Metabolic cardiovascular diseases have become a global health concern,and some of their risk factors are linked to several metabolic disorders.They are the leading causes of death in developing countries.Adipose tissu...Metabolic cardiovascular diseases have become a global health concern,and some of their risk factors are linked to several metabolic disorders.They are the leading causes of death in developing countries.Adipose tissues secrete a variety of adipokines that participate in regulating metabolism and various pathophysiological processes.Adiponectin is the most abundant pleiotropic adipokine and can increase insulin sensitivity,improve atherosclerosis,have anti-inflammatory properties,and exert a cardioprotective effect.Low adiponectin con-centrations are correlated with myocardial infarction,coronary atherosclerotic heart disease,hypertrophy,hypertension,and other metabolic cardiovascular dysfunctions.However,the relationship between adiponectin and cardiovascular diseases is complex,and the specific mechanism of action is not fully understood.Our summary and analysis of these issues are ex-pected to contribute to future treatment options.展开更多
Objective To evaluate the association of fasting plasma glucose(FPG)level over 5.3 mmol/L with the development of abnormal glucose metabolism and cardiovascular disease(CVD).Methods This was a retrospec-tive cohort st...Objective To evaluate the association of fasting plasma glucose(FPG)level over 5.3 mmol/L with the development of abnormal glucose metabolism and cardiovascular disease(CVD).Methods This was a retrospec-tive cohort study with 1 064 non-diabetic subjects(980males;84 females)aged 60 or over,who carried out annual health check-up in Chinese PLA General展开更多
CD4^(+)FOXP3^(+)regulatory T cells(Tregs)are a subset of CD4 T cells that play an essential role in maintaining peripheral immune tolerance,controlling acute and chronic inflammation,allergy,autoimmune diseases,and an...CD4^(+)FOXP3^(+)regulatory T cells(Tregs)are a subset of CD4 T cells that play an essential role in maintaining peripheral immune tolerance,controlling acute and chronic inflammation,allergy,autoimmune diseases,and anti-cancer immune responses.Over the past 20 years,a significant progress has been made since Tregs were first characterized in 1995.Many concepts and principles regarding Tregs generation,phenotypic features,subsets(tTregs,pTregs,iTregs,and iTreg35),tissue specificity(central Tregs,effector Tregs,and tissue resident Tregs),homeostasis(highly dynamic and apoptotic),regulation of Tregs by receptors for PAMPs and DAMPs,Treg plasticity(re-differentiation to other CD4 T helper cell subsets,Th1,Th2,Tfh,and Th17),and epigenetic regulation of Tregs phenotypes and functions have been innovated.In this concise review,we want to briefly analyze these eight new progresses in the study of Tregs.We have also proposed for the first time a novel concept that“physiological Tregs”have been re-shaped into“pathological Tregs”in various pathological environments.Continuing of the improvement in our understanding on this important cellular component about the immune tolerance and immune suppression would lead to the future development of novel therapeutics approaches for acute and chronic inflammatory diseases,allergy,allogeneic transplantation-related immunity,sepsis,autoimmune diseases,and cancers.展开更多
基金supported by grants from the National Natural Science Foundation of China(No.82000792)General Project of Chongqing Natural Science Foundation(China)(No.cstc2020jcyj-msxm0409)+2 种基金Chongqing Science and Technology Bureau and Health Commission of Chinese Medicine Technology Innovation and Application Development Project(China)(No.2020ZY013540)General Project of Graduate Education and Teaching Reform of Chongqing University,Chongqing,China(No.cquyjg20329)Science and Health Joint Project of Dazu District Science and Technology Bureau(China)(No.DZKJ,2022CCC1001).
文摘Metabolic cardiovascular diseases have become a global health concern,and some of their risk factors are linked to several metabolic disorders.They are the leading causes of death in developing countries.Adipose tissues secrete a variety of adipokines that participate in regulating metabolism and various pathophysiological processes.Adiponectin is the most abundant pleiotropic adipokine and can increase insulin sensitivity,improve atherosclerosis,have anti-inflammatory properties,and exert a cardioprotective effect.Low adiponectin con-centrations are correlated with myocardial infarction,coronary atherosclerotic heart disease,hypertrophy,hypertension,and other metabolic cardiovascular dysfunctions.However,the relationship between adiponectin and cardiovascular diseases is complex,and the specific mechanism of action is not fully understood.Our summary and analysis of these issues are ex-pected to contribute to future treatment options.
文摘Objective To evaluate the association of fasting plasma glucose(FPG)level over 5.3 mmol/L with the development of abnormal glucose metabolism and cardiovascular disease(CVD).Methods This was a retrospec-tive cohort study with 1 064 non-diabetic subjects(980males;84 females)aged 60 or over,who carried out annual health check-up in Chinese PLA General
文摘CD4^(+)FOXP3^(+)regulatory T cells(Tregs)are a subset of CD4 T cells that play an essential role in maintaining peripheral immune tolerance,controlling acute and chronic inflammation,allergy,autoimmune diseases,and anti-cancer immune responses.Over the past 20 years,a significant progress has been made since Tregs were first characterized in 1995.Many concepts and principles regarding Tregs generation,phenotypic features,subsets(tTregs,pTregs,iTregs,and iTreg35),tissue specificity(central Tregs,effector Tregs,and tissue resident Tregs),homeostasis(highly dynamic and apoptotic),regulation of Tregs by receptors for PAMPs and DAMPs,Treg plasticity(re-differentiation to other CD4 T helper cell subsets,Th1,Th2,Tfh,and Th17),and epigenetic regulation of Tregs phenotypes and functions have been innovated.In this concise review,we want to briefly analyze these eight new progresses in the study of Tregs.We have also proposed for the first time a novel concept that“physiological Tregs”have been re-shaped into“pathological Tregs”in various pathological environments.Continuing of the improvement in our understanding on this important cellular component about the immune tolerance and immune suppression would lead to the future development of novel therapeutics approaches for acute and chronic inflammatory diseases,allergy,allogeneic transplantation-related immunity,sepsis,autoimmune diseases,and cancers.
