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Promotion of structural plasticity in area V2 of visual cortex prevents against object recognition memory deficits in aging and Alzheimer's disease rodents
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作者 Irene Navarro-Lobato Mariam Masmudi-Martín +8 位作者 Manuel F.López-Aranda Juan F.López-Téllez Gloria Delgado Pablo Granados-Durán Celia Gaona-Romero Marta Carretero-Rey Sinforiano Posadas María E.Quiros-Ortega Zafar U.Khan 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第8期1835-1841,共7页
Memory deficit,which is often associated with aging and many psychiatric,neurological,and neurodegenerative diseases,has been a challenging issue for treatment.Up till now,all potential drug candidates have failed to ... Memory deficit,which is often associated with aging and many psychiatric,neurological,and neurodegenerative diseases,has been a challenging issue for treatment.Up till now,all potential drug candidates have failed to produce satisfa ctory effects.Therefore,in the search for a solution,we found that a treatment with the gene corresponding to the RGS14414protein in visual area V2,a brain area connected with brain circuits of the ventral stream and the medial temporal lobe,which is crucial for object recognition memory(ORM),can induce enhancement of ORM.In this study,we demonstrated that the same treatment with RGS14414in visual area V2,which is relatively unaffected in neurodegenerative diseases such as Alzheimer s disease,produced longlasting enhancement of ORM in young animals and prevent ORM deficits in rodent models of aging and Alzheimer’s disease.Furthermore,we found that the prevention of memory deficits was mediated through the upregulation of neuronal arbo rization and spine density,as well as an increase in brain-derived neurotrophic factor(BDNF).A knockdown of BDNF gene in RGS14414-treated aging rats and Alzheimer s disease model mice caused complete loss in the upregulation of neuronal structural plasticity and in the prevention of ORM deficits.These findings suggest that BDNF-mediated neuronal structural plasticity in area V2 is crucial in the prevention of memory deficits in RGS14414-treated rodent models of aging and Alzheimer’s disease.Therefore,our findings of RGS14414gene-mediated activation of neuronal circuits in visual area V2 have therapeutic relevance in the treatment of memory deficits. 展开更多
关键词 behavioral performance brain-derived neurotrophic factor cognitive dysfunction episodic memory memory circuit activation memory deficits memory enhancement object recognition memory prevention of memory loss regulator of G protein signaling
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Optimized operation scheme of flash-memory-based neural network online training with ultra-high endurance
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作者 Yang Feng Zhaohui Sun +6 位作者 Yueran Qi Xuepeng Zhan Junyu Zhang Jing Liu Masaharu Kobayashi Jixuan Wu Jiezhi Chen 《Journal of Semiconductors》 EI CAS CSCD 2024年第1期33-37,共5页
With the rapid development of machine learning,the demand for high-efficient computing becomes more and more urgent.To break the bottleneck of the traditional Von Neumann architecture,computing-in-memory(CIM)has attra... With the rapid development of machine learning,the demand for high-efficient computing becomes more and more urgent.To break the bottleneck of the traditional Von Neumann architecture,computing-in-memory(CIM)has attracted increasing attention in recent years.In this work,to provide a feasible CIM solution for the large-scale neural networks(NN)requiring continuous weight updating in online training,a flash-based computing-in-memory with high endurance(10^(9) cycles)and ultrafast programming speed is investigated.On the one hand,the proposed programming scheme of channel hot electron injection(CHEI)and hot hole injection(HHI)demonstrate high linearity,symmetric potentiation,and a depression process,which help to improve the training speed and accuracy.On the other hand,the low-damage programming scheme and memory window(MW)optimizations can suppress cell degradation effectively with improved computing accuracy.Even after 109 cycles,the leakage current(I_(off))of cells remains sub-10pA,ensuring the large-scale computing ability of memory.Further characterizations are done on read disturb to demonstrate its robust reliabilities.By processing CIFAR-10 tasks,it is evident that~90%accuracy can be achieved after 109 cycles in both ResNet50 and VGG16 NN.Our results suggest that flash-based CIM has great potential to overcome the limitations of traditional Von Neumann architectures and enable high-performance NN online training,which pave the way for further development of artificial intelligence(AI)accelerators. 展开更多
关键词 NOR flash memory computing-in-memory ENDURANCE neural network online training
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Design and implementation of dual-mode configurable memory architecture for CNN accelerator
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作者 山蕊 LI Xiaoshuo +1 位作者 GAO Xu HUO Ziqing 《High Technology Letters》 EI CAS 2024年第2期211-220,共10页
With the rapid development of deep learning algorithms,the computational complexity and functional diversity are increasing rapidly.However,the gap between high computational density and insufficient memory bandwidth ... With the rapid development of deep learning algorithms,the computational complexity and functional diversity are increasing rapidly.However,the gap between high computational density and insufficient memory bandwidth under the traditional von Neumann architecture is getting worse.Analyzing the algorithmic characteristics of convolutional neural network(CNN),it is found that the access characteristics of convolution(CONV)and fully connected(FC)operations are very different.Based on this feature,a dual-mode reronfigurable distributed memory architecture for CNN accelerator is designed.It can be configured in Bank mode or first input first output(FIFO)mode to accommodate the access needs of different operations.At the same time,a programmable memory control unit is designed,which can effectively control the dual-mode configurable distributed memory architecture by using customized special accessing instructions and reduce the data accessing delay.The proposed architecture is verified and tested by parallel implementation of some CNN algorithms.The experimental results show that the peak bandwidth can reach 13.44 GB·s^(-1)at an operating frequency of 120 MHz.This work can achieve 1.40,1.12,2.80 and 4.70 times the peak bandwidth compared with the existing work. 展开更多
关键词 distributed memory structure neural network accelerator reconfigurable arrayprocessor configurable memory structure
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The Effect of the Menstrual Cycle on Cognitive Performance: Spatial Reasoning, Visual & Numerical Memory
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作者 Anusha Asim Rifah Maryam +4 位作者 Zahra Sultan Areej Shahid Fatima Yousaf Ishika Khandelwal Isra Allana 《Journal of Behavioral and Brain Science》 2024年第10期276-296,共21页
The menstrual cycle has been a topic of interest in relation to behavior and cognition for many years, with historical beliefs associating it with cognitive impairment. However, recent research has challenged these be... The menstrual cycle has been a topic of interest in relation to behavior and cognition for many years, with historical beliefs associating it with cognitive impairment. However, recent research has challenged these beliefs and suggested potential positive effects of the menstrual cycle on cognitive performance. Despite these emerging findings, there is still a lack of consensus regarding the impact of the menstrual cycle on cognition, particularly in domains such as spatial reasoning, visual memory, and numerical memory. Hence, this study aimed to explore the relationship between the menstrual cycle and cognitive performance in these specific domains. Previous studies have reported mixed findings, with some suggesting no significant association and others indicating potential differences across the menstrual cycle. To contribute to this body of knowledge, we explored the research question of whether the menstrual cycles have a significant effect on cognition, particularly in the domains of spatial reasoning, visual and numerical memory in a regionally diverse sample of menstruating females. A total of 30 menstruating females from mixed geographical backgrounds participated in the study, and a repeated measures design was used to assess their cognitive performance in two phases of the menstrual cycle: follicular and luteal. The results of the study revealed that while spatial reasoning was not significantly related to the menstrual cycle (p = 0.256), both visual and numerical memory had significant positive associations (p < 0.001) with the luteal phase. However, since the effect sizes were very small, the importance of this relationship might be commonly overestimated. Future studies could thus entail designs with larger sample sizes, including neuro-biological measures of menstrual stages, and consequently inform competent interventions and support systems. 展开更多
关键词 Menstrual Health Menstrual Cycle MENSTRUATION Mental Health COGNITION Spatial Reasoning Visual memory Numerical memory
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Optimizing Memory Access Efficiency in CUDA Kernel via Data Layout Technique
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作者 Neda Seifi Abdullah Al-Mamun 《Journal of Computer and Communications》 2024年第5期124-139,共16页
Over the past decade, Graphics Processing Units (GPUs) have revolutionized high-performance computing, playing pivotal roles in advancing fields like IoT, autonomous vehicles, and exascale computing. Despite these adv... Over the past decade, Graphics Processing Units (GPUs) have revolutionized high-performance computing, playing pivotal roles in advancing fields like IoT, autonomous vehicles, and exascale computing. Despite these advancements, efficiently programming GPUs remains a daunting challenge, often relying on trial-and-error optimization methods. This paper introduces an optimization technique for CUDA programs through a novel Data Layout strategy, aimed at restructuring memory data arrangement to significantly enhance data access locality. Focusing on the dynamic programming algorithm for chained matrix multiplication—a critical operation across various domains including artificial intelligence (AI), high-performance computing (HPC), and the Internet of Things (IoT)—this technique facilitates more localized access. We specifically illustrate the importance of efficient matrix multiplication in these areas, underscoring the technique’s broader applicability and its potential to address some of the most pressing computational challenges in GPU-accelerated applications. Our findings reveal a remarkable reduction in memory consumption and a substantial 50% decrease in execution time for CUDA programs utilizing this technique, thereby setting a new benchmark for optimization in GPU computing. 展开更多
关键词 Data Layout Optimization CUDA Performance Optimization GPU memory Optimization Dynamic Programming Matrix Multiplication memory Access Pattern Optimization in CUDA
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Astrocytic endothelin-1 overexpression impairs learning and memory ability in ischemic stroke via altered hippocampal neurogenesis and lipid metabolism 被引量:5
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作者 Jie Li Wen Jiang +9 位作者 Yuefang Cai Zhenqiu Ning Yingying Zhou Chengyi Wang Sookja Ki Chung Yan Huang Jingbo Sun Minzhen Deng Lihua Zhou Xiao Cheng 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第3期650-656,共7页
Vascular etiology is the second most prevalent cause of cognitive impairment globally.Endothelin-1,which is produced and secreted by endothelial cells and astrocytes,is implicated in the pathogenesis of stroke.However... Vascular etiology is the second most prevalent cause of cognitive impairment globally.Endothelin-1,which is produced and secreted by endothelial cells and astrocytes,is implicated in the pathogenesis of stroke.However,the way in which changes in astrocytic endothelin-1 lead to poststroke cognitive deficits following transient middle cerebral artery occlusion is not well understood.Here,using mice in which astrocytic endothelin-1 was overexpressed,we found that the selective overexpression of endothelin-1 by astrocytic cells led to ischemic stroke-related dementia(1 hour of ischemia;7 days,28 days,or 3 months of reperfusion).We also revealed that astrocytic endothelin-1 overexpression contributed to the role of neural stem cell proliferation but impaired neurogenesis in the dentate gyrus of the hippocampus after middle cerebral artery occlusion.Comprehensive proteome profiles and western blot analysis confirmed that levels of glial fibrillary acidic protein and peroxiredoxin 6,which were differentially expressed in the brain,were significantly increased in mice with astrocytic endothelin-1 overexpression in comparison with wild-type mice 28 days after ischemic stroke.Moreover,the levels of the enriched differentially expressed proteins were closely related to lipid metabolism,as indicated by Kyoto Encyclopedia of Genes and Genomes pathway analysis.Liquid chromatography-mass spectrometry nontargeted metabolite profiling of brain tissues showed that astrocytic endothelin-1 overexpression altered lipid metabolism products such as glycerol phosphatidylcholine,sphingomyelin,and phosphatidic acid.Overall,this study demonstrates that astrocytic endothelin-1 overexpression can impair hippocampal neurogenesis and that it is correlated with lipid metabolism in poststroke cognitive dysfunction. 展开更多
关键词 astrocytic endothelin-1 dentate gyrus differentially expressed proteins HIPPOCAMPUS ischemic stroke learning and memory deficits lipid metabolism neural stem cells NEUROGENESIS proliferation
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Machine learning-assisted efficient design of Cu-based shape memory alloy with specific phase transition temperature 被引量:2
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作者 Mengwei Wu Wei Yong +2 位作者 Cunqin Fu Chunmei Ma Ruiping Liu 《International Journal of Minerals,Metallurgy and Materials》 SCIE EI CAS CSCD 2024年第4期773-785,共13页
The martensitic transformation temperature is the basis for the application of shape memory alloys(SMAs),and the ability to quickly and accurately predict the transformation temperature of SMAs has very important prac... The martensitic transformation temperature is the basis for the application of shape memory alloys(SMAs),and the ability to quickly and accurately predict the transformation temperature of SMAs has very important practical significance.In this work,machine learning(ML)methods were utilized to accelerate the search for shape memory alloys with targeted properties(phase transition temperature).A group of component data was selected to design shape memory alloys using reverse design method from numerous unexplored data.Component modeling and feature modeling were used to predict the phase transition temperature of the shape memory alloys.The experimental results of the shape memory alloys were obtained to verify the effectiveness of the support vector regression(SVR)model.The results show that the machine learning model can obtain target materials more efficiently and pertinently,and realize the accurate and rapid design of shape memory alloys with specific target phase transition temperature.On this basis,the relationship between phase transition temperature and material descriptors is analyzed,and it is proved that the key factors affecting the phase transition temperature of shape memory alloys are based on the strength of the bond energy between atoms.This work provides new ideas for the controllable design and performance optimization of Cu-based shape memory alloys. 展开更多
关键词 machine learning support vector regression shape memory alloys martensitic transformation temperature
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Fabrication and integration of photonic devices for phase-change memory and neuromorphic computing 被引量:1
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作者 Wen Zhou Xueyang Shen +2 位作者 Xiaolong Yang Jiangjing Wang Wei Zhang 《International Journal of Extreme Manufacturing》 SCIE EI CAS CSCD 2024年第2期2-27,共26页
In the past decade,there has been tremendous progress in integrating chalcogenide phase-change materials(PCMs)on the silicon photonic platform for non-volatile memory to neuromorphic in-memory computing applications.I... In the past decade,there has been tremendous progress in integrating chalcogenide phase-change materials(PCMs)on the silicon photonic platform for non-volatile memory to neuromorphic in-memory computing applications.In particular,these non von Neumann computational elements and systems benefit from mass manufacturing of silicon photonic integrated circuits(PICs)on 8-inch wafers using a 130 nm complementary metal-oxide semiconductor line.Chip manufacturing based on deep-ultraviolet lithography and electron-beam lithography enables rapid prototyping of PICs,which can be integrated with high-quality PCMs based on the wafer-scale sputtering technique as a back-end-of-line process.In this article,we present an overview of recent advances in waveguide integrated PCM memory cells,functional devices,and neuromorphic systems,with an emphasis on fabrication and integration processes to attain state-of-the-art device performance.After a short overview of PCM based photonic devices,we discuss the materials properties of the functional layer as well as the progress on the light guiding layer,namely,the silicon and germanium waveguide platforms.Next,we discuss the cleanroom fabrication flow of waveguide devices integrated with thin films and nanowires,silicon waveguides and plasmonic microheaters for the electrothermal switching of PCMs and mixed-mode operation.Finally,the fabrication of photonic and photonic–electronic neuromorphic computing systems is reviewed.These systems consist of arrays of PCM memory elements for associative learning,matrix-vector multiplication,and pattern recognition.With large-scale integration,the neuromorphic photonic computing paradigm holds the promise to outperform digital electronic accelerators by taking the advantages of ultra-high bandwidth,high speed,and energy-efficient operation in running machine learning algorithms. 展开更多
关键词 nanofabrication silicon photonics phase-change materials non-volatile photonic memory neuromorphic photonic computing
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Between the City and Images:An Analysis of Mainstream Media’s Paths of Constructing the Cultural Memory of a City:Taking Chengdu Radio and Television’s“Hi Chengdu”as an Example 被引量:1
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作者 Ding Ran Shi Lei 《Contemporary Social Sciences》 2024年第2期97-111,共15页
Mainstream media play a crucial role in constructing the cultural memory of a city.This study used 319 short videos released by“Hi Chengdu,”a new media product of Chengdu Radio and Television,as samples.Based on the... Mainstream media play a crucial role in constructing the cultural memory of a city.This study used 319 short videos released by“Hi Chengdu,”a new media product of Chengdu Radio and Television,as samples.Based on the grounded theory,a research framework encompassing“content,technology,and discourse”was established to explore the paths through which mainstream media construct the cultural memory.Regarding content,this paper emphasized temporal and spatial contexts and urban spaces,delving deep into the themes of the cultural memory and vehicles for it.In terms of technology,this paper discussed the practice of leveraging audio/visual-mode discourse to stitch together the impressions of a city and evoke emotional resonance to create a“flow”of memory.As for discourse,this paper looked at the performance of a communication ritual to frame concepts and shape urban identity.It is essential to break free from conventional thinking and leverage local culture as the primary driving force to further boost a city’s productivity,in order to excel in cultural communication. 展开更多
关键词 the cultural memory of a city short videos the grounded theory Chengdu Radio and Television “Hi Chengdu”
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The complex roles of m^(6)A modifications in neural stem cell proliferation, differentiation, and self-renewal and implications for memory and neurodegenerative diseases
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作者 Yanxi Li Jing Xue +8 位作者 Yuejia Ma Ke Ye Xue Zhao Fangliang Ge Feifei Zheng Lulu Liu Xu Gao Dayong Wang Qing Xia 《Neural Regeneration Research》 SCIE CAS 2025年第6期1582-1598,共17页
N6-methyladenosine(m^(6)A), the most prevalent and conserved RNA modification in eukaryotic cells, profoundly influences virtually all aspects of mRNA metabolism. mRNA plays crucial roles in neural stem cell genesis a... N6-methyladenosine(m^(6)A), the most prevalent and conserved RNA modification in eukaryotic cells, profoundly influences virtually all aspects of mRNA metabolism. mRNA plays crucial roles in neural stem cell genesis and neural regeneration, where it is highly concentrated and actively involved in these processes. Changes in m^(6)A modification levels and the expression levels of related enzymatic proteins can lead to neurological dysfunction and contribute to the development of neurological diseases. Furthermore, the proliferation and differentiation of neural stem cells, as well as nerve regeneration, are intimately linked to memory function and neurodegenerative diseases. This paper presents a comprehensive review of the roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, as well as its implications in memory and neurodegenerative diseases. m^(6)A has demonstrated divergent effects on the proliferation and differentiation of neural stem cells. These observed contradictions may arise from the time-specific nature of m^(6)A and its differential impact on neural stem cells across various stages of development. Similarly, the diverse effects of m^(6)A on distinct types of memory could be attributed to the involvement of specific brain regions in memory formation and recall. Inconsistencies in m^(6)A levels across different models of neurodegenerative disease, particularly Alzheimer's disease and Parkinson's disease, suggest that these disparities are linked to variations in the affected brain regions. Notably, the opposing changes in m^(6)A levels observed in Parkinson's disease models exposed to manganese compared to normal Parkinson's disease models further underscore the complexity of m^(6)A's role in neurodegenerative processes. The roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, and its implications in memory and neurodegenerative diseases, appear contradictory. These inconsistencies may be attributed to the timespecific nature of m^(6)A and its varying effects on distinct brain regions and in different environments. 展开更多
关键词 Alzheimer's disease cell self-renewal central nervous system memory MICROGLIA nerve regeneration neurodegenerative diseases NEUROGENESIS RNA methylation
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Effect of solution treatment on the microstructure,phase transformation behavior and functional properties of NiTiNb ternary shape memory alloys fabricated via laser powder bed fusion in-situ alloying
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作者 Rui Xi Hao Jiang +5 位作者 Guichuan Li Zhihui Zhang Huiliang Wei Guoqun Zhao Jan Van Humbeeck Xiebin Wang 《International Journal of Extreme Manufacturing》 SCIE EI CAS CSCD 2024年第4期202-223,共22页
Post-heat treatment is commonly employed to improve the microstructural homogeneity and enhance the mechanical performances of the additively manufactured metallic materials.In this work,a ternary(NiTi)91Nb9(at.%)shap... Post-heat treatment is commonly employed to improve the microstructural homogeneity and enhance the mechanical performances of the additively manufactured metallic materials.In this work,a ternary(NiTi)91Nb9(at.%)shape memory alloy was produced by laser powder bed fusion(L-PBF)using pre-alloyed NiTi and elemental Nb powders.The effect of solution treatment on the microstructure,phase transformation behavior and mechanical/functional performances was investigated.The in-situ alloyed(NiTi)91Nb9 alloy exhibits a submicron cellular-dendritic structure surrounding the supersaturated B2-NiTi matrix.Upon high-temperature(1273 K)solution treatment,Nb-rich precipitates were precipitated from the supersaturated matrix.The fragmentation and spheroidization of the NiTi/Nb eutectics occurred during solution treatment,leading to a morphological transition from mesh-like into rod-like and sphere-like.Coarsening of theβ-Nb phases occurred with increasing holding time.The martensite transformation temperature increases after solution treatment,mainly attributed to:(i)reduced lattice distortion due to the Nb expulsion from the supersaturated B2-NiTi,and(ii)the Ti expulsion from theβ-Nb phases that lowers the ratio Ni/Ti in the B2-NiTi matrix,which resulted from the microstructure changes from non-equilibrium to equilibrium state.The thermal hysteresis of the solutionized alloys is around 145 K after 20%pre-deformation,which is comparable to the conventional NiTiNb alloys.A short-term solution treatment(i.e.at 1273 K for 30 min)enhances the ductility and strength of the as-printed specimen,with the increase of fracture stress from(613±19)MPa to(781±20)MPa and the increase of fracture strain from(7.6±0.1)%to(9.5±0.4)%.Both the as-printed and solutionized samples exhibit good tensile shape memory effects with recovery rates>90%.This work suggests that post-process heat treatment is essential to optimize the microstructure and improve the mechanical performances of the L-PBF in-situ alloyed parts. 展开更多
关键词 shape memory alloy NiTiNb laser powder bed fusion in-situ alloying heat treatment
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Exercise preconditioning alleviates ischemia-induced memory deficits by increasing circulating adiponectin
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作者 Meifeng Zheng Borui Zhang +3 位作者 Sonata S Y Yau Kwok-Fai So Li Zhang Haining Ou 《Neural Regeneration Research》 SCIE CAS 2025年第5期1445-1454,共10页
Cerebral ischemia is a major health risk that requires preventive approaches in addition to drug therapy.Physical exercise enhances neurogenesis and synaptogenesis,and has been widely used for functional rehabilitatio... Cerebral ischemia is a major health risk that requires preventive approaches in addition to drug therapy.Physical exercise enhances neurogenesis and synaptogenesis,and has been widely used for functional rehabilitation after stroke.In this study,we determined whether exercise training before disease onset can alleviate the severity of cerebral ischemia.We also examined the role of exercise-induced circulating factors in these effects.Adult mice were subjected to 14 days of treadmill exercise training before surgery for middle cerebral artery occlusion.We found that this exercise pre-conditioning strategy effectively attenuated brain infarct area,inhibited gliogenesis,protected synaptic proteins,and improved novel object and spatial memory function.Further analysis showed that circulating adiponectin plays a critical role in these preventive effects of exercise.Agonist activation of adiponectin receptors by Adipo Ron mimicked the effects of exercise,while inhibiting receptor activation abolished the exercise effects.In summary,our results suggest a crucial role of circulating adiponectin in the effects of exercise pre-conditioning in protecting against cerebral ischemia and supporting the health benefits of exercise. 展开更多
关键词 ADIPONECTIN cerebral ischemia exercise pre-conditioning HIPPOCAMPUS memory function middle cerebral artery occlusion prefrontal cortex synaptic proteins treadmill exercise
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Improving comprehensive properties of Cu-11.9Al-2.5Mn shape memory alloy by adding multi-layer graphene carried by Cu_(51)Zr_(14)inoculant particles
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作者 Zhi-xian JIAO Qing-zhou WANG +4 位作者 Yan-jun DING Fu-xing YIN Chao-hui XU Cui-hong HAN Qi-xiang FAN 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2024年第10期3265-3281,共17页
In order to improve the comprehensive properties of the Cu-11.9Al-2.5Mn shape memory alloy(SMA),multilayer graphene(MLG)carried by Cu_(51)Zr_(14)inoculant particles was incorporated and dispersed into this alloy throu... In order to improve the comprehensive properties of the Cu-11.9Al-2.5Mn shape memory alloy(SMA),multilayer graphene(MLG)carried by Cu_(51)Zr_(14)inoculant particles was incorporated and dispersed into this alloy through preparing the preform of the cold-pressed MLG-Cu_(51)Zr_(14)composite powders.In the resultant novel MLG/Cu-Al-Mn composites,MLG in fragmented or flocculent form has a good bonding with the Cu-Al-Mn matrix.MLG can prevent the coarsening of grains of the Cu-Al-Mn SMA and cause thermal mismatch dislocations near the MLG/Cu-Al-Mn interfaces.The damping and mechanical properties of the MLG/Cu-Al-Mn composites are significantly improved.When the content of MLG reaches 0.2 wt.%,the highest room temperature damping of 0.0558,tensile strength of 801.5 MPa,elongation of 10.8%,and hardness of HV 308 can be obtained.On the basis of in-depth observation of microstructures,combined with the theory of internal friction and strengthening and toughening theories of metals,the relevant mechanisms are discussed. 展开更多
关键词 Cu−Al−Mn shape memory alloy multilayer graphene(MLG) microstructure interface damping mechanical properties
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The study of lithographic variation in resistive random access memory
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作者 Yuhang Zhang Guanghui He +2 位作者 Feng Zhang Yongfu Li Guoxing Wang 《Journal of Semiconductors》 EI CAS CSCD 2024年第5期69-79,共11页
Reducing the process variation is a significant concern for resistive random access memory(RRAM).Due to its ultrahigh integration density,RRAM arrays are prone to lithographic variation during the lithography process,... Reducing the process variation is a significant concern for resistive random access memory(RRAM).Due to its ultrahigh integration density,RRAM arrays are prone to lithographic variation during the lithography process,introducing electrical variation among different RRAM devices.In this work,an optical physical verification methodology for the RRAM array is developed,and the effects of different layout parameters on important electrical characteristics are systematically investigated.The results indicate that the RRAM devices can be categorized into three clusters according to their locations and lithography environments.The read resistance is more sensitive to the locations in the array(~30%)than SET/RESET voltage(<10%).The increase in the RRAM device length and the application of the optical proximity correction technique can help to reduce the variation to less than 10%,whereas it reduces RRAM read resistance by 4×,resulting in a higher power and area consumption.As such,we provide design guidelines to minimize the electrical variation of RRAM arrays due to the lithography process. 展开更多
关键词 layout LITHOGRAPHY process variation resistive random access memory
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Advances of embedded resistive random access memory in industrial manufacturing and its potential applications
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作者 Zijian Wang Yixian Song +7 位作者 Guobin Zhang Qi Luo Kai Xu Dawei Gao Bin Yu Desmond Loke Shuai Zhong Yishu Zhang 《International Journal of Extreme Manufacturing》 SCIE EI CAS CSCD 2024年第3期175-214,共40页
Embedded memory,which heavily relies on the manufacturing process,has been widely adopted in various industrial applications.As the field of embedded memory continues to evolve,innovative strategies are emerging to en... Embedded memory,which heavily relies on the manufacturing process,has been widely adopted in various industrial applications.As the field of embedded memory continues to evolve,innovative strategies are emerging to enhance performance.Among them,resistive random access memory(RRAM)has gained significant attention due to its numerousadvantages over traditional memory devices,including high speed(<1 ns),high density(4 F^(2)·n^(-1)),high scalability(~nm),and low power consumption(~pJ).This review focuses on the recent progress of embedded RRAM in industrial manufacturing and its potentialapplications.It provides a brief introduction to the concepts and advantages of RRAM,discusses the key factors that impact its industrial manufacturing,and presents the commercial progress driven by cutting-edge nanotechnology,which has been pursued by manysemiconductor giants.Additionally,it highlights the adoption of embedded RRAM in emerging applications within the realm of the Internet of Things and future intelligent computing,with a particular emphasis on its role in neuromorphic computing.Finally,the review discusses thecurrent challenges and provides insights into the prospects of embedded RRAM in the era of big data and artificial intelligence. 展开更多
关键词 embedded resistive random access memory industrial manufacturing intelligent computing advanced process node
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Efficient Penetration Testing Path Planning Based on Reinforcement Learning with Episodic Memory
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作者 Ziqiao Zhou Tianyang Zhou +1 位作者 Jinghao Xu Junhu Zhu 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第9期2613-2634,共22页
Intelligent penetration testing is of great significance for the improvement of the security of information systems,and the critical issue is the planning of penetration test paths.In view of the difficulty for attack... Intelligent penetration testing is of great significance for the improvement of the security of information systems,and the critical issue is the planning of penetration test paths.In view of the difficulty for attackers to obtain complete network information in realistic network scenarios,Reinforcement Learning(RL)is a promising solution to discover the optimal penetration path under incomplete information about the target network.Existing RL-based methods are challenged by the sizeable discrete action space,which leads to difficulties in the convergence.Moreover,most methods still rely on experts’knowledge.To address these issues,this paper proposes a penetration path planning method based on reinforcement learning with episodic memory.First,the penetration testing problem is formally described in terms of reinforcement learning.To speed up the training process without specific prior knowledge,the proposed algorithm introduces episodic memory to store experienced advantageous strategies for the first time.Furthermore,the method offers an exploration strategy based on episodic memory to guide the agents in learning.The design makes full use of historical experience to achieve the purpose of reducing blind exploration and improving planning efficiency.Ultimately,comparison experiments are carried out with the existing RL-based methods.The results reveal that the proposed method has better convergence performance.The running time is reduced by more than 20%. 展开更多
关键词 Intelligent penetration testing penetration testing path planning reinforcement learning episodic memory exploration strategy
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A novel one-time-programmable memory unit based on Schottky-type p-GaN diode
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作者 Chao Feng Xinyue Dai +4 位作者 Qimeng Jiang Sen Huang Jie Fan Xinhua Wang Xinyu Liu 《Journal of Semiconductors》 EI CAS CSCD 2024年第3期53-57,共5页
In this work,a novel one-time-programmable memory unit based on a Schottky-type p-GaN diode is proposed.During the programming process,the junction switches from a high-resistance state to a low-resistance state throu... In this work,a novel one-time-programmable memory unit based on a Schottky-type p-GaN diode is proposed.During the programming process,the junction switches from a high-resistance state to a low-resistance state through Schottky junction breakdown,and the state is permanently preserved.The memory unit features a current ratio of more than 10^(3),a read voltage window of 6 V,a programming time of less than 10^(−4)s,a stability of more than 108 read cycles,and a lifetime of far more than 10 years.Besides,the fabrication of the device is fully compatible with commercial Si-based GaN process platforms,which is of great significance for the realization of low-cost read-only memory in all-GaN integration. 展开更多
关键词 wide-bandgap semiconductor one-time programmable Schottky-type p-GaN diode read-only memory device
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Cognitive Navigation for Intelligent Mobile Robots:A Learning-Based Approach With Topological Memory Configuration
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作者 Qiming Liu Xinru Cui +1 位作者 Zhe Liu Hesheng Wang 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2024年第9期1933-1943,共11页
Autonomous navigation for intelligent mobile robots has gained significant attention,with a focus on enabling robots to generate reliable policies based on maintenance of spatial memory.In this paper,we propose a lear... Autonomous navigation for intelligent mobile robots has gained significant attention,with a focus on enabling robots to generate reliable policies based on maintenance of spatial memory.In this paper,we propose a learning-based visual navigation pipeline that uses topological maps as memory configurations.We introduce a unique online topology construction approach that fuses odometry pose estimation and perceptual similarity estimation.This tackles the issues of topological node redundancy and incorrect edge connections,which stem from the distribution gap between the spatial and perceptual domains.Furthermore,we propose a differentiable graph extraction structure,the topology multi-factor transformer(TMFT).This structure utilizes graph neural networks to integrate global memory and incorporates a multi-factor attention mechanism to underscore elements closely related to relevant target cues for policy generation.Results from photorealistic simulations on image-goal navigation tasks highlight the superior navigation performance of our proposed pipeline compared to existing memory structures.Comprehensive validation through behavior visualization,interpretability tests,and real-world deployment further underscore the adapt-ability and efficacy of our method. 展开更多
关键词 Graph neural networks(GNNs) spatial memory topological map visual navigation
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Recombinant chitinase-3-like protein 1 alleviates learning and memory impairments via M2 microglia polarization in postoperative cognitive dysfunction mice
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作者 Yujia Liu Xue Han +6 位作者 Yan Su Yiming Zhou Minhui Xu Jiyan Xu Zhengliang Ma Xiaoping Gu Tianjiao Xia 《Neural Regeneration Research》 SCIE CAS 2025年第9期2727-2736,共10页
Postoperative cognitive dysfunction is a seve re complication of the central nervous system that occurs after anesthesia and surgery,and has received attention for its high incidence and effect on the quality of life ... Postoperative cognitive dysfunction is a seve re complication of the central nervous system that occurs after anesthesia and surgery,and has received attention for its high incidence and effect on the quality of life of patients.To date,there are no viable treatment options for postoperative cognitive dysfunction.The identification of postoperative cognitive dysfunction hub genes could provide new research directions and therapeutic targets for future research.To identify the signaling mechanisms contributing to postoperative cognitive dysfunction,we first conducted Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses of the Gene Expression Omnibus GSE95426 dataset,which consists of mRNAs and long non-coding RNAs differentially expressed in mouse hippocampus3 days after tibial fracture.The dataset was enriched in genes associated with the biological process"regulation of immune cells,"of which Chill was identified as a hub gene.Therefore,we investigated the contribution of chitinase-3-like protein 1 protein expression changes to postoperative cognitive dysfunction in the mouse model of tibial fractu re surgery.Mice were intraperitoneally injected with vehicle or recombinant chitinase-3-like protein 124 hours post-surgery,and the injection groups were compared with untreated control mice for learning and memory capacities using the Y-maze and fear conditioning tests.In addition,protein expression levels of proinflammatory factors(interleukin-1βand inducible nitric oxide synthase),M2-type macrophage markers(CD206 and arginase-1),and cognition-related proteins(brain-derived neurotropic factor and phosphorylated NMDA receptor subunit NR2B)were measured in hippocampus by western blotting.Treatment with recombinant chitinase-3-like protein 1 prevented surgery-induced cognitive impairment,downregulated interleukin-1βand nducible nitric oxide synthase expression,and upregulated CD206,arginase-1,pNR2B,and brain-derived neurotropic factor expression compared with vehicle treatment.Intraperitoneal administration of the specific ERK inhibitor PD98059 diminished the effects of recombinant chitinase-3-like protein 1.Collectively,our findings suggest that recombinant chitinase-3-like protein 1 ameliorates surgery-induced cognitive decline by attenuating neuroinflammation via M2 microglial polarization in the hippocampus.Therefore,recombinant chitinase-3-like protein1 may have therapeutic potential fo r postoperative cognitive dysfunction. 展开更多
关键词 Chil1 hippocampus learning and memory M2 microglia NEUROINFLAMMATION postoperative cognitive dysfunction(POCD) recombinant CHI3L1
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An Enhanced Ensemble-Based Long Short-Term Memory Approach for Traffic Volume Prediction
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作者 Duy Quang Tran Huy Q.Tran Minh Van Nguyen 《Computers, Materials & Continua》 SCIE EI 2024年第3期3585-3602,共18页
With the advancement of artificial intelligence,traffic forecasting is gaining more and more interest in optimizing route planning and enhancing service quality.Traffic volume is an influential parameter for planning ... With the advancement of artificial intelligence,traffic forecasting is gaining more and more interest in optimizing route planning and enhancing service quality.Traffic volume is an influential parameter for planning and operating traffic structures.This study proposed an improved ensemble-based deep learning method to solve traffic volume prediction problems.A set of optimal hyperparameters is also applied for the suggested approach to improve the performance of the learning process.The fusion of these methodologies aims to harness ensemble empirical mode decomposition’s capacity to discern complex traffic patterns and long short-term memory’s proficiency in learning temporal relationships.Firstly,a dataset for automatic vehicle identification is obtained and utilized in the preprocessing stage of the ensemble empirical mode decomposition model.The second aspect involves predicting traffic volume using the long short-term memory algorithm.Next,the study employs a trial-and-error approach to select a set of optimal hyperparameters,including the lookback window,the number of neurons in the hidden layers,and the gradient descent optimization.Finally,the fusion of the obtained results leads to a final traffic volume prediction.The experimental results show that the proposed method outperforms other benchmarks regarding various evaluation measures,including mean absolute error,root mean squared error,mean absolute percentage error,and R-squared.The achieved R-squared value reaches an impressive 98%,while the other evaluation indices surpass the competing.These findings highlight the accuracy of traffic pattern prediction.Consequently,this offers promising prospects for enhancing transportation management systems and urban infrastructure planning. 展开更多
关键词 Ensemble empirical mode decomposition traffic volume prediction long short-term memory optimal hyperparameters deep learning
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