLQI,and HAMA scale were decreased in both groups after treatment,and the treatment group showed a better therapeutic effect(P<0.01).The response rates of PASI 50 and 75 were significantly higher than those in the control group[81.4%(96/118),43.2%(51/118)vs.41.5%(49/118),11.0%(13/118),respectively,P<0.05].During follow-up,the improvements in scores of PASI,Itch Rating Scale,DLQI,and HAMA of the treatment group were significantly greater than those of the control group(P<0.01).The response rates of PASI 50 and 75 in the treatment group were significantly higher than those in the control group,respectively(both P<0.05).No obvious adverse reaction was found in either group.Conclusion:ZMTM combined with Western medicines showed a better therapeutic effect in the treatment of psoriasis vulgaris without obvious adverse reaction.(Trial Registration No.ChiCTR-IOR-16008159)
文摘目的观察壮医药线点灸配合围针、外用药治疗艾滋病合并带状疱疹(AIDS patients with herpes zoster,AHZ)的疗效。方法采用随机对照方法,将60例AHZ患者随机分为试验组和对照组,每组30例。试验组采用壮医药线点灸配合围针及京万红烫伤膏治疗;对照组给予泛昔洛韦片、尼美舒利分散片、维生素B1及利巴韦林软膏进行治疗。疗程均为14天。观察两组患者临床疗效和治疗前后视觉模拟评分(vsualan-aloguescale,VAS)、睡眠质量评分(sleepqualityscore,QS)及1年内后遗神经痛发生率。结果试验组愈显率显著高于对照组(86.7%vs53.3%,P<0.01)。两组总有效率比较,差异无统计学意义(96.7%vs80.0%,P>0.05)。试验组治疗后VAS评分、QS积分、疼痛消失时间、皮损修复时间、结痂时间及后遗神经痛发生率均显著低于对照组(P<0.05,P<0.01)。结论壮医药线点灸配合围针及京万红烫伤膏治疗AHZ患者,具有快速止痛、缩短病程、提高患者睡眠质量的效果。
文摘目的:观察针刺联合壮医药线点灸对睡眠剥夺大鼠相关神经递质的影响。方法:80只SPF级Wistar大鼠随机分为对照组、模型组、治疗组、安定组4组,每组20只。模型组、治疗组、安定组通过睡眠剥夺进行失眠模型造模。治疗组在造模基础上给予针刺和壮医药线点灸治疗,每日1次,连续治疗14天。安定组按照3 mg·kg-1体质量给予安定灌胃,对照组则给予等体积生理盐水灌胃,均是每日1次,连续灌胃14天。检测增食素(Orexin)、去甲肾上腺素(Norepinephrine,NE)、5-羟色胺(5-Hydroxytryptamine,5-HT)、促肾上腺皮质激素释放激素(Corticotropin-Releasing Hormone,CRH)、促肾上腺皮质激素(Adrenocorticotropic Hormone,ACTH)水平,观察Orexin m RNA、c-Fos表达。结果:与对照组比较,模型组大鼠Orexin、ACTH、5-HT、NE、CRH水平升高或明显升高,差异均有统计学意义(P<0.05或P<0.01);模型组大鼠Orexin m RNA、c-Fos表达升高或明显升高,差异均有统计学意义(P<0.05或P<0.01)。与模型组比较,治疗组大鼠Orexin、ACTH、5-HT、NE、CRH水平下降或明显下降,差异也均有统计学意义(P<0.05或P<0.01);治疗组大鼠Orexin m RNA、c-Fos表达水平下降或明显下降,差异也均有统计学意义(P<0.05或P<0.01)。结论:针刺联合壮医药线点灸通过影响Orexin,进而调控下丘脑-垂体-肾上腺轴(Hypothalamic Pituitary Adrenal axis,HPA axis),降低应激反应性,促进觉醒向睡眠的转变可能是其治疗失眠的机制之一。
