Cancer risk and key components of metabolic syndrome：a population-based prospective cohort study in Chinese

Background The key components of metabolic syndrome （MS） are waist circumference,blood pressure,fast blood glucose,high density lipoprotein cholesterol （HDL-c） and triglycerides （TG）.These components have,separately and jointly,been associated with an increased risk of cardiovascular diseases.In this study,we aimed to explore the association between MS components and cancer risk in a population-based cohort in China.Methods We established a population-based cohort with 17 779 individuals aged 35 and above at baseline in 2004 and 2005 in Changzhou,Jiangsu Province,China.All participants were face-to-face interviewed to complete a questionnaire and were accepted physical examinations including blood tests for glucose and lipids and physical measurements for obesity and blood pressure.In 2009,a total of 16 284 subjects （6886 men and 9398 women,91.6%） attended the flow-up interviews and the participants or their family members reported all the hospitalizations and diseases including cancer occurred during the follow-up period.Multivariate Cox regression was used to estimate the hazard ratios （HRs） of metabolic syndrome components and cancer incidence.Results There was a dose-response association between cancer risk and the number of MS components presented at baseline （P for trend=0.012） and the HR （95% confidence interval （CI）） was 2.63 （1.27-5.45） for subjects carrying 3 or more metabolic syndrome components after adjustment for possible confounding factors.Specifically,the multivariate-adjusted HRs （95% CIs） for cancer risk in subjects with central obesity,high fasting glucose,low HDL-c were 1.94 （1.01-3.74）,2.04 （1.10-3.77） and 2.05 （1.09-3.88）,respectively.Conclusions In this population-based,prospective cohort study in China,we found MS components,e.g.,central obesity,high fasting glucose,low HDL-c were risk factors for cancer development.Early intervention of MS components may be also beneficial to reduce cancer burden.

Evaluation of DNA damage profile in obese women and its association to risk of metabolic syndrome,polycystic ovary syndrome and recurrent preeclampsia

Metabolic syndrome(MS)is a cluster of metabolic abnormalities.Obesity and MS are always accompanied by elevated oxidative stress which might affect cellular biomolecules such as DNA.The aim of the present study is to investigate DNA damage profile in obese premenopausal women and its relation to the risk of MS,polycystic ovary syndrome(PCOS)and history of recurrent pre-eclampsia.The study included 90 obese women included cases with MS(nZ30),PCOS(n Z30)and previous history of recurrent preeclampsia(nZ30)and,age-matched healthy non-obese control women(n Z 50).The assessment of leukocyte DNA damage was done by comet assay for all cases and controls.Anthropometry and biochemical parameters have been measured.Results showed that mean percent of DNA damage was significantly higher in MS,PCOS as well as in women with the recurrent preeclampsia as compared to healthy controls.The high level of mean DNA damage frequency in obese women was significantly associated with the increased number of metabolic syndrome components.Cases with 2,3 and 3e5 components showed significantly higher levels of DNA damage than controls.Moreover,cases with 3e5 MS components showed significant higher DNA compared to those with the two components.Regarding PCOS,significant positive association between the mean frequency of DNA damage and waist circumference was observed.The study suggests that metabolic abnormalities,PCOS and recurrent pre-eclampsia might be contributed in development of DNA damage in obese women.DNA damage can serve as an early marker for obesity complications in premenopausal women.