Background: Pituitary adenomas represent a quite frequent neurosurgical disease. Secreting pituitary adenomas are represented by PRL, GH, ACTH and TSH tumours;the rate of postoperative hormonal recurrence is not ineli...Background: Pituitary adenomas represent a quite frequent neurosurgical disease. Secreting pituitary adenomas are represented by PRL, GH, ACTH and TSH tumours;the rate of postoperative hormonal recurrence is not ineligible. Methods: We present 106 patients affected by secreting pituitary microadenomas operated through transsphenoidal approach from 1998 through to 2008;in 54 (group 1) patients, intraoperative absolute alcohol was applied, while in the other 52 (group 2) it was not employed. The indications and the intraoperative technique of absolute alcohol application are presented. Hormonal recurrence was treated by hypofractionated stereotactic radiotherapy and/or medical therapy. Results: Postoperative hormonal and clinical remission was achieved in 50 and 47 patients respectively of group one and group two. At the first follow-up control, after 3 months from surgery, no patient of both groups presented hormonal/clinical recurrence. Six months after surgery, no patient of group one presented hormonal recurrence, while two patients of group 2 presented hormonal recurrence. After 2 years from surgery, two patients of group 1 and 4 patients of group 2 presented hormonal recurrence. Three years after operation, hormonal hypersecretion recurred in three patients of group one and in six patients of group 2. At 5 years follow-up, six patients of group one and 8 of group two presented hormonal recurrence. Conclusions: Intraoperative application of absolute alcohol, in selected cases, resulted useful to achieve better results in secreting pituitary microadenomas concerning both postoperative hormonal recurrence and hormonal persistence.展开更多
Background:Mammary duct ectasia is an acute or chronic inflammatory breast disease that occurs mainly in nonlactating women.It rarely occurs in the accessory breast.The etiology of this condition remains unclear.The l...Background:Mammary duct ectasia is an acute or chronic inflammatory breast disease that occurs mainly in nonlactating women.It rarely occurs in the accessory breast.The etiology of this condition remains unclear.The long course and complex clinicalmanifestations of this disease in some patients make it easy to misdiagnose.Case Presentation:Herein,we report a case of bilateral accessory breast duct ectasia.A 34-year-old nonlactating Chinese woman presented with a mass in the right axilla.Physical examination and ultrasonography revealed inflammatory lesions in both accessory breasts.Laboratory data and magnetic resonance imaging revealed hyperprolactinemia and pituitary microadenoma.Penicillin and bromocriptine were administered to prevent infection and reduce serum prolactin levels.We performed a simple mastectomy of the bilateral accessory breasts.The outcome was satisfactory.Conclusion:This article reports the first case of bilateral accessory breast associated with pituitary microadenoma and reviews the literature to provide a reference for clinicians.展开更多
文摘Background: Pituitary adenomas represent a quite frequent neurosurgical disease. Secreting pituitary adenomas are represented by PRL, GH, ACTH and TSH tumours;the rate of postoperative hormonal recurrence is not ineligible. Methods: We present 106 patients affected by secreting pituitary microadenomas operated through transsphenoidal approach from 1998 through to 2008;in 54 (group 1) patients, intraoperative absolute alcohol was applied, while in the other 52 (group 2) it was not employed. The indications and the intraoperative technique of absolute alcohol application are presented. Hormonal recurrence was treated by hypofractionated stereotactic radiotherapy and/or medical therapy. Results: Postoperative hormonal and clinical remission was achieved in 50 and 47 patients respectively of group one and group two. At the first follow-up control, after 3 months from surgery, no patient of both groups presented hormonal/clinical recurrence. Six months after surgery, no patient of group one presented hormonal recurrence, while two patients of group 2 presented hormonal recurrence. After 2 years from surgery, two patients of group 1 and 4 patients of group 2 presented hormonal recurrence. Three years after operation, hormonal hypersecretion recurred in three patients of group one and in six patients of group 2. At 5 years follow-up, six patients of group one and 8 of group two presented hormonal recurrence. Conclusions: Intraoperative application of absolute alcohol, in selected cases, resulted useful to achieve better results in secreting pituitary microadenomas concerning both postoperative hormonal recurrence and hormonal persistence.
文摘Background:Mammary duct ectasia is an acute or chronic inflammatory breast disease that occurs mainly in nonlactating women.It rarely occurs in the accessory breast.The etiology of this condition remains unclear.The long course and complex clinicalmanifestations of this disease in some patients make it easy to misdiagnose.Case Presentation:Herein,we report a case of bilateral accessory breast duct ectasia.A 34-year-old nonlactating Chinese woman presented with a mass in the right axilla.Physical examination and ultrasonography revealed inflammatory lesions in both accessory breasts.Laboratory data and magnetic resonance imaging revealed hyperprolactinemia and pituitary microadenoma.Penicillin and bromocriptine were administered to prevent infection and reduce serum prolactin levels.We performed a simple mastectomy of the bilateral accessory breasts.The outcome was satisfactory.Conclusion:This article reports the first case of bilateral accessory breast associated with pituitary microadenoma and reviews the literature to provide a reference for clinicians.
