Evaluation of traditional Chinese medicines after the market has achieved fruitful results after years of development.The real-world research concept has been first proposed by Chief Researcher Xie Yanming in 2010 and...Evaluation of traditional Chinese medicines after the market has achieved fruitful results after years of development.The real-world research concept has been first proposed by Chief Researcher Xie Yanming in 2010 and to 2020 with the approval of the National Medical Products Administration to use real-world evidence to support drug development and review in 2020.Real-world data application and transformation continue to cause heated discussions in the industry.Real-world research concepts have been added new motivation into the evaluation of Chinese medicines after they are marketed.The development of the Chinese patent medicine industry is facing unprecedented opportunities and challenges.展开更多
A traditional Chinese medicine （TCM） has been authorized for sale in a European market for the first time, the Chinese Academy of Sciences announced on April 18, 2012.
Eleven new fluorine-containing FDA-approved drugs have been profiled and details of their discovery and preparation are discussed.Therapeutic areas include schizophrenia,migraine,multiple sclerosis,insomnia,rheumatoid...Eleven new fluorine-containing FDA-approved drugs have been profiled and details of their discovery and preparation are discussed.Therapeutic areas include schizophrenia,migraine,multiple sclerosis,insomnia,rheumatoid arthritis,anti-tuberculosis,breast cancer,lymphoma kinase inhibitor,serotonin receptor antagonist.New pharmaceuticals feature four examples of aromatic fluorine,three aromatic CF3 group,three aliphatic CF3 and one compound with aromatic CF3O group.Furthermore,among the new compounds,six are chiral and seven are derived from tailor-made amino acids.展开更多
文摘Evaluation of traditional Chinese medicines after the market has achieved fruitful results after years of development.The real-world research concept has been first proposed by Chief Researcher Xie Yanming in 2010 and to 2020 with the approval of the National Medical Products Administration to use real-world evidence to support drug development and review in 2020.Real-world data application and transformation continue to cause heated discussions in the industry.Real-world research concepts have been added new motivation into the evaluation of Chinese medicines after they are marketed.The development of the Chinese patent medicine industry is facing unprecedented opportunities and challenges.
文摘A traditional Chinese medicine （TCM） has been authorized for sale in a European market for the first time, the Chinese Academy of Sciences announced on April 18, 2012.
基金financial support from the financial support from the National Natural Science Foundation of China(No.21761132021)IKERBASQUE,Basque Foundation for Science+1 种基金The Hungarian Research Foundation(NKFIH No.K119282)Ministry of Human Capacities,Hungary grant 20391-3/2018/FEKUSTRAT。
文摘Eleven new fluorine-containing FDA-approved drugs have been profiled and details of their discovery and preparation are discussed.Therapeutic areas include schizophrenia,migraine,multiple sclerosis,insomnia,rheumatoid arthritis,anti-tuberculosis,breast cancer,lymphoma kinase inhibitor,serotonin receptor antagonist.New pharmaceuticals feature four examples of aromatic fluorine,three aromatic CF3 group,three aliphatic CF3 and one compound with aromatic CF3O group.Furthermore,among the new compounds,six are chiral and seven are derived from tailor-made amino acids.
