Purpose:The objectives of this investigation were to compare the World Health Organization abbreviated instrument for quality of life assessment(WHOQOL-bref)scores of osteoporotic and non-osteoporotic Brazilian patien...Purpose:The objectives of this investigation were to compare the World Health Organization abbreviated instrument for quality of life assessment(WHOQOL-bref)scores of osteoporotic and non-osteoporotic Brazilian patients and to evaluate the correlation between mandibular cortical index(MCI)and bone densitometry(DXA)results in both groups.Methods:This research was conducted with an initial sample of 74 female participants who underwent panoramic radiography and forearm densitometry.Participants were divided into two groups:osteoporotic and non-osteoporotic patients.A quality of life assessment questionnaire was administered.The scores from the questionnaire were compared between the two groups and the correlation between DXA and MCI was analyzed.Results:Psychological and social domains in osteoporotic patients presented lower scores(12.65 and 6.00 respectively)when compared to non-osteoporotic patients(14.70 and 13.97 respectively).MCI was inversely correlated with DXA.Conclusions:According to WHOQOL-bref,osteoporotic patients may have lower quality of life scores when considering psychological and social relationships.MCI is inversely correlated with T-scores but demonstrates greater correlation when considering non-osteoporotic patients with higher T-score values.展开更多
Background:Areal bone mineral density(aBMD)applied for osteoporosis diagnosis unavoidably results in the missingdiagnosis in patients with large bones and misdiagnosis in those with small bones.Therefore,we try to fin...Background:Areal bone mineral density(aBMD)applied for osteoporosis diagnosis unavoidably results in the missingdiagnosis in patients with large bones and misdiagnosis in those with small bones.Therefore,we try to find a new adjusted index of bone mineral content(BMC)to make up shortcomings of aBMD in osteoporosis diagnosis.Methods:In this multi-center epidemiological study,BMC and aBMD of lumbar spines(n=5510)and proximal femurs(n=4710)were measured with dual energy X-ray absorptiometry(DXA).We analyzed the correlation between the bone mass and body weight in all subjects including four age groups(<19 years,20-39 years,40-49 years,>50 years).And then the body weight was used for standardizing BMC(named wBMC)and applied for the epidemiological analysis of osteoporosis?Results:The correlation of body weight and BMC is 0.839 to 0.931 of lumbar vertebra 1-4(Li_4),and 0.71 to 0.95 of femoral neck in different age groups.When aBMD was applied for diagnosing osteoporosis,the prevalence was 7.55%,16.39%,and 25.83%in patients with a high,intermediate,and low body weight respectively.However,the prevalence was 21.8%,18.03%,and 11.64%by wBMC applied for diagnosing osteoporosis.Moreover,the prevalence of osteoporosis increased by 3.76%by wBMC with the body weight increased by 5 kg.The prevalence decreased by 1.94%when the body weight decreased by 5 kg.Conclusions:wBMC can reduce the missed diagnosis in patients with large body weight and reduce misdiagnosis in those with small body weight.Including children,wBMC may be feasible for osteoporosis diagnosis individuals at any age.展开更多
Background Periodontitis and osteoporosis are one of the frequently encountered diseases in post-menopausal women. Estrogen receptors （ERs） regulated bone metabolism. To investigate the possible effect of ER-elpha ...Background Periodontitis and osteoporosis are one of the frequently encountered diseases in post-menopausal women. Estrogen receptors （ERs） regulated bone metabolism. To investigate the possible effect of ER-elpha （a） gene polymorphisms on bone mineral density （BMD） in pre- and post-menopausal Chinese women with chronic periodontitis （CP）, we provided sufficient quantitative information concerning the correlation between ER gene polymorphisms and BMD in periodontitis. Methods Sixty-five post-menopausal and eighty pre-menopausal CP women, and sixty post-menopausal healthy individuals were recruited in this study. Genomic DNA was extracted from oral mucosa swab sample of each subject by the Chelex-100 method. Determination of the ER-a polymorphisms was performed by polymerese chain reaction-restriction fragment length polymorphism （PCR-RFLP） technique with Xbal and Pvull enzyme. The index for periodontal examination includes clinical attachment loss （CAL） and probing pocket depth （PPD）. BMD was measured by dual-energy X-ray absorptiometry （DEXA）. Results There were no significant differences between the ER-α genotypes of Pvull and Xbal and BMD in post-menopausal and pre-menopausal CP patients, respectively （P 〉0.05）. However, there was association between pre- and post-menopausal CP patients at BMD of lumbar spine L2-L4 （P=0.027） and Ward＇s BMD （P=0.004）. Furthermore, the post-menopausal CP women who carried Pvull TT genotype presented significantly lower Ward＇s BMD than the pre-menopausal CP women （P=-0.007）, meanwhile, the post-menopausal CP women who carried Xbal AA genotype presented significantly lower spine L2-L4 BMD than the pre-menopausal CP women （P=0.003）. Conclusions ER-α gene polymorphisms may be a susceptible indicator for BMD variation of lumbar spine L2-L4 and Ward in Chinese pre- and post-menopausal women patients with CP.展开更多
目的调查长春市16019例汉族人群骨密度,分析本地区峰值骨量及骨密度变化的人群规律。方法采用美国Osteometer Medi Tech公司生产的DTX-200型骨密度仪,检测受试者非受力侧前臂桡尺骨远端三分之一处骨密度（BMD）。将16019例检测结果按不...目的调查长春市16019例汉族人群骨密度,分析本地区峰值骨量及骨密度变化的人群规律。方法采用美国Osteometer Medi Tech公司生产的DTX-200型骨密度仪,检测受试者非受力侧前臂桡尺骨远端三分之一处骨密度（BMD）。将16019例检测结果按不同性别每5岁为一年龄组,应用SPSS13.0软件统计分析骨密度均值、T评分及骨量丢失百分率。结果长春市男、女性人群骨密度峰值分别为0.625±0.109、0.506±0.058,其峰值年龄为30～39岁年龄段,40岁以后开始缓慢下降,50～59岁年龄段男性骨质疏松发病率为7.7%,女性为6.97%;60～69岁年龄段男性骨质疏松发病率为18.13%,女性为35.97%;70～79岁年龄段男性骨质疏松发病率为36.41%,女性为59.55%,80岁以上男性骨质疏松发病率为57.53%,女性为75.56%。结论不同年龄及同年龄组两性之间比较骨密度测定值差异显著（P〈0.01）。50岁以后各年龄段女性骨质疏松发病率明显高于男性（P〈0.01）。本研究报告的骨密度峰值高于日本、丹麦同类型骨密度仪检测结果;与北京地区骨密度检测结果相近。与西双版纳傣族、西藏、甘肃东乡族比较,差异显著（P〈0.01）。展开更多
目的研究云南彝药恒古骨伤愈合剂对去势雌性大鼠骨密度的影响。方法将36只雌性SD大鼠随机平均分为对照组、手术组、给药组,每组12只。给药组和手术组大鼠行经腹双侧卵巢切除术,同时对给药组予恒古骨伤愈合剂;对照组大鼠经腹切除与卵巢...目的研究云南彝药恒古骨伤愈合剂对去势雌性大鼠骨密度的影响。方法将36只雌性SD大鼠随机平均分为对照组、手术组、给药组,每组12只。给药组和手术组大鼠行经腹双侧卵巢切除术,同时对给药组予恒古骨伤愈合剂;对照组大鼠经腹切除与卵巢重量相同的脂肪组织。术后第1周、第10周行双能射线骨密度测定,以了解其骨密度(bone mineral density,BMD)、骨矿盐含量(bone mineral conten,BMC)。术中术后10w内去势雌性大鼠无死亡情况。结果第10周给药组对比手术组,给药组全身BMD增加1.84%,差异具有统计学意义(P<0.05);给药组对比对照组,给药组全身BMD下降1.2%,但差异无统计学意义(P>0.05)。全身骨矿盐含量给药组>手术组>对照组,两两比较差异无统计学意义(P>0.05)。给药组和手术组体重相近,差异无统计学差异(P>0.05);但两组体重均大于对照组体重,且差异有显著统计学意义(P<0.01)。结论恒古骨伤愈合剂可以延缓去势雌性大鼠骨质疏松中骨量的丢失。展开更多
文摘Purpose:The objectives of this investigation were to compare the World Health Organization abbreviated instrument for quality of life assessment(WHOQOL-bref)scores of osteoporotic and non-osteoporotic Brazilian patients and to evaluate the correlation between mandibular cortical index(MCI)and bone densitometry(DXA)results in both groups.Methods:This research was conducted with an initial sample of 74 female participants who underwent panoramic radiography and forearm densitometry.Participants were divided into two groups:osteoporotic and non-osteoporotic patients.A quality of life assessment questionnaire was administered.The scores from the questionnaire were compared between the two groups and the correlation between DXA and MCI was analyzed.Results:Psychological and social domains in osteoporotic patients presented lower scores(12.65 and 6.00 respectively)when compared to non-osteoporotic patients(14.70 and 13.97 respectively).MCI was inversely correlated with DXA.Conclusions:According to WHOQOL-bref,osteoporotic patients may have lower quality of life scores when considering psychological and social relationships.MCI is inversely correlated with T-scores but demonstrates greater correlation when considering non-osteoporotic patients with higher T-score values.
文摘Background:Areal bone mineral density(aBMD)applied for osteoporosis diagnosis unavoidably results in the missingdiagnosis in patients with large bones and misdiagnosis in those with small bones.Therefore,we try to find a new adjusted index of bone mineral content(BMC)to make up shortcomings of aBMD in osteoporosis diagnosis.Methods:In this multi-center epidemiological study,BMC and aBMD of lumbar spines(n=5510)and proximal femurs(n=4710)were measured with dual energy X-ray absorptiometry(DXA).We analyzed the correlation between the bone mass and body weight in all subjects including four age groups(<19 years,20-39 years,40-49 years,>50 years).And then the body weight was used for standardizing BMC(named wBMC)and applied for the epidemiological analysis of osteoporosis?Results:The correlation of body weight and BMC is 0.839 to 0.931 of lumbar vertebra 1-4(Li_4),and 0.71 to 0.95 of femoral neck in different age groups.When aBMD was applied for diagnosing osteoporosis,the prevalence was 7.55%,16.39%,and 25.83%in patients with a high,intermediate,and low body weight respectively.However,the prevalence was 21.8%,18.03%,and 11.64%by wBMC applied for diagnosing osteoporosis.Moreover,the prevalence of osteoporosis increased by 3.76%by wBMC with the body weight increased by 5 kg.The prevalence decreased by 1.94%when the body weight decreased by 5 kg.Conclusions:wBMC can reduce the missed diagnosis in patients with large body weight and reduce misdiagnosis in those with small body weight.Including children,wBMC may be feasible for osteoporosis diagnosis individuals at any age.
基金This study was supported in part by the a grant from National Natural Science Foundation of China （No. 30572069）.Acknowledgements： The authors are grateful to Prof. LIU Jia-yun, Department of Clinical Molecular Biology, Xijing Hospital, Fourth Military Medical University, for his technical advice.
文摘Background Periodontitis and osteoporosis are one of the frequently encountered diseases in post-menopausal women. Estrogen receptors （ERs） regulated bone metabolism. To investigate the possible effect of ER-elpha （a） gene polymorphisms on bone mineral density （BMD） in pre- and post-menopausal Chinese women with chronic periodontitis （CP）, we provided sufficient quantitative information concerning the correlation between ER gene polymorphisms and BMD in periodontitis. Methods Sixty-five post-menopausal and eighty pre-menopausal CP women, and sixty post-menopausal healthy individuals were recruited in this study. Genomic DNA was extracted from oral mucosa swab sample of each subject by the Chelex-100 method. Determination of the ER-a polymorphisms was performed by polymerese chain reaction-restriction fragment length polymorphism （PCR-RFLP） technique with Xbal and Pvull enzyme. The index for periodontal examination includes clinical attachment loss （CAL） and probing pocket depth （PPD）. BMD was measured by dual-energy X-ray absorptiometry （DEXA）. Results There were no significant differences between the ER-α genotypes of Pvull and Xbal and BMD in post-menopausal and pre-menopausal CP patients, respectively （P 〉0.05）. However, there was association between pre- and post-menopausal CP patients at BMD of lumbar spine L2-L4 （P=0.027） and Ward＇s BMD （P=0.004）. Furthermore, the post-menopausal CP women who carried Pvull TT genotype presented significantly lower Ward＇s BMD than the pre-menopausal CP women （P=-0.007）, meanwhile, the post-menopausal CP women who carried Xbal AA genotype presented significantly lower spine L2-L4 BMD than the pre-menopausal CP women （P=0.003）. Conclusions ER-α gene polymorphisms may be a susceptible indicator for BMD variation of lumbar spine L2-L4 and Ward in Chinese pre- and post-menopausal women patients with CP.
文摘目的调查长春市16019例汉族人群骨密度,分析本地区峰值骨量及骨密度变化的人群规律。方法采用美国Osteometer Medi Tech公司生产的DTX-200型骨密度仪,检测受试者非受力侧前臂桡尺骨远端三分之一处骨密度（BMD）。将16019例检测结果按不同性别每5岁为一年龄组,应用SPSS13.0软件统计分析骨密度均值、T评分及骨量丢失百分率。结果长春市男、女性人群骨密度峰值分别为0.625±0.109、0.506±0.058,其峰值年龄为30～39岁年龄段,40岁以后开始缓慢下降,50～59岁年龄段男性骨质疏松发病率为7.7%,女性为6.97%;60～69岁年龄段男性骨质疏松发病率为18.13%,女性为35.97%;70～79岁年龄段男性骨质疏松发病率为36.41%,女性为59.55%,80岁以上男性骨质疏松发病率为57.53%,女性为75.56%。结论不同年龄及同年龄组两性之间比较骨密度测定值差异显著（P〈0.01）。50岁以后各年龄段女性骨质疏松发病率明显高于男性（P〈0.01）。本研究报告的骨密度峰值高于日本、丹麦同类型骨密度仪检测结果;与北京地区骨密度检测结果相近。与西双版纳傣族、西藏、甘肃东乡族比较,差异显著（P〈0.01）。
文摘目的研究云南彝药恒古骨伤愈合剂对去势雌性大鼠骨密度的影响。方法将36只雌性SD大鼠随机平均分为对照组、手术组、给药组,每组12只。给药组和手术组大鼠行经腹双侧卵巢切除术,同时对给药组予恒古骨伤愈合剂;对照组大鼠经腹切除与卵巢重量相同的脂肪组织。术后第1周、第10周行双能射线骨密度测定,以了解其骨密度(bone mineral density,BMD)、骨矿盐含量(bone mineral conten,BMC)。术中术后10w内去势雌性大鼠无死亡情况。结果第10周给药组对比手术组,给药组全身BMD增加1.84%,差异具有统计学意义(P<0.05);给药组对比对照组,给药组全身BMD下降1.2%,但差异无统计学意义(P>0.05)。全身骨矿盐含量给药组>手术组>对照组,两两比较差异无统计学意义(P>0.05)。给药组和手术组体重相近,差异无统计学差异(P>0.05);但两组体重均大于对照组体重,且差异有显著统计学意义(P<0.01)。结论恒古骨伤愈合剂可以延缓去势雌性大鼠骨质疏松中骨量的丢失。
