Objective:To summarize the medication rules of Chinese herbs to treat heart failure with preserved ejection fraction(HFPEF)based on data mining and to provide references for clinical utilization.Methods:The China Nati...Objective:To summarize the medication rules of Chinese herbs to treat heart failure with preserved ejection fraction(HFPEF)based on data mining and to provide references for clinical utilization.Methods:The China National Knowledge Infrastructure(CNKI),Wanfang database(Wanfang),VIP database(VIP),Chinese Biomedical Literature(CBM),PubMed,Embase,and Cochrane Library databases were searched from inception to October 2021 to identify relevant literature on treating HFPEF with Chinese herbs.Microsoft Excel 2019 was used to set up a database,and then,association rule analysis and hierarchical cluster analysis were performed by using apriori algorithm and hclust function respectively in R-Studio(Version 4.0.3).Results:A total of 182 qualified papers were included,involving a total of 92 prescriptions,130 Chinese herbs,and 872 individual herbs prescribed,with an average of 9.5 herbs per prescription.The six most frequently prescribed herbs were Astragali Radix(Huangqi),Salviae Miltiorrhizae Radix Et Rhizoma(Danshen),Poria(Fuling),Glycyrrhizae Radix Et Rhizoma(Gancao),Cinnamomi Ramulus(Guizhi),and Ginseng Radix Et Rhizoma(Renshen).There were 35 herbs used more than 5 times,involving 11 efficacy categories.The top three categories were deficiency-tonifying herbs,blood-activating and stasis-removing herbs,and dampnessdraining diuretic herbs.The most commonly used herbs were mainly warm and sweet.The primary meridian tropisms were Lung Meridian,Heart Meridian and Spleen Meridian.Association rule analysis yielded 26 association rules,such as Astragali Radix(Huangqi)&Salviae Miltiorrhizae Radix Et Rhizoma(Danshen),Poria(Fuling),Cinnamomi Ramulus(Guizhi)&Atractylodis Macrocephalae Rhizoma(Baizhu).Hierarchical cluster analysis yielded four herb classes,and their functions were mainly qi-replenishing and yang-warming,bloodactivating and diuresis-inducing.Conclusions:HFPEF is the syndrome of root vacuity and tip repletion,and its core pathogenesis is"deficiency","stasis",and"wafer",with"deficiency"being the most principal,which is closely related to Xin(heart),Fei(Lung),and Pi(Spleen).The treatment of this disease occurs by improving qi,warming yang,activating blood and inducing diuresis.Astragali Radix(Huangqi)with Salviae Miltiorrhizae Radix Et Rhizoma(Danshen)is the basic combination of herbs applied.展开更多
中药方剂(traditional Chinese medicine formula,TCMF)是中医治疗的一种主要手段。然而一首方剂往往包含多种草药,这其中只有几种草药对治疗特定的病症起重要作用。因此,找出方剂中的核心药物和其配伍规律对研究中药方剂有非常重要的...中药方剂(traditional Chinese medicine formula,TCMF)是中医治疗的一种主要手段。然而一首方剂往往包含多种草药,这其中只有几种草药对治疗特定的病症起重要作用。因此,找出方剂中的核心药物和其配伍规律对研究中药方剂有非常重要的意义。针对该问题,提出了一种基于效用度(effect degree,ED)的核心药物及配伍规律发现方法。该方法包含三个主要步骤,分别是基于药物效用度的核心药物发现算法、基于带药对效用度的点式互信息(pointwise mutual information with herb pair ED,PMIED)的药物组网算法、基于重叠社团的高效药物配伍规律发现算法。通过实验,发现了肺痿方剂的42种核心药物和30种药物配伍,经分析和中医专家确认,42种核心药物对肺痿确有良好疗效,30组药物配伍中有26组符合药物配伍关系且对肺痿有良好疗效。展开更多
基金Supported by the Key Special Project of the National Key R&D Program(No.2019YFC1710003 and No.2019YFC1710000)the Key Project of the National Natural Science Foundation of China(No.82030120)。
文摘Objective:To summarize the medication rules of Chinese herbs to treat heart failure with preserved ejection fraction(HFPEF)based on data mining and to provide references for clinical utilization.Methods:The China National Knowledge Infrastructure(CNKI),Wanfang database(Wanfang),VIP database(VIP),Chinese Biomedical Literature(CBM),PubMed,Embase,and Cochrane Library databases were searched from inception to October 2021 to identify relevant literature on treating HFPEF with Chinese herbs.Microsoft Excel 2019 was used to set up a database,and then,association rule analysis and hierarchical cluster analysis were performed by using apriori algorithm and hclust function respectively in R-Studio(Version 4.0.3).Results:A total of 182 qualified papers were included,involving a total of 92 prescriptions,130 Chinese herbs,and 872 individual herbs prescribed,with an average of 9.5 herbs per prescription.The six most frequently prescribed herbs were Astragali Radix(Huangqi),Salviae Miltiorrhizae Radix Et Rhizoma(Danshen),Poria(Fuling),Glycyrrhizae Radix Et Rhizoma(Gancao),Cinnamomi Ramulus(Guizhi),and Ginseng Radix Et Rhizoma(Renshen).There were 35 herbs used more than 5 times,involving 11 efficacy categories.The top three categories were deficiency-tonifying herbs,blood-activating and stasis-removing herbs,and dampnessdraining diuretic herbs.The most commonly used herbs were mainly warm and sweet.The primary meridian tropisms were Lung Meridian,Heart Meridian and Spleen Meridian.Association rule analysis yielded 26 association rules,such as Astragali Radix(Huangqi)&Salviae Miltiorrhizae Radix Et Rhizoma(Danshen),Poria(Fuling),Cinnamomi Ramulus(Guizhi)&Atractylodis Macrocephalae Rhizoma(Baizhu).Hierarchical cluster analysis yielded four herb classes,and their functions were mainly qi-replenishing and yang-warming,bloodactivating and diuresis-inducing.Conclusions:HFPEF is the syndrome of root vacuity and tip repletion,and its core pathogenesis is"deficiency","stasis",and"wafer",with"deficiency"being the most principal,which is closely related to Xin(heart),Fei(Lung),and Pi(Spleen).The treatment of this disease occurs by improving qi,warming yang,activating blood and inducing diuresis.Astragali Radix(Huangqi)with Salviae Miltiorrhizae Radix Et Rhizoma(Danshen)is the basic combination of herbs applied.
文摘中药方剂(traditional Chinese medicine formula,TCMF)是中医治疗的一种主要手段。然而一首方剂往往包含多种草药,这其中只有几种草药对治疗特定的病症起重要作用。因此,找出方剂中的核心药物和其配伍规律对研究中药方剂有非常重要的意义。针对该问题,提出了一种基于效用度(effect degree,ED)的核心药物及配伍规律发现方法。该方法包含三个主要步骤,分别是基于药物效用度的核心药物发现算法、基于带药对效用度的点式互信息(pointwise mutual information with herb pair ED,PMIED)的药物组网算法、基于重叠社团的高效药物配伍规律发现算法。通过实验,发现了肺痿方剂的42种核心药物和30种药物配伍,经分析和中医专家确认,42种核心药物对肺痿确有良好疗效,30组药物配伍中有26组符合药物配伍关系且对肺痿有良好疗效。
