Background： The vitamin D receptor （VDR） gene has been identified as a candidate gene liar susceptibility to Parkinson＇s disease （PD）, but results from genetic association studies to date are inconsistent. Here,...Background： The vitamin D receptor （VDR） gene has been identified as a candidate gene liar susceptibility to Parkinson＇s disease （PD）, but results from genetic association studies to date are inconsistent. Here, we conducted a meta-analysis of published case-control studies to evaluate the association of tile extensively studied VDR Apal （G/T）, Bsml （G/A）, Fokl （C/T）, and Taql （T/C） gene polymorphisms with risk of PD. Methods： Electronic search at PubMed, EMBASE, EBSCO, China National Knowledge Infrastructure, Weipu database, and Wanfang database was conducted to identify all relevant studies. Odds ratio （OR） with 95% confidence interval （（7） values was applied to evaluate the strength of the association. Results： A total of seven studies with 2034 PD cases and 2432 controls were included in the rneta-analysis following the inclusion and exclusion criteria. Overall, no significant association between Apal, Bsml, and Taql gene polymorphisms and PD susceptibility in all four genetic models was found （T vs. G： OR = 1.00, 95% CI： 0.89-1.12, P = 0.97; A vs. G： OR 0.94, 95% （7： 0.77-1.15, P =0.53; C vs. T： OR - 1.03, 95% （7： 0.85-1.25, P = 0.77） while a significant association between Fokl （C/T） and PD risk was observed （Cvs. T：OR 1.41,95%（7：1.14 1.75, P=0.001;CCvs. TT：OR-2.45,95%（_7：1.52 3.93, P=0.0002：CTvs. TT：OR-2.21,95% CI： 1.38--3.52, P =0.0009, CC vs. CT＋TT： OR - 2.32, 95% CI： 1.49-3.61, P = 0.0002）. Conclusions： Polymorphisms of Apal, BsmL and l,lql may not be associated with the susceptibility to PD while the Fokl （C/T） polymorphism is possibly associated with increased PD risk. However, conclusions should be cautiously interpreted due to the relatively small number of studies included.展开更多
基金a grant from the Natural Science Foundation of Shandong Province,China
文摘Background： The vitamin D receptor （VDR） gene has been identified as a candidate gene liar susceptibility to Parkinson＇s disease （PD）, but results from genetic association studies to date are inconsistent. Here, we conducted a meta-analysis of published case-control studies to evaluate the association of tile extensively studied VDR Apal （G/T）, Bsml （G/A）, Fokl （C/T）, and Taql （T/C） gene polymorphisms with risk of PD. Methods： Electronic search at PubMed, EMBASE, EBSCO, China National Knowledge Infrastructure, Weipu database, and Wanfang database was conducted to identify all relevant studies. Odds ratio （OR） with 95% confidence interval （（7） values was applied to evaluate the strength of the association. Results： A total of seven studies with 2034 PD cases and 2432 controls were included in the rneta-analysis following the inclusion and exclusion criteria. Overall, no significant association between Apal, Bsml, and Taql gene polymorphisms and PD susceptibility in all four genetic models was found （T vs. G： OR = 1.00, 95% CI： 0.89-1.12, P = 0.97; A vs. G： OR 0.94, 95% （7： 0.77-1.15, P =0.53; C vs. T： OR - 1.03, 95% （7： 0.85-1.25, P = 0.77） while a significant association between Fokl （C/T） and PD risk was observed （Cvs. T：OR 1.41,95%（7：1.14 1.75, P=0.001;CCvs. TT：OR-2.45,95%（_7：1.52 3.93, P=0.0002：CTvs. TT：OR-2.21,95% CI： 1.38--3.52, P =0.0009, CC vs. CT＋TT： OR - 2.32, 95% CI： 1.49-3.61, P = 0.0002）. Conclusions： Polymorphisms of Apal, BsmL and l,lql may not be associated with the susceptibility to PD while the Fokl （C/T） polymorphism is possibly associated with increased PD risk. However, conclusions should be cautiously interpreted due to the relatively small number of studies included.
