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Inhibition of tyrosinase activity and melanine pigmentation by 2-hydroxytyrosol 被引量:1
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作者 Ryuji Uchida Seiko Ishikawa Hiroshi Tomoda 《Acta Pharmaceutica Sinica B》 SCIE CAS 2014年第2期141-145,共5页
2-Hydroxytyrosol(2-HT),originally reported as a synthetic compound,was isolated for the first time as a fungal metabolite.2-HT was found to inhibit mushroom tyrosinase with an IC_(50) value of 13.0 mmol/L.Furthermore,... 2-Hydroxytyrosol(2-HT),originally reported as a synthetic compound,was isolated for the first time as a fungal metabolite.2-HT was found to inhibit mushroom tyrosinase with an IC_(50) value of 13.0 mmol/L.Furthermore,2-HT dose-dependently inhibited tyrosinase activity(IC_(50),32.5 mmol/L)in the cell-free extract of B16 melanoma cells andα-melanocyte stimulating hormone(α-MSH)-stimulated melanin formation in intact B16 melanoma cells. 展开更多
关键词 2-Hydroxytyrosol Metarhizium sp. Tyrosinase inhibitor melanine formation B16 melanoma cells
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