The current communication reports in vitro characterization of the optimized hollow floating microballoons of amoxicillin on the basis of micromeritic properties and in vitro minimum inhibitory concentration(MIC).Amox...The current communication reports in vitro characterization of the optimized hollow floating microballoons of amoxicillin on the basis of micromeritic properties and in vitro minimum inhibitory concentration(MIC).Amoxicillin loaded hollow microballoons were prepared by emulsion solvent diffusion method.The morphological characterization was done on the basis of scanning electron microscopy(SEM).Fourier Transformed Infrared Spectroscopy(FTIR)was used to investigate drugepolymer interactions.The correlation between the in vitro buoyancy of microballoons and their physical properties,e.g.density and porosity were elucidated.The results of FTIR spectroscopy revealed the absence of any drugepolymer interactions.The porosity values of more than 69%and diameter to thickness ratio greater than 2.90,proved a high cavity volume within the microballoons in all size ranges.The spherical shape of microballoons with hollow internal cavity was confirmed from SEM photomicrographs.The in vitro MIC results showed a sustained drug effect from the microballoons.In conclusion,it can be said that the developed microballoons can be used for the effective treatment of Helicobacter pylori induced gastric ulcer.展开更多
In this study,hydrogen-storage glass microballoons were introduced into emulsion explosives to improve the detonation performance of the explosives.The effect of hydrogen-storage pressure on the detonation characteris...In this study,hydrogen-storage glass microballoons were introduced into emulsion explosives to improve the detonation performance of the explosives.The effect of hydrogen-storage pressure on the detonation characteristics of emulsion explosives was systematically investigated.Detonation velocity experiments shows that the change of sensitizing gas and the increase of hydrogen pressure have different effects on the detonation velocity.The experimental parameters of underwater explosion increase first and then decreases with the increase of hydrogen pressure.The decrease of these parameters indicates that the strength of glass microballoons is the limiting factor to improve the detonation performance of hydrogen-storage emulsion explosives.Compared with the traditional emulsion explosives,the maximum peak pressure of shock wave of hydrogen-storage emulsion explosives increases by 10.6%at 1.0 m and 10.2%at 1.2 m,the maximum values of shock impulse increase by 5.7%at 1.0 m and 19.4%at 1.2 m.The stored hydrogen has dual effects of sensitizers and energetic additives,which can improve the energy output of emulsion explosives.展开更多
Background Percutaneous microballoon compression （PMC） for trigeminal neuralgia is an important therapeutic method. The aim of this study was to review the effects of PMC for trigeminal neuralgia in 276 patients. Me...Background Percutaneous microballoon compression （PMC） for trigeminal neuralgia is an important therapeutic method. The aim of this study was to review the effects of PMC for trigeminal neuralgia in 276 patients. Methods From December 2000 to May 2003, 276 patients with trigeminal neuralgia were treated with PMC. The course of the disease ranged from 3 months to 38 years. Under the guidance of C-arm X-ray, 14# needle was placed into the foramen ovale using the classical Hakanson＇s technique. Fogarty balloon catheter was navigated into the Meckel＇s cave tenderly. A small amount of Omnipaque was slowly injected to inflate the balloon and compress the trigeminal ganglion for 3 to10 minutes. Results A total of 290 PMC were performed on the 276 patients. Among them, 252 had immediate relief from pain. The patients were followed up for a mean of 18.7 months （range, 4 to 32）, 14 of them had a recurrence. Of the 14 patients, 12 were re-operated with PMC, and the pain was all controlled successfully. Conclusions PMC is an effective and technically simple method for trigeminal neuralgia. For older patients with trigeminal neuralgia, it may be the first choice.展开更多
目的探讨C臂CT引导下经皮三叉神经半月节球囊压迫术治疗三叉神经痛的应用价值。方法回顾性分析采用C臂CT(Xper-CT)引导下经皮三叉神经半月节球襄压迫术治疗三叉神经痛患者40例,所有患者均进行C臂CT程序扫描,并通过X-travision工作站进...目的探讨C臂CT引导下经皮三叉神经半月节球囊压迫术治疗三叉神经痛的应用价值。方法回顾性分析采用C臂CT(Xper-CT)引导下经皮三叉神经半月节球襄压迫术治疗三叉神经痛患者40例,所有患者均进行C臂CT程序扫描,并通过X-travision工作站进行颅骨后处理重建,引导穿刺针进入卵圆孔及球囊到位,确定球囊头端位于Meckel’s腔,充盈球囊。术后记录手术剂量面积乘积(dose area product,DAP)、空气比释动能(cumulative air kerma,CAK)、曝光时间(fluo time,FT),分析辐射剂量。结果40例患者均通过C臂CT后处理重建技术引导卵圆孔穿刺成功(其中小卵圆孔2例);40例患者中通过C臂CT后处理重建技术确定球囊一次性到位并获得满意梨形21例(52%),通过C臂CT后处理重建技术分析后多次调整球囊位置及方向,使球囊头端位于岩骨切迹,并获得满意梨形12例(30%),7例(18%)患者未获得满意梨形。术后40例患者疼痛完全消失17例(42%),疼痛满意缓解21例(53%);疼痛缓解不满意2例(5%);总有效率95%。术后伴面部麻木26例(65%),咀嚼肌无力9例(23%)。40例患者DAP、CAK、FT分别为(79.39±23.15)Gycm^(2)、(245.07±84.04)mGy、(5.20±1.30)min。结论C臂CT引导下经皮三叉神经半月节球囊压迫术直观准确显示穿刺针、卵圆孔、球囊、岩骨脊的三维结构及其相互位置关系,尤其对解剖变异或异常增生的显示更具优势。展开更多
目的比较微球囊压迫与卡马西平治疗三叉神经痛的效果及安全性。方法选取收治的120例原发性三叉神经痛患者,用随机数字表法均分为微球囊压迫组和药物治疗组,每组60例。微球囊压迫组采用经皮穿刺微球囊神经节压迫治疗,药物治疗组口服卡马...目的比较微球囊压迫与卡马西平治疗三叉神经痛的效果及安全性。方法选取收治的120例原发性三叉神经痛患者,用随机数字表法均分为微球囊压迫组和药物治疗组,每组60例。微球囊压迫组采用经皮穿刺微球囊神经节压迫治疗,药物治疗组口服卡马西平治疗。比较2组治疗结束后的临床疗效、治疗前后的疼痛视觉模拟评分(visual analogue scale,VAS)和生活质量综合评定问卷-74(general quality of life inventory-74,GQOL-74)评分、治疗前后血清炎症因子[白细胞介素-1β(interleukin-1β,IL-1β)、白细胞介素-6(interleukin-6,IL-6)及肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)]的水平。比较2组不良反应的发生情况。结果微球囊压迫组的治疗总有效率高于药物治疗组(91.67%vs.75.00%,P<0.05)。治疗后,微球囊压迫组患者各时间点的VAS均低于药物治疗组,GQOL-74评分均高于药物治疗组(P<0.05)。与治疗前比较,2组患者血清IL-1β、IL-6、TNF-α的水平均明显降低(P<0.05),但2组比较差异无统计学意义(P>0.05)。微球囊压迫组术后不良反应的发生率为6.67%,显著低于药物治疗组(20.00%)(P<0.05)。结论微球囊压迫与口服卡马西平均对三叉神经痛有明显效果,且均能降低患者血清炎症因子的水平、缓解患者的疼痛症状,但与口服卡马西平比较,微球囊压迫的疗效更好,且安全性更高。展开更多
The preparation of monodisperse colloidal microlatex particles of polystyrene and poly(styrene butene diacid) by the use of microwave radiation and under normal ambient pressure is reported. There is no surfactant in ...The preparation of monodisperse colloidal microlatex particles of polystyrene and poly(styrene butene diacid) by the use of microwave radiation and under normal ambient pressure is reported. There is no surfactant in the system.The total synthesis time has been reduced from more then 10h(conventional method) to less than 1 h(microwave mothod). The dynamic experimental results indicate that the reaction proecss is very sharp in comparison with conventional polymerization. No constant rate stage existed.展开更多
文摘The current communication reports in vitro characterization of the optimized hollow floating microballoons of amoxicillin on the basis of micromeritic properties and in vitro minimum inhibitory concentration(MIC).Amoxicillin loaded hollow microballoons were prepared by emulsion solvent diffusion method.The morphological characterization was done on the basis of scanning electron microscopy(SEM).Fourier Transformed Infrared Spectroscopy(FTIR)was used to investigate drugepolymer interactions.The correlation between the in vitro buoyancy of microballoons and their physical properties,e.g.density and porosity were elucidated.The results of FTIR spectroscopy revealed the absence of any drugepolymer interactions.The porosity values of more than 69%and diameter to thickness ratio greater than 2.90,proved a high cavity volume within the microballoons in all size ranges.The spherical shape of microballoons with hollow internal cavity was confirmed from SEM photomicrographs.The in vitro MIC results showed a sustained drug effect from the microballoons.In conclusion,it can be said that the developed microballoons can be used for the effective treatment of Helicobacter pylori induced gastric ulcer.
基金financially supported by the National Natural Science Foundation of China under Project NO. 51874267 and NO. 51674229
文摘In this study,hydrogen-storage glass microballoons were introduced into emulsion explosives to improve the detonation performance of the explosives.The effect of hydrogen-storage pressure on the detonation characteristics of emulsion explosives was systematically investigated.Detonation velocity experiments shows that the change of sensitizing gas and the increase of hydrogen pressure have different effects on the detonation velocity.The experimental parameters of underwater explosion increase first and then decreases with the increase of hydrogen pressure.The decrease of these parameters indicates that the strength of glass microballoons is the limiting factor to improve the detonation performance of hydrogen-storage emulsion explosives.Compared with the traditional emulsion explosives,the maximum peak pressure of shock wave of hydrogen-storage emulsion explosives increases by 10.6%at 1.0 m and 10.2%at 1.2 m,the maximum values of shock impulse increase by 5.7%at 1.0 m and 19.4%at 1.2 m.The stored hydrogen has dual effects of sensitizers and energetic additives,which can improve the energy output of emulsion explosives.
文摘Background Percutaneous microballoon compression （PMC） for trigeminal neuralgia is an important therapeutic method. The aim of this study was to review the effects of PMC for trigeminal neuralgia in 276 patients. Methods From December 2000 to May 2003, 276 patients with trigeminal neuralgia were treated with PMC. The course of the disease ranged from 3 months to 38 years. Under the guidance of C-arm X-ray, 14# needle was placed into the foramen ovale using the classical Hakanson＇s technique. Fogarty balloon catheter was navigated into the Meckel＇s cave tenderly. A small amount of Omnipaque was slowly injected to inflate the balloon and compress the trigeminal ganglion for 3 to10 minutes. Results A total of 290 PMC were performed on the 276 patients. Among them, 252 had immediate relief from pain. The patients were followed up for a mean of 18.7 months （range, 4 to 32）, 14 of them had a recurrence. Of the 14 patients, 12 were re-operated with PMC, and the pain was all controlled successfully. Conclusions PMC is an effective and technically simple method for trigeminal neuralgia. For older patients with trigeminal neuralgia, it may be the first choice.
文摘目的探讨C臂CT引导下经皮三叉神经半月节球囊压迫术治疗三叉神经痛的应用价值。方法回顾性分析采用C臂CT(Xper-CT)引导下经皮三叉神经半月节球襄压迫术治疗三叉神经痛患者40例,所有患者均进行C臂CT程序扫描,并通过X-travision工作站进行颅骨后处理重建,引导穿刺针进入卵圆孔及球囊到位,确定球囊头端位于Meckel’s腔,充盈球囊。术后记录手术剂量面积乘积(dose area product,DAP)、空气比释动能(cumulative air kerma,CAK)、曝光时间(fluo time,FT),分析辐射剂量。结果40例患者均通过C臂CT后处理重建技术引导卵圆孔穿刺成功(其中小卵圆孔2例);40例患者中通过C臂CT后处理重建技术确定球囊一次性到位并获得满意梨形21例(52%),通过C臂CT后处理重建技术分析后多次调整球囊位置及方向,使球囊头端位于岩骨切迹,并获得满意梨形12例(30%),7例(18%)患者未获得满意梨形。术后40例患者疼痛完全消失17例(42%),疼痛满意缓解21例(53%);疼痛缓解不满意2例(5%);总有效率95%。术后伴面部麻木26例(65%),咀嚼肌无力9例(23%)。40例患者DAP、CAK、FT分别为(79.39±23.15)Gycm^(2)、(245.07±84.04)mGy、(5.20±1.30)min。结论C臂CT引导下经皮三叉神经半月节球囊压迫术直观准确显示穿刺针、卵圆孔、球囊、岩骨脊的三维结构及其相互位置关系,尤其对解剖变异或异常增生的显示更具优势。
文摘目的比较微球囊压迫与卡马西平治疗三叉神经痛的效果及安全性。方法选取收治的120例原发性三叉神经痛患者,用随机数字表法均分为微球囊压迫组和药物治疗组,每组60例。微球囊压迫组采用经皮穿刺微球囊神经节压迫治疗,药物治疗组口服卡马西平治疗。比较2组治疗结束后的临床疗效、治疗前后的疼痛视觉模拟评分(visual analogue scale,VAS)和生活质量综合评定问卷-74(general quality of life inventory-74,GQOL-74)评分、治疗前后血清炎症因子[白细胞介素-1β(interleukin-1β,IL-1β)、白细胞介素-6(interleukin-6,IL-6)及肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)]的水平。比较2组不良反应的发生情况。结果微球囊压迫组的治疗总有效率高于药物治疗组(91.67%vs.75.00%,P<0.05)。治疗后,微球囊压迫组患者各时间点的VAS均低于药物治疗组,GQOL-74评分均高于药物治疗组(P<0.05)。与治疗前比较,2组患者血清IL-1β、IL-6、TNF-α的水平均明显降低(P<0.05),但2组比较差异无统计学意义(P>0.05)。微球囊压迫组术后不良反应的发生率为6.67%,显著低于药物治疗组(20.00%)(P<0.05)。结论微球囊压迫与口服卡马西平均对三叉神经痛有明显效果,且均能降低患者血清炎症因子的水平、缓解患者的疼痛症状,但与口服卡马西平比较,微球囊压迫的疗效更好,且安全性更高。
文摘The preparation of monodisperse colloidal microlatex particles of polystyrene and poly(styrene butene diacid) by the use of microwave radiation and under normal ambient pressure is reported. There is no surfactant in the system.The total synthesis time has been reduced from more then 10h(conventional method) to less than 1 h(microwave mothod). The dynamic experimental results indicate that the reaction proecss is very sharp in comparison with conventional polymerization. No constant rate stage existed.
