Microwave radiation was applied to the detection of metamizole sodium by cyclic voltammetry. The electrochemical characteristics of metamizole sodium were studied by cyclic voltammetry at GC electrode under microwave ...Microwave radiation was applied to the detection of metamizole sodium by cyclic voltammetry. The electrochemical characteristics of metamizole sodium were studied by cyclic voltammetry at GC electrode under microwave radiation and a considerable current enhancement was observed for metamizole sodium in aqueous 0.05 mol/L H2SO4. Under the optional conditions, metamizole sodium was determined in the absence and presence of microwave activation. In the absence of microwave activation cyclic voltammogram of metamizole sodium shows good linear relationship in a concentration range of 8.0×10^-5-1.0×10^-3 mol/L in aqueous 0.05 mol/L H2SO4 with a detection limit of 6.75× 10^-6 mol/L（S/N=3） and the equation of linear regression is Ip=12.973c-0.1905（R^2=0.9996, n=6）; in the presence of 80 W microwave activation cyclic voltammogram of metamizole sodiumin shows good linear relationship in a concentration range of 4.0× 10^-5-1.0×10^-3 mol/L in aqueous 0.05 mol/L H2SO4 with a detection limit of 4,41 × 10^-6 mol/L（S/N=3） and the equation of linear regression is Ip=25.107c-0.1193（R^2=0.9973, n=7）. The current in the presence of 80 W microwave activation increases to about 2 orders of magnitude compared with that in the absence of microwave activation. The proposed method in the presence of microwave activation showed high selectivity and sensitivity, and the sampling of the disposal method is simple. The method was verified by the determination of Metamizole Sodium tablet with satisfactory results.展开更多
Metamizole sodium was chosen as a representative of unstable analytes for investigation by discussing the effects of oxygen and solvent on its degradation reaction using the capillary electmphoresis technique. A possi...Metamizole sodium was chosen as a representative of unstable analytes for investigation by discussing the effects of oxygen and solvent on its degradation reaction using the capillary electmphoresis technique. A possible degradation mechanism was deduced from the observed behavior and was confirmed by infra-red spectroscopic study. The degradation reaction could be inhibited obviously by methanol instead of water as the solvent of analyte. Under the optimized conditions： separation voltage of 20 kV, and 5 mmol/L disodium hydrogen phosphate and 5 mmol/L borax with 10% methanol（pH 9. 12） as the running buffer, the standard curve of metamizole sodium was linear in a range of 3.77- 74. 07 mg/L. A satisfactory result was achieved when the technique was used to detect metamizole sodium in tablet.展开更多
基金Supported by the National Natural Science Foundation of China(No.20665001)the Natural Science Foundation of Guangxi Province,China(No.0832062)
文摘Microwave radiation was applied to the detection of metamizole sodium by cyclic voltammetry. The electrochemical characteristics of metamizole sodium were studied by cyclic voltammetry at GC electrode under microwave radiation and a considerable current enhancement was observed for metamizole sodium in aqueous 0.05 mol/L H2SO4. Under the optional conditions, metamizole sodium was determined in the absence and presence of microwave activation. In the absence of microwave activation cyclic voltammogram of metamizole sodium shows good linear relationship in a concentration range of 8.0×10^-5-1.0×10^-3 mol/L in aqueous 0.05 mol/L H2SO4 with a detection limit of 6.75× 10^-6 mol/L（S/N=3） and the equation of linear regression is Ip=12.973c-0.1905（R^2=0.9996, n=6）; in the presence of 80 W microwave activation cyclic voltammogram of metamizole sodiumin shows good linear relationship in a concentration range of 4.0× 10^-5-1.0×10^-3 mol/L in aqueous 0.05 mol/L H2SO4 with a detection limit of 4,41 × 10^-6 mol/L（S/N=3） and the equation of linear regression is Ip=25.107c-0.1193（R^2=0.9973, n=7）. The current in the presence of 80 W microwave activation increases to about 2 orders of magnitude compared with that in the absence of microwave activation. The proposed method in the presence of microwave activation showed high selectivity and sensitivity, and the sampling of the disposal method is simple. The method was verified by the determination of Metamizole Sodium tablet with satisfactory results.
基金Supported by the National Basic Research Program of China(No.2006CB605305).
文摘Metamizole sodium was chosen as a representative of unstable analytes for investigation by discussing the effects of oxygen and solvent on its degradation reaction using the capillary electmphoresis technique. A possible degradation mechanism was deduced from the observed behavior and was confirmed by infra-red spectroscopic study. The degradation reaction could be inhibited obviously by methanol instead of water as the solvent of analyte. Under the optimized conditions： separation voltage of 20 kV, and 5 mmol/L disodium hydrogen phosphate and 5 mmol/L borax with 10% methanol（pH 9. 12） as the running buffer, the standard curve of metamizole sodium was linear in a range of 3.77- 74. 07 mg/L. A satisfactory result was achieved when the technique was used to detect metamizole sodium in tablet.
