OBJECTIVE:To evidently assess the applicability of regulate menstrual cycle(MC)characteristics in Traditional Chinese Medicine(TCM)as an indicator for fertility.METHODS:A community-based prospective cohort study was c...OBJECTIVE:To evidently assess the applicability of regulate menstrual cycle(MC)characteristics in Traditional Chinese Medicine(TCM)as an indicator for fertility.METHODS:A community-based prospective cohort study was conducted in China.Between January 2010 and December 2012,women who were willing to conceive within 2 years were enrolled in the study.Other than the MC length pattern,a well-adopted MC characteristic,menstrual blood color and clots were specifically concerned for women enrolled.All participants were followed up in 2 years by trained nurses.Pregnancy rate,fecundability odds ratio(FOR)and risk of miscarriage were assessed as fertility outcomes.RESULTS:A total of 2109 women were effectively included in this cohort for analysis.Results show that women with irregular MC length were less likely to achieve conception(FOR_(irregular)=0.59;95%CI=0.45-0.77,P<0.001).Menstrual blood in bright red color was also associated with decline in likelihood of conception(FOR=0.79;95%CI=0.63-0.98,P=0.04).Women with menstrual blood in light red were at higher risk of miscarriage(OR=2.39;95%CI=0.91-6.28,P=0.08).No significant impact was found between menstrual blood clots and fertility outcomes(FOR=1.02,95%CI=0.83-1.25,P=0.88;OR=1.2695%CI=0.77-2.07,P=0.35).CONCLUSIONS:MC characteristics can be an effective and simple indicator for women’s fertility.Increasing the knowledge of MC characteristics for women in reproductive ages would bring great benefits to their preconception health conditions.展开更多
目的研究中药人工周期联合地屈孕酮片对宫内膜异位症(EMs)不孕患者妊娠及血清学的影响。方法选取2014年3月至2016年3月间在南通市中医院接受治疗的EMs不孕患者96例,依据随机数表法将患者分成两组:对照组(48例)使用地屈孕酮片治疗,观察组...目的研究中药人工周期联合地屈孕酮片对宫内膜异位症(EMs)不孕患者妊娠及血清学的影响。方法选取2014年3月至2016年3月间在南通市中医院接受治疗的EMs不孕患者96例,依据随机数表法将患者分成两组:对照组(48例)使用地屈孕酮片治疗,观察组(48例)在对照组基础上结合中药治疗;观察患者治疗后妊娠情况、治疗前后血清肿瘤坏死因子-α(TNF-α)、白介素6(IL-6)水平变化情况,使用B超检测患者A型子宫内膜数量,卵泡发育状况,子宫内膜的厚度和排卵日内卵巢血流动力学情况。结果观察组和对照组患者妊娠率分别为54.17%、37.50%,差异有统计学意义(P<0.05);治疗后观察组和对照组患者血清TNF-α[(17.45±4.26)ng/m L vs(22.07±4.36)ng/m L]、IL-6[(18.24±3.16)pg/m L vs(23.17±3.50)pg/m L]、舒张期末流速(EDV)[(11.02±1.43)cm/s vs(9.30±1.86)cm/s]、搏动指数(PI)[(0.69±0.31)vs(1.21±1.05)]、收缩期峰值流速(PSV)[(21.10±1.89)cm/s vs(18.24±1.93)cm/s]比较,差异均有统计学意义(P<0.05)。结论中药人工周期联合地屈孕酮片可改善患者卵泡和子宫内膜的发育与生长,降低炎症因子水平,提高妊娠率。展开更多
基金Supported by Scientific research of Zhejiang Provincial Department of Health(Wireless Sensor Model of Menstrual Cycle Health Monitoring,No.2016ZA049)Young Scientists of Zhejiang Provincial Department of Health(Effects of Tiaojing Decoction on Expression of TGF-β3/Smads Pathway in Premature Ovarian Failure Model Rats,No.2020ZQ021)National Science Foundation for Fostering Talents in Basic Research of the National Natural Science Foundation of China(Establishment and Evaluation of Female Pre Pregnancy Health Risk Identification and Evaluation Model,No.81202737)。
文摘OBJECTIVE:To evidently assess the applicability of regulate menstrual cycle(MC)characteristics in Traditional Chinese Medicine(TCM)as an indicator for fertility.METHODS:A community-based prospective cohort study was conducted in China.Between January 2010 and December 2012,women who were willing to conceive within 2 years were enrolled in the study.Other than the MC length pattern,a well-adopted MC characteristic,menstrual blood color and clots were specifically concerned for women enrolled.All participants were followed up in 2 years by trained nurses.Pregnancy rate,fecundability odds ratio(FOR)and risk of miscarriage were assessed as fertility outcomes.RESULTS:A total of 2109 women were effectively included in this cohort for analysis.Results show that women with irregular MC length were less likely to achieve conception(FOR_(irregular)=0.59;95%CI=0.45-0.77,P<0.001).Menstrual blood in bright red color was also associated with decline in likelihood of conception(FOR=0.79;95%CI=0.63-0.98,P=0.04).Women with menstrual blood in light red were at higher risk of miscarriage(OR=2.39;95%CI=0.91-6.28,P=0.08).No significant impact was found between menstrual blood clots and fertility outcomes(FOR=1.02,95%CI=0.83-1.25,P=0.88;OR=1.2695%CI=0.77-2.07,P=0.35).CONCLUSIONS:MC characteristics can be an effective and simple indicator for women’s fertility.Increasing the knowledge of MC characteristics for women in reproductive ages would bring great benefits to their preconception health conditions.
文摘目的研究中药人工周期联合地屈孕酮片对宫内膜异位症(EMs)不孕患者妊娠及血清学的影响。方法选取2014年3月至2016年3月间在南通市中医院接受治疗的EMs不孕患者96例,依据随机数表法将患者分成两组:对照组(48例)使用地屈孕酮片治疗,观察组(48例)在对照组基础上结合中药治疗;观察患者治疗后妊娠情况、治疗前后血清肿瘤坏死因子-α(TNF-α)、白介素6(IL-6)水平变化情况,使用B超检测患者A型子宫内膜数量,卵泡发育状况,子宫内膜的厚度和排卵日内卵巢血流动力学情况。结果观察组和对照组患者妊娠率分别为54.17%、37.50%,差异有统计学意义(P<0.05);治疗后观察组和对照组患者血清TNF-α[(17.45±4.26)ng/m L vs(22.07±4.36)ng/m L]、IL-6[(18.24±3.16)pg/m L vs(23.17±3.50)pg/m L]、舒张期末流速(EDV)[(11.02±1.43)cm/s vs(9.30±1.86)cm/s]、搏动指数(PI)[(0.69±0.31)vs(1.21±1.05)]、收缩期峰值流速(PSV)[(21.10±1.89)cm/s vs(18.24±1.93)cm/s]比较,差异均有统计学意义(P<0.05)。结论中药人工周期联合地屈孕酮片可改善患者卵泡和子宫内膜的发育与生长,降低炎症因子水平,提高妊娠率。
