Background:A number of studies document the prevalence of Taenia solium infections in Nigeria,yet these studies do not cover porcine cysticercosis in private home slaughter slabs where there is no routine meat inspect...Background:A number of studies document the prevalence of Taenia solium infections in Nigeria,yet these studies do not cover porcine cysticercosis in private home slaughter slabs where there is no routine meat inspection and backyard pig keeping,slaughtering and sale are common practice.Methods:An environmental and sanitary assessment was conducted within two unregistered home pig slaughter slabs in selected parts of the Kaduna metropolis in Nigeria.Slaughter premises were inspected for availability of basic facilities and questionnaires were used to elicit necessary informative data.Butchers were examined for taeniasis by stool microscopy and copro-antigen enzyme linked immunosorbent assay(copro-Ag ELISA)to ascertain T.solium-taeniasis.Pigs slaughtered at the premises were examined for cysticerci.Results:Home slaughter conditions were substandard,unhygienic and lacked the basic facilities of a proper slaughterhouse.Prevalence of porcine cysticercosis was 9.3%.The butchers participating in the study had very poor knowledge of T.solium infections and 30%tested positive for taeniasis by copro-Ag ELISA at the time of the study.Conclusion:Home slaughter of pigs in the areas studied should be considered and integrated as a component of prevention and control programmes-particularly through educational interventions-in order to equip individuals involved with a good understanding of the risks associated with animal husbandry and human practices.展开更多
A biochemical some enzymes of glycolysis and a partial reversed tricarboxylic acid cycle together with hydrolytic enzymes in the cyst wall of Echinococcus granulosus was carried out. Lactate dehydrogenase (LDH), pyruv...A biochemical some enzymes of glycolysis and a partial reversed tricarboxylic acid cycle together with hydrolytic enzymes in the cyst wall of Echinococcus granulosus was carried out. Lactate dehydrogenase (LDH), pyruvate kinase (PK), phosphoenolpyruvate carboxykinase (PEPCK), and adenosine triphosphatase (ATPase) showed their high level of activity, suggesting that the proliferation of E. granulosus cyst wall is an energy-dependent process and the major pathways for glucose metabolism is glycolysis. Treatment of E. granulosus-in-fected mice with mebendazole and albendazole resulted in marked inhibition of PK, PEPCK and ATPase of E. granulosus cyst wall, whereas praziquantel had no effect, indicating that PK, PEPCK, and ATPase might be chemotherapeutic targets and the differences in the inhibitory effects might account for the efficacy of the three antihydatid drugs.展开更多
文摘Background:A number of studies document the prevalence of Taenia solium infections in Nigeria,yet these studies do not cover porcine cysticercosis in private home slaughter slabs where there is no routine meat inspection and backyard pig keeping,slaughtering and sale are common practice.Methods:An environmental and sanitary assessment was conducted within two unregistered home pig slaughter slabs in selected parts of the Kaduna metropolis in Nigeria.Slaughter premises were inspected for availability of basic facilities and questionnaires were used to elicit necessary informative data.Butchers were examined for taeniasis by stool microscopy and copro-antigen enzyme linked immunosorbent assay(copro-Ag ELISA)to ascertain T.solium-taeniasis.Pigs slaughtered at the premises were examined for cysticerci.Results:Home slaughter conditions were substandard,unhygienic and lacked the basic facilities of a proper slaughterhouse.Prevalence of porcine cysticercosis was 9.3%.The butchers participating in the study had very poor knowledge of T.solium infections and 30%tested positive for taeniasis by copro-Ag ELISA at the time of the study.Conclusion:Home slaughter of pigs in the areas studied should be considered and integrated as a component of prevention and control programmes-particularly through educational interventions-in order to equip individuals involved with a good understanding of the risks associated with animal husbandry and human practices.
文摘A biochemical some enzymes of glycolysis and a partial reversed tricarboxylic acid cycle together with hydrolytic enzymes in the cyst wall of Echinococcus granulosus was carried out. Lactate dehydrogenase (LDH), pyruvate kinase (PK), phosphoenolpyruvate carboxykinase (PEPCK), and adenosine triphosphatase (ATPase) showed their high level of activity, suggesting that the proliferation of E. granulosus cyst wall is an energy-dependent process and the major pathways for glucose metabolism is glycolysis. Treatment of E. granulosus-in-fected mice with mebendazole and albendazole resulted in marked inhibition of PK, PEPCK and ATPase of E. granulosus cyst wall, whereas praziquantel had no effect, indicating that PK, PEPCK, and ATPase might be chemotherapeutic targets and the differences in the inhibitory effects might account for the efficacy of the three antihydatid drugs.
