Vitamin C-based cluster therapy,which involves the combined application of hydrocortisone,vitamin C,and thiamine(HAT),is a recently proposed new treatment option for sepsis on top of conventional treatment.This therap...Vitamin C-based cluster therapy,which involves the combined application of hydrocortisone,vitamin C,and thiamine(HAT),is a recently proposed new treatment option for sepsis on top of conventional treatment.This therapy has a strong theoretical basis,but its clinical efficacy remains inconclusive.This review summarizes the rationale for HAT therapy for sepsis and describes the evaluation of its efficacy in clinical observational studies and randomized controlled trials,with the aim of providing a reference for the future clinical practice application of HAT therapy in sepsis.展开更多
基金supported by the United Fund of the National Natural Science Foundation of China (grant number:U2004110)the National Natural Science Foundation of China (grant number:82172129)+3 种基金the Central Government Guides Local Science and Technology Development funds (grant number:Z20221343037)the Medical Science and Technology Tackling Plan Provincial and Ministerial Major Projects of Henan Province (grant number:SBGJ202101015)the special fund for young and middle-aged medical research of China International Medical Exchange Foundation (grant number:Z-2018-35)the integrated thinking research fund of China International Medical Exchange Foundation (grant number:Z-2016-23-2001).
文摘Vitamin C-based cluster therapy,which involves the combined application of hydrocortisone,vitamin C,and thiamine(HAT),is a recently proposed new treatment option for sepsis on top of conventional treatment.This therapy has a strong theoretical basis,but its clinical efficacy remains inconclusive.This review summarizes the rationale for HAT therapy for sepsis and describes the evaluation of its efficacy in clinical observational studies and randomized controlled trials,with the aim of providing a reference for the future clinical practice application of HAT therapy in sepsis.
