AIM: To assess “top-down” treatment for deep remission of early moderate to severe Crohn’s disease (CD) by double balloon enteroscopy.
BACKGROUND： To date, many 6-hydroxydopamine （6-OHDA）-lesioned rat models have been established by injecting 6-OHDA into two or more sites in the substantia nigra pars compacta, striatum or median forebrain bundle. ...BACKGROUND： To date, many 6-hydroxydopamine （6-OHDA）-lesioned rat models have been established by injecting 6-OHDA into two or more sites in the substantia nigra pars compacta, striatum or median forebrain bundle. The success rate of models established by this method is satisfactory, but it can raise the death rate, and is elaborate and tedious to perform. OBJECTIVE： To observe the difference between injections of 6-OHDA into the striatum from one site and two sites, and to explore the feasibility of establishing Parkinson＇s disease rat models via striatal one-site double injection. DESIGN, TIME AND SETTING： A randomized, controlled animal experiment based on a modeling comparison was performed at the Pharmacology Laboratory of Traditional Chinese Medicine, Academy of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine between August 2005 and April 2006. MATERIALS： A total of 46 male Wistar rats were purchased from Beijing Weitong Lihua Experimental Animal Technical Co., Ltd., China. 6-OHDA hydrogen bromide was sourced from Sigma Co., Ltd., USA. METHODS： All 46 rats were randomized to three groups： one-site injection （n = 18）, two-site injection （n = 18）, and control （n = 10）. Lesions in rat brains were established by infusing 5 μg 6-OHDA into the striatum at the following coordinates： anteroposterior （AP） 1.0 mm, mediolateral （ML） 2.7 mm, dorsoventral （DV）-5.2 or-6.0 mm for the one-site injection group, and AP 1.0 mm, ML 2.5 mm, DV -4.5 mm/AP-0.4 mm, ML 3.5 mm, DV-4.5 mm for the two-site injection group, respectively. Rats in the control group were injected with the same volume of 0.01% ascorbic acid as above. MAIN OUTCOME MEASURES： Tyrosine hydroxylase-positive neurons were detected by immunohistochemistry. Success rates of PD models established by one-site and two-site injection techniques were examined. RESULTS： One rat died in the one-site injection group and four in the two-site injection group. Thus behavioral testing was performed on 31 rats. There was no significant difference in the success rate of PD model establishment between one-site injection and two-site injection groups [82% （14/17） vs. 86% （12/14）, P 〉 0.05]. The numbers of tyrosine hydroxylase -positive neurons in one-site injection and two-site injection groups were not significantly different （ P 〉 0.05）, but they were significantly lower than in the control group（P 〈 0.01 ）. CONCLUSION： A Parkinson＇s disease model can be established in rats via striatal one-site double injection.展开更多
T.S.Eliot,a great American poet in the twentieth century,is a spokesman of the Imagist Movement.He emphasizes describing the rotten Western civilization and the decayed morals after the First World War.Prufrock that T...T.S.Eliot,a great American poet in the twentieth century,is a spokesman of the Imagist Movement.He emphasizes describing the rotten Western civilization and the decayed morals after the First World War.Prufrock that T.S.Eliot described in his early poems is timid,hesitant,sensitive,anxious,lack of will and confidence;This paper will analyze the detailed behaviors of the characters in Eliot's early poems and reveal the major image of modern men more clearly.展开更多
Dear Editor,I am Dr. Yao Fu, from the Department of Ophthalmology,Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. I write to present a rare case of Ascher syndrome...Dear Editor,I am Dr. Yao Fu, from the Department of Ophthalmology,Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. I write to present a rare case of Ascher syndrome.Ascher syndrome was described first in 1920, presenting as a combination of blepharochalasis, double lip, and non-toxic goitre(1)It is considered to be a rare, sporadic.展开更多
AIM To evaluate the efficacy of doubling time(DT) of gastrointestinal submucosal tumors(GIST).METHODS From April 1987 through November 2012, a total of 323 patients were given a final histopathological diagnosis of GI...AIM To evaluate the efficacy of doubling time(DT) of gastrointestinal submucosal tumors(GIST).METHODS From April 1987 through November 2012, a total of 323 patients were given a final histopathological diagnosis of GISTs on surgical resection or endoscopic ultrasound-guided fine-needle aspiration(EUS-FNA) in Kitasato University East Hospital or Kitasato University Hospital. We studied 53 of these patients(34 with resected tumors and 19 with unresected tumors) whose tumors could be measured on EUS on at least two successive occasions. The histopathological diagnosis was GIST in 34 patients, leiomyoma in 5, schwannoma in 3, ectopic pancreas in 1, hamartoma in 1, cyst in 1, Brunner's adenoma in 1, and spindle-cell tumor in 7. We retrospectively calculated the DT of GISTs on the basis of the time course of EUS findings to estimate the growth rate of such tumors.RESULTS The DT was 17.2 mo for GIST, as compared with 231.2 mo for leiomyoma, 104.7 mo for schwannoma, 274.9mo for ectopic pancreas, 61.2 mo for hamartoma, 49.0 mo for cyst, and 134.7 mo for Brunner's adenoma. The GISTs were divided into risk classes on the basis of tumor diameters and mitotic figures(Fletcher's classification). The classification was extremely low risk or low risk in 28 patients, intermediate risk in 3, and high risk in 3. DT of GIST according to risk was 24.0 mo for extremely low-risk plus low-risk GIST, 17.1 mo for intermediate-risk GIST, and 3.9 mo for high-risk GIST. DT of GIST was significantly shorter than that of leiomyoma plus schwannoma(P < 0.05), and DT of high-risk GIST was significantly shorter than that of extremely low-risk plus low-risk GIST(P < 0.05).CONCLUSION For GIST, a higher risk grade was associated with a significantly shorter DT. Small SMTs should initially be followed up within 6 mo after detection.展开更多
Men＇s health awareness, including the research and study of quality of life, sexual desires and risk factors, has increased worldwide. In Thailand, this advancement is made possible by cooperation, research and spons...Men＇s health awareness, including the research and study of quality of life, sexual desires and risk factors, has increased worldwide. In Thailand, this advancement is made possible by cooperation, research and sponsorship from the local Thai community. This article aims to illustrate the sexual attitudes of Thai people, to determine the degree of erectile dysfunction （ED） and to investigate how to manage and cope with ED in a Thai community. We reviewed the relevant literature from Thai-based articles and surveys in regard to men＇s health, sexual attitudes, the prevalence of ED and common risk factors in the Thai community. The primary risk factor for ED in Thai men was age-related health decline and the presence of vascular disease. Most Thai men will seek consultation from their partner in regard to ED. The main presentation of metabolic disease in Thai patients was dyslipidemia. New selective serotonin reuptake inhibitors are not available for premature ejaculation in Thai communities. The debate in regard to malpractice compensation is an issue that should be closely monitored. There is currently a shortage of home care for the elderly in Thailand. The insights provided by the articles helped recruit the study patients and in turn, helped us gain knowledge that can be translated into improved men＇s health care in Thailand.展开更多
Aim: We developed a scale to measure the social activities of community-dwelling older men requiring support. Methods: The participants were a group of 134 men, ≥65 years old, who required support and were living in ...Aim: We developed a scale to measure the social activities of community-dwelling older men requiring support. Methods: The participants were a group of 134 men, ≥65 years old, who required support and were living in Hokkaido, Japan. An anonymous questionnaire was administered through individual interviews. Valid responses were obtained from 121/134 interviewees. The construct validity of the resulting scale was assessed by exploratory factor analysis (EFA). Criterion-related validity was tested with Spearman’s rank correlation test based on the Social Activities Index for Elderly People (SAI-E). Reliability was assessed by Cronbach’s alpha. Results: A Social Activities Scale for Community-dwelling Older Men Requiring Support (SASOMS) scale was created, comprised of the following three subscales: daily interactions with familiar people;intimate relationships with family members;and interactions with others through activity programs (e.g., exercise, games, recreation, etc.). The created SASOMS scale correlated with the SAI-E (r = 0.557), and its criterion-related validity was confirmed. The alpha coefficient of the new scale was 0.791, and its internal consistency was confirmed. Conclusions: The reliability and validity of the developed SASOMS scale was confirmed, demonstrating that it can be used to assess social activities specifically in older men requiring support. Our results suggest that the scale can be used effectively by care providers who support older men requiring care. The usability of the SASOMS should continue to be improved, and it is necessary to verify its validity in longitudinal studies.展开更多
Using series iteration techniques identities and apply each of these identities in we derive a number of general double series order to deduce several hypergeometric reduction formulas involving the Srivastava-Daoust ...Using series iteration techniques identities and apply each of these identities in we derive a number of general double series order to deduce several hypergeometric reduction formulas involving the Srivastava-Daoust double hypergeometric function. The results presented in this article are based essentially upon the hypergeometric summation theorems of Kummer and Dixon.展开更多
Nonsequential double ionization （NSDI） processes of nonaligned diatomic molecules N2 and O2 are studied using the S-matrix theory. Our results show that the NSDI process significantly depends on the molecular symmet...Nonsequential double ionization （NSDI） processes of nonaligned diatomic molecules N2 and O2 are studied using the S-matrix theory. Our results show that the NSDI process significantly depends on the molecular symmetry and structure. The ratio of NSDI rate to single ionization rate as a function of the field intensity is obtained. It is found that N2 behaves closely with its companion atom Ar in the ratios over the entire intensity range, while O2 exhibits an obvious suppression effect, which is qualitatively consistent with the experiment.展开更多
文摘AIM: To assess “top-down” treatment for deep remission of early moderate to severe Crohn’s disease (CD) by double balloon enteroscopy.
文摘BACKGROUND： To date, many 6-hydroxydopamine （6-OHDA）-lesioned rat models have been established by injecting 6-OHDA into two or more sites in the substantia nigra pars compacta, striatum or median forebrain bundle. The success rate of models established by this method is satisfactory, but it can raise the death rate, and is elaborate and tedious to perform. OBJECTIVE： To observe the difference between injections of 6-OHDA into the striatum from one site and two sites, and to explore the feasibility of establishing Parkinson＇s disease rat models via striatal one-site double injection. DESIGN, TIME AND SETTING： A randomized, controlled animal experiment based on a modeling comparison was performed at the Pharmacology Laboratory of Traditional Chinese Medicine, Academy of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine between August 2005 and April 2006. MATERIALS： A total of 46 male Wistar rats were purchased from Beijing Weitong Lihua Experimental Animal Technical Co., Ltd., China. 6-OHDA hydrogen bromide was sourced from Sigma Co., Ltd., USA. METHODS： All 46 rats were randomized to three groups： one-site injection （n = 18）, two-site injection （n = 18）, and control （n = 10）. Lesions in rat brains were established by infusing 5 μg 6-OHDA into the striatum at the following coordinates： anteroposterior （AP） 1.0 mm, mediolateral （ML） 2.7 mm, dorsoventral （DV）-5.2 or-6.0 mm for the one-site injection group, and AP 1.0 mm, ML 2.5 mm, DV -4.5 mm/AP-0.4 mm, ML 3.5 mm, DV-4.5 mm for the two-site injection group, respectively. Rats in the control group were injected with the same volume of 0.01% ascorbic acid as above. MAIN OUTCOME MEASURES： Tyrosine hydroxylase-positive neurons were detected by immunohistochemistry. Success rates of PD models established by one-site and two-site injection techniques were examined. RESULTS： One rat died in the one-site injection group and four in the two-site injection group. Thus behavioral testing was performed on 31 rats. There was no significant difference in the success rate of PD model establishment between one-site injection and two-site injection groups [82% （14/17） vs. 86% （12/14）, P 〉 0.05]. The numbers of tyrosine hydroxylase -positive neurons in one-site injection and two-site injection groups were not significantly different （ P 〉 0.05）, but they were significantly lower than in the control group（P 〈 0.01 ）. CONCLUSION： A Parkinson＇s disease model can be established in rats via striatal one-site double injection.
文摘T.S.Eliot,a great American poet in the twentieth century,is a spokesman of the Imagist Movement.He emphasizes describing the rotten Western civilization and the decayed morals after the First World War.Prufrock that T.S.Eliot described in his early poems is timid,hesitant,sensitive,anxious,lack of will and confidence;This paper will analyze the detailed behaviors of the characters in Eliot's early poems and reveal the major image of modern men more clearly.
基金Supported by Shanghai Science and Technology Development Funds(No.17411963800)Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant(No.20161421)+1 种基金Clinical Research Program of Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine(No.JYLJ014)the Science and Technology Commission of Shanghai(No.17DZ2260100)
文摘Dear Editor,I am Dr. Yao Fu, from the Department of Ophthalmology,Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. I write to present a rare case of Ascher syndrome.Ascher syndrome was described first in 1920, presenting as a combination of blepharochalasis, double lip, and non-toxic goitre(1)It is considered to be a rare, sporadic.
文摘AIM To evaluate the efficacy of doubling time(DT) of gastrointestinal submucosal tumors(GIST).METHODS From April 1987 through November 2012, a total of 323 patients were given a final histopathological diagnosis of GISTs on surgical resection or endoscopic ultrasound-guided fine-needle aspiration(EUS-FNA) in Kitasato University East Hospital or Kitasato University Hospital. We studied 53 of these patients(34 with resected tumors and 19 with unresected tumors) whose tumors could be measured on EUS on at least two successive occasions. The histopathological diagnosis was GIST in 34 patients, leiomyoma in 5, schwannoma in 3, ectopic pancreas in 1, hamartoma in 1, cyst in 1, Brunner's adenoma in 1, and spindle-cell tumor in 7. We retrospectively calculated the DT of GISTs on the basis of the time course of EUS findings to estimate the growth rate of such tumors.RESULTS The DT was 17.2 mo for GIST, as compared with 231.2 mo for leiomyoma, 104.7 mo for schwannoma, 274.9mo for ectopic pancreas, 61.2 mo for hamartoma, 49.0 mo for cyst, and 134.7 mo for Brunner's adenoma. The GISTs were divided into risk classes on the basis of tumor diameters and mitotic figures(Fletcher's classification). The classification was extremely low risk or low risk in 28 patients, intermediate risk in 3, and high risk in 3. DT of GIST according to risk was 24.0 mo for extremely low-risk plus low-risk GIST, 17.1 mo for intermediate-risk GIST, and 3.9 mo for high-risk GIST. DT of GIST was significantly shorter than that of leiomyoma plus schwannoma(P < 0.05), and DT of high-risk GIST was significantly shorter than that of extremely low-risk plus low-risk GIST(P < 0.05).CONCLUSION For GIST, a higher risk grade was associated with a significantly shorter DT. Small SMTs should initially be followed up within 6 mo after detection.
文摘Men＇s health awareness, including the research and study of quality of life, sexual desires and risk factors, has increased worldwide. In Thailand, this advancement is made possible by cooperation, research and sponsorship from the local Thai community. This article aims to illustrate the sexual attitudes of Thai people, to determine the degree of erectile dysfunction （ED） and to investigate how to manage and cope with ED in a Thai community. We reviewed the relevant literature from Thai-based articles and surveys in regard to men＇s health, sexual attitudes, the prevalence of ED and common risk factors in the Thai community. The primary risk factor for ED in Thai men was age-related health decline and the presence of vascular disease. Most Thai men will seek consultation from their partner in regard to ED. The main presentation of metabolic disease in Thai patients was dyslipidemia. New selective serotonin reuptake inhibitors are not available for premature ejaculation in Thai communities. The debate in regard to malpractice compensation is an issue that should be closely monitored. There is currently a shortage of home care for the elderly in Thailand. The insights provided by the articles helped recruit the study patients and in turn, helped us gain knowledge that can be translated into improved men＇s health care in Thailand.
文摘Aim: We developed a scale to measure the social activities of community-dwelling older men requiring support. Methods: The participants were a group of 134 men, ≥65 years old, who required support and were living in Hokkaido, Japan. An anonymous questionnaire was administered through individual interviews. Valid responses were obtained from 121/134 interviewees. The construct validity of the resulting scale was assessed by exploratory factor analysis (EFA). Criterion-related validity was tested with Spearman’s rank correlation test based on the Social Activities Index for Elderly People (SAI-E). Reliability was assessed by Cronbach’s alpha. Results: A Social Activities Scale for Community-dwelling Older Men Requiring Support (SASOMS) scale was created, comprised of the following three subscales: daily interactions with familiar people;intimate relationships with family members;and interactions with others through activity programs (e.g., exercise, games, recreation, etc.). The created SASOMS scale correlated with the SAI-E (r = 0.557), and its criterion-related validity was confirmed. The alpha coefficient of the new scale was 0.791, and its internal consistency was confirmed. Conclusions: The reliability and validity of the developed SASOMS scale was confirmed, demonstrating that it can be used to assess social activities specifically in older men requiring support. Our results suggest that the scale can be used effectively by care providers who support older men requiring care. The usability of the SASOMS should continue to be improved, and it is necessary to verify its validity in longitudinal studies.
文摘Using series iteration techniques identities and apply each of these identities in we derive a number of general double series order to deduce several hypergeometric reduction formulas involving the Srivastava-Daoust double hypergeometric function. The results presented in this article are based essentially upon the hypergeometric summation theorems of Kummer and Dixon.
基金Project supported by the National Natural Science Foundation of China (Grant Nos. 11074026, 11074155, and 11104225)the Program for New Century Excellent Talents in University of the Ministry of Education of China (Grant No. NCET-08-0883)the National Basic Research Program of China (Grant No. 2011CB808100)
文摘Nonsequential double ionization （NSDI） processes of nonaligned diatomic molecules N2 and O2 are studied using the S-matrix theory. Our results show that the NSDI process significantly depends on the molecular symmetry and structure. The ratio of NSDI rate to single ionization rate as a function of the field intensity is obtained. It is found that N2 behaves closely with its companion atom Ar in the ratios over the entire intensity range, while O2 exhibits an obvious suppression effect, which is qualitatively consistent with the experiment.
