Inflammatory cells infiltrated in glomeruli and proliferating glomerular cells were immunohistochemically studied in 87 renal biopsies from patients withglomerulonephritides(GN) of various types, by using monoclonal a...Inflammatory cells infiltrated in glomeruli and proliferating glomerular cells were immunohistochemically studied in 87 renal biopsies from patients withglomerulonephritides(GN) of various types, by using monoclonal antibody toMac387 and PCNA(proliferative cell nuclear antigen) respectively. The resultsshowed that the expressions of Mac387 and PCNA were generally increased inproliferative GN , compared with non-proliferative GN. The expression of Mac387was related to the severity of mesangial cell proliferation determined by light microscopy, but the increase of PCNA expression was found in severely proliferativeGN. Although certain relationship between Mac387 and PCNA expression onglomerular cells was observed. it was not statistically significant. Finally, thepossible mechanism of glomerular mesangial proliferation was discussed.展开更多
文摘Inflammatory cells infiltrated in glomeruli and proliferating glomerular cells were immunohistochemically studied in 87 renal biopsies from patients withglomerulonephritides(GN) of various types, by using monoclonal antibody toMac387 and PCNA(proliferative cell nuclear antigen) respectively. The resultsshowed that the expressions of Mac387 and PCNA were generally increased inproliferative GN , compared with non-proliferative GN. The expression of Mac387was related to the severity of mesangial cell proliferation determined by light microscopy, but the increase of PCNA expression was found in severely proliferativeGN. Although certain relationship between Mac387 and PCNA expression onglomerular cells was observed. it was not statistically significant. Finally, thepossible mechanism of glomerular mesangial proliferation was discussed.
