Molecular mechanism and research progress of traditional Chinese medicine in the treatment of prostate cancer

Prostate cancer(PCa)is one of the most common malignant tumors in the male genitourinary system,ranking second in incidence worldwide.Traditional Chinese medicine(TCM),as an important component of complementary and alternative medicine,shows unique advantages in cancer treatment.Chinese herbal medicine is usually composed of multiple ingredients and involves multiple signaling pathways,which showed function of inducing apoptosis of cancer cells,arresting the cell cycle,inhibiting invasion and metastasis,reducing drug resistance,and regulating immune function.Physical therapy is also an important treatment of TCM.Currently,Physical therapy such as acupuncture or Tai Chi and Qigong are gaining increased recognition in the management of PCa,particularly in addressing issues like urinary incontinence and bone metastasis-related pain.This article reviews the TCM treatment and therapy of PCa,in order to provide new research avenues and treatment options for the treatment of PCa with TCM and improve the quality of life of patients.

Feasibility and simulation model of a pilot scale membrane bioreactor for wastewater treatment and reuse from Chinese traditional medicine

The lack and pollution of water resource make wastewater reuse necessary. The pilot scale long-term tests for submerged membrane bioreactor were conducted to treat the effluents of anaerobic or aerobic treatment process for the high-strength Chinese traditional medicine wastewater. This article was focused on the feasibility of the wastewater treatment and reuse at shorter hydraulic retention time （HRT） of 5.0, 3.2 and 2.13 h. MLSS growth, membrane flux, vacuum values and chemical cleaning periods were also investigated. The experimental results of treating two-phase anaerobic treatment effluent demonstrated that the CODfilt was less than 100 mg/L when the influent COD was between 500-10000 mg/L at HRT of 5.0 h, which could satisfy the normal discharged standard in China. The experimental results to treat cross flow aerobic reactor effluent demonstrated that the average value of CODfilt was 17.28 mg/L when the average value of influent COD was 192.84 mg/L at HRT of 2.13 h during 106 d, which could completely meet the normal standard for water reuse. The maximum MLSS and MLVSS reached 24000 and 14500 mg/L at HRT of 3.2 h respectively. Membrane flux had maximal resume degrees of 94.7% at vacuum value of 0.02 MPa after cleaning. Chemical cleaning periods of membrane module were 150 d. A simulation model of operational parameters was also established based on the theory of back propagation neural network and linear regression of traditional mathematical model. The simulation model showed that the optimum operational parameters were suggested as follows： HRT was 5.0 h, SRT was 100 d, the range of COD loading rate was between 10.664-20.451 kg/（m3.d）, the range of MLSS was between 7543-13694 mg/L.

Drug Deslgn Based on Chinese Traditional Medicine

There are two new trends in the development of novel Pharmaceuticals. Biotechnology provides a novel approach to rational drug design. At the same time, there has been a growing interest in the use of herbal products. Chinese medical herbs are rich in the natural resources and have been used for thousands years in China. We consider the Chinese medicine system as a natural combinatorial chemi-

Chinese traditional medicine for induction of ovulation

This is a review paper of some effective recipes of Chinese traditional medicine usedin ovulation induction and treatment of gynecological diseases. Some clinical results bygynecologists using Chinese traditional medicine in combination with western medicineand results from research on traditional medicine with modern technology are presented.A list of frequently used traditional medicine for ovulation induction are selected from the famous Compendium of Materica Medica(本草纲目)by Li Shi-zhen(李时珍).

Treatment of Chinese Traditional Medicine Wastewater by Photosynthetic Bacteria

The influence factors treating wastewater of Chinese traditional medicine extraction by photosynthetic bacteria are tested and discussed. The results indicate that the method of photosynthetic bacteria can eliminate COD and BOD from wastewater in high efficiency. And it also has high load shock resistance. On the conditions of slight aerobic and semi-darkness, treating wastewater of Chinese traditional medicine extraction, the method has better efficiency to eliminate COD and BOD from the wastewater than those by anaerobic illumination and aerobic darkness treatments. After pretreatment of hydrolytic acidization, the removal rate of COD in the wastewater reached more than 85 %, and that rate of BOD reached more than 90% in the treating system of photosynthetic bacteria. It may be more feasible and advantageous than traditional anaerobic biological process to treat organic wastewater using PSB system.

Study on the functional liquid of Chinese traditional medicine in anti-anoxic effect

A kind of functional liquid was extracted from compound Chinese traditional medicine over 20 different varieties such as ginseng, danggui and so on. The anti-anoxic effects were observed by the ways of oxygen lack in normal atmosphere of mice, decapitation and erythrocyte count and hemoglobin in the mice. Experiments done in this study included observing the best dose and the best time of appearing anti-anoxic effects in mice. Results were found that the functional liquid could prolong not only the survival time and the brain survival time of the mouse, but also increasing the number of erythrocytes (RBC) and the content of hemoglobin (Hb); and the functional liquid has markedly protecting cardio-cerebral function; If the dosage of the functional liquid control on the 0.3ml/day for each mouse, the best effects should appear after four hour. And the functional liquid had no obvious effect on the weight of the mice within thirty days.

Application of Chinese Traditional Medicine in Kidney Transplantation

Kidney transplantation is one of the important means in saving the life of patients with renal diseases of the terminal stage. However, rejection reaction often results in the loss of the grafted organs’ function. Almost half the recipients have been found to suffer from loss of graft function due to rejection reaction within 10 years of post-transplantation. Part of them have bad quality of life

Treatment of Chinese traditional medicine wastewater in a submerged membrane bioreactor

A pilot scale test was conducted in a submerged membrane bioreactor SMBR with capacity of 10. 0 m^3/d for 120 days to treat high-strength Chinese traditional medicine wastewater. Performance of the SMBR was investigated with a sludge retention time （ TSR ） of 50 days, a hydraulic retention time （ THR ） of 8.0 h, membrane flux of 8. 0 IV（ m^2 · h） and dissolved oxygen （DO） concentration of 2. 0 - 3. 0 mg/L, respectively. It was observed that the SMBR had high capacity of COD and suspended solid （SS） removal. The influent COD concentration was fluctuated between I 000 and 5 000 mg/L, while the averaged effluent COl） concentration was only 44. 6 mg/L. The influent SS concentration was fluctuated between 1 000 and 1 600 mg/L, while little effluent SS was detected. It was found that the COD remove rate increased with mixed liquor suspended solids （MLSS） and organic loading rate （ROL）. In order to obtain good-quality effluent, the operational conditions of the SMBR were suggested as follows： the temperature was controlled above 10 ℃, MLSS about 7000 mg/L, R,L under 24. 76 kg/（ m^3 · d）, low vacuum value and constant water flux.

Varieties of Chinese Traditional Medicines Protected by the State (Part One)

Approved by the Ministry of Public Health,the following Medicines,producedby the named enterprises,are listed as varieties of Chinese traditionalmedicines that are protected by the state.

Etiological analysis of chloasma from view of Western and Chinese traditional medicine

Chloasma is a common and refractory skin disease,which is a discosmetic dermatosis in which pigment is deposited on the face,cheeks,forehead and other parts due to the pigment metabolism disorder.It is manifested as facial yellow-brown patches,with different shades,different shapes,and often symmetrically distributed.The prevalence rate of chloasma is still increasing year by year,which reflects the physical and mental health of women.Because the cause of disease is unknown,and at present there is no uniform treatment.This paper discusses the etiology of chloasma from modern medicine and traditional Chinese medicine to provide reference for clinical therapy.

Hepar Fule Tablets——Chinese Traditional Medicine for Antihepatic Cancer

Hepar Fule tablets, approved by the Ministry of Public Health. are produced solely by the Lengshijiang Medicine Factory, Hunan province. They were invented by Doctor Pan Minqiu, a famous expert in hepatic diseases and cancer, after a dozen years’ painstaking research. They are made, based on a reasonable prescription, advanced technology and strict quality control from 21 Chinese medicines, including radix codonopsis pilosulae,

A Patient with End-stage Respiratory Failure Gets Recovery from Mechanical Ventilation by Utilization of Chinese Traditional Medicine

Ventilator-assisted ventilation and lung transplantation are the final treatments for the patients with end-stage respiratory failure.A patient,who has been diagnosed as end-stage respiratory failure and received tracheal intubation with mechanical ventilation,received the treatment of Chinese herbal medicine on the principle of TCM and got some recovery gradually.After two months,the patient got rid of mechanical ventilation successfully.This case implies that TCM will be an alternative treatment for the patients with the similar conditions.

Integration of traditional,complementary,and alternative medicine with modern biomedicine:the scientization,evidence,and challenges for integration of traditional Chinese medicine

Traditional medicine has garnered significant global recognition,with an estimated 80%of the global population using it.Therefore,it is essential to fully understand the integration of traditional medicines into current healthcare systems.This review aims to provide a comprehensive overview of the standard process to modernize traditional medicine scientifically in the context of modern biomedicine,further termed here as“scientization”.Specifically,we aim to summarize the advancements made in understanding the efficacy,effectiveness,and underlying mechanisms of herbal medicine.We also examined the transition from experience-to evidence-based medicine during acupuncture.Furthermore,we explore the development of universal safety and quality control standards.Finally,we discuss international trade and export markets for Chinese medical products.The development and integration of traditional medicine have allowed it to further improve human health,resulting in a more comprehensive health solution for the global population.

Research progress of traditional Chinese medicine in the treatment of endocrine metabolic diseases in 2023

This study aimed to provide a comprehensive review of the research progress in Chinese medicine in the treatment of endocrine metabolic diseases in 2023,covering traditional Chinese medicine(TCM)monomers,TCM extracts,and TCM combinations,including non-alcoholic fatty liver disease,type 2 diabetes mellitus and its complications,obesity,hyperuricaemia,and thyroid disorders.After systematic sorting and summary,we found that in 2023,the research focusing on the application of TCM for endocrine metabolic diseases was still on the mechanism of action at the cellular and molecular levels,which not only influenced the classical pathways of lipid metabolism,but also delved into the key mechanisms of anti-inflammation,anti-oxidation,anti-insulin resistance,and so on.Additionally,TCM has shown remarkable results in the treatment of endocrine metabolic diseases by improving intestinal flora disorders and abnormal cellular iron death.These research results provide valuable ideas,methods,and tools for TCM in the prevention and treatment of endocrine metabolic diseases,and provide important references and guidance for future research and practice.

Annual advances of Chinese minority traditional medicine in 2019

Traditional medicine systems practiced by various ethnic minorities represent an important part of traditional Chinese medicine.The past 12 months have witnessed extensive research pertaining to different Chinese minority traditional medicine(CMTM).The annual CMTM review evaluates research published during 2019 in different CMTM including Tibetan medicine,Uyghur medicine,Mongolian medicine,Korean medicine and Zhuang medicine.Research in the field of Tibetan medicine focused on pharmacology,pharmacy,plant sciences,medicinal chemistry and integrated complementary medicine and the top three countries were China,USA and India.Research in Uyghur medicine mainly pertained to chemistry,pharmacology,pharmacy,and food science technology and the publications were mainly from China.Research in Mongolian medicine mainly pertained to pharmacology,pharmacy,analytical chemistry,biochemistry,molecular biology and experimental research;the publications were mainly from China and Mongolia.In short,research related to traditional medicine of various ethnic minorities was mainly conducted in China and the neighboring countries.The research focus for each minority medicine is essentially on the effects and mechanisms of action of the active ingredients of the ethnodrugs and the special prescriptions or therapies.The generated evidence will facilitate further developments in this field.

Analysis of the rule of medication of compound Chinese traditional patent medicine for digestive system tumors based on data mining

Objective:Based on the data mining method,explore the medication rules of Chinese patent medicines for the treatment of digestive system tumors.Method:Based on the"Chinese Traditional Medicine Prescription Database"in https://db.yaozh.com/,collect Chinese patent medicines for the treatment of digestive system tumors,establish an Excel table,and use the ancient and modern medical case cloud platform(V2.2.1)to perform frequency statistics,association rules,and drugs on the data Clustering and complex network analysis.Results:A total of 36 Chinese patent medicines for the treatment of digestive system tumors were screened.The medicinal properties were mainly warm and cold,the taste was bitter and sweet,and the meridians were mainly liver and spleen meridians.High frequency Chinese medicine include Astragalus,Scutellaria-barbata,Ginseng,Curcuma,Triangle,Atractylodes,Hedyotis diffusa,etc.Correlation analysis obtained 17 drug combinations,High-frequency drug pairs include Scutellaria-barbata-Astragalus,Ginseng-Astragalus,Curcuma-Astragalus,Scutellaria-barbata-Curcuma,etc.Cluster analysis found 3 types of drugs.The core drug network is composed of 27 drugs,and the core compatibility network consists of 3 groups of drugs.Conclusion:The Chinese patent compound medicine for the treatment of digestive system tumors has the characteristics of combining cold and warming,replenishing and reducing treatment,and treating the liver and spleen at the same time.The medicine is mainly used to replenish qi and invigorate the spleen,promote blood circulation and remove blood stasis,and clear away heat and detoxification.Replenish qi,nourish yin,invigorate blood,and detoxify are mainly compatible with each other,reflecting the pathogenesis characteristics of"deficiency,stasis,and toxin"in digestive system tumors.Data mining can provide references for the prescription and compatibility of Chinese patent medicines.

Ergogenic Capacity of a 7-Chinese Traditional Medicine Extract in Aged Mice

The ergogenic properties of a 7-Chinese traditional medicine water extract (Ligustrum lucidum ait, LLA), which is composed of the essences of Lycii fructus, Crataegi fructus, Phyllanthi fructus, Chrysanthemi flos, Coicis semen, Ganoderma lucidum, and Zizyphi fructus, were studied using aged mice. Mice were chronically (one month) administered LLA (0.1% and 1%) in the drinking water. Mice pre-treated with LLA showed a good appetite;however, they exhibited a lower rate of body weight increase compared to control mice. In mice subjected to the rotarod test, 1% LLA treatment provided effective adaption to fatigue and significantly increased the duration of mice on the rotarod. In locomotor activity test, 1% LLA potentiated mice mobility and significantly increased rearing behavior. In the antioxidant experiment, 1% LLA treatment significantly increased superoxide dismutase activity in the spleen and liver glutathione levels. These findings suggest that LLA may be utilized as an antifatigue agent, which may function through its antioxidant activity.

Annual advances of Chinese minority traditional medicine in 2020

Chinese minority traditional medicine is a traditional medicine formed during the long-term medical practice of various ethnic groups and is the crystallization of the wisdom of the people in all ethnic groups in China.The unique meaning carried by Chinese minority traditional medicine makes it an inseparable and important part of traditional Chinese medicine.The rich clinical experience and theoretical studies with different Chinese minority traditional medicine provide new ideas and new methods for Chinese medicine development.The pieces of literature published in 2020 on the traditional application analyzed the phytochemical composition,pharmacological effects,and mechanisms of the different ethnic groups including Tibetan,Mongolian,Zhuang,Dai,and Uyghur medicines,among others.This study found that some projects were stalled or delayed due to the coronavirus disease 2019 outbreak in 2020 compared with 2019,resulting in a decrease in the number of articles in certain fields.However,studied on Chinese minority traditional medicine have shown an overall upward trend this year with the Tibetan,Mongolian,and Dai medicines as the top three.In addition,the Chinese minority traditional medicine application under the coronavirus disease 2019 epidemic situation background was also summarized.Consequently,this study found that among the Chinese minority traditional medicine-related publications in 2020,publications using Chinese minority traditional medicine to treat coronavirus disease 2019 account for a certain percentage.Thus,this article systematically reviews and summarizes the related research of Chinese minority traditional medicine published in 2020 and provides references for future Chinese minority traditional medicine development.

The Internationalization of Traditional Chinese Medicine into the Western World

This paper introduces the internationalization of traditional Chinese medicine into the western world.Internationalization of traditional Chinese medicine(TCM)into the Western world is not a simple or easy task.Its exposure and exportation into the rest of the world should be a task taken on with a special focus and determination on staying strong along the way.Keeping the truth,strength,and integrity in TCM medicine as it is exported is the highest priority and the best way to promote it.Doing this will give it a solid foundation in its new land and for its new patients.Let’s study and analyze what really is required to help TCM avoid all problems and hardships of this exportation process as TCM goes west.