The coronavirus disease 2019(COVID-19)pandemic caused by the novel beta coronavirus severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)crippled the whole world and has resulted in large number of morbidity and...The coronavirus disease 2019(COVID-19)pandemic caused by the novel beta coronavirus severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)crippled the whole world and has resulted in large number of morbidity and mortality.The origin of the SARS-CoV-2 is still disputed.The risk of infection with SARS-CoV-2 is dependent on several risk factors as observed in many studies.The severity of the disease depends on many factors including the viral strain,host immunogenetics,environmental factors,host genetics,host nutritional status and presence of comorbidities like hypertension,diabetes,Chronic Obstructive Pulmonary Disease,cardiovascular disease,renal impairment.Diabetes is a metabolic disorder mainly characterized by hyperglycemia.Diabetic individuals are intrinsically prone to infections.SARS-CoV-2 infection in patients with diabetes result inβ-cell damage and cytokine storm.Damage to the cells impairs the equilibrium of glucose,leading to hyperglycemia.The ensuing cytokine storm causes insulin resistance,especially in the muscles and liver,which also causes a hyperglycemic state.All of these increase the severity of COVID-19.Genetics also play pivotal role in disease pathogenesis.This review article focuses from the probable sources of coronaviruses and SARS-CoV-2 to its impacts on individuals with diabetes and host genetics in pre-and post-pandemic era.展开更多
A research team jointly led by Dr.SHI Zhengli and Dr.ZHOU Peng from the CAS Wuhan Institute of Virology and their collaborators have discovered a novel MERS-like coronavirus in Malayan pangolins,the world’s most traf...A research team jointly led by Dr.SHI Zhengli and Dr.ZHOU Peng from the CAS Wuhan Institute of Virology and their collaborators have discovered a novel MERS-like coronavirus in Malayan pangolins,the world’s most trafficked mammals(doi:10.1016/j.cell.2023.01.019).展开更多
磁能恢复开关MERS(magnetic energy recovery switch)是一种新型的无功补偿装置,它相较于其他无功补偿装置,具有结构简单、易于控制和损耗低等诸多优点,但在进行无功功率补偿的过程中会产生谐波电流。首先,在对MERS的结构和控制方法阐...磁能恢复开关MERS(magnetic energy recovery switch)是一种新型的无功补偿装置,它相较于其他无功补偿装置,具有结构简单、易于控制和损耗低等诸多优点,但在进行无功功率补偿的过程中会产生谐波电流。首先,在对MERS的结构和控制方法阐述的基础上建立了三相对称系统中SVC-MERS的数学模型,讨论分析了控制参数对三相对称系统中线电流谐波特性的影响;进而提出了控制参数的优化设计方法。仿真和实验结果表明,通过控制参数的优化设计可以有效地减小三相对称系统中线电流的谐波含量,所提控制参数的优化设计方法是可行的。展开更多
文摘The coronavirus disease 2019(COVID-19)pandemic caused by the novel beta coronavirus severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)crippled the whole world and has resulted in large number of morbidity and mortality.The origin of the SARS-CoV-2 is still disputed.The risk of infection with SARS-CoV-2 is dependent on several risk factors as observed in many studies.The severity of the disease depends on many factors including the viral strain,host immunogenetics,environmental factors,host genetics,host nutritional status and presence of comorbidities like hypertension,diabetes,Chronic Obstructive Pulmonary Disease,cardiovascular disease,renal impairment.Diabetes is a metabolic disorder mainly characterized by hyperglycemia.Diabetic individuals are intrinsically prone to infections.SARS-CoV-2 infection in patients with diabetes result inβ-cell damage and cytokine storm.Damage to the cells impairs the equilibrium of glucose,leading to hyperglycemia.The ensuing cytokine storm causes insulin resistance,especially in the muscles and liver,which also causes a hyperglycemic state.All of these increase the severity of COVID-19.Genetics also play pivotal role in disease pathogenesis.This review article focuses from the probable sources of coronaviruses and SARS-CoV-2 to its impacts on individuals with diabetes and host genetics in pre-and post-pandemic era.
文摘A research team jointly led by Dr.SHI Zhengli and Dr.ZHOU Peng from the CAS Wuhan Institute of Virology and their collaborators have discovered a novel MERS-like coronavirus in Malayan pangolins,the world’s most trafficked mammals(doi:10.1016/j.cell.2023.01.019).
文摘磁能恢复开关MERS(magnetic energy recovery switch)是一种新型的无功补偿装置,它相较于其他无功补偿装置,具有结构简单、易于控制和损耗低等诸多优点,但在进行无功功率补偿的过程中会产生谐波电流。首先,在对MERS的结构和控制方法阐述的基础上建立了三相对称系统中SVC-MERS的数学模型,讨论分析了控制参数对三相对称系统中线电流谐波特性的影响;进而提出了控制参数的优化设计方法。仿真和实验结果表明,通过控制参数的优化设计可以有效地减小三相对称系统中线电流的谐波含量,所提控制参数的优化设计方法是可行的。
