A new γ-alkylated-γ-butyrolactone, named melongenolide A(1), along with nine known compounds were obtained from the roots of Solanum melongena, and their structures were identified as melongenolide A(1),(+)-syringar...A new γ-alkylated-γ-butyrolactone, named melongenolide A(1), along with nine known compounds were obtained from the roots of Solanum melongena, and their structures were identified as melongenolide A(1),(+)-syringaresinol(2),(+)- lyoniresinol(3), 5,5′-dimethoxy lariciresinol(4),(+)-(7R,8R)-4-hydroxy-3,3′,5′-trimethoxy-8′,9′-dinor-8,4′-oxyneoligna-7, 9-diol-7′- aldehyde(5), kaempferol-3-O-(2′′,6′′-di-O-p-trans-coumaroyl)-β-glucoside(6), arjunolic acid(7), vanillic acid(8), scoparone(9), and β-sitosterol(10). Compounds 2, 6, and 7 showed potent inhibitory effects on nitric oxide production in lipopolysaccharide-induced RAW 264.7 macrophages, with IC50 values being 5.62 ± 0.86, 11.47 ± 0.98, and 27.75 ± 1.26 μmol·L-1, respectively.展开更多
基金supported by the Program for New Century Excellent Talents in University(NCET-13-0693,to LI J)the Project of Standards Improvement of TCM for CP2015(to LI J)+1 种基金TCM support project from Ministry of Industry and Information Technology of China(to LI J.)National Key Technology R&D Program"New Drug Innovation"of China(No.2013ZX 09402201001)
文摘A new γ-alkylated-γ-butyrolactone, named melongenolide A(1), along with nine known compounds were obtained from the roots of Solanum melongena, and their structures were identified as melongenolide A(1),(+)-syringaresinol(2),(+)- lyoniresinol(3), 5,5′-dimethoxy lariciresinol(4),(+)-(7R,8R)-4-hydroxy-3,3′,5′-trimethoxy-8′,9′-dinor-8,4′-oxyneoligna-7, 9-diol-7′- aldehyde(5), kaempferol-3-O-(2′′,6′′-di-O-p-trans-coumaroyl)-β-glucoside(6), arjunolic acid(7), vanillic acid(8), scoparone(9), and β-sitosterol(10). Compounds 2, 6, and 7 showed potent inhibitory effects on nitric oxide production in lipopolysaccharide-induced RAW 264.7 macrophages, with IC50 values being 5.62 ± 0.86, 11.47 ± 0.98, and 27.75 ± 1.26 μmol·L-1, respectively.
