Stochastic characterization of radiation interaction is of importance to cell damage. Microdosimetry is to investi- gate the random structures of particle tracks in order to understand the dose-effect in cellular scal...Stochastic characterization of radiation interaction is of importance to cell damage. Microdosimetry is to investi- gate the random structures of particle tracks in order to understand the dose-effect in cellular scales. In the review, we introduced the basic concepts of microdosimetry as well as the experimental methods （TEPC） and Monte Carlo simula- tions. Three basic biophysical models are interpreted and compared, including the target model, linear-quadratic model, and microdosimetric-kinetic model. The bottlenecks in the current microdosimetry research are also discussed, which need the interdisciplinary contributions from biology, physics, mathematics, computer science and electric engineering.展开更多
Single particle microbeam （SPM） is uniquely capable of delivering precisely the predefined number of charged particles to determined individual cells or sub-cellular targets in situ. It has been recognized as a powe...Single particle microbeam （SPM） is uniquely capable of delivering precisely the predefined number of charged particles to determined individual cells or sub-cellular targets in situ. It has been recognized as a powerful technique for unveiling ionization irradiation mechanisms of organism. This article describes some investigations on the irradiation quality of SPM of major world laboratories by means of Monte Carlo method based on dosimetry and microdosimetry. Those parameters are helpful not only to improve SPM irradiating cell experiments but also to study the biological effects of cells irradiated by SPM.展开更多
基金Project supported by the National Natural Science Foundation of China(Grant Nos.11304212 and 11575124)the Natural Science Foundation of Jiangsu Province,China(Grant Nos.BK20130279)+1 种基金the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)the International Thermonuclear Experimental Reactor(ITER)Special Program of China(Grant No.2014GB112006)
文摘Stochastic characterization of radiation interaction is of importance to cell damage. Microdosimetry is to investi- gate the random structures of particle tracks in order to understand the dose-effect in cellular scales. In the review, we introduced the basic concepts of microdosimetry as well as the experimental methods （TEPC） and Monte Carlo simula- tions. Three basic biophysical models are interpreted and compared, including the target model, linear-quadratic model, and microdosimetric-kinetic model. The bottlenecks in the current microdosimetry research are also discussed, which need the interdisciplinary contributions from biology, physics, mathematics, computer science and electric engineering.
基金the National Science Foundation for Distinguished Young Scholars of China(No.10225526)the Knowledge Innovation Program of the Chinese Academy Sciences(No.KSCX2-SW-324)the Foundation for University Key Teachers by the Ministry of Education of China(No.2005jq1135)
文摘Single particle microbeam （SPM） is uniquely capable of delivering precisely the predefined number of charged particles to determined individual cells or sub-cellular targets in situ. It has been recognized as a powerful technique for unveiling ionization irradiation mechanisms of organism. This article describes some investigations on the irradiation quality of SPM of major world laboratories by means of Monte Carlo method based on dosimetry and microdosimetry. Those parameters are helpful not only to improve SPM irradiating cell experiments but also to study the biological effects of cells irradiated by SPM.
