Objective:To synthesize the knowledge about the association of total physical activity(TPA),leisure-time phys-ical activity(LTPA),occupational physical activity(OPA)and lung cancer risk and explore the dose-response r...Objective:To synthesize the knowledge about the association of total physical activity(TPA),leisure-time phys-ical activity(LTPA),occupational physical activity(OPA)and lung cancer risk and explore the dose-response relationship between LTPA level and lung cancer.Methods:PubMed and Web of Science were searched up to 17 November 2021.The summary relative risks(RRs)and 95%confidence intervals(CIs)were calculated by random-effects or fixed-effects model.The dose-response analysis was conducted with restricted cubic splines.Results:We identified 25 articles(42 cohort studies)that assessed the physical activity-lung cancer association,including 9,983,295 study participants and 85,988 incident cases of lung cancer.When comparing the highest to the lowest level of TPA and LTPA,lung cancer risk reduced 22%(RR,0.78;95%CI:0.70,0.86)and 12%(RR,0.88;95%CI:0.83,0.93),respectively.We found an approximately U-shaped association between LTPA and lung cancer(P non-linearity<0.001),with the lowest risk at 15 metabolic equivalent of task hours per week(h/wk)of LTPA.Compared to participants with sitting occupations,lung cancer risk significantly increased among those being unemployed(RR,1.33;95%CI:1.17,1.51)or with standing occupations(RR,1.37;95%CI:1.15,1.63),but not among those with light or high OPA.Conclusions:Our meta-analysis supported a protective effect of TPA and LTPA,but not OPA,on lung cancer risk.The novel finding of a U-shaped association between LTPA and lung cancer risk warrants further investigation.展开更多
基金supported by the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences(grant number:2021-RC310-009).
文摘Objective:To synthesize the knowledge about the association of total physical activity(TPA),leisure-time phys-ical activity(LTPA),occupational physical activity(OPA)and lung cancer risk and explore the dose-response relationship between LTPA level and lung cancer.Methods:PubMed and Web of Science were searched up to 17 November 2021.The summary relative risks(RRs)and 95%confidence intervals(CIs)were calculated by random-effects or fixed-effects model.The dose-response analysis was conducted with restricted cubic splines.Results:We identified 25 articles(42 cohort studies)that assessed the physical activity-lung cancer association,including 9,983,295 study participants and 85,988 incident cases of lung cancer.When comparing the highest to the lowest level of TPA and LTPA,lung cancer risk reduced 22%(RR,0.78;95%CI:0.70,0.86)and 12%(RR,0.88;95%CI:0.83,0.93),respectively.We found an approximately U-shaped association between LTPA and lung cancer(P non-linearity<0.001),with the lowest risk at 15 metabolic equivalent of task hours per week(h/wk)of LTPA.Compared to participants with sitting occupations,lung cancer risk significantly increased among those being unemployed(RR,1.33;95%CI:1.17,1.51)or with standing occupations(RR,1.37;95%CI:1.15,1.63),but not among those with light or high OPA.Conclusions:Our meta-analysis supported a protective effect of TPA and LTPA,but not OPA,on lung cancer risk.The novel finding of a U-shaped association between LTPA and lung cancer risk warrants further investigation.
