Shugan Jieyu capsule effects on peripheral blood micro-124, micro- 132, and brain-derived neurotrophic factor in patients with mild to moderate depression

BACKGROUND To assess the effectiveness of Shugan Jieyu capsules on peripheral blood miR-124,miR-132,and brain-derived neurotrophic factor(BDNF)levels in patients with mild to moderate depression following coronary artery intervention[percuta-neous coronary intervention(PCI)]for coronary heart disease.Patients with mild-to-moderate depression of the liver-qi stagnation type after PCI for coronary heart disease at the 305th Hospital of the People’s Liberation Army were enrolled from June 2022 to November 2023 and randomly assigned to two groups:Experimental(treated with Shugan Jieyu capsules)and control(tr-eated with escitalopram oxalate tablets).This study compared the antidepressant effects of these treatments using 17-item Hamilton Rating Scale for Depression(HAMD-17)scores,metabolic equivalents,low-density lipoprotein cholesterol,BDNF,high-sensitivity C-reactive protein levels,miR-124 and miR-132 levels,distribution of immune-related lymphocyte subsets,and traditional Chinese me-dicine syndrome scores before and after 6 weeks of treatment.RESULTS No significant difference was observed in any index between the two groups before treatment(P>0.05).After treatment,the total efficacy rates were 93.33%and 90.00%in the experimental and control groups,respectively.Experimental group had significantly lower scores for the main and secondary syndromes compared to the control group(P<0.05).No significant difference was observed in the metabolic equivalents between the two groups be-fore and after treatment(P>0.05).The levels of low-density lipoprotein cholesterol,high-sensitivity C-reactive pro-tein,and miR-132 were significantly lower,whereas those of miR-124,BDNF,CD3+T lymphocytes,CD3+CD4+T helper lymphocytes,and CD3+CD4+/CD3+CD8+cells were significantly higher in the experimental group com-pared to the control group(P<0.05).The incidence of adverse reactions during experimental group was signi-ficantly lower than that in control group(P<0.05).CONCLUSION Shugan Jieyu capsules have good efficacy in patients with mild-to-moderate depression after PCI,and its me-chanism may contribute to the regulation of miR-124,miR-132,BDNF levels,and lymphoid immune cells.

Impacts of Micro- and Nano-Plastics on Soil Properties and Plant Production in Agroecosystems: A Mini-Review

Micro- and nano-plastics (MNPs) are tiny plastic particles resulting from plastic product degradation. Soil MNPs have been identified as potential influential factors affecting various soil properties and crop biomass productivity. This mini-review provides a synthesis of recent findings concerning their effects on soil physicochemical properties, microorganisms, organic carbon content, soil nutrients, greenhouse gas emissions, soil fauna, and their impacts on plant ecophysiology, growth, and production. The results indicate that MNPs may markedly impede soil aggregation ability, increase porosity, decrease soil bulk density, enhance water retention capacity, influence soil pH and electrical conductivity, and escalate soil water evaporation. Exposure to MNPs may predominantly induce changes in soil microbial composition, reducing the diversity and complexity of microbial communities and microbial activity while enhancing soil organic carbon stability, influencing soil nutrient dynamics, and stimulating organic carbon decomposition and denitrification processes, leading to elevated soil respiration and methane emissions, and potentially decreasing soil nitrous oxide emission. Additionally, MNPs may adversely affect soil fauna, diminish seed germination rates, promote plant root growth, yet impair plant photosynthetic efficacy and biomass productivity. These findings contribute to a better understanding of the impacts and mechanistic foundations of MNPs. Future research avenues are suggested to further explore the impacts and economic implications.

Effects of Hypergravity on Physiological and Biochemical Characteristics of Chinese Cabbage

The Chinese cabbage seed used in this study was Xinfengkang 90. The tested seeds were treated with 1 000×g, 2 000×g and 4 000×g of hypergravity for 20, 40 and 60 min respectively. The Chinese cabbage leaves were col ected at the early seedling stage for the determination of free proline content, POD activity and SOD activity. The results showed the free proline content was lowest in the seeds treated with 40-min 2 000-g gravity, while it was highest for the 60-min 4 000-g gravity treatment. Compared to the control, al the hypergravity treatments inhibited the synthesis of free proline. The POD activity was highest in the seeds treated with 20-min 1 000-g gravity, while it was lowest in the seeds treated with 60-min 2 000-g gravity. Considering the SOD activity, the 40-min 1 000-g gravity treatment was highest, and the 60-min 4 000-g gravity treatment was lowest. lt was indicated that appropriate hypergravity treatment was conducive to increasing the SOD activity.

Effects of Hypergravity on Salt Tolerance of Wheat Seedlings

[ Objective] The study aimed to reveal the effects of hypergravity on salt tolerance of wheat seedlings. [ Method ] The seed germination rate （Gr） and germination index （Gi） of wheat seedlings were measured under hypergravity of 600 × g or 1 000 × g for 4 h and under the stress of 0.4% or 0.9% salt solution. The catalase （CAT） activity and malondialdehyde （MDA） content of wheat seedlings were also measured under 0.4% salt stress. [Result] Compared with seedlings in CK group （no hypergravity or salt stress）, the Gr and Gi of the seedlings in salt stress treatment decreased to different extents; while the Gr and Gi of the seedlings in treatment group （hypergravity and salt stress） increased compared with that in salt stress group. CAT in seedlings of hypergravity treatment was higher than that of CK group and 0.4% salt treatment group, meanwhile the MDA showed an opposite result. [ Conclusion] Hypergravity could enhance the salt resistance of wheat in specific range, and hypergravity of 600 × g for 4 h performed better than that of 1 000 ×g for 4 h.

Ultrafast Synthesis of Metal-Layered Hydroxides in a Dozen Seconds for High-Performance Aqueous Zn(Micro-)Battery

Efficient synthesis of transition metal hydroxides on conductive substrate is essential for enhancing their merits in industrialization of energy storage field.However,most of the synthetic routes at present mainly rely on traditional bottom-up method,which involves tedious steps,time-consuming treatments,or additional alkaline media,and is unfavorable for high-efficiency production.Herein,we present a facile,ultrafast and general avenue to synthesize transition metal hydroxides on carbon substrate within 13 s by Joule-heating method.With high reaction kinetics caused by the instantaneous high temperature,seven kinds of transition metal-layered hydroxides(TM-LDHs)are formed on carbon cloth.Therein,the fastest synthesis rate reaches~0.46 cm^(2)s^(-1).Density functional theory calculations further demonstrate the nucleation energy barriers and potential mechanism for the formation of metal-based hydroxides on carbon substrates.This efficient approach avoids the use of extra agents,multiple steps,and long production time and endows the LDHs@carbon cloth with outstanding flexibility and machinability,showing practical advantages in both common and micro-zinc ion-based energy storage devices.To prove its utility,as a cathode in rechargeable aqueous alkaline Zn(micro-)battery,the NiCo LDH@carbon cloth exhibits a high energy density,superior to most transition metal LDH materials reported so far.

In-situ hydrocarbon formation and accumulation mechanisms of micro- and nano-scale pore-fracture in Gulong shale, Songliao Basin, NE China

By conducting experimental analyses, including thermal pyrolysis, micro-/nano-CT, argon-ion polishing field emission scanning electron microscopy (FE-SEM), confocal laser scanning microscopy (CLSM), and two-dimensional nuclear magnetic resonance (2D NMR), the Gulong shale oil in the Songliao Basin was investigated with respect to formation model, pore structure and accumulation mechanism. First, in the Gulong shale, there are a large number of pico-algae, nano-algae and dinoflagellates, which were formed in brackish water environment and constituted the hydrogen-rich oil source materials of shale. Second, most of the oil-generating materials of the Qingshankou Formation shale exist in the form of organo-clay complex. During organic matter thermal evolution, clay minerals had double effects of suppression and catalytic hydrogenation, which expanded shale oil window and increased light hydrocarbon yield. Third, the formation of storage space in the Gulong Shale was related to dissolution and hydrocarbon generation. With the diagenesis, micro-/nano-pores increased, pore diameter decreased and more bedding fractures appeared, which jointly gave rise to the unique reservoir with dual media (i.e. nano-scale pores and micro-scale bedding fractures) in the Gulong shale. Fourth, the micro-/nano-scale oil storage unit in the Gulong shale exhibits independent oil/gas occurrence phase, and shows that all-size pores contain oils, which occur in condensate state in micropores or in oil-gas two phase (or liquid) state in macropores/mesopores. The understanding about Gulong shale oil formation and accumulation mechanism has theoretical and practical significance for advancing continental shale oil exploration in China.

结合中医呼吸导引术的循环抗阻训练对女性心肺功能和超重耐力的影响

目的:通过测试8周基于中医呼吸导引术理论的循环抗阻训练前后青年女性最大摄氧量(VO_(2)max)、通气阈(VT)、心率(HR)、人体z轴的重力加速度(+Gz)超重耐力耐受时间等指标的变化,探讨循环抗阻训练的有效性及有氧运动能力与+Gz超重耐力的关系。方法:24名20~32岁无系统训练经验的青年女性按照安全随机抽样方法随机分为对照组和观察组,观察组进行8周中等强度的循环抗阻训练,训练3次/周,60 min/次,8周前后2组受试者分别进行运动心肺功能测试和超重耐力检查。结果:观察组8周前后自身比较,以及8周后观察组与对照组比较:VO_(2)max(P<0.05)、VT(P<0.01)、+Gz超重耐力耐受时间(P<0.05)均显著性增加;2)VO_(2)max数值在36~42 mL/(min·kg)区间范围内,受试者完成+3.5Gz的人数较多;3)VO_(2)max小于等于42 mL/(min·kg)时,超重耐力耐受时间与VO_(2)max、VT显著正相关(P<0.01)。结论:8周循环抗阻训练能够有效提高青年女性受试者的有氧运动能力和+Gz超重耐力水平;2)VO_(2)max数值在36~42 mL/(min·kg)区间范围内,女性受试者+Gz超重耐力耐受时间较高;3)通气阈心率(HRvt)可以作为一种无创运动强度控制手段在提高+Gz超重耐力的有氧耐力训练中进行科学使用。

UH模型超固结状态演化分析及离心模型试验验证

本构模型是土力学求解强度变形问题的关键。研究揭示了剑桥模型在超临界侧强度过高、超固结状态下无法应力三维化、应力应变关系发生突变等存在的问题,分析了UH模型建立的超固结状态耦合演化机制及在弹塑性理论框架下实现的超固结状态与正常固结状态计算理论的统一,并基于三轴试验预测证明了UH模型能更加合理地描述超固结状态下土的应力应变关系。通过开展载荷板离心模型试验以及数值模拟验证可以发现,相较于剑桥模型,UH模型计算的地基土荷载变形曲线、侧压力系数分布更加准确,其本质是单元的应力应变关系更加科学、合理。研究证明UH模型的应用能显著提高超固结状态土体强度变形计算的准确性和实用性,对复杂岩土工程问题的计算求解具有重要理论价值和实践意义。

基于氦气置换的超大型土工离心机缩比模型温控实验研究

为了解决常压下超重力离心模拟与实验装置(CHIEF)的温控问题,提出以氦气置换机室内空气的温控方法,建立区分不同热源的传热模型,通过降低风阻功率减少源头热量产生.建造CHIEF的缩比模型实验装置(机室直径缩比为1∶20),分别在空气和氦气介质下测定风阻功率和机室内的温度.实验结果表明,氦气置换空气后,风阻功率降低了82.4%,机室内的最高温度从56.4℃降至32.9℃,机室内的最大温差从6.8℃降至4.1℃.传热模型的分析结果表明,气体与机室侧壁面的摩擦产热是造成机室温度升高的主要原因,氦气置换后的原型机机室温度可控制在25.7℃,实现了机室最高温度不超过(40±5)℃的温控目标.

重力场作用下的油田滤床反冲洗技术及其发展

针对重力场水力反冲洗技术应用于油田采出水处理领域时反冲洗效率低的瓶颈问题,基于场的视角分析了机械辅助、空气辅助及水化学辅助等手段强化重力场作用下的反冲洗技术以及存在的问题。将超重力技术用于强化重力场水力反冲洗过程,构建旋流场和重力场耦合的超重力反冲洗体系,突破单独重力场反冲洗效率低的技术瓶颈,是未来油田滤床反冲洗技术的发展趋势。

超重条件下相变热沉结构拓扑优化及温控性能研究

利用相变热沉有望解决高速飞行器大热耗电子设备的热控难题。为强化相变热沉温控性能,基于固体各向同性罚函数的变密度拓扑优化方法对相变热沉进行传热拓扑优化设计。而飞行器在机动飞行过程中常处于超重状态,其可能会影响相变热沉的性能。因此,对拓扑优化的导热式优化热沉(Ⅰ)和自然对流式优化热沉(Ⅱ)在超重(1g~7g)下的温控性能进行了数值研究。研究结果表明:热沉Ⅱ吸热速度和温控性能优于热沉Ⅰ,PCM总融化时长缩短11 s;以60℃为目标,在1g、3g、5g、和7g下,热沉Ⅱ的温控时长比热沉Ⅰ分别延长了19.75%、17.44%、4.01%和1.62%;超重会强化PCM间的自然对流,显著提升热沉温控性能,但其强化效应随超重的增强而减弱;超重对热沉Ⅰ的强化作用大于热沉Ⅱ,且会缩短热沉间性能差异。

Geophysical fluid dynamics in the hypergravity field

Hypergravity can be realized by creating a field imposed by centripetal acceleration in a centrifuge apparatus.Such an apparatus is often used to test soil response in geotechnical engineering problems.Here we present the potential usage of a centrifuge apparatus to study various topics in hydrodynamics.The scaling law associated with hydrodynamics is first reviewed,and the advantage of controlling the body force is described.One of the perceived disadvantages in such experiments is the unwanted presence of the Coriolis effect in the centrifuge.However,we propose exploiting this effect to our advantage to study geophysical fluid-dynamic problems that occur particularly in the equatorial region.

Analytical solutions for equivalent elastic compliance of cubic lattice structures subjected to hypergravity conditions

In order to comprehensively understand the mechanical behavior of biological entities and aerospace applications subjected to hypergravity environments,we delve into the impact of hypergravity on the equivalent compliance of cubic lattice structures.Capitalizing on the periodic spatial distribution,we employ a unit cell methodology to deduce the homogenized stress-strain relationship for the lattice structures,subsequently obtaining the associated equivalent compliance.The equivalent compliance can be conveniently reduced to instances without hypergravity influence.Furthermore,numerical simulations are executed to validate the derivations and to illustrate that hypergravity indeed affects the mechanical properties of lattice structures.We introduce a non-dimensional hypergravity factor,which quantifies the impact of hypergravity magnitude relative to the Young’s modulus of the base material.Our findings reveal that the hypergravity factor influences perpendicular compliance quadratically and parallel compliance linearly.Simultaneously,the perpendicular shear compliance remains unaffected,whereas the parallel shear compliance experiences an inverse effect.Additionally,the lattice structure transforms into a gradient material oriented in the hypergravity direction,consequently generating a scale effect.

短期超重力负荷对小鼠神经发生及空间工作记忆能力的作用分析

目的分析短期超重力负荷对于小鼠大脑神经发生和空间工作记忆的影响。方法将雄性C57BL/6小鼠随机分为对照组、9 G超重力离心组(9 G组)和15 G超重力离心组(15 G组),每组8只。实验组小鼠分别在9 G和15 G离心力条件下进行离心处理,每日15 min,为期3周。而后对各组小鼠进行水迷宫、八臂迷宫、旷场和高架十字迷宫行为学分析,比较小鼠的空间学习和工作记忆、焦虑水平和运动功能的组间差异,并通过免疫荧光染色技术分析小鼠大脑侧脑室下带和海马齿状回颗粒层下带的神经发生表型。结果与对照组相比,9 G组和15 G组小鼠在离心处理后体质量显著下降(P<0.05,P<0.01);三组小鼠的各项行为学指标无统计学差异;与对照组和9 G组相比,15 G组小鼠脑冠状切面侧脑室面积显著减小(P<0.01),15 G组小鼠侧脑室CD24^(+)的室管膜细胞数目显著减少(P<0.01);三组小鼠侧脑室下带和海马齿状回颗粒层下带的神经发生无显著差异。结论短期超重力负荷对于小鼠的神经发生、空间学习和工作记忆、焦虑水平和运动功能无显著影响,提示短期超重力环境作用(如短期飞行训练)后生物体大脑具有较强的适应性和稳态维持能力,尚能应对这种短暂的重力环境变化;另一方面,15 G组小鼠侧脑室截面积显著减小且室管膜细胞数目减少,提示高强度或长期的超重力负荷可能经由脑室缺陷损害大脑的结构和高级脑功能。

MICRO-Ⅱ网络数据采集方案

从工厂底层自动化及信息集成技术角度 ,详细介绍了GD公司MICRO Ⅱ控制系统的特点及其网络结构 ,提出了实现MICRO Ⅱ系统网络数据采集的 2种解决方案的可行性。通过对MICRO Ⅱ数据采集的实现 ,完全可以改变GDX1/X2包装机组目前的“信息孤岛”状态。

Osteoblast Behavior on Hierarchical Micro-/Nano-Structured Titanium Surface

In the present work, osteoblast behavior on a hierarchical micro-/nano-structured titanium surface was investigated. A hi- erarchical hybrid micro-/nano-structured titanium surface topography was produced via Electrolytic Etching （EE）. MG-63 cells were cultured on disks for 2 h to 7 days. The osteoblast response to the hierarchical hybrid micro-/nano-structured titanium surface was evaluated through the osteoblast cell morphology, attachment and proliferation. For comparison, MG-63 cells were also cultured on Sandblasted and Acid-etched （SEA） as well as Machined （M） surfaces respectively. The results show signifi- cant differences in the adhesion rates and proliferation levels of MG-63 cells on EE, SLA, and M surfaces. Both adhesion rate and proliferation level on EE surface are higher than those on SLA and M surfaces. Therefore, we may expect that, comparing with SLA and M surfaces, bone growth on EE surface could be accelerated and bone formation could be promoted at an early stage, which could be applied in the clinical practices for immediate and early-stage loadings.

Macro-and Micro-Properties of Two Natural Marine Clays in China

In this paper,macro-and micro-properties of natural marine clay in two different and representative regions of China are investigated in detail.In addition to in-situ tests,soil samples are collected by use of Shelby tubes for laboratory examination in Shanghai and Zhuhai respectively,two coastal cities in China.In the laboratory tests,macro-properties such as consolidation characteristics and undrained shear strength are measured.Moreover,X-ray diffraction test,scanning electron microscope test,and mercury intrusion test are carried out for the investigation of their micro-properties including clay minerals and microstructure.The study shows that：（1）both clays are Holocene series formations,classified as either normal or underconsolidated soils.The initial gradient of the stress-strain curves shows their increase with increasing consolidation pressure;however,the Shanghai and the Zhuhai clays are both structural soils with the latter shown to be more structured than the former.As a result,the Zhuhai clay shows strain softening behavior at low confining pressures,but strain hardening at high pressures.In contrast,the Shanghai clay mainly manifests strain-hardening.（2）An activity ranges from 0.75 to 1.30 for the Shanghai marine clay and from 0.5 to 0.85 for the Zhuhai marine clay.The main clay mineral is illite in the Shanghai clay and kaolinite in the Zhuhai clay.The Zhuhai clay is mainly characterized by a flocculated structure,while the typical Shanghai clay shows a dispersed structure.The porous structure of the Shanghai clay is characterized mainly by large and medium-sized pores,while the Zhuhai clay porous structure is mainly featured by small and medium-sized pores.The differences in their macro-and micro-properties can be attributed to different sedimentation environments.

Femtosecond Laser Thermal Accumulation-Triggered Micro-/Nanostructures with Patternable and Controllable Wettability Towards Liquid Manipulating

Versatile liquid manipulating surfaces combining patternable and controllable wettability have recently motivated considerable attention owing to their significant advantages in droplet-solid impacting behaviors,microdroplet self-removal,and liquid–liquid interface reaction applications.However,developing a facile and efficient method to fabricate these versatile surfaces remains an enormous challenge.In this paper,a strategy for the fabrication of liquid manipulating surfaces with patternable and controllable wettability on Polyimide(PI)film based on femtosecond laser thermal accumulation engineering is proposed.Because of its controllable micro-/nanostructures and chemical composition through adjusting the local thermal accumulation,the wettability of PI film can be tuned from superhydrophilicity(~3.6°)to superhydrophobicity(~151.6°).Furthermore,three diverse surfaces with patternable and heterogeneous wettability were constructed and various applications were successfully realized,including water transport,droplet arrays,and liquid wells.This work may provide a facile strategy for achieving patternable and controllable wettability efficiently and developing multifunctional liquid steering surfaces.

Micro- and nanoporous materials capable of absorbing solvents and oils reversibly： the state of the art

Treatment of petroleum spills and organic solvent pollution in general is an important issue; several techniques are under development to remove oil from water. The use of absorbents is one of the most common techniques to tackle this problem. These absorbents can be classified based on their characteristics of recyclability into irreversible and reversible ones. In this review, we discuss the application of several materials as oil absorbents, according to their classification and characteristics such as hydrophobicity, surface area and oil absorption capacity. Also, the fabrication methods for some materials are presented and analyzed.

Preparation and Mechanical Properties of Micro- and Nano-sized SiC/Fluoroelastomer Composites

Microand nano-sized SiC/fluoroelastomer （FKM） composites were prepared by a mechanical mixing method. These composites were first characterized by a rotorless rheometer. Then the effects of micro- and nano-sized SiC on hardness, static and dynamic mechanical properties of the composites were investigated. The increasing amount of the SiC filler increased the curing efficiency of the biphenyl curing system, which was evident from the rheometric properties of the resulting composites. The tensile properties of composite increased with the increasing of micro- and nano-sized SiC content. When the micro- and nano-sized SiC content was higher than 20 phr, the composites showed almost unchanged tensile properties. The increasing of the tensile property was mainly attributed to the well dispersed micro- and nano-sized SiC particles characterized by SEM images. Compared to pure FKM, the composites exhibited a higher glass transition temperature and lower tan peak value.