Whole-process case management effects on mental state and selfcare ability in patients with liver cancer

BACKGROUND Regarding the incidence of malignant tumors in China,the incidence of liver cancer ranks fourth,second only to lung,gastric,and esophageal cancers.The case fatality rate ranks third after lung and cervical cancer.In a previous study,the whole-process management model was applied to patients with breast cancer,which effectively reduced their negative emotions and improved treatment adherence and nursing satisfaction.METHODS In this single-center,randomized,controlled study,60 randomly selected patients with liver cancer who had been admitted to our hospital from January 2021 to January 2022 were randomly divided into an observation group(n=30),who received whole-process case management on the basis of routine nursing mea-sures,and a control group(n=30),who were given routine nursing measures.We compared differences between the two groups in terms of anxiety,depression,the level of hope,self-care ability,symptom distress,sleep quality,and quality of life.RESULTS Post-intervention,Hamilton anxiety scale,Hamilton depression scale,memory symptom assessment scale,and Pittsburgh sleep quality index scores in both groups were lower than those pre-intervention,and the observation group had lower scores than the control group(P<0.05).Herth hope index,self-care ability assessment scale-revision in Chinese,and quality of life measurement scale for patients with liver cancer scores in both groups were higher than those pre-intervention,with higher scores in the observation group compared with the control group(P<0.05).CONCLUSION Whole-process case management can effectively reduce anxiety and depression in patients with liver cancer,alleviate symptoms and problems,and improve the level of hope,self-care ability,sleep quality,and quality of life,as well as provide feasible nursing alternatives for patients with liver cancer.

A Method for Classification and Evaluation of Pilot’s Mental States Based on CNN

How to accurately recognize the mental state of pilots is a focus in civil aviation safety.The mental state of pilots is closely related to their cognitive ability in piloting.Whether the cognitive ability meets the standard is related to flight safety.However,the pilot’s working state is unique,which increases the difficulty of analyzing the pilot’s mental state.In this work,we proposed a Convolutional Neural Network(CNN)that merges attention to classify the mental state of pilots through electroencephalography(EEG).Considering the individual differences in EEG,semi-supervised learning based on improvedK-Means is used in themodel training to improve the generalization ability of the model.We collected the EEG data of 12 pilot trainees during the simulated flight and compared the method in this paper with other methods on this data.The method in this paper achieved an accuracy of 86.29%,which is better than 4D-aNN and HCNN etc.Negative emotion will increase the probability of fatigue appearing,and emotion recognition is also meaningful during the flight.Then we conducted experiments on the public dataset SEED,and our method achieved an accuracy of 93.68%.In addition,we combine multiple parameters to evaluate the results of the classification network on a more detailed level and propose a corresponding scoring mechanism to display the mental state of the pilots directly.

Analysis of influencing factors of anxiety and depression in patients with periodontitis

BACKGROUND Periodontitis is a chronic oral disease caused by pathogenic microorganisms that corrode tooth tissue,form periodontal pockets,absorb alveolar bone,and finally lead to tooth loss.During treatment,patients are prone to anxiety,tension,and other negative emotions,which affect their ability to face the disease and may also lead to aggravation of the original condition and affect oral health.Therefore,it is important to improve the negative psychology of patients with periodontitis to clarify the factors that may lead to negative psychological emotions.AIM To investigate the risk factors that may lead to anxiety and depression in patients with periodontitis.METHODS One hundred patients with periodontitis were selected between March 2022 and March 2023 at our hospital.All patients were assessed with the Zung Self-rating Depression Scale(SDS)(≥53 points indicate a depressive state)and Zung Selfrating Anxiety Scale(SAS)(≥50 points indicates an anxious state).In this study,patients who experienced anxiety or depression were included in the occurrence group and those without anxiety or depression were included in the nonoccurrence group.The baseline data of the two groups were compared to explore the risk factors for anxiety and depression in patients with periodontitis.RESULTS A total of 100 patients with periodontitis were included in this study.According to the SDS,38 patients(38.00%)developed depression,with an average SDS score of(68.52±5.85)points.According to the SAS,40 patients(40.00%)developed anxiety,and the average SAS score was(72.15±4.15)points.In this study,56 patients with anxiety or depression were included.Compared with the nonoccurrence group,the occurrence group had higher ages(≥60 years),lower level of hope(low level),educational level(high school or below),disease perception(poor),and sleep disorder(yes).The negative coping dimension scores of the simplified coping style questionnaire(SCSQ)and Dental Fear Scale(DFS)in the occurrence group were higher,whereas the score of the positive coping dimension of the SCSQ was significantly lower(P<0.05).There were no significant differences in the other data between the groups(P>0.05).The results of multiple logistics regression analysis showed that age(≥60 years),level of hope(low level),educational level(high school or below),disease perception(poor),sleep disorder(yes),high negative coping dimension scores of SCSQ,high score of DFS,and low positive coping dimension scores of SCSQ were all factors contributing to the anxiety and depression in patients with periodontitis(odds ratio>1,P<0.05).CONCLUSION Age,hope level,educational level,disease perception,sleep disorders,coping style,and dental fear were all associated with anxiety and depression in patients with periodontitis.

A CHILDES Analysis of Mental State Verbs in Mandarin-speaking Children

Mental state verbs(MSVs)are believed to be closely related with the development of Theory of Mind(ToM).Studies on MSVs have yielded fruitful results abroad over the past three decades,especially in ToM,while it still has a long way to go for the Mandarin-speaking children.The present study focuses on mental state verbs in Mandarin-speaking children and explores the universality of ToM,as well as the development features.An analysis of their spontaneous speech from the CHILDES archives reveals,first,that Mandarin-speaking children use desire terms much earlier than other terms,suggesting a pattern of theory-of-mind development similar to that in English;second,the developmental trend of the MSVs is relatively steady while the number of different categories varies a lot.This study suggests a consistency in the overall sequence,but variation in the timing of beginning and end points,which is helpful to further related investigation.

Implication of emotions in the state of health

Background:At the beginning of the 70s,Dr.Candace Pert discovered for the first time the first component of the molecules of emotion,explaining and demonstrating how the mind and the body are interconnected.This study aims to confirm the importance of emotions and how they intervene or are related to different types of pathologies,thus confirming the importance that this relationship represents for the state of health.Method:A systematic review has been carried out on the implication that emotions have on the state of health.A generalized search was carried out,preferably in articles published and related to our study in the last five years,mainly basing the bibliographic review on H ealth S ciences and S ocial S ciences databases.Results:We have been able to verify how emotions,in general,can favor or worsen diseases such as heart,mental,eating disorders,autoimmune diseases,or cancer,among others;in addition to the importance of positive and negative emotions in all kinds of diseases.Conclusions:We have seen throughout this study how emotions interfere with our state of health,especially due to the greater number of negative emotions that surround us daily to the detriment of the positive emotions that we know favor the state of not only physical and emotional health but also of social and general well-being.We need to look for situations or environments that,in a certain sense,foster positive emotions every day and in any place where we find ourselves(home,work,street,etc.).

Application of traditional Chinese medicine acupoint needle embedding combined with emotional nursing in patients with gynecological malignant tumors

BACKGROUND Few relevant literature reports on applying acupoint press-needle embedding combined with emotional nursing in patients with a gynecological malignant tumor.AIM To explore the effect of traditional Chinese medicine acupoint needle embedding combined with emotional nursing on chemotherapy-related nausea and vomiting(CINV),cancer-related fatigue(CRF)and psychological state in patients with gynecological malignant tumors.METHODS Retrospective analysis of the clinical information of 84 patients with gynecological malignant tumors treated in our hospital from August 2020 to December 2022 Led to the development of an observation group(n=42)and a control group(n=42)based on various nursing approaches.Ondansetron hydrochloride injection was administered to the individuals in the control group.However,the observation group received emotional nursing based on the control group and acupoint pressneedle embedding of traditional Chinese medicine.Patients in both groups received the chemotherapy regimen of paclitaxel liposome+carbo-platin/cisplatin.For four weeks,both groups intervened.The CINV grade,quality of life,CRF,psychological status and sleep quality scores of the two groups before and RESULTS After intervention,the degree of CINV in the observation group was significantly better than that in the control group.After intervention,the scores of each dimension and total score of FLIE scale were significantly higher than those in the control group.After intervention,the scores of each dimension and total score of Piper Fatigue Scale were significantly lower than those in the control group(P<0.05).After intervention,the scores of avoidance and yield dimensions in the observation group were significantly lower than those in the control group,and the scores of confrontation dimension were significantly higher than those in the control group(P<0.05).After intervention,the sleep quality score of the observation group was significantly lower than that of the control group,and the Karnofsky Performance Status scale score was significantly higher than that of the control group(P<0.05).CONCLUSION The acupuncture point needle embedding of traditional Chinese medicine combined with emotional nursing can further reduce the incidence of chemotherapy-related nausea and vomiting in patients with gynecological malignant tumors,improve the quality of life and the degree of CRF,alleviate the bad psychological state,adopt a positive way to face the disease and treatment,and improve the quality of sleep and quality of life.

Analysis of the Application Effect of Dual-Perspective Care Mode in Patients with Magnetic Resonance Imaging Examination

Objectives:This paper aims to explore application effect of the dual-perspective care mode for safety and comfort needs in patients with magnetic resonance imaging(MRI)examination.Methods:A total of 132 patients with MRI examination who were admitted to our hospital from September 2018 to February 2020 were selected as the research objects,and they were divided into control group and intervention group by random number table method,with 66 cases in each group.Patients in the control group received routine nursing care,while patients in the intervention group received the dual-perspective nursing care.The psychological state,nursing safety quality,nursing satisfaction,and quality of life scores of the two groups were compared and analyzed.Results:The Self-Rating Anxiety Scale(SAS)(32.05±2.63)and Self-Rating Depression Scale(SDS)(33.14±4.15)of patients in the intervention group receiving dual-perspective nursing mode were lower than those in the control group,and the improvement level of psychological states such as anxiety and depression was significantly better than that in the control group,the difference was statistically significant(P<0.05).Intervention group patients in early treatment of dangerous situation(3.26±1.08),implementation of safety measures(3.32±1.15),prevention of accidental injury(3.17±0.95),and other eight nursing safety quality index scores were higher than the control group(P<0.05).The nursing satisfaction of patients in the intervention group(93.94%)was significantly higher than that in the control group(75.76%),and the differences were statistically significant(P<0.05).In addition,the five life quality indexes of the intervention group were higher than those of the control group,including physiological(90.51±6.39),psychological(91.33±5.76),and emotional(90.45±5.39).Conclusion:The dual-perspective nursing intervention for the safety and comfort needs of patients with MRI examination can effectively improve the anxiety and depression in the diagnosis and treatment,ensure the safety and comfort of the examination process,improve patients'satisfaction with nursing,so as to ensure the effectiveness and accuracy of the examination results,which has great clinical application value.

Effects of comprehensive nursing on postoperative complications,mental status and quality of life in patients with glioma

BACKGROUND The complexity and refractory of brain glioma requires treatment that should involve a multidisciplinary approach to improve quality of care and fulfill patients’needs.AIM To explore the effects of comprehensive nursing on postoperative complications,psychological state and quality of life in patients with brain glioma.METHODS A total of 106 patients with confirmed brain gliomas admitted to Nanchong Central Hospital between January 2019 and May 2021 were selected by random sampling.They were categorized into an observation group and a control group using a random number table with 53 patients in each group.Patients in the observation group were given comprehensive nursing in addition to conventional nursing and patients in the control group were given conventional nursing.The overall incidence of postoperative complications including limb dysfunction,high fever and epilepsy was compared between the two groups.The mental status was evaluated in the two groups before and after intervention using self-rating anxiety scale(SAS)and self-rating depression scale(SDS).Quality of life was assessed and compared using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire between the two groups before and after the intervention.RESULTS After intervention,the overall incidence of postoperative complications was significantly lower in the observation group(7.55%)than that in the control group(20.75%)(P<0.05).Before intervention,there was no significant difference in SAS and SDS scores between the two groups(P>0.05).However,after intervention,scores of SAS and SDS decreased in the two groups compared with those before intervention,and the scores of SAS and SDS were lower in the observation group than in the control group(all P<0.05).There was no significant difference in quality of life between the two groups before the intervention(P>0.05).In contrast,quality of life increased in the two groups compared with those before intervention,and it was higher in the observation group than in the control group(P<0.05).CONCLUSION Comprehensive nursing can reduce the incidence of postoperative complications,improve the psychological state of anxiety and depression and improve quality of life in patients with brain glioma.

Effect of Chaishao Jieyu Decoction combined with Pingxiao Capsule on the patients with luminal breast cancer after operation

Objective:To study the improvement of Chaishao Jieyu decoction combined with Pingxiao capsule on the mental state、immune function and endometrium of patients with luminal breast cancer undergoing endocrine therapy after operation.Methods:60 cases of luminal breast cancer patients after operation,according to the method of random grouping would be divided into the control group and the observation group,each group 30 cases.The control group were treated with tamoxifen.On the basis,the observation group accepted oral administration of Chaishao Jieyu Decoction and Pingxiao capsule.The levels of 5-HT、DA、T lymphocyte subsets、IGF-1 and endometrial thickness were compared.Results:At the end of treatment,the observation group's 5-HT、DA、CD3+、CD4+levels were obviously higher than the control group(P<0.05),the observation group's CD8+levels、IGF-1 levels and endometrial thickness were significantly lower than the control group(P<0.05).Conclusion:Chaishao Jieyu Decoction combined with Pingxiao capsule can significantly improve the mental state、immune function of patients with luminal breast cancer undergoing endocrine therapy after surgery,and inhibit their endometrial thickening,the effect is exact.

Effect of Chaishao Jieyu Decoction on postoperative colorectal cancer patients with liver depression and spleen deficiency

Objective:To study the effect of Chaishao Jieyu Decoction on the improvement of mental state、immune function and diarrhea of Liver Depression and Spleen Deficiency patients with colorectal cancer after operation.Methods:76 cases of colorectal cancer patients after operation,according to the method of random grouping would be divided into the chinese medicine treatment(CMT)group and the western medicine control(WMC)group,each group 38 cases.The WMC group were treated with montmorillonite.The CMT group accepted oral administration of Chaishao Jieyu Decoction.The levels of anxiety and depression score,quality of life,T lymphocyte subsets and TNF-α,and improvement of diarrhea were compared.Results:With the therapy ending,the standards of SAS and SDS in CMT group were reduced signficantly than the WMC group(P<0.05),The score of QOL was obviously higher than the WMC group(P<0.05),the treatment group's CD3+、CD4+subsets levels increased obviously than the WMC group(P<0.05),the CD8+subsets and Tumor necrosis factor-alpha-levels were obviously lower than the WMC group(P<0.05),the improvement of diarrhea of the CMT group was obviously better than the WMC group(P<0.05).Conclusion:Chaishao Jieyu Decoction can effectively improve the mental state and diarrhea symptoms of postoperative patients with colorectal cancer,and significantly improve the immune function of the body,the Chaishao Jieyu Decoction's effect is excellent.

Multi-agent Belief,Goal and Exceptions Reasoning

Temporal logics are often adopted as basic tools to specifying mental states such as belief and goal of agents. Although there are works on non-monotonic extension of linear temporal logic (LTL) and branching time temporal logic (CTL),the non-monotonic extension of alternating-time temporal logic (ATL) which is an important kind of multi-agent cooperation logics has not been discussed yet in literature. To solve this problem,this paper proposed non-monotonic alternating-time temporal logic with belief and goal,namely N-ATL-BG,to facilitate the non-monotonic reasoning of mental states of agents. The semantic model,syntax and semantics of this new logic are developed. A model checking algorithm which can be finished in polynomial time is proposed for this new logic. Examples are given to show its usage.

Can the prediction model using regression with optimal scale improve the power to predict the Parkinson's dementia?

BACKGROUND Efficiently detecting Parkinson's disease(PD)with dementia(PDD)as soon as possible is an important issue in geriatric medicine.AIM To develop a model for predicting PDD based on various neuropsychological tests using data from a nationwide survey conducted by the Korean Centers for Disease Control and Prevention and to present baseline data for the early detection of PDD.METHODS This study comprised 289 patients who were 60 years or older with PD[110 with PDD and 179 Parkinson's Disease-Mild Cognitive Impairment(PD-MCI)].Regression with optimal scaling(ROS)was used to identify independent relationships between the neuropsychological test results and PDD.RESULTS In the ROS analysis,Korean version of mini mental state ex-amination(MMSE)(KOREAN version of MMSE)(b=-0.52,SE=0.16)and Hoehn and Yahr staging(b=0.44,SE=0.19)were significantly effective models for distinguishing PDD from PD-MCI(P<0.05),even after adjusting for all of the Parkinson's motor symptom and neuropsychological test results.The optimal number of categories(scaling factors)for KOREAN version of MMSE and Hoehn and Yahr Scale was 10 and 7,respectively.CONCLUSION The results of this study suggest that among the various neuropsychological tests conducted,the optimal classification scores for KOREAN version of MMSE and Hoehn and Yahr Scale could be utilized as an effective screening test for the early discrimination of PDD from PD-MCI.

Frailty Syndrome Prevalence and Its Correlation with Cognitive Function in Elderly Surgical Inpatients

Background: Frailty is a geriatric syndrome, and a common negative consequence of aging, which shares some obvious characteristics as cognitive impairment. Preventing and relieving frailty may reduce the possibility of developing cognitive impairment. Objective: This study aimed to investigate frailty prevalence and its correlation with cognitive function in elderly surgical inpatients. Methods: We enrolled a random sample of elderly surgical inpatients from Jingzhou from June 2020 to August 2020. We used a self-made registration sheet to collect their demographic data (gender, age, nationality, educational level and monthly income), and used the FRAIL Scale to assess the prevalence of frailty, and used the Mini-Mental State Examination (MMSE) to assess cognitive function. We used multiple linear regression analysis to explore the correlation between frailty level and demographic data, then Pearson correlation analysis was performed to analyze the correlation between frailty and cognitive function. Results: In the 143 elderly surgical inpatients, prevalence of frail was seen in 29 (20.3%), and pre-frail state was found in 64 (44.8%). Only 50 (34.9%) were in healthy state. Cognitive impairment was seen in 28 (19.5%). Pearson correlation analysis showed that the frail scoring was correlated with cognitive function in elderly surgical inpatients (r = -0.378, P < 0.05). Conclusion: The prevalence of frailty is high in elderly surgical inpatients, which is closely related to age and gender. Elderly surgical inpatients have high cognitive impairment, and frailty appears strongly associated with cognitive status. The findings suggest that attention should be paid to the frailty and cognitive function in the elderly surgical inpatients by pro-vision of effective interventions.

Metaphor in Cinema Revisited

The theory of rhetorical figures in cinema is highly problematic, besides it can be considered as outdated as the semiotic theory of cinema,1 yet it is convenient to reexamine the idea of＂cinematographic metaphor＂ in order to throw some light on the dominant idea of cinema as narrative medium. In this paper we will examine： （l） the supposedly existing metaphor of urban and industrial man as sheep at the beginn!ng of Chaplin＇s film Modern Times; and （2） the sequence of the awakening stone lion in Eisenstein＇s Battleship Potemkin as metaphor of the proletarian revolt against czarism. We will arrive to the notion of a purely metaphoric film, which together with Zavattini＇s ideal film showing 90 minutes in the life of a man to whom nothing happens, will helps us draw some conclusions about montage and narrativity in cinema. Especially interesting in this connection is the fact that symbolical shots as the mentioned ones are like description in literature, that is, they have nothing to do neither with the time of the story nor with the time of the discourse.

A Brief Clinical Assessment of Cognitive Deficit with Impaired Daily Living Functioning in Parkinson’s Patients with and without Dementia

Cognitive decline in Parkinson’s disease (PD) is defined as dementia which affects activities of daily living (ADL) function. Dementia is one of the recognized issues in the treatment of Parkinson’s disease patients (PDP) as it is becoming a major contributor to morbidity. The objective of our study was to evaluate the cognitive decline in Parkinson’s disease patients (PDP) and the influence of cognition on daily living function deterioration in cognitively impaired and cognitively unimpaired PDP. Cognitively impaired PDP (n = 24), and cognitively unimpaired PDP (n = 16) were administered MoCA and MMSE performance based tests for cognitive measurements and Alzheimer’s Disease Cooperative Study Activities of Daily Living Inventory (ADCS-ADL) to determine everyday functioning. The significances of MoCA and MMSE among cognitively impaired PDP and cognitively unimpaired PDP in univariant analysis were P < 0.001 and P < 0.05. In partial correlation, MoCA was strongly related to ADL function as compare to MMSE (r = 0.623, P = 0.001). Cognitively impaired PDP showed significantly lower score on visuo-construction and attention. Among all variables of MoCA domains, attention is strongly associated with instrumental activity daily living (IADL) scores (logistic regression coefficient = 0.672, P = 0.01). These results suggest that dementia affects daily living performances especially the IADL tasks like attention and execution. Therefore, the assessment of complex daily activities particularly IADL is probably useful for the diagnosis of early stage cognitive impairment in PDP. Further MMSE test is less sensitive than MoCA for detecting significant cognitive decline in PDP and impaired attention is an important determinant of ADL functions in cognitively impaired PDP.

Interpretation of Symbolism in Willa.Cather novel ＂A Lost Lady＂

＂ A Lost Lady＂ is at beginning of the 20th century, a important work of creation of a famous American writer Willa Cather, through a story that a woman in a social swirl in old age gradually fall and sink, it reflects the commercialization of human society and other traditional values and lifestyle impact and erosion, and the desire of mankind for a better civilization. Works use artistic symbolism to play a certain role in the development of the plot, the characters change shape and opposition figures to portray the psychological state.

Influence of Fuzheng Huayu Tablet(扶正化瘀片) on Mental State and Social Function of Patients with Post-Hepatitis B Liver Cirrhosis

Objective： To observe the influence of Fuzheng Huayu Tablet （扶正化瘀片, FZHYT） on mental state and social activity of patients with post-hepatitis B liver cirrhosis （LC-HB）. Methods： Adopting grouped randomized double-blinded control method, 180 LC-HB patients in 3 research centers were distributed to 2 groups, the treated group and the control group, 90 in each group. Patients in the treated group were administered with FZHYT; while those in the control group treated with conventional therapy combined with placebo, the course for all patients were 6 months. Their mental state and social activity were evaluated before treatment, after 3 months＇ treatment and at terminal of the 6-month therapeutic course by estimating with Zung self-rating anxiety scale （SAS）, self-rating depression scale （SDS） and social deficit screening scale （SDSS）. Additionally, the basic demographic materials, liver function, cirrhosis index, hepatic and splenic images, blood coagulation function, etc. in the patients were tested and compared as well. Results： As compared with before treatment, the normal rate of SAS and SDS scores increased and the social deficit rate decreased in the treated group significantly after treatment, showing statistical significance （P〈0.05 or P〈0.01）; while in the control group, change was only shown in the social deficit （P〈0.01）, inter-group comparisons after treatment showed significant differences in all the three indexes （P〈0.05 or P〈0.01）. Additionally, after treatment, levels of liver function, cirrhosis, blood coagulation function and splenomegaly in the treated group were all improved significantly （P〈0.05 or P〈0.01）, and the improvements were better than those in the control group （P〈0.01） in levels of total bilirubin （TBIL）, albumin （ALB）, type 1V collagen （1V-C）, prothrombin time （PT）, prothrombin activity （PTA）. Conclusion： Most patients of LC-HB have mental disturbance and social activity deficit, which could definitely be improved by intervention with Chinese FZHYT.

Accidentally True Beliefs and the Williamsonian Mental State of Knowing

In this paper,I will explore some philosophical implications of Williamson’s thesis that knowing is a state of mind(KSM).Using the fake barn case,I will introduce a way to evaluate Williamson’s KSM thesis and determine whether the Williamsonian mental state of knowing can be plausibly distinguished from certain other similar but epistemologically distinctive states of mind(i.e.,accidentally true beliefs).Then,some tentative externalist accounts of the supposed differences between the Williamsonian mental state of knowing and accidentally true beliefs will be critically assessed,implying that the evaluated traditional versions of externalism in semantics and epistemology do not fit well with Williamson’s KSM thesis.Ultimately,I suggest that the extended-mind or extended-knower approach may be more promising,which indicates that active externalism would be called for by Williamson’s KSM thesis.

Tiaobu Xinshen Recipe (调补心肾方) Improved Mild Cognitive Impairment of Alzheimer’s Disease Patients with Xin (Heart) and Shen (Kidney) Deficiency

Objective: To observe the intervention effects of Tiaobu Xinshen Recipe(调补心肾方, TXR) on patients with mild cognitive impairment caused by Alzheimer’s disease(MCI-AD). Methods: Totally 88 MCI-AD patients with syndrome of Xin(Heart) and Shen(Kidney) deficiency were assigned to the experimental group(47 cases, treated with TXR) and the control group(41 cases, treated with donepezil hydrochloride) using a random number table. Final recruited qualified patients were 44 cases in the experimental group and 39 cases in the control group. The therapeutic course was 12 weeks. Neuropsychological scales [mini mental state examination(MMSE) and Montreal cognitive assessment(MoCA)], and Chinese medicine(CM) dementia syndromes scales were performed in all patients, and results were compared between groups or intra-group before and after treatment. Results: MMSE and Mo CA scores of the two groups were increased after treatment compared with those before treatment(P<0.05). But there was no statistical difference in MMSE or MOCA scores after treatment between the two groups(P>0.05). CM dementia syndrome score was significantly decreased after treatment in the experimental group compared with the control group(P<0.01). Visual spatial and executive function scores and delayed recall scores of the two groups were increased compared with those before treatment(P<0.01). Conclusion: TXR could effectively improve cognitive impairment of MCI-AD patients with syndrome of Xin and Shen deficiency.