Irritable bowel syndrome (IBS) is a functional bowel disorder that includes abdominal pain or discomfort associated with defecation or a change in bowel habits with features of disordered defecation.This disease lacks...Irritable bowel syndrome (IBS) is a functional bowel disorder that includes abdominal pain or discomfort associated with defecation or a change in bowel habits with features of disordered defecation.This disease lacks morphological changes and biochemical abnormalities to explain the symptoms.展开更多
The gradual development of Chinese medicine is based on constant accumulation and summary of experience in clinical practice,but without the benefit of undergoing the experimental medicine stage.Although Chinese medic...The gradual development of Chinese medicine is based on constant accumulation and summary of experience in clinical practice,but without the benefit of undergoing the experimental medicine stage.Although Chinese medicine has formed a systematic and unique theory system through thousands of years,with the development of evidence-based medicine,the bondage of the research methods of experience medicine to Chinese medicine is appearing.The rapid transition and transformation from experience medicine to evidence-based medicine have become important content in the development of Chinese medicine.According to the features of Chinese medicine,we propose the research idea of“taking two ways simultaneously,”which is the study both in the ideal condition and in the real world.Analyzing and constructing the theoretical basis and methodology of clinical research in the real world,and building the stage for research technique is key to the effective clinical research of Chinese medicine.Only by gradually maturing and completing the clinical research methods of the real world could we realize“taking two ways simultaneously”and complementing each other,continuously produce scientific and reliable evidence of Chinese medicine,as well as transform and develop Chinese medicine from experience medicine to evidence-based medicine.展开更多
Neurologic impairments are usually irreversible as a result of limited regeneration in the central nervous system.Therefore,based on the regenerative capacity of stem cells,transplantation therapies of various stem ce...Neurologic impairments are usually irreversible as a result of limited regeneration in the central nervous system.Therefore,based on the regenerative capacity of stem cells,transplantation therapies of various stem cells have been tested in basic research and preclinical trials,and some have shown great prospects.This manuscript overviews the cellular and molecular characteristics of embryonic stem cells,induced pluripotent stem cells,neural stem cells,retinal stem/progenitor cells,mesenchymal stem/stromal cells,and their derivatives in vivo and in vitro as sources for regenerative therapy.These cells have all been considered as candidates to treat several major neurological disorders and diseases,owing to their self-renewal capacity,multi-directional differentiation,neurotrophic properties,and immune modulation effects.We also review representative basic research and recent clinical trials using stem cells for neurodegenerative diseases,including Parkinson＇s disease,Alzheimer＇s disease,and age-related macular degeneration,as well as traumatic brain injury and glioblastoma.In spite of a few unsuccessful cases,risks of tumorigenicity,and ethical concerns,most results of animal experiments and clinical trials demonstrate efficacious therapeutic effects of stem cells in the treatment of nervous system disease.In summary,these emerging findings in regenerative medicine are likely to contribute to breakthroughs in the treatment of neurological disorders.Thus,stem cells are a promising candidate for the treatment of nervous system diseases.展开更多
Acute kidney injury （AKI）,a concept that replaces the traditional concept known as acute renal failure（ARF）, has been adopted by more and more nephrologists and intensive-care specialists in recent years.The defin...Acute kidney injury （AKI）,a concept that replaces the traditional concept known as acute renal failure（ARF）, has been adopted by more and more nephrologists and intensive-care specialists in recent years.The definition and diagnostic criteria of AKI are quite different from those of ARF. It should be noted that although the study of the pathophysiology of AKI, as well as supportive therapies such as blood purification therapy, has obtained significant progress, the incidence of end- stage renal diseases and mortality rate caused by AKI are still high. Therefore, it has a great practical significance to make efforts to study prevention and treatment of AKI.展开更多
Diabetic peripheral neuropathy （DPN） is a common chronic complication in diabetic patients, closely correlated with the development of the disease and with poorly controlled glucose levels. The common clinical signs...Diabetic peripheral neuropathy （DPN） is a common chronic complication in diabetic patients, closely correlated with the development of the disease and with poorly controlled glucose levels. The common clinical signs show paresthesia, mostly manifesting as multiple peripheral neuritis, such as having a chilly or causalgic feeling, anaesthesia, formication, and pain, etc.展开更多
At the 3rd World Integrative Medicine Congress in Guangzhou, China, September 22-24, 2007, I had a lucky opportunity to be invited to give a talk. The topic of my talk was ＇How to write and submit scientific papers f...At the 3rd World Integrative Medicine Congress in Guangzhou, China, September 22-24, 2007, I had a lucky opportunity to be invited to give a talk. The topic of my talk was ＇How to write and submit scientific papers for publication： guidance for Chinese scholars in the field of integrative medicine＇. My primary purpose for accepting the invitation to speak at the conference was educational, that of delivering scientific writing guidelines, but my personal reasons included my interest in learning about the Chinese version of integrating Traditional Chinese Medicine and Western Medicine. In addition, I was making first trip to China's Mainland. In this brief report, I would like to share my sketch of the conference and my impressions.展开更多
文摘Irritable bowel syndrome (IBS) is a functional bowel disorder that includes abdominal pain or discomfort associated with defecation or a change in bowel habits with features of disordered defecation.This disease lacks morphological changes and biochemical abnormalities to explain the symptoms.
基金supported by Key Project of Chinese National Programs for Fundamental Research and Development(973 Program)“Study on Fundamental Principles,Methodology,and Technology Platform of Clinical Evaluation Based on Syndrome Differentiation in TCM”(Number:2006CB504601).
文摘The gradual development of Chinese medicine is based on constant accumulation and summary of experience in clinical practice,but without the benefit of undergoing the experimental medicine stage.Although Chinese medicine has formed a systematic and unique theory system through thousands of years,with the development of evidence-based medicine,the bondage of the research methods of experience medicine to Chinese medicine is appearing.The rapid transition and transformation from experience medicine to evidence-based medicine have become important content in the development of Chinese medicine.According to the features of Chinese medicine,we propose the research idea of“taking two ways simultaneously,”which is the study both in the ideal condition and in the real world.Analyzing and constructing the theoretical basis and methodology of clinical research in the real world,and building the stage for research technique is key to the effective clinical research of Chinese medicine.Only by gradually maturing and completing the clinical research methods of the real world could we realize“taking two ways simultaneously”and complementing each other,continuously produce scientific and reliable evidence of Chinese medicine,as well as transform and develop Chinese medicine from experience medicine to evidence-based medicine.
基金supported by the National Natural Science Foundation of China,No.31471044a grant from the Ministry of Science and Technology of China,No.2015AA020918
文摘Neurologic impairments are usually irreversible as a result of limited regeneration in the central nervous system.Therefore,based on the regenerative capacity of stem cells,transplantation therapies of various stem cells have been tested in basic research and preclinical trials,and some have shown great prospects.This manuscript overviews the cellular and molecular characteristics of embryonic stem cells,induced pluripotent stem cells,neural stem cells,retinal stem/progenitor cells,mesenchymal stem/stromal cells,and their derivatives in vivo and in vitro as sources for regenerative therapy.These cells have all been considered as candidates to treat several major neurological disorders and diseases,owing to their self-renewal capacity,multi-directional differentiation,neurotrophic properties,and immune modulation effects.We also review representative basic research and recent clinical trials using stem cells for neurodegenerative diseases,including Parkinson＇s disease,Alzheimer＇s disease,and age-related macular degeneration,as well as traumatic brain injury and glioblastoma.In spite of a few unsuccessful cases,risks of tumorigenicity,and ethical concerns,most results of animal experiments and clinical trials demonstrate efficacious therapeutic effects of stem cells in the treatment of nervous system disease.In summary,these emerging findings in regenerative medicine are likely to contribute to breakthroughs in the treatment of neurological disorders.Thus,stem cells are a promising candidate for the treatment of nervous system diseases.
文摘Acute kidney injury （AKI）,a concept that replaces the traditional concept known as acute renal failure（ARF）, has been adopted by more and more nephrologists and intensive-care specialists in recent years.The definition and diagnostic criteria of AKI are quite different from those of ARF. It should be noted that although the study of the pathophysiology of AKI, as well as supportive therapies such as blood purification therapy, has obtained significant progress, the incidence of end- stage renal diseases and mortality rate caused by AKI are still high. Therefore, it has a great practical significance to make efforts to study prevention and treatment of AKI.
文摘Diabetic peripheral neuropathy （DPN） is a common chronic complication in diabetic patients, closely correlated with the development of the disease and with poorly controlled glucose levels. The common clinical signs show paresthesia, mostly manifesting as multiple peripheral neuritis, such as having a chilly or causalgic feeling, anaesthesia, formication, and pain, etc.
文摘At the 3rd World Integrative Medicine Congress in Guangzhou, China, September 22-24, 2007, I had a lucky opportunity to be invited to give a talk. The topic of my talk was ＇How to write and submit scientific papers for publication： guidance for Chinese scholars in the field of integrative medicine＇. My primary purpose for accepting the invitation to speak at the conference was educational, that of delivering scientific writing guidelines, but my personal reasons included my interest in learning about the Chinese version of integrating Traditional Chinese Medicine and Western Medicine. In addition, I was making first trip to China's Mainland. In this brief report, I would like to share my sketch of the conference and my impressions.
