Objective: To evaluate the anti-mycobacterial activity of Melia azedarach L.(M. azedarach) and Lobelia chinensis Lour.(L. chinensis) extracts against the growth of Mycobacterium tuberculosis(M. tuberculosis).Methods: ...Objective: To evaluate the anti-mycobacterial activity of Melia azedarach L.(M. azedarach) and Lobelia chinensis Lour.(L. chinensis) extracts against the growth of Mycobacterium tuberculosis(M. tuberculosis).Methods: The anti-M. tuberculosis activity of M. azedarach and L. chinensis extracts were evaluated using different indicator methods such as resazurin microtiter assay(REMA) and mycobacteria growth indicator tube(MGIT) 960 system assay. The M. tuberculosis was incubated with various concentrations(50–800 mg/m L) of the extracts for 5 days in the REMA, and for 4 weeks in MGIT 960 system assay.Results: M. azedarach and L. chinensis extracts showed their anti-M. tuberculosis activity by strongly inhibiting the growth of M. tuberculosis in a concentration-dependent manner in the REMA and the MGIT 960 system assay. Particularly, the methanol extract of M. azedarach and n-hexane extract of L. chinensis consistently exhibited their effects by effectively inhibiting the growth of M. tuberculosis in MGIT 960 system for 4 weeks with a single-treatment, indicating higher anti-M. tuberculosis activity than other extracts,and their minimum inhibitory concentrations were measured as 400 mg/m L and 800 mg/m L, respectively.Conclusions: These results demonstrate that M. azedarach and L. chinensis extracts not only have unique anti-M. tuberculosis activity, but also induce the selective antiM. tuberculosis effects by consistently inhibiting or blocking the growth of M. tuberculosis through a new pharmacological action. Therefore, this study suggests the potential of them as effective candidate agents of next-generation for developing a new anti-tuberculosis drug, as well as the advantage for utilizing traditional medicinal plants as one of effective strategies against tuberculosis.展开更多
The corrosion inhibition characteristics of aqueous extract of seeds of Melia azedarach L.(MA) have been studied as eco-friendly green inhibitor for corrosion control of C-steel in 2 mol·L^(-1) HCl solution by gr...The corrosion inhibition characteristics of aqueous extract of seeds of Melia azedarach L.(MA) have been studied as eco-friendly green inhibitor for corrosion control of C-steel in 2 mol·L^(-1) HCl solution by gravimetric and electrochemical methods. The results depict that, the extract inhibits efficiently the corrosion of carbon steel in hydrochloric acid. The efficiency of extract is increased with increasing the extract concentration but independent on the studied temperature. The adsorption of the extract components onto the steel surface was found to be spontaneous, and follows Langmuir adsorption isotherm. The surface morphology of C-steel, in the absence and presence of MA extract in 2.0 mol·L^(-1) hydrochloric acid solution, was studied using scanning electron microscopy(SEM).展开更多
Objective:To assess ethanolic extract of the leaves of Melia azedarach L.(Family-Meliaceae)for its possible antioxidant,analgesic and antibacterial activities in association with performing phytochemical evaluation.Me...Objective:To assess ethanolic extract of the leaves of Melia azedarach L.(Family-Meliaceae)for its possible antioxidant,analgesic and antibacterial activities in association with performing phytochemical evaluation.Methods:A number of phytochemical tests of this extract were utilized to distinguish the existence of different sorts of compounds.Qualitative and quantitative antioxidant activities were assessed by TLC and DPPH scavenging assay respectively.Acetic acid induced writhing test in mice and disk diffusion assay of the leaves extract were carried out to demonstrate the analgesic and antibacterial activities respectively.Results:The phytochemical assessment revealed the existence of alkaloids,flavonoids,glycosides,saponins and tannins like compounds.Ethanolic extract of the leaves demonstrated antioxidant,analgesic and antibacterial activities in vitro.Conclusion:Considering the study,this could justify the leaves extract’s bioactivities but,to substantiate the activity of individual compound further investigation is necessary.展开更多
基金supported by C&K pharmaceutical company in Korea
文摘Objective: To evaluate the anti-mycobacterial activity of Melia azedarach L.(M. azedarach) and Lobelia chinensis Lour.(L. chinensis) extracts against the growth of Mycobacterium tuberculosis(M. tuberculosis).Methods: The anti-M. tuberculosis activity of M. azedarach and L. chinensis extracts were evaluated using different indicator methods such as resazurin microtiter assay(REMA) and mycobacteria growth indicator tube(MGIT) 960 system assay. The M. tuberculosis was incubated with various concentrations(50–800 mg/m L) of the extracts for 5 days in the REMA, and for 4 weeks in MGIT 960 system assay.Results: M. azedarach and L. chinensis extracts showed their anti-M. tuberculosis activity by strongly inhibiting the growth of M. tuberculosis in a concentration-dependent manner in the REMA and the MGIT 960 system assay. Particularly, the methanol extract of M. azedarach and n-hexane extract of L. chinensis consistently exhibited their effects by effectively inhibiting the growth of M. tuberculosis in MGIT 960 system for 4 weeks with a single-treatment, indicating higher anti-M. tuberculosis activity than other extracts,and their minimum inhibitory concentrations were measured as 400 mg/m L and 800 mg/m L, respectively.Conclusions: These results demonstrate that M. azedarach and L. chinensis extracts not only have unique anti-M. tuberculosis activity, but also induce the selective antiM. tuberculosis effects by consistently inhibiting or blocking the growth of M. tuberculosis through a new pharmacological action. Therefore, this study suggests the potential of them as effective candidate agents of next-generation for developing a new anti-tuberculosis drug, as well as the advantage for utilizing traditional medicinal plants as one of effective strategies against tuberculosis.
文摘The corrosion inhibition characteristics of aqueous extract of seeds of Melia azedarach L.(MA) have been studied as eco-friendly green inhibitor for corrosion control of C-steel in 2 mol·L^(-1) HCl solution by gravimetric and electrochemical methods. The results depict that, the extract inhibits efficiently the corrosion of carbon steel in hydrochloric acid. The efficiency of extract is increased with increasing the extract concentration but independent on the studied temperature. The adsorption of the extract components onto the steel surface was found to be spontaneous, and follows Langmuir adsorption isotherm. The surface morphology of C-steel, in the absence and presence of MA extract in 2.0 mol·L^(-1) hydrochloric acid solution, was studied using scanning electron microscopy(SEM).
基金the authorities of Pharmacy Discipline,Life Science School,Khulna University for supporting fund(Grant No.KU:PHRM:2011/April-071112).
文摘Objective:To assess ethanolic extract of the leaves of Melia azedarach L.(Family-Meliaceae)for its possible antioxidant,analgesic and antibacterial activities in association with performing phytochemical evaluation.Methods:A number of phytochemical tests of this extract were utilized to distinguish the existence of different sorts of compounds.Qualitative and quantitative antioxidant activities were assessed by TLC and DPPH scavenging assay respectively.Acetic acid induced writhing test in mice and disk diffusion assay of the leaves extract were carried out to demonstrate the analgesic and antibacterial activities respectively.Results:The phytochemical assessment revealed the existence of alkaloids,flavonoids,glycosides,saponins and tannins like compounds.Ethanolic extract of the leaves demonstrated antioxidant,analgesic and antibacterial activities in vitro.Conclusion:Considering the study,this could justify the leaves extract’s bioactivities but,to substantiate the activity of individual compound further investigation is necessary.
