First-principles calculations were used to study the energetics and electronic structures of Ni and Sc co-doped MgH<sub>2</sub> system. The preferential positions for dopants were determined by the minimal...First-principles calculations were used to study the energetics and electronic structures of Ni and Sc co-doped MgH<sub>2</sub> system. The preferential positions for dopants were determined by the minimal total electronic energy. The results of formation enthalpy indicate that Ni and Sc co-doped MgH<sub>2</sub> system is more stable than Ni single-doped system. The hydrogen desorption enthalpies of these two hydrides are investigated. Ni and Sc co-doping can improve the dehydrogenation properties of MgH<sub>2</sub>. The lowest hydrogen desorption enthalpy of 0.30 eV appears in co-doped system, which is significantly lower than that of Ni doping. The electronic structure analysis illustrates that the hybridization of dopants with Mg and H atom together weakens the Mg-H interaction. And the Mg-H bonds are more susceptible to dissociate by Ni and Sc co-doping because of the reduced magnitude of Mg-H hybridization peaks. These behaviors effectively improve the dehydrogenation properties of Ni and Sc co-doped cases.展开更多
目的:观察针刺结合乳乐冲剂对乳腺增生(MGH)大鼠乳房组织、泌乳素(PRL)及其受体(PRLR)表达的影响,探讨其作用机制,为临床治疗MGH提供参考。方法:将55只雌性SD大鼠随机分为空白组、模型组、针刺组、乳乐组、针药组。除空白组外,其余各组...目的:观察针刺结合乳乐冲剂对乳腺增生(MGH)大鼠乳房组织、泌乳素(PRL)及其受体(PRLR)表达的影响,探讨其作用机制,为临床治疗MGH提供参考。方法:将55只雌性SD大鼠随机分为空白组、模型组、针刺组、乳乐组、针药组。除空白组外,其余各组均采用外源性雌、孕激素联合刺激制作大鼠MGH模型。造模成功后第1天起各治疗组开始施予相应治疗方法。针刺组取甲(天宗、肝俞、足三里)、乙(屋翳、合谷、膻中)两组穴,每次针刺一组穴,两组穴交替;乳乐组灌服乳乐冲剂(柴胡疏肝散化裁),每次3 m L;针药组先行中药灌服(同乳乐组),再予针刺(同针刺组),均每日1次。连续治疗30 d后腹主动脉采血,采用酶联免疫分析(ELISA)法检测血清PRL;光镜下观察乳腺组织苏木素-伊红(HE)染色切片和SABC免疫组化法PRLR阳性表达情况。结果:模型组大鼠乳房组织形态学符合增生表现,与空白组比较,血清PRL含量及PRLR阳性表达显著增高(均P<0.01);与模型组比较,各治疗组大鼠乳腺组织增生均明显改善,PRL水平及PRLR阳性表达显著降低(P<0.05,P<0.01),其中针药组改善最为明显(均P<0.05)。结论:针刺、乳乐冲剂、针药结合治疗MGH均有效,其机制可能是通过降低血清PRL水平,抑制PRL与PRLR的结合,间接抑制雌二醇水平,从而使增生的乳腺得以复旧。相对于单纯针刺和口服乳乐冲剂,针药结合方案总体疗效更佳。展开更多
文摘First-principles calculations were used to study the energetics and electronic structures of Ni and Sc co-doped MgH<sub>2</sub> system. The preferential positions for dopants were determined by the minimal total electronic energy. The results of formation enthalpy indicate that Ni and Sc co-doped MgH<sub>2</sub> system is more stable than Ni single-doped system. The hydrogen desorption enthalpies of these two hydrides are investigated. Ni and Sc co-doping can improve the dehydrogenation properties of MgH<sub>2</sub>. The lowest hydrogen desorption enthalpy of 0.30 eV appears in co-doped system, which is significantly lower than that of Ni doping. The electronic structure analysis illustrates that the hybridization of dopants with Mg and H atom together weakens the Mg-H interaction. And the Mg-H bonds are more susceptible to dissociate by Ni and Sc co-doping because of the reduced magnitude of Mg-H hybridization peaks. These behaviors effectively improve the dehydrogenation properties of Ni and Sc co-doped cases.
文摘目的:观察针刺结合乳乐冲剂对乳腺增生(MGH)大鼠乳房组织、泌乳素(PRL)及其受体(PRLR)表达的影响,探讨其作用机制,为临床治疗MGH提供参考。方法:将55只雌性SD大鼠随机分为空白组、模型组、针刺组、乳乐组、针药组。除空白组外,其余各组均采用外源性雌、孕激素联合刺激制作大鼠MGH模型。造模成功后第1天起各治疗组开始施予相应治疗方法。针刺组取甲(天宗、肝俞、足三里)、乙(屋翳、合谷、膻中)两组穴,每次针刺一组穴,两组穴交替;乳乐组灌服乳乐冲剂(柴胡疏肝散化裁),每次3 m L;针药组先行中药灌服(同乳乐组),再予针刺(同针刺组),均每日1次。连续治疗30 d后腹主动脉采血,采用酶联免疫分析(ELISA)法检测血清PRL;光镜下观察乳腺组织苏木素-伊红(HE)染色切片和SABC免疫组化法PRLR阳性表达情况。结果:模型组大鼠乳房组织形态学符合增生表现,与空白组比较,血清PRL含量及PRLR阳性表达显著增高(均P<0.01);与模型组比较,各治疗组大鼠乳腺组织增生均明显改善,PRL水平及PRLR阳性表达显著降低(P<0.05,P<0.01),其中针药组改善最为明显(均P<0.05)。结论:针刺、乳乐冲剂、针药结合治疗MGH均有效,其机制可能是通过降低血清PRL水平,抑制PRL与PRLR的结合,间接抑制雌二醇水平,从而使增生的乳腺得以复旧。相对于单纯针刺和口服乳乐冲剂,针药结合方案总体疗效更佳。
