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Automatic recognition of sonar targets using feature selection in micro-Doppler signature
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作者 Abbas Saffari Seyed-Hamid Zahiri Mohammad Khishe 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2023年第2期58-71,共14页
Currently,the use of intelligent systems for the automatic recognition of targets in the fields of defence and military has increased significantly.The primary advantage of these systems is that they do not need human... Currently,the use of intelligent systems for the automatic recognition of targets in the fields of defence and military has increased significantly.The primary advantage of these systems is that they do not need human participation in target recognition processes.This paper uses the particle swarm optimization(PSO)algorithm to select the optimal features in the micro-Doppler signature of sonar targets.The microDoppler effect is referred to amplitude/phase modulation on the received signal by rotating parts of a target such as propellers.Since different targets'geometric and physical properties are not the same,their micro-Doppler signature is different.This Inconsistency can be considered a practical issue(especially in the frequency domain)for sonar target recognition.Despite using 128-point fast Fourier transform(FFT)for the feature extraction step,not all extracted features contain helpful information.As a result,PSO selects the most optimum and valuable features.To evaluate the micro-Doppler signature of sonar targets and the effect of feature selection on sonar target recognition,the simplest and most popular machine learning algorithm,k-nearest neighbor(k-NN),is used,which is called k-PSO in this paper because of the use of PSO for feature selection.The parameters measured are the correct recognition rate,reliability rate,and processing time.The simulation results show that k-PSO achieved a 100%correct recognition rate and reliability rate at 19.35 s when using simulated data at a 15 dB signal-tonoise ratio(SNR)angle of 40°.Also,for the experimental dataset obtained from the cavitation tunnel,the correct recognition rate is 98.26%,and the reliability rate is 99.69%at 18.46s.Therefore,the k-PSO has an encouraging performance in automatically recognizing sonar targets when using experimental datasets and for real-world use. 展开更多
关键词 micro-doppler signature Automatic recognition Feature selection K-NN PSO
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Modeling simulation and experiment of micro-Doppler signature of precession 被引量:2
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作者 Hongwei Gao Lianggui Xie Shuliang Wen 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2010年第4期544-549,共6页
Spatial precession is a special micro-motion of the spinning-directional target, and the micro-Doppler signature of the cone-shaped target with precession is studied. The micro-motion model of precession is built firs... Spatial precession is a special micro-motion of the spinning-directional target, and the micro-Doppler signature of the cone-shaped target with precession is studied. The micro-motion model of precession is built first, and then the micro-Doppler model is developed based on the proposed concept of micro-motion ma- trix, by which the theoretical formula of micro-Doppler signature of precession is derived. In order to further approach to the actual case, the occlusion effect is firstly considered in micro-Doppler, and the simulated result with occlusion effect is well in accordance with the measured result in microwave anechoic chamber, which suggests that the micro-motion model and micro-Doppler model of precession are both valid. 展开更多
关键词 precession micro-doppler micro-motion matrix occlusion effect.
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Working condition recognition of sucker rod pumping system based on 4-segment time-frequency signature matrix and deep learning
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作者 Yun-Peng He Hai-Bo Cheng +4 位作者 Peng Zeng Chuan-Zhi Zang Qing-Wei Dong Guang-Xi Wan Xiao-Ting Dong 《Petroleum Science》 SCIE EI CAS CSCD 2024年第1期641-653,共13页
High-precision and real-time diagnosis of sucker rod pumping system(SRPS)is important for quickly mastering oil well operations.Deep learning-based method for classifying the dynamometer card(DC)of oil wells is an eff... High-precision and real-time diagnosis of sucker rod pumping system(SRPS)is important for quickly mastering oil well operations.Deep learning-based method for classifying the dynamometer card(DC)of oil wells is an efficient diagnosis method.However,the input of the DC as a two-dimensional image into the deep learning framework suffers from low feature utilization and high computational effort.Additionally,different SRPSs in an oil field have various system parameters,and the same SRPS generates different DCs at different moments.Thus,there is heterogeneity in field data,which can dramatically impair the diagnostic accuracy.To solve the above problems,a working condition recognition method based on 4-segment time-frequency signature matrix(4S-TFSM)and deep learning is presented in this paper.First,the 4-segment time-frequency signature(4S-TFS)method that can reduce the computing power requirements is proposed for feature extraction of DC data.Subsequently,the 4S-TFSM is constructed by relative normalization and matrix calculation to synthesize the features of multiple data and solve the problem of data heterogeneity.Finally,a convolutional neural network(CNN),one of the deep learning frameworks,is used to determine the functioning conditions based on the 4S-TFSM.Experiments on field data verify that the proposed diagnostic method based on 4S-TFSM and CNN(4S-TFSM-CNN)can significantly improve the accuracy of working condition recognition with lower computational cost.To the best of our knowledge,this is the first work to discuss the effect of data heterogeneity on the working condition recognition performance of SRPS. 展开更多
关键词 Sucker-rod pumping system Dynamometer card Working condition recognition Deep learning Time-frequency signature Time-frequency signature matrix
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Signature of Superconductivity in Pressurized La_(4)Ni_(3)O_(10)
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作者 李庆 张英杰 +3 位作者 项浙宁 张宇航 祝熙宇 闻海虎 《Chinese Physics Letters》 SCIE EI CAS CSCD 2024年第1期77-84,共8页
The discovery of high-temperature superconductivity near 80K in bilayer nickelate La_(3)Ni_(2)O_(7)under high pressures has renewed the exploration of superconducting nickelate in bulk materials.The extension of super... The discovery of high-temperature superconductivity near 80K in bilayer nickelate La_(3)Ni_(2)O_(7)under high pressures has renewed the exploration of superconducting nickelate in bulk materials.The extension of superconductivity in other nickelates in a broader family is also essential.Here,we report the experimental observation of superconducting signature in trilayer nickelate La_(4)Ni_(3)O_(10)under high pressures.By using a modified solgel method and post-annealing treatment under high oxygen pressure,we successfully obtained polycrystalline La_(4)Ni_(3)O_(10)samples with different transport behaviors at ambient pressure.Then we performed high-pressure electrical resistance measurements on these samples in a diamond-anvil-cell apparatus.Surprisingly,the signature of possible superconducting transition with a maximum transition temperature(T_(c))of about 20K under high pressures is observed,as evidenced by a clear drop of resistance and the suppression of resistance drops under magnetic fields.Although the resistance drop is sample-dependent and relatively small,it appears in all of our measured samples.We argue that the observed superconducting signal is most likely to originate from the main phase of La_(4)Ni_(3)O_(10).Our findings will motivate the exploration of superconductivity in a broader family of nickelates and shed light on the understanding of the underlying mechanisms of high-T_(c) superconductivity in nickelates. 展开更多
关键词 MATERIALS SUPERCONDUCTIVITY signature
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Stable Isotopic Signatures of NO3 in Waste Water Effluent and Los Angeles River
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作者 Isaac Hall Mohammad Hassan Rezaie Boroon 《Journal of Water Resource and Protection》 CAS 2024年第1期102-122,共21页
A metropolitan city such as Los Angeles (LA) is an ideal study site with a very high population density, and it houses at least 3 treatment plants where sewage is treated preliminarily and then progressing to tertiary... A metropolitan city such as Los Angeles (LA) is an ideal study site with a very high population density, and it houses at least 3 treatment plants where sewage is treated preliminarily and then progressing to tertiary treatment before discharging into the LA River. We will gain a better understanding of the water quality in the LA River and the nitrate load in the watershed system by examining the influence of waste water treatment plants (WWTPs). The goal of this study is to pinpoint the exact source of nitrate in the LA River using the isotope signatures. We have selected sampling locations both upstream and downstream of the WWTP. This serves to monitor nitrate levels, aiding in the assessment of treatment plant effectiveness, pinpointing nitrate pollution sources, and ensuring compliance with environmental regulations. The research explores the isotopic composition of NO3 in relation to atmospheric nitrogen and Vienna Standard Mean Ocean Water, shedding light on the contributions from various sources such as manure, sewage, soil organic nitrogen, and nitrogen fertilizers. Specifically, there is a change in the δ15NAir value between the dry and wet seasons. The isotope values in the Tillman WWTP sample changed between dry and wet seasons. Notably, the presence of nitrate originating from manure and sewage is consistent across seasons, emphasizing the significant impact of anthropogenic and agricultural activities on water quality. This investigation contributes to the broader understanding of nitrogen cycling in urban water bodies, particularly in the context of wastewater effluent discharge. The findings hold implications for water quality management and highlight the need for targeted interventions to mitigate the impact of nitrogen-containing compounds on aquatic ecosystems. Overall, the study provides a valuable framework for future research and environmental stewardship efforts aimed at preserving the health and sustainability of urban water resources. This data informs decisions regarding additional treatment or mitigation actions to safeguard downstream water quality and ecosystem health. 展开更多
关键词 Metropolitan City Los Angeles Treatment Plants Sewage Treatment Nitrate Source Isotope signatures Water Quality
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Dynamic Signature Verification Using Pattern Recognition
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作者 Emmanuel Nwabueze Ekwonwune Duroha Austin Ekekwe +1 位作者 Chinyere Iheakachi Ubochi Henry Chinedu Oleribe 《Journal of Software Engineering and Applications》 2024年第5期214-227,共14页
Dynamic signature is a biometric modality that recognizes an individual’s anatomic and behavioural characteristics when signing their name. The rampant case of signature falsification (Identity Theft) was the key mot... Dynamic signature is a biometric modality that recognizes an individual’s anatomic and behavioural characteristics when signing their name. The rampant case of signature falsification (Identity Theft) was the key motivating factor for embarking on this study. This study was necessitated by the damages and dangers posed by signature forgery coupled with the intractable nature of the problem. The aim and objectives of this study is to design a proactive and responsive system that could compare two signature samples and detect the correct signature against the forged one. Dynamic Signature verification is an important biometric technique that aims to detect whether a given signature is genuine or forged. In this research work, Convolutional Neural Networks (CNNsor ConvNet) which is a class of deep, feed forward artificial neural networks that has successfully been applied to analysing visual imagery was used to train the model. The signature images are stored in a file directory structure which the Keras Python library can work with. Then the CNN was implemented in python using the Keras with the TensorFlow backend to learn the patterns associated with the signature. The result showed that for the same CNNs-based network experimental result of average accuracy, the larger the training dataset, the higher the test accuracy. However, when the training dataset are insufficient, better results can be obtained. The paper concluded that by training datasets using CNNs network, 98% accuracy in the result was recorded, in the experimental part, the model achieved a high degree of accuracy in the classification of the biometric parameters used. 展开更多
关键词 VERIFICATION SECURITY BIOMETRICS signature AUTHENTICATION Model Pattern Recognition Dynamic
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Identification of a novel inflammatory-related gene signature to evaluate the prognosis of gastric cancer patients
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作者 Jia-Li Hu Mei-Jin Huang +5 位作者 Halike Halina Kun Qiao Zhi-Yuan Wang Jia-Jie Lu Cheng-Liang Yin Feng Gao 《World Journal of Gastrointestinal Oncology》 SCIE 2024年第3期945-967,共23页
BACKGROUND Gastric cancer(GC)is a highly aggressive malignancy with a heterogeneous nature,which makes prognosis prediction and treatment determination difficult.Inflammation is now recognized as one of the hallmarks ... BACKGROUND Gastric cancer(GC)is a highly aggressive malignancy with a heterogeneous nature,which makes prognosis prediction and treatment determination difficult.Inflammation is now recognized as one of the hallmarks of cancer and plays an important role in the aetiology and continued growth of tumours.Inflammation also affects the prognosis of GC patients.Recent reports suggest that a number of inflammatory-related biomarkers are useful for predicting tumour prognosis.However,the importance of inflammatory-related biomarkers in predicting the prognosis of GC patients is still unclear.AIM To investigate inflammatory-related biomarkers in predicting the prognosis of GC patients.was constructed using the least absolute shrinkage and selection operator Cox regression model based on the GEO database.GC patients from the GSE26253 cohort were used for validation.Univariate and multivariate Cox analyses were used to determine the independent prognostic factors,and a prognostic nomogram was established.The calibration curve and the area under the curve based on receiver operating characteristic analysis were utilized to evaluate the predictive value of the nomogram.The decision curve analysis results were plotted to quantify and assess the clinical value of the nomogram.Gene set enrichment analysis was performed to explore the potential regulatory pathways involved.The relationship between tumour immune infiltration status and risk score was analysed via Tumour Immune Estimation Resource and CIBERSORT.Finally,we analysed the association between risk score and patient sensitivity to commonly used chemotherapy and targeted therapy agents.RESULTS A prognostic model consisting of three inflammatory-related genes(MRPS17,GUF1,and PDK4)was constructed.Independent prognostic analysis revealed that the risk score was a separate prognostic factor in GC patients.According to the risk score,GC patients were stratified into high-and low-risk groups,and patients in the high-risk group had significantly worse prognoses according to age,sex,TNM stage and Lauren type.Consensus clustering identified three subtypes of inflammation that could predict GC prognosis more accurately than traditional grading and staging.Finally,the study revealed that patients in the low-risk group were more sensitive to certain drugs than were those in the high-risk group,indicating a link between inflammation-related genes and drug sensitivity.CONCLUSION In conclusion,we established a novel three-gene prognostic signature that may be useful for predicting the prognosis and personalizing treatment decisions of GC patients. 展开更多
关键词 Gastric cancer Inflammation Immune infiltration Prognosis signature Subt
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Identification and validation of novel prognostic fatty acid metabolic gene signatures in colon adenocarcinoma through systematic approaches
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作者 HENG ZHANG WENJING CHENG +3 位作者 HAIBO ZHAO WEIDONG CHEN QIUJIE ZHANG QING-QING YU 《Oncology Research》 SCIE 2024年第2期297-308,共12页
Colorectal cancer(CRC)belongs to the class of significantly malignant tumors found in humans.Recently,dysregulated fatty acid metabolism(FAM)has been a topic of attention due to its modulation in cancer,specifically C... Colorectal cancer(CRC)belongs to the class of significantly malignant tumors found in humans.Recently,dysregulated fatty acid metabolism(FAM)has been a topic of attention due to its modulation in cancer,specifically CRC.However,the regulatory FAM pathways in CRC require comprehensive elucidation.Methods:The clinical and gene expression data of 175 fatty acid metabolic genes(FAMGs)linked with colon adenocarcinoma(COAD)and normal cornerstone genes were gathered through The Cancer Genome Atlas(TCGA)-COAD corroborating with the Molecular Signature Database v7.2(MSigDB).Initially,crucial prognostic genes were selected by uni-and multi-variate Cox proportional regression analyses;then,depending upon these identified signature genes and clinical variables,a nomogram was generated.Lastly,to assess tumor immune characteristics,concomitant evaluation of tumor immune evasion/risk scoring were elucidated.Results:A 8-gene signature,including ACBD4,ACOX1,CD36,CPT2,ELOVL3,ELOVL6,ENO3,and SUCLG2,was generated,and depending upon this,CRC patients were categorized within high-risk(H-R)and low-risk(L-R)cohorts.Furthermore,risk and age-based nomograms indicated moderate discrimination and good calibration.The data confirmed that the 8-gene model efficiently predicted CRC patients’prognosis.Moreover,according to the conjoint analysis of tumor immune evasion and the risk scorings,the H-R cohort had an immunosuppressive tumor microenvironment,which caused a substandard prognosis.Conclusion:This investigation established a FAMGs-based prognostic model with substantially high predictive value,providing the possibility for improved individualized treatment for CRC individuals. 展开更多
关键词 Fatty acid metabolism Colorectal cancer Gene signatures Machine learning
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Electricity Carbon Quota Trading Scheme based on Certificateless Signature and Blockchain
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作者 Xiaodong Yang Runze Diao +2 位作者 Tao Liu Haoqi Wen Caifen Wang 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第2期1695-1712,共18页
The carbon tradingmarket can promote“carbon peaking”and“carbon neutrality”at low cost,but carbon emission quotas face attacks such as data forgery,tampering,counterfeiting,and replay in the electricity trading mar... The carbon tradingmarket can promote“carbon peaking”and“carbon neutrality”at low cost,but carbon emission quotas face attacks such as data forgery,tampering,counterfeiting,and replay in the electricity trading market.Certificateless signatures are a new cryptographic technology that can address traditional cryptography’s general essential certificate requirements and avoid the problem of crucial escrowbased on identity cryptography.However,most certificateless signatures still suffer fromvarious security flaws.We present a secure and efficient certificateless signing scheme by examining the security of existing certificateless signature schemes.To ensure the integrity and verifiability of electricity carbon quota trading,we propose an electricity carbon quota trading scheme based on a certificateless signature and blockchain.Our scheme utilizes certificateless signatures to ensure the validity and nonrepudiation of transactions and adopts blockchain technology to achieve immutability and traceability in electricity carbon quota transactions.In addition,validating electricity carbon quota transactions does not require time-consuming bilinear pairing operations.The results of the analysis indicate that our scheme meets existential unforgeability under adaptive selective message attacks,offers conditional identity privacy protection,resists replay attacks,and demonstrates high computing and communication performance. 展开更多
关键词 Electricity carbon trading certificateless signature blockchain forgery attack carbon quota
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Quantum circuit-based proxy blind signatures:A novel approach and experimental evaluation on the IBM quantum cloud platform
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作者 娄小平 昝慧茹 徐雪娇 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第5期247-253,共7页
This paper presents a novel approach to proxy blind signatures in the realm of quantum circuits,aiming to enhance security while safeguarding sensitive information.The main objective of this research is to introduce a... This paper presents a novel approach to proxy blind signatures in the realm of quantum circuits,aiming to enhance security while safeguarding sensitive information.The main objective of this research is to introduce a quantum proxy blind signature(QPBS)protocol that utilizes quantum logical gates and quantum measurement techniques.The QPBS protocol is constructed by the initial phase,proximal blinding message phase,remote authorization and signature phase,remote validation,and de-blinding phase.This innovative design ensures a secure mechanism for signing documents without revealing the content to the proxy signer,providing practical security authentication in a quantum environment under the assumption that the CNOT gates are securely implemented.Unlike existing approaches,our proposed QPBS protocol eliminates the need for quantum entanglement preparation,thus simplifying the implementation process.To assess the effectiveness and robustness of the QPBS protocol,we conduct comprehensive simulation studies in both ideal and noisy quantum environments on the IBM quantum cloud platform.The results demonstrate the superior performance of the QPBS algorithm,highlighting its resilience against repudiation and forgeability,which are key security concerns in the realm of proxy blind signatures.Furthermore,we have established authentic security thresholds(82.102%)in the presence of real noise,thereby emphasizing the practicality of our proposed solution. 展开更多
关键词 proxy blind signature quantum circuits quantum computation IBM quantum cloud platform
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Ghost Module Based Residual Mixture of Self-Attention and Convolution for Online Signature Verification
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作者 Fangjun Luan Xuewen Mu Shuai Yuan 《Computers, Materials & Continua》 SCIE EI 2024年第4期695-712,共18页
Online Signature Verification (OSV), as a personal identification technology, is widely used in various industries.However, it faces challenges, such as incomplete feature extraction, low accuracy, and computational h... Online Signature Verification (OSV), as a personal identification technology, is widely used in various industries.However, it faces challenges, such as incomplete feature extraction, low accuracy, and computational heaviness. Toaddress these issues, we propose a novel approach for online signature verification, using a one-dimensionalGhost-ACmix Residual Network (1D-ACGRNet), which is a Ghost-ACmix Residual Network that combines convolutionwith a self-attention mechanism and performs improvement by using Ghost method. The Ghost-ACmix Residualstructure is introduced to leverage both self-attention and convolution mechanisms for capturing global featureinformation and extracting local information, effectively complementing whole and local signature features andmitigating the problem of insufficient feature extraction. Then, the Ghost-based Convolution and Self-Attention(ACG) block is proposed to simplify the common parts between convolution and self-attention using the Ghostmodule and employ feature transformation to obtain intermediate features, thus reducing computational costs.Additionally, feature selection is performed using the random forestmethod, and the data is dimensionally reducedusing Principal Component Analysis (PCA). Finally, tests are implemented on the MCYT-100 datasets and theSVC-2004 Task2 datasets, and the equal error rates (EERs) for small-sample training using five genuine andforged signatures are 3.07% and 4.17%, respectively. The EERs for training with ten genuine and forged signaturesare 0.91% and 2.12% on the respective datasets. The experimental results illustrate that the proposed approacheffectively enhances the accuracy of online signature verification. 展开更多
关键词 Online signature verification feature selection ACG block ghost-ACmix residual structure
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Identification of an immune-related gene signature for predicting prognosis and immunotherapy efficacy in liver cancer via cell-cell communication
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作者 Jun-Tao Li Hong-Mei Zhang +1 位作者 Wei Wang Dong-Qing Wei 《World Journal of Gastroenterology》 SCIE CAS 2024年第11期1609-1620,共12页
BACKGROUND Liver cancer is one of the deadliest malignant tumors worldwide.Immunotherapy has provided hope to patients with advanced liver cancer,but only a small fraction of patients benefit from this treatment due t... BACKGROUND Liver cancer is one of the deadliest malignant tumors worldwide.Immunotherapy has provided hope to patients with advanced liver cancer,but only a small fraction of patients benefit from this treatment due to individual differences.Identifying immune-related gene signatures in liver cancer patients not only aids physicians in cancer diagnosis but also offers personalized treatment strategies,thereby improving patient survival rates.Although several methods have been developed to predict the prognosis and immunotherapeutic efficacy in patients with liver cancer,the impact of cell-cell interactions in the tumor microenvir-onment has not been adequately considered.AIM To identify immune-related gene signals for predicting liver cancer prognosis and immunotherapy efficacy.METHODS Cell grouping and cell-cell communication analysis were performed on single-cell RNA-sequencing data to identify highly active cell groups in immune-related pathways.Highly active immune cells were identified by intersecting the highly active cell groups with B cells and T cells.The significantly differentially expressed genes between highly active immune cells and other cells were subsequently selected as features,and a least absolute shrinkage and selection operator(LASSO)regression model was constructed to screen for diagnostic-related features.Fourteen genes that were selected more than 5 times in 10 LASSO regression experiments were included in a multivariable Cox regression model.Finally,3 genes(stathmin 1,cofilin 1,and C-C chemokine ligand 5)significantly associated with survival were identified and used to construct an immune-related gene signature.RESULTS The immune-related gene signature composed of stathmin 1,cofilin 1,and C-C chemokine ligand 5 was identified through cell-cell communication.The effectiveness of the identified gene signature was validated based on experi-mental results of predictive immunotherapy response,tumor mutation burden analysis,immune cell infiltration analysis,survival analysis,and expression analysis.CONCLUSION The findings suggest that the identified gene signature may contribute to a deeper understanding of the activity patterns of immune cells in the liver tumor microenvironment,providing insights for personalized treatment strategies. 展开更多
关键词 Liver cancer Cell-cell communication Gene signature PROGNOSIS IMMUNOTHERAPY Single-cell RNA sequencing
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Identification and validation of a new prognostic signature based on cancer-associated fibroblast-driven genes in breast cancer
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作者 Zi-Zheng Wu Yuan-Jun Wei +3 位作者 Tong Li Jie Zheng Yin-Feng Liu Meng Han 《World Journal of Clinical Cases》 SCIE 2024年第4期700-720,共21页
BACKGROUND Breast cancer(BC),a leading malignant disease,affects women all over the world.Cancer associated fibroblasts(CAFs)stimulate epithelial-mesenchymal transition,and induce chemoresistance and immunosuppression... BACKGROUND Breast cancer(BC),a leading malignant disease,affects women all over the world.Cancer associated fibroblasts(CAFs)stimulate epithelial-mesenchymal transition,and induce chemoresistance and immunosuppression.AIM To establish a CAFs-associated prognostic signature to improve BC patient out-come estimation.METHODS We retrieved the transcript profile and clinical data of 1072 BC samples from The Cancer Genome Atlas(TCGA)databases,and 3661 BC samples from the The Gene Expression Omnibus.CAFs and immune cell infiltrations were quantified using CIBERSORT algorithm.CAF-associated gene identification was done by weighted gene co-expression network analysis.A CAF risk signature was established via univariate,least absolute shrinkage and selection operator regression,and mul-tivariate Cox regression analyses.The receiver operating characteristic(ROC)and Kaplan-Meier curves were employed to evaluate the predictability of the model.Subsequently,a nomogram was developed with the risk score and patient clinical signature.Using Spearman's correlations analysis,the relationship between CAF risk score and gene set enrichment scores were examined.Patient samples were collected to validate gene expression by quantitative real-time polymerase chain reaction(qRT-PCR).RESULTS Employing an 8-gene(IL18,MYD88,GLIPR1,TNN,BHLHE41,DNAJB5,FKBP14,and XG)signature,we attemp-ted to estimate BC patient prognosis.Based on our analysis,high-risk patients exhibited worse outcomes than low-risk patients.Multivariate analysis revealed the risk score as an independent indicator of BC patient prognosis.ROC analysis exhibited satisfactory nomogram predictability.The area under the curve showed 0.805 at 3 years,and 0.801 at 5 years in the TCGA cohort.We also demonstrated that a reduced CAF risk score was strongly associated with enhanced chemotherapeutic outcomes.CAF risk score was significantly correlated with most hallmark gene sets.Finally,the prognostic signature were further validated by qRT-PCR.CONCLUSION We introduced a newly-discovered CAFs-associated gene signature,which can be employed to estimate BC patient outcomes conveniently and accurately. 展开更多
关键词 Breast cancer Prognosis Gene signature The Cancer Genome Atlas The Gene Expression Omnibus
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An Efficient and Provably Secure SM2 Key-Insulated Signature Scheme for Industrial Internet of Things
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作者 Senshan Ouyang Xiang Liu +3 位作者 Lei Liu Shangchao Wang Baichuan Shao Yang Zhao 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第1期903-915,共13页
With the continuous expansion of the Industrial Internet of Things(IIoT),more andmore organisations are placing large amounts of data in the cloud to reduce overheads.However,the channel between cloud servers and smar... With the continuous expansion of the Industrial Internet of Things(IIoT),more andmore organisations are placing large amounts of data in the cloud to reduce overheads.However,the channel between cloud servers and smart equipment is not trustworthy,so the issue of data authenticity needs to be addressed.The SM2 digital signature algorithm can provide an authentication mechanism for data to solve such problems.Unfortunately,it still suffers from the problem of key exposure.In order to address this concern,this study first introduces a key-insulated scheme,SM2-KI-SIGN,based on the SM2 algorithm.This scheme boasts strong key insulation and secure keyupdates.Our scheme uses the elliptic curve algorithm,which is not only more efficient but also more suitable for IIoT-cloud environments.Finally,the security proof of SM2-KI-SIGN is given under the Elliptic Curve Discrete Logarithm(ECDL)assumption in the random oracle. 展开更多
关键词 KEY-INSULATED SM2 algorithm digital signature Industrial Internet of Things(IIoT) provable security
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Genomic signatures of selection,local adaptation and production type characterisation of East Adriatic sheep breeds
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作者 Boris Lukic Ino Curik +4 位作者 Ivana Drzaic Vlatko Galić Mario Shihabi LubošVostry Vlatka Cubric-Curik 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2024年第2期546-562,共17页
Background The importance of sheep breeding in the Mediterranean part of the eastern Adriatic has a long tradition since its arrival during the Neolithic migrations.Sheep production system is extensive and generally c... Background The importance of sheep breeding in the Mediterranean part of the eastern Adriatic has a long tradition since its arrival during the Neolithic migrations.Sheep production system is extensive and generally carried out in traditional systems without intensive systematic breeding programmes for high uniform trait production(carcass,wool and milk yield).Therefore,eight indigenous Croatian sheep breeds from eastern Adriatic treated here as metapopulation(EAS),are generally considered as multipurpose breeds(milk,meat and wool),not specialised for a particular type of production,but known for their robustness and resistance to certain environmental conditions.Our objective was to identify genomic regions and genes that exhibit patterns of positive selection signatures,decipher their biological and productive functionality,and provide a"genomic"characterization of EAS adaptation and determine its production type.Results We identified positive selection signatures in EAS using several methods based on reduced local variation,linkage disequilibrium and site frequency spectrum(eROHi,iHS,nSL and CLR).Our analyses identified numerous genomic regions and genes(e.g.,desmosomal cadherin and desmoglein gene families)associated with environmental adaptation and economically important traits.Most candidate genes were related to meat/production and health/immune response traits,while some of the candidate genes discovered were important for domestication and evolutionary processes(e.g.,HOXa gene family and FSIP2).These results were also confirmed by GO and QTL enrichment analysis.Conclusions Our results contribute to a better understanding of the unique adaptive genetic architecture of EAS and define its productive type,ultimately providing a new opportunity for future breeding programmes.At the same time,the numerous genes identified will improve our understanding of ruminant(sheep)robustness and resistance in the harsh and specific Mediterranean environment. 展开更多
关键词 Composite-likelihood ratio East Adriatic sheep Extreme ROH islands Genomic selection signatures Integrated haplotype score Number of segregating sites by length
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Molecular cascades and cell type-specific signatures in ASD revealed by single-cell genomics
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作者 Brie Wamsley 《四川生理科学杂志》 2024年第5期993-993,共1页
Genomic profiling in postmortem brain from autistic individuals has consistently revealed convergent molecular changes.What drives these changes and how they relate to genetic susceptibility in this complex condition ... Genomic profiling in postmortem brain from autistic individuals has consistently revealed convergent molecular changes.What drives these changes and how they relate to genetic susceptibility in this complex condition are not well understood.We performed deep single-nucleus RNA sequencing(snRNA-seq)to examine cell composition and transcriptomics,identifying dysregulation of cell type-specific gene regulatory networks(GRNs)in autism spectrum disorder(ASD). 展开更多
关键词 signature ASD MOLECULAR
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ATOLL ST200 Signature
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《视听前线》 2024年第5期16-17,共2页
品牌ATOLL由Stephane DUBREUIL、Emmanuel DUBREUIL两兄弟于1997年9月创立。ATOLL自创办以来,一直致力于设计“好声不贵的亲民Hi-Fi产品”。其主要的成本优先放在声音表现上,是法系音响品牌中少有的性价比高产品,恪守的售价和优秀的音... 品牌ATOLL由Stephane DUBREUIL、Emmanuel DUBREUIL两兄弟于1997年9月创立。ATOLL自创办以来,一直致力于设计“好声不贵的亲民Hi-Fi产品”。其主要的成本优先放在声音表现上,是法系音响品牌中少有的性价比高产品,恪守的售价和优秀的音质表现在同档之中更具有竞争力,您一定能在有限的预算中找到一款适宜的Atol产品,100%法国制造并不完全是贵价的! 展开更多
关键词 signature 音响品牌 ATO DUB 音质 性价比高
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鲜活生动的表现 ATOLL IN300 Signature合并式放大器
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作者 Chris Frankland 剑萍(编译) 《视听前线》 2024年第5期32-35,共4页
我第一次接触法国的ATOLL这个品牌是在四年前,当时我们当地的经销商借出了一台该品牌的放大器作评估。我记得对这台机器的印象非常深刻。但后来这个英国经销商停止进口这个品牌,所以ATOLL暂时从我的脑海消失了,直到我在最近的一次展会... 我第一次接触法国的ATOLL这个品牌是在四年前,当时我们当地的经销商借出了一台该品牌的放大器作评估。我记得对这台机器的印象非常深刻。但后来这个英国经销商停止进口这个品牌,所以ATOLL暂时从我的脑海消失了,直到我在最近的一次展会上发现了由新的经销商再度引入的它。因此,现在是时候对ATOLL进行评测了,这次所选的是内置解码器的IN300 Signature合并式放大器。 展开更多
关键词 合并式放大器 signature 解码器 ATO 经销商
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基于有限马尔可夫链嵌入法的智慧路灯系统联合Signature计算
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作者 易鹤 李想 路靖雯 《运筹与管理》 CSCD 北大核心 2023年第9期79-85,共7页
智慧路灯是现代化建设背景下的重要基础设施载体,集照明设备和传感设备于一体,并且可以根据实际应用的场景布放各种功能模块。城市管理部门需要根据不同路段的车道类型,选择适合的路灯型号和铺设方式。为了描述路段上由智慧路灯构成的... 智慧路灯是现代化建设背景下的重要基础设施载体,集照明设备和传感设备于一体,并且可以根据实际应用的场景布放各种功能模块。城市管理部门需要根据不同路段的车道类型,选择适合的路灯型号和铺设方式。为了描述路段上由智慧路灯构成的可靠性系统的结构特性,本文构建了共用部件的线形n中取连续k型冗余系统模型,并针对这类系统给出了基于有限马尔可夫链嵌入法的联合Signature计算方法。和基于定义的方法相比,该方法有统一的表达式,不仅提高了计算效率,还降低了计算的复杂度。最后,本文通过算例演示了该方法的运算效率,并讨论了其可能的应用与改进。 展开更多
关键词 联合signature n中取连续k型系统 有限马尔可夫链嵌入法 智慧路灯
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Quantum homomorphic broadcast multi-signature based on homomorphic aggregation 被引量:1
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作者 徐鑫 殷爱菡 《Chinese Physics B》 SCIE EI CAS CSCD 2023年第7期254-261,共8页
Quantum multi-signature has attracted extensive attention since it was put forward.Beside its own improvement,related research is often combined with other quantum signature.However,this type of quantum signature has ... Quantum multi-signature has attracted extensive attention since it was put forward.Beside its own improvement,related research is often combined with other quantum signature.However,this type of quantum signature has one thing in common,that is,the generation and verification of signature depend heavily on the shared classical secret key.In order to increase the reliability of signature,the homomorphic aggregation technique is applied to quantum multi-signature,and then we propose a quantum homomorphic multi-signature protocol.Unlike previous quantum multi-signature protocols,this protocol utilizes homomorphic properties to complete signature generation and verification.In the signature generation phase,entanglement swapping is introduced,so that the individual signatures of multiple users are aggregated into a new multi-signature.The original quantum state is signed by the shared secret key to realize the verification of the signature in the verification phase.The signature process satisfies the homomorphic property,which can improve the reliability of the signature. 展开更多
关键词 quantum signature homomorphic aggregation homomorphic multi-signature Bell state
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