d-Allulose, a rare sugar, exerts anti-obesity effects by inhibiting hepatic lipogenesis and promoting energy expenditure. Medium-chain triglycerides (MCTs) consist of three medium-chain fatty acids connected by glycer...d-Allulose, a rare sugar, exerts anti-obesity effects by inhibiting hepatic lipogenesis and promoting energy expenditure. Medium-chain triglycerides (MCTs) consist of three medium-chain fatty acids connected by glycerol. MCTs have been extensively investigated for their ability to reduce body fat accumulation. We previously investigated the anti-obesity effects of a combination of dietary d-allulose and MCT (5% - 13%) in rats;however, we could not confirm the anti-obesity effects of MCT or observed synergetic effects between d-allulose and MCT on body fat loss. We speculated that our previous studies were influenced by the excessive amount of MCT in the diets. Therefore, in this study, we aimed to investigate the anti-obesity effects of the simultaneous intake of d-allulose and MCT in rats fed an obesity-inducing high-fat diet with a low amount of MCTs (2%). Thirty-two male Wistar rats (3-week-old) were randomly divided into four groups: control, d-allulose, MCT, and d-allulose + MCT groups. Rats in each group were fed ad libitum on a control (no d-Allulose or MCT), 5% d-allulose, 2% MCT, or 5% d-allulose + 2% MCT diets for 16 weeks. Abdominal adipose tissue weights were significantly lower in the d-allulose diet group than in the control group, whereas no differences were observed between results of the MCT-supplemented groups. The total body fat mass was significantly lower in the d-allulose and MCT diet groups than in the control group, but no differences were observed between the MCT-supplemented groups. These results suggested that anti-obesity effects of dietary d-allulose were observed, and the effects of dietary MCTs were weaker than those of d-allulose. Moreover, we confirmed the interaction between dietary d-allulose and MCT on indicators of obesity. Interestingly, their effects were not synergistic, as MCT supplementation offset the anti-obesity effects of dietary d-allulose. However, the specific mechanisms underlying those effects remain unknown, warranting further investigation.展开更多
目的:观察丙泊酚中长链脂肪乳在婴幼儿麻醉中的应用效果,并评价其对血流动力学、苏醒期质量以及肝功能的影响。方法:选择行择期手术的1个月至3岁患儿50例,ASAⅠ~Ⅱ级,随机分为丙泊酚中长链脂肪乳组(M组)和七氟烷组(S组),每组25例,M组和...目的:观察丙泊酚中长链脂肪乳在婴幼儿麻醉中的应用效果,并评价其对血流动力学、苏醒期质量以及肝功能的影响。方法:选择行择期手术的1个月至3岁患儿50例,ASAⅠ~Ⅱ级,随机分为丙泊酚中长链脂肪乳组(M组)和七氟烷组(S组),每组25例,M组和S组分别以丙泊酚中长链脂肪乳和七氟烷行麻醉诱导和维持。观察麻醉诱导前(T0)、气管插管时(T1)、术毕(T2)、拔管即刻(T3)的心率(HR)、平均动脉压(MAP);记录停药至自主呼吸恢复时间,自主呼吸恢复至拔管时间,同时记录患儿苏醒期躁动及恶心呕吐的情况;在术前、术毕和术后24 h抽取静脉血2 m L,测定丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)含量。结果:与T0相比,2组T1时刻的HR、MAP均显著降低(P<0.05);M组自主呼吸恢复至拔管的时间显著短于S组(P<0.01);M组躁动及恶心呕吐发生率显著少于S组(P<0.05~P<0.01);2组术毕及术后24 h ALT及AST与术前差异无统计学意义(P>0.05)。结论:丙泊酚中长链脂肪乳可安全用于婴幼儿麻醉,具有苏醒期躁动及恶心呕吐发生率低等优点,且短时间内手术使用并不影响肝功能。展开更多
文摘d-Allulose, a rare sugar, exerts anti-obesity effects by inhibiting hepatic lipogenesis and promoting energy expenditure. Medium-chain triglycerides (MCTs) consist of three medium-chain fatty acids connected by glycerol. MCTs have been extensively investigated for their ability to reduce body fat accumulation. We previously investigated the anti-obesity effects of a combination of dietary d-allulose and MCT (5% - 13%) in rats;however, we could not confirm the anti-obesity effects of MCT or observed synergetic effects between d-allulose and MCT on body fat loss. We speculated that our previous studies were influenced by the excessive amount of MCT in the diets. Therefore, in this study, we aimed to investigate the anti-obesity effects of the simultaneous intake of d-allulose and MCT in rats fed an obesity-inducing high-fat diet with a low amount of MCTs (2%). Thirty-two male Wistar rats (3-week-old) were randomly divided into four groups: control, d-allulose, MCT, and d-allulose + MCT groups. Rats in each group were fed ad libitum on a control (no d-Allulose or MCT), 5% d-allulose, 2% MCT, or 5% d-allulose + 2% MCT diets for 16 weeks. Abdominal adipose tissue weights were significantly lower in the d-allulose diet group than in the control group, whereas no differences were observed between results of the MCT-supplemented groups. The total body fat mass was significantly lower in the d-allulose and MCT diet groups than in the control group, but no differences were observed between the MCT-supplemented groups. These results suggested that anti-obesity effects of dietary d-allulose were observed, and the effects of dietary MCTs were weaker than those of d-allulose. Moreover, we confirmed the interaction between dietary d-allulose and MCT on indicators of obesity. Interestingly, their effects were not synergistic, as MCT supplementation offset the anti-obesity effects of dietary d-allulose. However, the specific mechanisms underlying those effects remain unknown, warranting further investigation.
文摘目的:观察丙泊酚中长链脂肪乳在婴幼儿麻醉中的应用效果,并评价其对血流动力学、苏醒期质量以及肝功能的影响。方法:选择行择期手术的1个月至3岁患儿50例,ASAⅠ~Ⅱ级,随机分为丙泊酚中长链脂肪乳组(M组)和七氟烷组(S组),每组25例,M组和S组分别以丙泊酚中长链脂肪乳和七氟烷行麻醉诱导和维持。观察麻醉诱导前(T0)、气管插管时(T1)、术毕(T2)、拔管即刻(T3)的心率(HR)、平均动脉压(MAP);记录停药至自主呼吸恢复时间,自主呼吸恢复至拔管时间,同时记录患儿苏醒期躁动及恶心呕吐的情况;在术前、术毕和术后24 h抽取静脉血2 m L,测定丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)含量。结果:与T0相比,2组T1时刻的HR、MAP均显著降低(P<0.05);M组自主呼吸恢复至拔管的时间显著短于S组(P<0.01);M组躁动及恶心呕吐发生率显著少于S组(P<0.05~P<0.01);2组术毕及术后24 h ALT及AST与术前差异无统计学意义(P>0.05)。结论:丙泊酚中长链脂肪乳可安全用于婴幼儿麻醉,具有苏醒期躁动及恶心呕吐发生率低等优点,且短时间内手术使用并不影响肝功能。
