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Extraluminal factors contributing to inflammatory bowel disease 被引量:3
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作者 Arvind Batra Thorsten Stroh Britta Siegmund 《World Journal of Gastroenterology》 SCIE CAS CSCD 2011年第5期572-577,共6页
Many identified and yet unknown factors contribute to the pathogenesis of inflammatory bowel disease(IBD).The genome-wide association studies clearly support the earlier developed concept that IBD occurs in geneticall... Many identified and yet unknown factors contribute to the pathogenesis of inflammatory bowel disease(IBD).The genome-wide association studies clearly support the earlier developed concept that IBD occurs in genetically predisposed individuals who are exposed to distinct environmental factors,which together result in dysregulation of the mucosal immune system.Thus,the majority of previous studies have focused on the immune response within the intestinal wall.The present review aims to emphasize the contribution of three extraluminal structures to this inflammatory process,namely the mesenteric fat tissue,the lymphatics and the microvasculature.Broadening our view across the intestinal wall will not only facilitate our understanding of the disease,but will also us to identify future therapeutic targets. 展开更多
关键词 Inflammatory bowel disease Extraluminalstructures Mesenteric fat tissue LYMPHATICS microvas-culature
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