A Rh(Ⅰ)-catalyzed highly regio-and enantioselective allylic alkylation of Meldrum acid with racemic allylic substrates bearing alkyl groups has been developed.The applying of chiral bisoxazopinephosphine ligand is es...A Rh(Ⅰ)-catalyzed highly regio-and enantioselective allylic alkylation of Meldrum acid with racemic allylic substrates bearing alkyl groups has been developed.The applying of chiral bisoxazopinephosphine ligand is essential for the high yields and selectivities.This method provides a rapid access to various chiral β-alkyl-γ,δ-unsaturated carboxylic acids and their derivatives.展开更多
基金financially supported by the National Natural Science Foundation of China(NSFC,Nos.21602130 and 21961023)the startup funding from Shanghai Jiao Tong University.
文摘A Rh(Ⅰ)-catalyzed highly regio-and enantioselective allylic alkylation of Meldrum acid with racemic allylic substrates bearing alkyl groups has been developed.The applying of chiral bisoxazopinephosphine ligand is essential for the high yields and selectivities.This method provides a rapid access to various chiral β-alkyl-γ,δ-unsaturated carboxylic acids and their derivatives.
